JP2018517717A5 - - Google Patents

Download PDF

Info

Publication number
JP2018517717A5
JP2018517717A5 JP2017564097A JP2017564097A JP2018517717A5 JP 2018517717 A5 JP2018517717 A5 JP 2018517717A5 JP 2017564097 A JP2017564097 A JP 2017564097A JP 2017564097 A JP2017564097 A JP 2017564097A JP 2018517717 A5 JP2018517717 A5 JP 2018517717A5
Authority
JP
Japan
Prior art keywords
dosage form
weight
estetrol
solid pharmaceutical
pharmaceutical dosage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017564097A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018517717A (ja
JP6863547B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2016/064074 external-priority patent/WO2016203011A1/en
Publication of JP2018517717A publication Critical patent/JP2018517717A/ja
Publication of JP2018517717A5 publication Critical patent/JP2018517717A5/ja
Application granted granted Critical
Publication of JP6863547B2 publication Critical patent/JP6863547B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017564097A 2015-06-18 2016-06-17 エステトロール成分を含有する口腔内崩壊性投与単位 Active JP6863547B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15172747.6 2015-06-18
EP15172747 2015-06-18
PCT/EP2016/064074 WO2016203011A1 (en) 2015-06-18 2016-06-17 Orodispersible dosage unit containing an estetrol component

Publications (3)

Publication Number Publication Date
JP2018517717A JP2018517717A (ja) 2018-07-05
JP2018517717A5 true JP2018517717A5 (enExample) 2020-12-10
JP6863547B2 JP6863547B2 (ja) 2021-04-21

Family

ID=53442623

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017564097A Active JP6863547B2 (ja) 2015-06-18 2016-06-17 エステトロール成分を含有する口腔内崩壊性投与単位

Country Status (43)

Country Link
US (3) US20160367567A1 (enExample)
EP (1) EP3106148B1 (enExample)
JP (1) JP6863547B2 (enExample)
KR (1) KR102664563B1 (enExample)
CN (2) CN107771075A (enExample)
AU (1) AU2016280863B2 (enExample)
CA (1) CA2988498C (enExample)
CL (1) CL2017003208A1 (enExample)
CO (1) CO2017012766A2 (enExample)
CR (1) CR20180042A (enExample)
CU (1) CU24523B1 (enExample)
CY (1) CY1120467T1 (enExample)
DK (1) DK3106148T3 (enExample)
DO (1) DOP2017000293A (enExample)
EA (1) EA035651B1 (enExample)
EC (1) ECSP17085669A (enExample)
ES (1) ES2671160T3 (enExample)
GE (1) GEP20217308B (enExample)
GT (1) GT201700270A (enExample)
HK (1) HK1251940A1 (enExample)
HR (1) HRP20180889T1 (enExample)
HU (1) HUE037383T2 (enExample)
IL (1) IL256283B (enExample)
LT (1) LT3106148T (enExample)
MX (1) MX385820B (enExample)
MY (1) MY195019A (enExample)
NO (1) NO3106148T3 (enExample)
NZ (1) NZ737948A (enExample)
PE (1) PE20180398A1 (enExample)
PH (1) PH12017502325B1 (enExample)
PL (1) PL3106148T3 (enExample)
PT (1) PT3106148T (enExample)
RS (1) RS57328B1 (enExample)
SA (1) SA517390550B1 (enExample)
SG (1) SG10202010432UA (enExample)
SI (1) SI3106148T1 (enExample)
SM (1) SMT201800232T1 (enExample)
SV (1) SV2017005595A (enExample)
TN (1) TN2017000499A1 (enExample)
TR (1) TR201808438T4 (enExample)
UA (1) UA123098C2 (enExample)
WO (1) WO2016203011A1 (enExample)
ZA (1) ZA201708287B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6425540B2 (ja) 2011-06-01 2018-11-21 エステトラ エス.ペ.エール.エル. エステトロール中間体を製造するための方法
EP2714712B1 (en) 2011-06-01 2016-08-24 Estetra S.P.R.L. Process for the production of estetrol intermediates
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
KR102662025B1 (ko) 2015-06-18 2024-05-02 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 에스테트롤 성분을 함유하는 구강분해성 투여 단위
LT3310345T (lt) 2015-06-18 2021-06-25 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
HUE054551T2 (hu) 2015-06-18 2021-09-28 Estetra Sprl Ösztetrolt tartalmazó, szájban diszpergálódó tabletta
NZ737948A (en) 2015-06-18 2023-03-31 Estetra Sprl Orodispersible dosage unit containing an estetrol component
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
JOP20200260A1 (ar) * 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI801561B (zh) * 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物
US20230346695A1 (en) 2020-09-29 2023-11-02 Millicent Pharma Limited Orodispersible formulations

