JP2018524338A5 - - Google Patents

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JP2018524338A5
JP2018524338A5 JP2017567489A JP2017567489A JP2018524338A5 JP 2018524338 A5 JP2018524338 A5 JP 2018524338A5 JP 2017567489 A JP2017567489 A JP 2017567489A JP 2017567489 A JP2017567489 A JP 2017567489A JP 2018524338 A5 JP2018524338 A5 JP 2018524338A5
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JP6745824B2 (ja
JP2018524338A (ja
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Priority claimed from PCT/JP2016/069189 external-priority patent/WO2016208775A1/en
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JP2017567489A 2015-06-26 2016-06-23 複素環化合物 Active JP6745824B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2015129043 2015-06-26
JP2015129043 2015-06-26
JP2015206797 2015-10-20
JP2015206797 2015-10-20
PCT/JP2016/069189 WO2016208775A1 (en) 2015-06-26 2016-06-23 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor

Publications (3)

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JP2018524338A JP2018524338A (ja) 2018-08-30
JP2018524338A5 true JP2018524338A5 (cg-RX-API-DMAC10.html) 2019-07-25
JP6745824B2 JP6745824B2 (ja) 2020-08-26

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JP2017567489A Active JP6745824B2 (ja) 2015-06-26 2016-06-23 複素環化合物

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US (5) US10323027B2 (cg-RX-API-DMAC10.html)
EP (1) EP3313836B1 (cg-RX-API-DMAC10.html)
JP (1) JP6745824B2 (cg-RX-API-DMAC10.html)
KR (1) KR20180019234A (cg-RX-API-DMAC10.html)
CN (1) CN107922403A (cg-RX-API-DMAC10.html)
AU (1) AU2016284654B9 (cg-RX-API-DMAC10.html)
CA (1) CA2988572A1 (cg-RX-API-DMAC10.html)
CL (1) CL2017003127A1 (cg-RX-API-DMAC10.html)
CO (1) CO2017012859A2 (cg-RX-API-DMAC10.html)
CR (1) CR20170568A (cg-RX-API-DMAC10.html)
DO (1) DOP2017000309A (cg-RX-API-DMAC10.html)
EA (1) EA201890152A1 (cg-RX-API-DMAC10.html)
HK (1) HK1248698A1 (cg-RX-API-DMAC10.html)
IL (1) IL256059A (cg-RX-API-DMAC10.html)
MX (1) MX2017016875A (cg-RX-API-DMAC10.html)
PE (1) PE20180500A1 (cg-RX-API-DMAC10.html)
PH (1) PH12017502351A1 (cg-RX-API-DMAC10.html)
TN (1) TN2017000508A1 (cg-RX-API-DMAC10.html)
TW (1) TW201710255A (cg-RX-API-DMAC10.html)
UA (1) UA121503C2 (cg-RX-API-DMAC10.html)
UY (1) UY36750A (cg-RX-API-DMAC10.html)
WO (1) WO2016208775A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201708387B (cg-RX-API-DMAC10.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2988572A1 (en) * 2015-06-26 2016-12-29 Takeda Pharmaceutical Company Limited 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor
WO2016206101A1 (en) 2015-06-26 2016-12-29 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
EP3366679B1 (en) 2015-10-20 2021-03-24 Takeda Pharmaceutical Company Limited Heterocyclic compound
JP6860551B2 (ja) 2016-03-11 2021-04-14 武田薬品工業株式会社 芳香環化合物
CA3054773A1 (en) * 2017-02-28 2018-09-07 Takeda Pharmaceutical Company Limited Method for producing heterocyclic compound
JP7145875B2 (ja) 2017-04-18 2022-10-03 武田薬品工業株式会社 アセチルコリン受容体のモジュレーターとして有用な複素環化合物
EP3627152A4 (en) 2017-05-19 2021-02-24 Takeda Pharmaceutical Company Limited Screening method
CN110709401B (zh) 2017-06-20 2023-06-13 武田药品工业株式会社 杂环化合物
HRP20231236T1 (hr) 2017-06-20 2024-02-16 Takeda Pharmaceutical Company Limited Heterociklički spoj i njegova uporaba kao pozitivnog alosteričnog modulatora kolinergičkog muskarinskog m1 receptora
AU2019351469B2 (en) * 2018-09-28 2024-10-03 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2020067456A1 (ja) 2018-09-28 2020-04-02 武田薬品工業株式会社 複素環化合物
EP3858823A4 (en) 2018-09-28 2022-07-06 Takeda Pharmaceutical Company Limited Condensed-cyclic compound
KR102288434B1 (ko) * 2018-10-18 2021-08-12 에이치케이이노엔 주식회사 신규한 (이소프로필-트리아졸릴)피리디닐 치환된 벤조옥사지논 또는 벤조티아지논 유도체 및 이의 용도
EP3870173A4 (en) 2018-10-24 2022-06-22 Vanderbilt University WDR5 INHIBITORS AND MODULATORS
US20220242849A1 (en) * 2019-06-04 2022-08-04 Vanderbilt University Wdr5 inhibitors and modulators
CN114539035B (zh) * 2021-03-10 2023-08-18 山东新时代药业有限公司 一种七氟烷的合成方法
WO2025231260A1 (en) * 2024-05-01 2025-11-06 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m1
WO2025231259A1 (en) * 2024-05-01 2025-11-06 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m1

