|
JPS58180487A
(ja)
|
1982-04-16 |
1983-10-21 |
Kyowa Hakko Kogyo Co Ltd |
抗生物質dc−81およびその製造法
|
|
US5583024A
(en)
|
1985-12-02 |
1996-12-10 |
The Regents Of The University Of California |
Recombinant expression of Coleoptera luciferase
|
|
JPH0684377B2
(ja)
|
1986-04-17 |
1994-10-26 |
協和醗酵工業株式会社 |
新規化合物dc―88a及びdc―89a1
|
|
ATE240740T1
(de)
|
1991-03-15 |
2003-06-15 |
Amgen Inc |
Pegylation von polypeptiden
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
EP0647450A1
(en)
|
1993-09-09 |
1995-04-12 |
BEHRINGWERKE Aktiengesellschaft |
Improved prodrugs for enzyme mediated activation
|
|
JPH07309761A
(ja)
|
1994-05-20 |
1995-11-28 |
Kyowa Hakko Kogyo Co Ltd |
デュオカルマイシン誘導体の安定化法
|
|
JPH08336393A
(ja)
|
1995-04-13 |
1996-12-24 |
Mitsubishi Chem Corp |
光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
|
|
AU5711196A
(en)
|
1996-03-14 |
1997-10-01 |
Human Genome Sciences, Inc. |
Apoptosis inducing molecule i
|
|
CA2248868A1
(en)
|
1996-03-22 |
1997-09-25 |
Human Genome Sciences, Inc. |
Apoptosis inducing molecule ii
|
|
US6218519B1
(en)
|
1996-04-12 |
2001-04-17 |
Pro-Neuron, Inc. |
Compounds and methods for the selective treatment of cancer and bacterial infections
|
|
WO1998013059A1
(en)
|
1996-09-27 |
1998-04-02 |
Bristol-Myers Squibb Company |
Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells
|
|
US6759509B1
(en)
|
1996-11-05 |
2004-07-06 |
Bristol-Myers Squibb Company |
Branched peptide linkers
|
|
US6165476A
(en)
|
1997-07-10 |
2000-12-26 |
Beth Israel Deaconess Medical Center |
Fusion proteins with an immunoglobulin hinge region linker
|
|
US6602677B1
(en)
|
1997-09-19 |
2003-08-05 |
Promega Corporation |
Thermostable luciferases and methods of production
|
|
CA2309541C
(en)
|
1997-11-03 |
2011-01-11 |
Human Genome Sciences, Inc. |
Vegi, an inhibitor of angiogenesis and tumor growth
|
|
HUP0100813A3
(en)
*
|
1998-02-25 |
2003-08-28 |
Lexigen Pharmaceuticals Corp L |
Enhancing the circulating half-life of antibody-based fusion proteins
|
|
EA003398B1
(ru)
|
1998-05-22 |
2003-04-24 |
Дайити Фармасьютикал Ко., Лтд. |
Лекарственный комплекс c полимерным носителем
|
|
GB9818731D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Compounds
|
|
US6268488B1
(en)
|
1999-05-25 |
2001-07-31 |
Barbas, Iii Carlos F. |
Prodrug activation using catalytic antibodies
|
|
US20040052793A1
(en)
|
2001-02-22 |
2004-03-18 |
Carter Paul J. |
Caspase activivated prodrugs therapy
|
|
US20040018194A1
(en)
|
2000-11-28 |
2004-01-29 |
Francisco Joseph A. |
Recombinant anti-CD30 antibodies and uses thereof
|
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
US7091186B2
(en)
|
2001-09-24 |
2006-08-15 |
Seattle Genetics, Inc. |
p-Amidobenzylethers in drug delivery agents
|
|
WO2003026577A2
(en)
|
2001-09-24 |
2003-04-03 |
Seattle Genetics, Inc. |
P-amidobenzylethers in drug delivery agents
|
|
CA2467242A1
(en)
|
2001-11-20 |
2003-05-30 |
Seattle Genetics, Inc. |
Treatment of immunological disorders using anti-cd30 antibodies
|
|
US20050180972A1
(en)
|
2002-07-31 |
2005-08-18 |
Wahl Alan F. |
Anti-CD20 antibody-drug conjugates for the treatment of cancer and immune disorders
|
|
AU2003256038A1
(en)
|
2002-08-30 |
2004-03-19 |
Ramot At Tel Aviv University Ltd. |
Self-immolative dendrimers releasing many active moieties upon a single activating event
|
|
WO2004043493A1
(en)
|
2002-11-14 |
2004-05-27 |
Syntarga B.V. |
Prodrugs built as multiple self-elimination-release spacers