Family Cites Families (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138588A (en) 1962-08-24 1964-06-23 American Home Prod 17-ketals of estrone and derivatives thereof
US3433785A (en) 1966-07-11 1969-03-18 Sterling Drug Inc 15,16-disubstituted aromatic steroids,intermediates and processes
US4826831A (en) 1983-08-05 1989-05-02 Pre Jay Holdings Limited Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens
CA1306950C (en) 1987-04-10 1992-09-01 Alec D. Keith Buccal administration of estrogens
US5073374A (en) 1988-11-30 1991-12-17 Schering Corporation Fast dissolving buccal tablet
GB2228412B (en) 1989-02-28 1993-04-14 Syntex Inc Nicardipine pharmaceutical composition for parenteral administration
US5340586A (en) 1991-04-12 1994-08-23 University Of Southern California Methods and formulations for use in treating oophorectomized women
US5340585A (en) 1991-04-12 1994-08-23 University Of Southern California Method and formulations for use in treating benign gynecological disorders
US5895783A (en) 1993-07-16 1999-04-20 Schering Aktiengesellschaft Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
JPH07101977A (ja) 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
DE4344405C2 (de) 1993-12-24 1995-12-07 Marika Dr Med Ehrlich Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption
WO1997004752A1 (en) 1995-07-26 1997-02-13 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions of conjugated estrogens and methods for their use
FR2772272B1 (fr) 1997-12-16 2000-01-14 Rhone Poulenc Rorer Sa Compositions pharmaceutiques a base de dalfopristine et de quinupristine et leur preparation
JP2001526212A (ja) 1997-12-19 2001-12-18 スミスクライン・ビーチャム・コーポレイション 咀嚼分散性錠剤の製造法
US7815937B2 (en) 1998-10-27 2010-10-19 Biovail Laboratories International Srl Quick dissolve compositions and tablets based thereon
US6117446A (en) 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
US6180682B1 (en) * 1999-01-26 2001-01-30 Virgil A. Place Buccal drug delivery system for use in male contraception
TW548277B (en) 1999-07-16 2003-08-21 Akzo Nobel Nv Orally active androgens
IL149424A (en) 1999-12-02 2007-05-15 Organon Nv Androgens are converted to methylene at positions 15,14
US20020132801A1 (en) 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
FR2809619B1 (fr) 2000-06-06 2004-09-24 Pharmatop Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention
EP1216713A1 (en) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions of estrogen-cyclodextrin complexes
PT1390040E (pt) * 2001-05-18 2007-04-30 Pantarhei Bioscience Bv Composição farmacêutica para ser utilizado na terapia hormonal de substituição.
EP1260225A1 (en) 2001-05-18 2002-11-27 Pantarhei Bioscience B.V. A pharmaceutical composition for use in hormone replacement therapy
EP1293210B1 (en) * 2001-05-23 2003-11-19 Pantarhei Bioscience B.V. Means and method for hormonal contraception
US20020193356A1 (en) 2001-05-23 2002-12-19 Van Beek Agatha Antonia Magdalena Means and method for hormonal contraception
CA2448278C (en) 2001-05-23 2010-06-08 Christian Franz Holinka Drug delivery system comprising a tetrahidroxilated estrogen for use in hormonal contraception
EP1390041B1 (en) 2001-05-23 2009-11-25 Pantarhei Bioscience B.V. Drug delivery system comprising a tetrahydroxylated estrogen for use in hormonal contraception
WO2003018026A1 (en) 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
EP1446128B1 (en) 2001-11-15 2006-12-06 Pantarhei Bioscience B.V. Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