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5538983A (en) 1990-05-16 1996-07-23 The Rockefeller University Method of treating amyloidosis by modulation of calcium
AU665207B2 (en) 1991-07-29 1995-12-21 Warner-Lambert Company Quinazoline derivatives as acetylcholinesterase inhibitors
IT1255179B (it) 1992-06-26 1995-10-20 Enzo Cereda Azaciclo e azabiciclo alchiliden idrossilamine
US5744476A (en) 1994-06-27 1998-04-28 Interneuron Pharmaceuticals, Inc. Dopamine D1 agonists for the treatment of dementia
JP2992677B2 (ja) 1995-06-05 1999-12-20 武田薬品工業株式会社 骨形成促進医薬組成物
WO1998030243A1 (en) 1997-01-08 1998-07-16 Warner-Lambert Company Acetylcholinesterase inhibitors in combination with muscarinic agonists for the treatment of alzheimer's disease
US6569897B1 (en) 1998-01-16 2003-05-27 Purdue Research Foundation Alkenyldiarylmethane non-nucleoside HIV-1 reverse transcriptase inhibitors
BR9907300A (pt) 1998-01-27 2000-10-24 Aventis Pharm Prod Inc Inibidores do fator xa oxoaza-heterociclila substituìdos
JP2003529531A (ja) 1998-11-25 2003-10-07 アヴェンティス ファーマシューティカルズ インコーポレイテッド 置換オキソアザへテロシクリルXa因子阻害剤
SK1182002A3 (en) 1999-07-28 2002-11-06 Aventis Pharm Prod Inc Substituted oxoazaheterocyclyl compounds
JP2001131173A (ja) 1999-08-23 2001-05-15 Kyorin Pharmaceut Co Ltd 二環式複素環誘導体
JP2005231995A (ja) 1999-12-22 2005-09-02 Meiji Seika Kaisha Ltd オピオイドδ受容体アゴニスト/アンタゴニストとして有用なスピロ化合物
US7084126B1 (en) 2000-05-01 2006-08-01 Healthpartners Research Foundation Methods and compositions for enhancing cellular function through protection of tissue components
JP2004502655A (ja) 2000-06-30 2004-01-29 イーライ・リリー・アンド・カンパニー 精神病の処置のための組み合わせ療法
AU2002245692A1 (en) 2001-03-15 2002-10-03 David Pharmaceuticals Methods for restoring cognitive function following systemic stress
US20040023951A1 (en) 2001-06-18 2004-02-05 Bymaster Franklin Porter Combination therapy for treatment of psychoses
US20030004913A1 (en) 2001-07-02 2003-01-02 Koninklijke Philips Electronics N.V. Vision-based method and apparatus for detecting an event requiring assistance or documentation
UA79940C2 (en) 2001-11-26 2007-08-10 Cortex Pharma Inc Carbonylbenzoxazine compounds for enhancing of glutamatergic synaptic responses
US20040044023A1 (en) 2002-08-30 2004-03-04 Marc Cantillon Compositions and methods for treating or preventing memory impairment
US20060233843A1 (en) 2003-02-19 2006-10-19 Conn P J Treatment of psychosis with a muscarinic m1 receptor ectopic activator
RU2358735C2 (ru) 2003-03-28 2009-06-20 Акадиа Фармасьютикалз Инк. Агонисты м1 мускариновых рецепторов для противоболевой терапии
US20040266659A1 (en) 2003-06-27 2004-12-30 Stephen LaBerge Substances that enhance recall and lucidity during dreaming
GB0504019D0 (en) 2005-02-26 2005-04-06 Astrazeneca Ab Amide derivatives
JP2008537961A (ja) 2005-04-15 2008-10-02 ボード、オブ、トラスティーズ、オブ、ミシガン、ステイト、ユニバーシティ Gpcrモジュレーター
GB0516570D0 (en) 2005-08-12 2005-09-21 Astrazeneca Ab Amide derivatives
US20110319386A1 (en) 2005-08-26 2011-12-29 Braincells Inc. Neurogenesis by muscarinic receptor modulation
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
