TWI881480B - 克立咪唑(clemizole)化合物於預防及治療肝癌之用途 - Google Patents

克立咪唑(clemizole)化合物於預防及治療肝癌之用途 Download PDF

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TWI881480B
TWI881480B TW112136665A TW112136665A TWI881480B TW I881480 B TWI881480 B TW I881480B TW 112136665 A TW112136665 A TW 112136665A TW 112136665 A TW112136665 A TW 112136665A TW I881480 B TWI881480 B TW I881480B
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liver
clemizole
compound
chloroquine
individual
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TW112136665A
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TW202402283A (zh
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傑佛瑞 S 葛蘭
愛德華 A 潘
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美商伊格集團國際股份有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW112136665A 2015-06-30 2016-06-30 克立咪唑(clemizole)化合物於預防及治療肝癌之用途 TWI881480B (zh)

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US201562187061P 2015-06-30 2015-06-30
US62/187,061 2015-06-30

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TW202402283A TW202402283A (zh) 2024-01-16
TWI881480B true TWI881480B (zh) 2025-04-21

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TW112136665A TWI881480B (zh) 2015-06-30 2016-06-30 克立咪唑(clemizole)化合物於預防及治療肝癌之用途
TW111123545A TWI830262B (zh) 2015-06-30 2016-06-30 克立咪唑(clemizole)化合物於預防及治療肝癌之用途
TW105120868A TWI771272B (zh) 2015-06-30 2016-06-30 克立咪唑（ｃｌｅｍｉｚｏｌｅ）化合物於預防及治療肝癌之用途

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TW111123545A TWI830262B (zh) 2015-06-30 2016-06-30 克立咪唑(clemizole)化合物於預防及治療肝癌之用途
TW105120868A TWI771272B (zh) 2015-06-30 2016-06-30 克立咪唑（ｃｌｅｍｉｚｏｌｅ）化合物於預防及治療肝癌之用途

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US (3) US10688083B2 (enExample)
EP (1) EP3317274A4 (enExample)
JP (2) JP7068827B2 (enExample)
KR (2) KR20230129590A (enExample)
CN (2) CN113274386A (enExample)
AU (4) AU2016288699B2 (enExample)
CA (2) CA3178499A1 (enExample)
HK (1) HK1249508A1 (enExample)
IL (4) IL300476B2 (enExample)
MX (3) MX394605B (enExample)
NZ (1) NZ776616A (enExample)
TW (3) TWI881480B (enExample)
WO (1) WO2017004454A1 (enExample)
ZA (2) ZA201708471B (enExample)

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CN113527201A (zh) * 2020-04-14 2021-10-22 瀚海新拓(杭州)生物医药有限公司 光学活性氯喹和羟氯喹及其类似物、其制备方法、组合物和用途
CN111551645B (zh) * 2020-04-30 2022-11-08 上海中西三维药业有限公司 一种硫酸羟氯喹有关物质的检测方法及其应用
WO2021217574A1 (en) * 2020-04-30 2021-11-04 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Treatment or prevention of coronaviridae infection
CN111909087A (zh) * 2020-06-15 2020-11-10 珠海润都制药股份有限公司 一种手性氨基氯喹啉的制备方法
CN111662229B (zh) * 2020-07-08 2023-03-24 精华制药集团南通有限公司 一种磷酸氯喹的制备工艺
CN111793026A (zh) * 2020-07-23 2020-10-20 珠海润都制药股份有限公司 一种硫酸羟氯喹及其对映体的晶型和制备方法
CN114057640A (zh) * 2020-08-05 2022-02-18 凯特立斯（深圳）科技有限公司 一种光学纯(r)/(s)-羟氯喹侧链的不对称合成方法
CN112225697B (zh) * 2020-10-16 2023-01-03 宁波大学 一种对映体纯氯喹及磷酸氯喹的制备方法
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CA3178499A1 (en) 2017-01-05
AU2024266943A1 (en) 2024-12-19
BR112017028601A2 (pt) 2018-08-28
NZ776616A (en) 2024-11-29
JP2022105149A (ja) 2022-07-12
WO2017004454A8 (en) 2018-01-25
MX2017016681A (es) 2018-07-06
IL310969A (en) 2024-04-01
IL279020B2 (en) 2023-07-01
TW202317103A (zh) 2023-05-01
KR20180032578A (ko) 2018-03-30
WO2017004454A1 (en) 2017-01-05
MX2023003792A (es) 2023-04-26
TW202402283A (zh) 2024-01-16
KR20230129590A (ko) 2023-09-08
US20180200228A1 (en) 2018-07-19
IL300476A (en) 2023-04-01
AU2021201234A1 (en) 2021-03-11
CA2989634A1 (en) 2017-01-05
AU2016288699A1 (en) 2018-01-18
ZA202004136B (en) 2025-08-27
HK1249508A1 (zh) 2018-11-02
TW201717941A (zh) 2017-06-01
TWI830262B (zh) 2024-01-21
AU2023201397A1 (en) 2023-04-06
JP2018519340A (ja) 2018-07-19
US12090141B2 (en) 2024-09-17
ZA201708471B (en) 2022-05-25
MX394605B (es) 2025-03-24
IL279020A (enExample) 2020-12-31
MX2022008100A (es) 2022-07-11
EP3317274A4 (en) 2019-05-08
NZ738291A (en) 2021-06-25
US20240398761A1 (en) 2024-12-05
US10688083B2 (en) 2020-06-23
JP7068827B2 (ja) 2022-05-17
CN107922404A (zh) 2018-04-17
JP2024083475A (ja) 2024-06-21
IL279020B1 (en) 2023-03-01
CN107922404B (zh) 2021-06-29
CA2989634C (en) 2022-12-06
TWI771272B (zh) 2022-07-21
AU2023201397B2 (en) 2024-10-03
IL300476B1 (en) 2024-03-01
IL256233A (en) 2018-02-28
US20210052553A1 (en) 2021-02-25
JP7470151B2 (ja) 2024-04-17
IL300476B2 (en) 2024-07-01
EP3317274A1 (en) 2018-05-09
AU2016288699B2 (en) 2020-11-26
CN113274386A (zh) 2021-08-20

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