US6723348B2 (en) 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
HU227198B1 (en) 2001-11-27 2010-10-28 Richter Gedeon Nyrt Pharmaceutical composition for emergency contraception containing levonorgestrel
EA007599B1 (ru) 2002-02-21 2006-12-29 Шеринг Акциенгезельшафт Фармацевтические композиции, содержащие один или несколько стероидов, один или несколько тетрагидрофолатных компонентов и витамин в
US20050147670A1 (en) 2002-05-29 2005-07-07 Impax Laboratories Inc. Oral disintegrating dosage forms
CA2489270C (en) 2002-06-11 2012-08-07 Pantarhei Bioscience B.V. A method of treating human skin and a skin care composition for use in such a method
AU2003274946A1 (en) 2002-06-11 2003-12-22 Pantarhei Bioscience B.V. Method of treating or preventing immune mediated disorders and pharmaceutical formulation for use therein
ATE382356T1 (de) 2002-07-12 2008-01-15 Pantarhei Bioscience Bv Pharmazeutische zusammensetzung enthaltend estetrolderivate und anwendung in der krebsbehandlung
HRP20050291A2 (en) 2002-08-28 2005-10-31 Zeev Shoham �ILRobert Casper et al. �CAGideon Kopernik �IL Estrogen replacement regimen
SI1556058T1 (sl) 2002-10-23 2008-02-29 Pantarhei Bioscience Bv Farmacevtski sestavki, ki obsegajo estetrolne derivate, za uporabo pri zdravljenju raka
WO2004041289A1 (en) 2002-11-05 2004-05-21 Schering Aktiengesellschaft Cardiovascular protection using anti-aldosteronic progestins
WO2004041839A2 (en) 2002-11-08 2004-05-21 Pantarhei Bioscience B.V. Synthesis of estetrol via estrone derived steroids
DE602004002591T9 (de) 2003-05-22 2008-01-03 Pantarhei Bioscience B.V. Verwendung von zusammensetzungen enthaltend ein oestrogen zur behandlung und verhinderung von muskelskelettschmerzen
PL1670440T3 (pl) 2003-09-29 2014-11-28 Novo Nordisk Healthcare Ag Preparaty HRT
ES2933479T3 (es) 2003-09-29 2023-02-09 Novo Nordisk Healthcare Ag Estabilidad mejorada de formulaciones de progestágenos
JP3841804B2 (ja) 2003-10-15 2006-11-08 富士化学工業株式会社 口腔内速崩壊性錠剤用の組成物
EP1535618A1 (en) 2003-11-26 2005-06-01 Schering Aktiengesellschaft Pharmaceutical preparation for continuous hormonal treatment over a period of longer than 21-28 days comprising two estrogen and/or progestin compositions
MY151322A (en) 2004-04-30 2014-05-15 Bayer Ip Gmbh Management of breakthrough bleeding in extended hormonal contraceptive regimens
GB0410616D0 (en) 2004-05-13 2004-06-16 Unilever Plc Antiperspirant or deodorant compositions
ES2438734T3 (es) 2004-05-28 2014-01-20 Richter Gedeon Nyrt. Anticonceptivo que contiene ácido fólico
DE102004026670A1 (de) 2004-05-28 2005-12-15 Grünenthal GmbH Hormonales Kontrazeptivum enthaltend eine Kombination aus Ethinylestradiol und Chlormadinonacetat
EP1773292B1 (en) 2004-07-01 2009-03-11 LEK Pharmaceuticals D.D. Rapidly disintegrating orodispersible composition containing nonfilamentous coprocessed polyols particles and silicified microcrystalline cellulose
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
UA88943C2 (ru) 2005-02-03 2009-12-10 Нікомед Фарма Ас Быстрый способ влажного гранулирования для получения композиций, которые содержат кальций
IS7724A (is) 2005-03-02 2006-09-03 Actavis Group Samsetning á töflum með hraða sundrun sem innihalda þungt magnesíum karbónat
UY29527A1 (es) 2005-05-13 2006-12-29 Schering Ag Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato.
CN102796160A (zh) 2005-05-26 2012-11-28 索尔瓦药物有限公司 17β-HSD1和STS抑制剂
