JP2018519340A5 - - Google Patents
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- JP2018519340A5 JP2018519340A5 JP2017568408A JP2017568408A JP2018519340A5 JP 2018519340 A5 JP2018519340 A5 JP 2018519340A5 JP 2017568408 A JP2017568408 A JP 2017568408A JP 2017568408 A JP2017568408 A JP 2017568408A JP 2018519340 A5 JP2018519340 A5 JP 2018519340A5
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- clemizole
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- CJXAEXPPLWQRFR-UHFFFAOYSA-N clemizole Chemical compound C1=CC(Cl)=CC=C1CN1C2=CC=CC=C2N=C1CN1CCCC1 CJXAEXPPLWQRFR-UHFFFAOYSA-N 0.000 claims description 57
- 239000008194 pharmaceutical composition Substances 0.000 claims description 47
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- 229950002020 clemizole Drugs 0.000 claims description 37
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- 206010028980 Neoplasm Diseases 0.000 claims description 21
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- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 14
- 208000009011 Cytochrome P-450 CYP3A Inhibitors Diseases 0.000 claims description 10
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 claims description 9
- 229960000311 ritonavir Drugs 0.000 claims description 9
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 claims description 9
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| CN113354581B (zh) * | 2020-03-06 | 2023-06-20 | 华南理工大学 | 手性氯喹及其磷酸盐的制备方法及其应用 |
| CN113527201A (zh) * | 2020-04-14 | 2021-10-22 | 瀚海新拓(杭州)生物医药有限公司 | 光学活性氯喹和羟氯喹及其类似物、其制备方法、组合物和用途 |
| CN111551645B (zh) * | 2020-04-30 | 2022-11-08 | 上海中西三维药业有限公司 | 一种硫酸羟氯喹有关物质的检测方法及其应用 |
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