WO2007044937A2 (en) 2005-10-13 2007-04-19 President And Fellows Of Harvard College Compositions and methods to modulate memory
MY159523A (en) 2005-12-21 2017-01-13 Janssen Pharmaceutica Nv Triazolopyridazines as tyrosine kinase modulators
GB0607952D0 (en) 2006-04-21 2006-05-31 Minster Res Ltd Novel treatment
GB0607946D0 (en) 2006-04-21 2006-05-31 Minster Res The Ltd Mono and combination therapy
GB0607949D0 (en) 2006-04-21 2006-05-31 Minster Res The Ltd Mono and combination therapy
PE20121506A1 (es) 2006-07-14 2012-11-26 Amgen Inc Compuestos triazolopiridinas como inhibidores de c-met
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
US8217177B2 (en) 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
US7834023B2 (en) 2006-09-20 2010-11-16 Portola Pharmaceuticals, Inc. Substituted dihydroquinazolines as platelet ADP receptor inhibitors
ES2374995T3 (es) 2007-01-03 2012-02-23 Les Laboratoires Servier Compuesto de [1,2,3]-benzotriazinona 3-sustituido para mejorar las respuestas sinápticas glutamatérgicas.
WO2008113072A2 (en) 2007-03-15 2008-09-18 Board Of Regents, The University Of Texas System Gpcr enhanced neuroprotection to treat brain injury
CA2697454C (en) 2007-08-29 2015-11-03 Schering Corporation 2-carboxy substituted indole derivatives and methods of use thereof
TW200924751A (en) 2007-08-29 2009-06-16 Schering Corp 2,3-substituted indole derivatives and methods of use thereof
MX2010002318A (es) 2007-08-29 2010-03-22 Schering Corp Derivados azaindol 2,3-sustituidos para tratar infecciones virales.
HUE037639T2 (hu) 2007-09-21 2018-09-28 Acadia Pharm Inc Pimavanszerin együttes beadása más szerekkel
CA2700332A1 (en) 2007-09-21 2009-03-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
US8765757B2 (en) 2007-11-16 2014-07-01 Merck Sharp & Dohme Corp. 3-heterocyclic substituted indole derivatives and methods of use thereof
CA2705587A1 (en) 2007-11-16 2009-05-22 Schering Corporation 3-aminosulfonyl substituted indole derivatives and methods of use thereof
US20110024198A1 (en) 2008-02-19 2011-02-03 Baker Hughes Incorporated Bearing systems containing diamond enhanced materials and downhole applications for same
WO2010042603A1 (en) 2008-10-08 2010-04-15 Cingulate Neuro Therapeutics, Llc Amyloid and depression
PE20120031A1 (es) 2008-11-20 2012-02-05 Merck Sharp & Dohme Compuestos aril metil benzoquinazolinona como moduladores alostericos positivos del receptor m1
EP2398324B1 (en) 2009-02-23 2014-09-03 Merck Sharp & Dohme Corp. PYRAZOLO [4,3-c]CINNOLIN-3-ONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
EP2403340A4 (en) 2009-03-05 2012-10-31 Mithridion Inc COMPOUNDS AND COMPOSITIONS FOR IMPROVED PERCEPTION, MANUFACTURING METHOD AND TREATMENT PROCESS
EP2421366B1 (en) 2009-04-20 2013-08-28 Merck Sharp & Dohme Corp. Heterocyclic fused cinnoline m1 receptor positive allosteric modulators
ES2353093B1 (es) 2009-05-20 2012-01-03 Consejo Superior De Investigaciones Científicas (Csic) Uso de derivados de quinazolinas y sus composiciones farmacéuticas en enfermedades neurodegenerativas.
EP3061821B1 (en) 2009-07-22 2019-07-10 Puretech Health LLC Compositions for treatment of disorders ameliorated by muscarinic receptor activation