US20070048369A1 (en) * 2005-08-26 2007-03-01 National Starch And Chemical Investment Holding Corporation Mucosal delivery tablet
CN101378762A (zh) * 2006-01-09 2009-03-04 潘塔希生物科学股份有限公司 一种治疗急性血管疾病的方法
CA2636638C (en) 2006-01-09 2014-02-18 Pantarhei Bioscience B.V. A method of treating an acute vascular disorder
WO2007106264A2 (en) 2006-03-02 2007-09-20 Warner Chilcott Company, Inc. Extended cycle multiphasic oral contraceptive method
SG174785A1 (en) 2006-06-08 2011-10-28 Warner Chilcott Co Llc Methods to administer solid dosage forms of ethinyl estradiol and prodrugs thereof with improved bioavailabilty
US20080113953A1 (en) 2006-06-08 2008-05-15 Warner Chilcott Company, Inc. Methods to administer solid dosage forms of ethinyl estradiol and prodrugs thereof with improved bioavailability
US20070286819A1 (en) * 2006-06-08 2007-12-13 Warner Chilcott Company, Inc. Methods to administer ethinyl estradiol and prodrugs thereof with improved bioavailability
BRPI0713999A2 (pt) 2006-07-06 2012-11-20 Bayer Schering Pharma Ag produÇço farmacÊutica para contracepÇço e para reduÇço do risco de malformaÇÕes congÊnitas
CN101489563A (zh) 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
TW200831139A (en) 2006-11-29 2008-08-01 Wyeth Corp Estrogen/SERM and estrogen/progestin bi-layer tablets
CA2674776A1 (en) 2006-12-20 2008-07-03 Duramed Pharmaceuticals, Inc. Orally disintegrating solid dosage forms comprising progestin and methods of making and use thereof
DE602008001783D1 (de) 2007-01-08 2010-08-26 Pantarhei Bioscience Bv Verfahren zur behandlung oder prävention von unfruchtbarkeit bei weiblichen säugern und pharmazeutisches kit zur anwendung dieses verfahrens
MX2009007254A (es) 2007-01-12 2009-08-12 Wyeth Corp Composiciones de tableta en tableta.
EP1972618A1 (en) 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes
WO2008156365A1 (en) 2007-06-21 2008-12-24 Pantarhei Bioscience B.V. Treatment of meconium aspiration syndrome with estrogens
ES2376793T3 (es) 2007-07-19 2012-03-16 Pantarhei Bioscience B.V. Tratamiento o prevención de trastornos hipertensivos del embarazo o retraso del crecimiento fetal
FR2920311B1 (fr) 2007-08-31 2010-06-18 Galenix Innovations Composition solide, orodispersible et/ou dispersible, sans excipient a effet notoire et son procede de preparation
JP5399749B2 (ja) 2008-03-27 2014-01-29 沢井製薬株式会社 プロトンポンプ阻害剤を含有する被覆微粒子
WO2010033832A2 (en) 2008-09-19 2010-03-25 Evestra, Inc. Estriol formulations
CN101780073B (zh) 2009-01-21 2013-07-03 重庆圣华曦药业股份有限公司 非布司他分散片药物及其制备方法
EP3031451B1 (en) 2009-01-26 2018-03-07 Shin-Etsu Chemical Co., Ltd Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose
DE102009007771B4 (de) 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Bukkales Applikationssystem, 17α-Estradiol enthaltend
WO2010109019A1 (en) 2009-03-26 2010-09-30 Royal College Of Surgeons In Ireland Orodispersible tablets
NZ597239A (en) 2009-06-23 2013-07-26 Bayer Pharma AG Pharmaceutical composition for emergency contraception
ITMI20091109A1 (it) 2009-06-23 2010-12-24 Wyeth Corp Forma polimorfa d di bazedoxifene acetato e metodi per la sua preparazione
CN102058604A (zh) 2009-11-17 2011-05-18 北京万全阳光医学技术有限公司 一种含有地诺孕素和戊酸雌二醇的药物组合物及其制备方法
KR20130097073A (ko) 2010-04-15 2013-09-02 바이엘 인텔렉쳐 프로퍼티 게엠베하 초저-용량의 hrt용 고체 경구 투여 형태
EP2399904A1 (en) 2010-05-26 2011-12-28 Nabriva Therapeutics AG Process for the preparation of pleuromutilins
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
