JP2018517759A5 - - Google Patents
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- JP2018517759A5 JP2018517759A5 JP2017566021A JP2017566021A JP2018517759A5 JP 2018517759 A5 JP2018517759 A5 JP 2018517759A5 JP 2017566021 A JP2017566021 A JP 2017566021A JP 2017566021 A JP2017566021 A JP 2017566021A JP 2018517759 A5 JP2018517759 A5 JP 2018517759A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- dcp
- subject
- leukemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- IIJQICKYWPGJDT-UHFFFAOYSA-L azane;cyclobutane-1,1-dicarboxylate;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound N.N.[Pt+2].OC(=O)C1(C([O-])=O)CCC1.OC(=O)C1(C([O-])=O)CCC1 IIJQICKYWPGJDT-UHFFFAOYSA-L 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- 230000003211 malignant effect Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 1
- 241001116389 Aloe Species 0.000 claims 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000009098 adjuvant therapy Methods 0.000 claims 1
- 235000011399 aloe vera Nutrition 0.000 claims 1
- AENCTOAEVOLYHR-UHFFFAOYSA-N azanide cyclobutane-1,1-dicarboxylic acid platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1.OC(=O)C1(C(O)=O)CCC1 AENCTOAEVOLYHR-UHFFFAOYSA-N 0.000 claims 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 1
- 229960001467 bortezomib Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 1
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 1
- 229940110767 coenzyme Q10 Drugs 0.000 claims 1
- 229940109262 curcumin Drugs 0.000 claims 1
- 235000012754 curcumin Nutrition 0.000 claims 1
- 239000004148 curcumin Substances 0.000 claims 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 235000003969 glutathione Nutrition 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000001167 myeloblast Anatomy 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562182124P | 2015-06-19 | 2015-06-19 | |
| US62/182,124 | 2015-06-19 | ||
| PCT/US2016/038333 WO2016205782A1 (en) | 2015-06-19 | 2016-06-20 | Composition containing carboplatin and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018517759A JP2018517759A (ja) | 2018-07-05 |
| JP2018517759A5 true JP2018517759A5 (cg-RX-API-DMAC7.html) | 2019-07-11 |
Family
ID=57546650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566021A Pending JP2018517759A (ja) | 2015-06-19 | 2016-06-20 | カルボプラチンを含む組成物及び用途 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10980768B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3297440A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2018517759A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20180014834A (cg-RX-API-DMAC7.html) |
| CN (1) | CN108697093A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016279096B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112017027277A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2988989A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016205782A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017024727A2 (pt) | 2015-05-18 | 2018-07-31 | Syn Nat Products Entpr Llc | cocristal, composição farmacêutica, método de tratamento de uma doença em um indivíduo e processo de produção de um cocristal |
| BR112017027277A2 (pt) | 2015-06-19 | 2018-09-04 | Syn Nat Products Entpr Llc | ?método para o tratamento ou prevenção de uma doença e métodos para matar uma célula? |
| AU2016279099B2 (en) | 2015-06-19 | 2021-09-23 | Syn-Nat Products Enterprise LLC | Pharmaceutical composition of carboplatin based co-crystals and use thereof |
| CN107847521A (zh) | 2015-06-25 | 2018-03-27 | 新纳特产品公司 | 药物共晶组合物及其用途 |
| AU2018372753B2 (en) * | 2017-11-21 | 2024-03-21 | Medoncare Pharmaceutical Co., Ltd | Combination product comprising dicycloplatin and preparation method and use thereof |
| CN108884119A (zh) * | 2018-02-22 | 2018-11-23 | 昆明贵研药业有限公司 | 一种双二羧酸二氨络铂(ii)衍生物的制备方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922689A (en) | 1995-09-11 | 1999-07-13 | Unitech Pharmaceuticals, Inc. | Cisplatin analogs for cancer treatment |
| US6297245B1 (en) | 1998-08-04 | 2001-10-02 | Unitech Pharmaceuticals | Cisplatin and folic acid administered to treat breast cancer |
| KR100317473B1 (ko) | 1999-05-11 | 2001-12-22 | 이계호 | 신규의 백금(ｉｖ)착제 및 그 제조방법 |
| CN1121380C (zh) * | 2000-03-03 | 2003-09-17 | 北京兴大豪斯科技有限公司 | 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物 |
| CN1314357A (zh) * | 2000-03-16 | 2001-09-26 | 杨旭清 | 双环酸铂抗癌药 |
| AUPQ641100A0 (en) | 2000-03-23 | 2000-04-15 | Australia Nuclear Science & Technology Organisation | Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents |
| JP2004532260A (ja) | 2001-05-31 | 2004-10-21 | ザ チャイニーズ ユニバーシティ オブ ホンコン | デメチルカンタリジンをプラチナ含有抗がん剤と組み合わせて含む組成物およびその用途 |
| US7259270B2 (en) | 2001-11-30 | 2007-08-21 | Jingzun Wang | Supermolecular carboplatin derivatives, their preparation and pharmaceutical composition containing them as active ingredient and applications of the compositions |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| GEP20074134B (en) | 2002-08-19 | 2007-06-25 | Pfizer Prod Inc | Combination therapy for hyperproliferative diseases |
| WO2005016946A2 (en) | 2003-08-13 | 2005-02-24 | University Of South Florida | Platinum complexes for the treatment of tumors |
| DE602004025726D1 (de) * | 2003-11-14 | 2010-04-08 | Genvec Inc | Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc). |
| MX2007008810A (es) | 2005-01-21 | 2007-11-21 | Astex Therapeutics Ltd | Compuestos farmaceuticos. |
| CN100391437C (zh) * | 2005-09-12 | 2008-06-04 | 重庆医科大学附属第二医院 | 抗急性髓性白血病的gm-csf靶向药物脂质体及制备方法 |
| BRPI0708004A2 (pt) | 2006-01-30 | 2011-05-17 | Platco Technologies Proprietary Ltd | preparação de complexos de platina (ii) |
| CN1857221A (zh) * | 2006-04-14 | 2006-11-08 | 济南帅华医药科技有限公司 | 一种同载铂类化合物及其增效剂的抗癌缓释剂 |
| ES2556677T3 (es) * | 2006-08-02 | 2016-01-19 | Sunesis Pharmaceuticals, Inc. | Utilización combinada de ácido (+)-1,4-dihidro-7-[(3S,4S)-3-metoxi-4-(metilamino)-1-pirrolidinil]-4-oxo-1-(2-tiazolil)-1,8-naftiridin-3-carboxílico y citarabina (Ara-C) para el tratamiento de la leucemia |
| NZ591394A (en) * | 2008-09-15 | 2013-03-28 | Kasina Laila Innova Pharmaceuticals Private Ltd | Anti-cancer drugs and uses relating thereto for metastatic malignant melanoma and other cancers |
| CZ302618B6 (cs) | 2009-09-10 | 2011-08-03 | Univerzita Palackého | Cyklobutan-1,1-dikarboxylátokomplexy platiny s deriváty N6-benzyladeninu, zpusoby jejich prípravy a použití techto komplexu jako léciv v protinádorové terapii |
| US20110287110A1 (en) * | 2010-04-23 | 2011-11-24 | Mark Wesley Dewhirst | Combination cancer treatment |
| JP6091431B2 (ja) * | 2011-01-31 | 2017-03-15 | ルコラス−エム．ディー．リミテッド | 医薬的使用 |
| CN102924528B (zh) * | 2012-10-29 | 2015-04-15 | 东南大学 | 抗肿瘤二价铂配合物以及该配合物和其配体的制备方法 |
| EP2924044B1 (en) * | 2012-11-17 | 2018-10-31 | Beijing Shuobai Pharmaceutical Co., LTD | Platinum compound of malonic acid derivative having leaving group containing amino or alkylamino |
| CN103494838B (zh) | 2013-09-30 | 2016-05-11 | 武汉大学 | 一种化疗药物组合物 |
| MX361488B (es) | 2013-10-17 | 2018-12-07 | Vertex Pharma | Cocristales de (s)-n-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il ) amino)propan-2-il)quinolina-4-carboxamida y sus derivados deuterados como inhibidores de proteínas cinasa dependientes de adn (adn-pk). |
| CN111638234B (zh) * | 2014-08-13 | 2024-09-03 | 北京默加农生物技术发展有限公司 | 一种以双环铂为有效成分的药物的检测方法 |
| CN104127402B (zh) * | 2014-08-15 | 2019-08-30 | 北京默加农生物技术发展有限公司 | 双环铂在制备抗病毒药物和抗菌药物中的应用 |
| CN104693245A (zh) * | 2015-03-13 | 2015-06-10 | 卓越同达医药科技开发（苏州）有限公司 | 超分子抗癌药物双环铂的制备方法 |
| KR102432526B1 (ko) | 2015-04-10 | 2022-08-12 | 신-낫 프로덕츠 엔터프라이즈 엘엘씨 | 디시클로플라틴의 제조방법 |
| KR102569221B1 (ko) | 2015-04-22 | 2023-08-21 | 신-낫 프로덕츠 엔터프라이즈 엘엘씨 | 공결정 조성물 및 그의 약제학적 용도 |
| BR112017024727A2 (pt) | 2015-05-18 | 2018-07-31 | Syn Nat Products Entpr Llc | cocristal, composição farmacêutica, método de tratamento de uma doença em um indivíduo e processo de produção de um cocristal |
| AU2016279099B2 (en) | 2015-06-19 | 2021-09-23 | Syn-Nat Products Enterprise LLC | Pharmaceutical composition of carboplatin based co-crystals and use thereof |
| BR112017027277A2 (pt) | 2015-06-19 | 2018-09-04 | Syn Nat Products Entpr Llc | ?método para o tratamento ou prevenção de uma doença e métodos para matar uma célula? |
| CN107847521A (zh) | 2015-06-25 | 2018-03-27 | 新纳特产品公司 | 药物共晶组合物及其用途 |
-
2016
- 2016-06-20 BR BR112017027277A patent/BR112017027277A2/pt not_active IP Right Cessation
- 2016-06-20 US US15/736,170 patent/US10980768B2/en active Active
- 2016-06-20 CA CA2988989A patent/CA2988989A1/en not_active Abandoned
- 2016-06-20 KR KR1020187001614A patent/KR20180014834A/ko not_active Ceased
- 2016-06-20 CN CN201680035788.7A patent/CN108697093A/zh active Pending
- 2016-06-20 WO PCT/US2016/038333 patent/WO2016205782A1/en not_active Ceased
- 2016-06-20 JP JP2017566021A patent/JP2018517759A/ja active Pending
- 2016-06-20 EP EP16812606.8A patent/EP3297440A4/en not_active Withdrawn
- 2016-06-20 AU AU2016279096A patent/AU2016279096B2/en not_active Ceased