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
BR112012003464B8 (pt) 2009-08-31 2021-05-25 Merck Sharp & Dohme compostos de piranil aril metil benzoquinaozlinona, uso dos mesmos, e, composição farmacêutica
US8895580B2 (en) 2009-10-21 2014-11-25 Merck Sharp & Dohme Corp. Quinolinone-pyrazolone M1 receptor positive allosteric modulators
EP2512245B1 (en) 2009-12-14 2014-07-23 Merck Sharp & Dohme Corp. Pyridoquinazolinone m1 receptor positive allosteric modulators
US8383638B2 (en) 2009-12-21 2013-02-26 Merck Sharp & Dohme Aminobenzoquinazolinone M1 receptor positive allosteric modulators
EP2582241B1 (en) * 2010-06-15 2016-04-06 Merck Sharp & Dohme Corp. Heterocyclic fused phenanthrolinone m1 receptor positive allosteric modulators
WO2012003147A1 (en) 2010-07-01 2012-01-05 Merck Sharp & Dohme Corp. Isoindolone m1 receptor positive allosteric modulators
WO2012047702A1 (en) * 2010-10-04 2012-04-12 Merck Sharp & Dohme Corp. Dihydrobenzoquinazolinone m1 receptor positive allosteric modulators
WO2012149524A1 (en) 2011-04-29 2012-11-01 The University Of Toledo Muscarinic agonists as enhancers of working memory and cognitive flexibility
WO2012158473A1 (en) * 2011-05-17 2012-11-22 Merck Sharp & Dohme Corp. N-methyl tetrahydroquinoline m1 receptor positive allosteric modulators
WO2012170599A1 (en) 2011-06-10 2012-12-13 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
WO2013129622A1 (ja) 2012-03-02 2013-09-06 武田薬品工業株式会社 複素環化合物およびその用途
KR102109992B1 (ko) 2012-03-23 2020-05-13 피티씨 테라퓨틱스, 인크. 척수성 근위축증을 치료하기 위한 화합물
US20130289019A1 (en) 2012-04-26 2013-10-31 Amazing Grace, Inc. Methods of treating behaviorial and/or mental disorders
JP6211530B2 (ja) 2012-11-19 2017-10-11 武田薬品工業株式会社 含窒素複素環化合物
JP6075408B2 (ja) 2012-11-22 2017-02-08 株式会社デンソー 物標検出装置
RU2642779C2 (ru) 2012-12-27 2018-01-26 Ф.Хоффманн-Ля Рош Аг Ингибиторы сомт
WO2014117920A1 (en) 2013-02-04 2014-08-07 Merck Patent Gmbh Spiro-quinazolinone derivatives useful for the treatment of neurological diseases and conditions
US10738024B2 (en) 2013-05-06 2020-08-11 Indiana University Research And Technology Corporation Compounds for treatment of angiogenesis-mediated diseases
JP6063400B2 (ja) 2014-01-08 2017-01-18 株式会社日立ビルシステム エレベータの異常監視装置
MY195742A (en) 2014-04-23 2023-02-08 Takeda Pharmaceuticals Co Isoindoline-1-One Derivatives as Cholinergic Muscarinic M1 Receptor Positive Alloesteric Modulator Activity for the Treatment of Alzheimers Disease
EP3144308B1 (en) 2014-05-16 2020-06-24 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound
WO2015190564A1 (ja) 2014-06-13 2015-12-17 武田薬品工業株式会社 含窒素複素環化合物
CA2988572A1 (en) * 2015-06-26 2016-12-29 Takeda Pharmaceutical Company Limited 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor
WO2017044693A1 (en) 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
EP3366679B1 (en) 2015-10-20 2021-03-24 Takeda Pharmaceutical Company Limited Heterocyclic compound
JP6860551B2 (ja) 2016-03-11 2021-04-14 武田薬品工業株式会社 芳香環化合物
WO2018122845A1 (en) 2016-12-29 2018-07-05 Rvx Therapeutics Ltd. Methods and compositions for potentiating cns drugs and reducing their side effects

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