WO2012055840A1 (en) 2010-10-28 2012-05-03 Bayer Pharma Aktiengesellschaft Composition and preparation for treatment of dysmenorrhea and menstrual pain and use of a hormonal agent and a zinc salt for treatment of menstrual disorders
CN107028900A (zh) 2010-12-02 2017-08-11 艾戴尔医药公司 快速分散颗粒、口腔崩解片以及方法
JP2012240917A (ja) 2011-05-16 2012-12-10 Zensei Yakuhin Kogyo Kk 製剤化用微粒子とそれを含む製剤
JP6425540B2 (ja) 2011-06-01 2018-11-21 エステトラ エス.ペ.エール.エル. エステトロール中間体を製造するための方法
EP2714712B1 (en) 2011-06-01 2016-08-24 Estetra S.P.R.L. Process for the production of estetrol intermediates
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
US10179107B2 (en) 2011-07-19 2019-01-15 Pantarhei Bioscience B.V. Tablet containing dehydroepiandrosterone (DHEA)
SMT201700310T1 (it) 2011-08-11 2017-07-18 Estetra Sprl Uso dell'esterolo come contraccettivo di emergenza
US9731018B2 (en) 2011-09-16 2017-08-15 Ferring B.V. Fast dissolving pharmaceutical composition
SI2764008T1 (sl) 2011-10-07 2016-10-28 Estetra S.P.R.L. Postopek za pripravo estetrola
EP2790688B1 (en) 2011-12-13 2019-11-20 Arstat, Inc. A multiphasic contraceptive regimen for an oral formulation of progestin and estrogen
US9808470B2 (en) 2012-04-19 2017-11-07 Universite De Liege Estrogenic components for use in the treatment of neurological disorders
EP2653163A1 (en) 2012-04-19 2013-10-23 Université de Liège Estrogenic components for use in the treatment of neurological disorders
US9238265B2 (en) 2012-09-27 2016-01-19 General Electric Company Backstrike protection during machining of cooling features
WO2014159377A1 (en) * 2013-03-14 2014-10-02 Teva Women's Health, Inc. Compositions containing tanaproget and natural estrogens
JP6126456B2 (ja) 2013-05-17 2017-05-10 東和薬品株式会社 打錠用顆粒とその製造方法、その打錠用顆粒を用いた口腔内崩壊錠
MX2015016038A (es) 2013-05-21 2016-03-21 Predictive Therapheutics Llc Agente terapéutico y método de uso.
JP6254289B2 (ja) 2013-09-18 2017-12-27 クリスタル ファルマ、エセ、ア、ウCrystal Pharma,S.A.U. エステトロールの製造プロセス
US12274276B2 (en) 2013-10-03 2025-04-15 Altria Client Services Llc Dissolvable-chewable tablet
MA39105B1 (fr) * 2013-12-12 2018-05-31 Donesta Bioscience B V Unité de dosage solide se désintégrant par voie orale contenant un constituant estétrol
ES2957543T3 (es) 2014-09-29 2024-01-22 Univ California Composiciones y métodos para mantener la función cognitiva
BR112017024783A2 (pt) 2015-05-18 2018-08-07 Agile Therapeutics Inc composições contraceptivas e métodos para eficácia melhorada e modulação dos efeitos colaterais
LT3310345T (lt) 2015-06-18 2021-06-25 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
NZ737948A (en) 2015-06-18 2023-03-31 Estetra Sprl Orodispersible dosage unit containing an estetrol component
HUE054551T2 (hu) 2015-06-18 2021-09-28 Estetra Sprl Ösztetrolt tartalmazó, szájban diszpergálódó tabletta
KR102662025B1 (ko) 2015-06-18 2024-05-02 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 에스테트롤 성분을 함유하는 구강분해성 투여 단위
LT3313408T (lt) 2015-06-23 2024-03-12 Laboratorios Leon Farma Sa Kontraceptikas drospirenono pagrindu, skirtas pacientėms, turinčioms antsvorio
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
AU2016425935B2 (en) 2016-10-28 2023-01-19 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
US20200046729A1 (en) 2016-08-05 2020-02-13 Estetra Sprl Methods using combined oral contraceptive compositions with reduced cardiovascular effects
MA51733A (fr) 2018-02-07 2020-12-16 Estetra Sprl Composition contraceptive présentant des effets cardiovasculaires réduits
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物

