JP2018517900A5 - - Google Patents
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- Publication number
- JP2018517900A5 JP2018517900A5 JP2017557438A JP2017557438A JP2018517900A5 JP 2018517900 A5 JP2018517900 A5 JP 2018517900A5 JP 2017557438 A JP2017557438 A JP 2017557438A JP 2017557438 A JP2017557438 A JP 2017557438A JP 2018517900 A5 JP2018517900 A5 JP 2018517900A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- medium
- stem cells
- tgfβ1
- measuring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 17
- 238000000034 method Methods 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 11
- 239000002609 medium Substances 0.000 claims 6
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- 239000001963 growth medium Substances 0.000 claims 3
- 238000002965 ELISA Methods 0.000 claims 2
- 206010061246 Intervertebral disc degeneration Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 208000018180 degenerative disc disease Diseases 0.000 claims 2
- 208000021600 intervertebral disc degenerative disease Diseases 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 1
- 241001137251 Corvidae Species 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000007640 basal medium Substances 0.000 claims 1
- 229940098773 bovine serum albumin Drugs 0.000 claims 1
- 230000002648 chondrogenic effect Effects 0.000 claims 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 1
- 229940099552 hyaluronan Drugs 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 238000010899 nucleation Methods 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020190850A JP7335222B2 (ja) | 2015-05-05 | 2020-11-17 | 効力検定 |
| JP2023132587A JP7754893B2 (ja) | 2015-05-05 | 2023-08-16 | 効力検定 |
| JP2025165654A JP2026012704A (ja) | 2015-05-05 | 2025-10-01 | 効力検定 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015901605A AU2015901605A0 (en) | 2015-05-05 | Potency assay | |
| AU2015901605 | 2015-05-05 | ||
| PCT/EP2016/060049 WO2016177805A1 (en) | 2015-05-05 | 2016-05-04 | Potency assay |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020190850A Division JP7335222B2 (ja) | 2015-05-05 | 2020-11-17 | 効力検定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018517900A JP2018517900A (ja) | 2018-07-05 |
| JP2018517900A5 true JP2018517900A5 (https=) | 2019-06-06 |
| JP6797833B2 JP6797833B2 (ja) | 2020-12-09 |
Family
ID=56087237
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557438A Active JP6797833B2 (ja) | 2015-05-05 | 2016-05-04 | 効力検定 |
| JP2020190850A Active JP7335222B2 (ja) | 2015-05-05 | 2020-11-17 | 効力検定 |
| JP2023132587A Active JP7754893B2 (ja) | 2015-05-05 | 2023-08-16 | 効力検定 |
| JP2025165654A Pending JP2026012704A (ja) | 2015-05-05 | 2025-10-01 | 効力検定 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020190850A Active JP7335222B2 (ja) | 2015-05-05 | 2020-11-17 | 効力検定 |
| JP2023132587A Active JP7754893B2 (ja) | 2015-05-05 | 2023-08-16 | 効力検定 |
| JP2025165654A Pending JP2026012704A (ja) | 2015-05-05 | 2025-10-01 | 効力検定 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11795435B2 (https=) |
| EP (2) | EP3292199B1 (https=) |
| JP (4) | JP6797833B2 (https=) |
| KR (2) | KR102582602B1 (https=) |
| CN (2) | CN115141872A (https=) |
| AU (3) | AU2016258980B2 (https=) |
| CA (1) | CA2984987C (https=) |
| ES (2) | ES3018944T3 (https=) |
| WO (1) | WO2016177805A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202004680UA (en) | 2017-11-22 | 2020-06-29 | Mesoblast Int Sarl | Cellular compositions and methods of treatment i |
| CA3112505C (en) * | 2018-09-20 | 2023-06-20 | Citospin, S.L. | Method for obtaining an enriched population of functional mesenchymal stem cells, cells obtained thereof and compositions comprising the same |
| JP2022515916A (ja) * | 2019-01-02 | 2022-02-22 | メゾブラスト・インターナショナル・エスアーエールエル | 腰痛を治療するための方法 |
| US20230221303A1 (en) * | 2020-04-20 | 2023-07-13 | Longeveron Inc. | Potency assay |
| KR20240101473A (ko) * | 2022-12-23 | 2024-07-02 | 주식회사 강스템바이오텍 | 연골 분화능이 증진된 줄기세포의 선별 방법 및 이를 포함하는 세포 치료제 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3089815A (en) | 1951-10-11 | 1963-05-14 | Lieb Hans | Injectable pharmaceutical preparation, and a method of making same |