|
|
EP1720908A2
(en)
|
2004-02-17 |
2006-11-15 |
Absalus, Inc. |
Super-humanized antibodies against respiratory syncytial virus
|
|
CA2556752C
(en)
|
2004-02-23 |
2016-02-02 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
DK1791565T3
(en)
|
2004-09-23 |
2016-08-01 |
Genentech Inc |
Cysteingensplejsede antibodies and conjugates
|
|
JP2008521828A
(ja)
*
|
2004-11-29 |
2008-06-26 |
シアトル ジェネティックス, インコーポレイテッド |
操作された抗体およびイムノコンジュゲート
|
|
AU2006210724A1
(en)
|
2005-02-03 |
2006-08-10 |
Antitope Limited |
Human antibodies and proteins
|
|
SI1934174T1
(sl)
|
2005-10-07 |
2011-08-31 |
Exelixis Inc |
Inhibitorji MEK in postopki za njihovo uporabo
|
|
RS52060B
(sr)
|
2006-01-25 |
2012-04-30 |
Sanofi |
Citotoksični agensi koji sadrže nove derivate tomaimicina
|
|
EP1914242A1
(en)
*
|
2006-10-19 |
2008-04-23 |
Sanofi-Aventis |
Novel anti-CD38 antibodies for the treatment of cancer
|
|
CL2008001334A1
(es)
|
2007-05-08 |
2008-09-22 |
Genentech Inc |
Anticuerpo anti-muc16 disenado con cisteina; conjugado que lo comprende; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso para tratar el cancer.
|
|
NZ584514A
(en)
|
2007-10-19 |
2012-07-27 |
Genentech Inc |
Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
|
|
GB0819095D0
(en)
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
EP2711018A1
(en)
|
2009-06-22 |
2014-03-26 |
MedImmune, LLC |
Engineered Fc regions for site-specific conjugation
|
|
WO2011108714A1
(ja)
*
|
2010-03-04 |
2011-09-09 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
SI2528625T1
(sl)
*
|
2010-04-15 |
2013-11-29 |
Spirogen Sarl |
Pirolobenzodiazepini in njihovi konjugati
|
|
CA2795349C
(en)
|
2010-04-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Targeted pyrrolobenzodiazepine conjugates
|
|
JP5875083B2
(ja)
|
2010-04-15 |
2016-03-02 |
メディミューン リミテッド |
増殖性疾患治療用ピロロベンゾジアゼピン
|
|
WO2012064733A2
(en)
*
|
2010-11-09 |
2012-05-18 |
Medimmune, Llc |
Antibody scaffold for homogenous conjugation
|
|
SG11201400770SA
(en)
|
2011-09-20 |
2014-04-28 |
Spirogen Sarl |
Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
|
|
JP2015502397A
(ja)
|
2011-12-23 |
2015-01-22 |
ファイザー・インク |
部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用
|
|
WO2014057118A1
(en)
*
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sarl |
Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
|
|
HRP20190366T1
(hr)
|
2012-10-12 |
2019-04-19 |
Medimmune Limited |
Pirolobenzodiazepini i njihovi konjugati
|
|
ES2680153T3
(es)
*
|
2012-10-12 |
2018-09-04 |
Adc Therapeutics Sa |
Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
|
|
EP2906297B1
(en)
*
|
2012-10-12 |
2017-12-06 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-antibody conjugates
|
|
MX338711B
(es)
|
2012-10-12 |
2016-04-28 |
Medimmune Ltd |
Pirrolobenzodiazepinas y conjugados de las mismas.
|
|
SI2906252T1
(sl)
*
|
2012-10-12 |
2017-10-30 |
Adc Therapeutics Sa |
Pirolobenzodiazepin-anti-HER2 protitelesni konjugati
|
|
EP2906296B1
(en)
*
|
2012-10-12 |
2018-03-21 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-antibody conjugates
|
|
HRP20182129T1
(hr)
*
|
2012-10-12 |
2019-02-08 |
Adc Therapeutics Sa |
Konjugati protutijelo - pirolobenzodiazepin
|
|
JP6392765B2
(ja)
*
|
2012-10-12 |
2018-09-19 |
エイディーシー・セラピューティクス・エス・アーAdc Therapeutics Sa |
ピロロベンゾジアゼピン−抗体結合体
|
|
KR20160047567A
(ko)
*
|
2013-08-28 |
2016-05-02 |
스템센트알엑스 인코포레이티드 |
조작된 항-dll3 접합체 및 사용 방법
|