Similar Documents

Publication Publication Date Title
JP2018517717A5 (enExample)
JP2018517715A5 (enExample)
JP5600058B2 (ja) メラトニンタブレットならびに調剤及び使用方法
JP2018521985A5 (enExample)
JP6751475B2 (ja) エダラボン・(+)−2−ボルネオールの舌下投与用医薬組成物
JP7090616B2 (ja) カルバメート化合物を含む口腔内崩壊錠
JP2018517718A5 (enExample)
JP2010523673A5 (enExample)
TW200800142A (en) Fast-disintegrating epinephrine tablets for buccal or sublingual administration
SI3106148T1 (en) ORODISPERSIBILITY DOSING UNIT, CONTAINING ESTETROL COMPONENT
CN104023712A (zh) 高硬度快速崩解片及其制备方法
TW201919632A (zh) 治療子宮內膜異位症、子宮纖維瘤、多囊性卵巢症候群或子宮腺肌症之醫藥調配物
BR112015010271B1 (pt) produto de comicronização, processo para o preparo de um produto de comicronização, composição farmacêutica e seus usos
NO329896B1 (no) Farmasoytisk sammensetning og anvendelse derav
JP5318400B2 (ja) レボフロキサシン含有錠剤
KR101531030B1 (ko) 미르타자핀 함유 구강붕해정
JP5295506B2 (ja) レボフロキサシン含有錠剤
AU2011379627B2 (en) Sublingual pharmaceutical composition containing an antihistamine agent and method for the preparation thereof
CN113347975B (zh) 用于治疗侵蚀性手骨关节炎的孟鲁司特
JP2020203874A (ja) ロキソプロフェン又はその塩とカノコソウとを含有する経口用医薬組成物
KR20130021888A (ko) 실데나필 유리 염기를 포함하는 구강 붕해정
US20180318228A1 (en) Method for a slow release of drugs from orally dissolving capsules
AU2018216886A1 (en) A lozenge
EP2248516A1 (en) Orally disintegrating compositions of emoxypine
JP2022088344A (ja) ロキソプロフェン又はその塩、カンゾウ、および酸化マグネシウムを含有する経口用医薬組成物