| US4593089A (en) | 1980-07-30 | 1986-06-03 | Abbott Laboratories | Fluorescent polarization immunoassay utilizing substituted triazinylaminofluorescein aminoglycosides |
| US4751190A (en) | 1985-07-22 | 1988-06-14 | Abbott Laboratories | Fluorescence polarization immunoassay and reagents for use therein |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US4983393A (en) | 1987-07-21 | 1991-01-08 | Maximed Corporation | Intra-vaginal device and method for sustained drug release |
| AU8200191A (en) | 1990-07-09 | 1992-02-04 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | High efficiency packaging of mutant adeno-associated virus using amber suppressions |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| DE69233013T2 (de) | 1991-08-20 | 2004-03-04 | The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer | Adenovirus vermittelter gentransfer in den gastrointestinaltrakt |
| DE4211351A1 (de) | 1992-04-04 | 1993-10-07 | Behringwerke Ag | Verfahren zur Analyse partikelverstärkter Agglutinationsreaktionen auf Zentrifugalanalysatoren durch Bestimmung der Trübungsaufhellung |
| WO1994026877A1 (en) | 1993-05-17 | 1994-11-24 | The Regents Of The University Of California | Ribozyme gene therapy for hiv infection and aids |
| US6541213B1 (en) | 1996-03-29 | 2003-04-01 | University Of Washington | Microscale diffusion immunoassay |
| CA2244326C (en) | 1997-08-11 | 2006-03-28 | Shinichi Eda | Microparticle enhanced light scattering agglutination assay and microparticle reagents therefor |
| US6566051B1 (en) | 1999-01-15 | 2003-05-20 | Medtox Scientific, Inc. | Lateral flow test strip |
| AU2003901668A0 (en) | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| WO2001097872A1 (en) | 2000-06-22 | 2001-12-27 | Austin Sam L | Bioadhesive compositions and methods of preparation and use |
| US7205159B2 (en) | 2001-08-20 | 2007-04-17 | Proteome Systems Intellectual Property Pty Ltd. | Diagnostic testing process and apparatus |
| WO2004046729A2 (en) | 2002-11-21 | 2004-06-03 | The University Of Leicester | Bodily fluid markers of tissue hypoxia |
| CN101248171B (zh) | 2005-04-12 | 2015-11-25 | 迈索布拉斯特股份有限公司 | 通过组织非特异性碱性磷酸酶分离成人多潜能细胞 |
| KR100802011B1 (ko) * | 2005-08-10 | 2008-02-12 | 인하대학교 산학협력단 | 층분리배양법을 이용한 골수에서의 중간엽 줄기세포분리방법 |
| JP2011196840A (ja) * | 2010-03-19 | 2011-10-06 | Univ Of Tokyo | 急性大動脈解離の検査方法 |
| BE1020528A3 (fr) * | 2011-10-11 | 2013-12-03 | Bone Therapeutics Sa | Utilisations du facteur de croissance et differenciation 8 (gdf 8). |
| SG11201509430WA (en) | 2013-05-16 | 2015-12-30 | Agency Science Tech & Res | Heparan sulphates |
| KR20150016117A (ko) | 2013-07-30 | 2015-02-11 | 코아스템(주) | 인간 골수 유래 중간엽 줄기세포를 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 약제학적 조성물 |
| CN103990181B (zh) * | 2014-05-26 | 2015-07-08 | 中国人民解放军第四军医大学 | 一种具有诱导活性微载体-细胞复合物的制备方法及其应用 |
-
2016
- 2016-05-04 AU AU2016258980A patent/AU2016258980B2/en active Active
- 2016-05-04 JP JP2017557438A patent/JP6797833B2/ja active Active
- 2016-05-04 EP EP16725775.7A patent/EP3292199B1/en active Active
- 2016-05-04 CN CN202210727621.4A patent/CN115141872A/zh active Pending
- 2016-05-04 WO PCT/EP2016/060049 patent/WO2016177805A1/en not_active Ceased
- 2016-05-04 ES ES22150277T patent/ES3018944T3/es active Active
- 2016-05-04 ES ES16725775T patent/ES2911266T3/es active Active
- 2016-05-04 EP EP22150277.6A patent/EP4015624B1/en active Active
- 2016-05-04 CA CA2984987A patent/CA2984987C/en active Active
- 2016-05-04 US US15/571,178 patent/US11795435B2/en active Active
- 2016-05-04 KR KR1020177034098A patent/KR102582602B1/ko active Active
- 2016-05-04 KR KR1020237032315A patent/KR102885856B1/ko active Active
- 2016-05-04 CN CN201680030528.0A patent/CN107771220B/zh active Active
-
2020
- 2020-11-17 JP JP2020190850A patent/JP7335222B2/ja active Active
-
2022
- 2022-05-11 AU AU2022203140A patent/AU2022203140B2/en active Active
-
2023
- 2023-08-16 JP JP2023132587A patent/JP7754893B2/ja active Active
- 2023-09-06 US US18/461,866 patent/US20240076621A1/en not_active Abandoned
-
2024
- 2024-08-20 US US18/810,282 patent/US20240409898A1/en active Pending
-
2025
- 2025-07-02 AU AU2025205043A patent/AU2025205043A1/en active Pending
- 2025-10-01 JP JP2025165654A patent/JP2026012704A/ja active Pending
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