JP2018516563A5 - - Google Patents
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- JP2018516563A5 JP2018516563A5 JP2017559860A JP2017559860A JP2018516563A5 JP 2018516563 A5 JP2018516563 A5 JP 2018516563A5 JP 2017559860 A JP2017559860 A JP 2017559860A JP 2017559860 A JP2017559860 A JP 2017559860A JP 2018516563 A5 JP2018516563 A5 JP 2018516563A5
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021179465A JP2022031673A (ja) | 2015-05-29 | 2021-11-02 | Ｃｒｉｓｐｒ核酸を用いて、細菌、古細菌、藻類、および、酵母をスクリーニングする方法 |
| JP2023109947A JP2023126899A (ja) | 2015-05-29 | 2023-07-04 | Ｃｒｉｓｐｒ核酸を用いて、細菌、古細菌、藻類、および、酵母をスクリーニングする方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562168355P | 2015-05-29 | 2015-05-29 | |
| US62/168,355 | 2015-05-29 | ||
| US201662296853P | 2016-02-18 | 2016-02-18 | |
| US62/296,853 | 2016-02-18 | ||
| PCT/US2016/034812 WO2016196361A1 (en) | 2015-05-29 | 2016-05-27 | Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021179465A Division JP2022031673A (ja) | 2015-05-29 | 2021-11-02 | Ｃｒｉｓｐｒ核酸を用いて、細菌、古細菌、藻類、および、酵母をスクリーニングする方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018516563A JP2018516563A (ja) | 2018-06-28 |
| JP2018516563A5 true JP2018516563A5 (cg-RX-API-DMAC7.html) | 2020-07-30 |
Family
ID=57396918
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559860A Pending JP2018516563A (ja) | 2015-05-29 | 2016-05-27 | Ｃｒｉｓｐｒ核酸を用いて、細菌、古細菌、藻類、および、酵母をスクリーニングする方法 |
| JP2021179465A Pending JP2022031673A (ja) | 2015-05-29 | 2021-11-02 | Ｃｒｉｓｐｒ核酸を用いて、細菌、古細菌、藻類、および、酵母をスクリーニングする方法 |
| JP2023109947A Pending JP2023126899A (ja) | 2015-05-29 | 2023-07-04 | Ｃｒｉｓｐｒ核酸を用いて、細菌、古細菌、藻類、および、酵母をスクリーニングする方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021179465A Pending JP2022031673A (ja) | 2015-05-29 | 2021-11-02 | Ｃｒｉｓｐｒ核酸を用いて、細菌、古細菌、藻類、および、酵母をスクリーニングする方法 |
| JP2023109947A Pending JP2023126899A (ja) | 2015-05-29 | 2023-07-04 | Ｃｒｉｓｐｒ核酸を用いて、細菌、古細菌、藻類、および、酵母をスクリーニングする方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10136649B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP4039816A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2018516563A (cg-RX-API-DMAC7.html) |
| KR (2) | KR102451796B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN108026536A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2016270649B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2983023A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201792663A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1253712A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016196361A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2734621B1 (en) | 2011-07-22 | 2019-09-04 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| WO2015066119A1 (en) | 2013-10-30 | 2015-05-07 | North Carolina State University | Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri |
| US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
| US10787654B2 (en) | 2014-01-24 | 2020-09-29 | North Carolina State University | Methods and compositions for sequence guiding Cas9 targeting |
| CN106460003A (zh) | 2014-04-08 | 2017-02-22 | 北卡罗来纳州立大学 | 用于使用crispr相关基因rna引导阻遏转录的方法和组合物 |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| EP3186375A4 (en) | 2014-08-28 | 2019-03-13 | North Carolina State University | Novel CAS9 PROTEINS AND CHARACTERISTICS FOR DNA TARGETING AND GENOME EDITING |
| EP3291679B1 (en) | 2015-05-06 | 2021-12-15 | SNIPR Technologies Limited | Altering microbial populations & modifying microbiota |
| HK1253712A1 (zh) * | 2015-05-29 | 2019-06-28 | North Carolina State University | 使用crispr核酸筛选细菌、古细菌、藻类和酵母的方法 |
| CN107922918B (zh) | 2015-06-15 | 2022-10-21 | 北卡罗来纳州立大学 | 用于有效递送核酸和基于rna的抗微生物剂的方法和组合物 |
| EP3356533A1 (en) * | 2015-09-28 | 2018-08-08 | North Carolina State University | Methods and compositions for sequence specific antimicrobials |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| WO2017112620A1 (en) | 2015-12-22 | 2017-06-29 | North Carolina State University | Methods and compositions for delivery of crispr based antimicrobials |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| KR102827276B1 (ko) | 2016-08-03 | 2025-07-01 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CN110214180A (zh) | 2016-10-14 | 2019-09-06 | 哈佛大学的校长及成员们 | 核碱基编辑器的aav递送 |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| GB2575930A (en) | 2017-03-23 | 2020-01-29 | Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| WO2018217981A1 (en) * | 2017-05-26 | 2018-11-29 | North Carolina State University | Altered guide rnas for modulating cas9 activity and methods of use |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING |
| CN107904208B (zh) * | 2017-12-25 | 2019-11-01 | 云舟生物科技（广州）有限公司 | 细胞表型研究用的细胞克隆及其筛选方法和应用 |
| EP4066851A1 (en) | 2018-03-25 | 2022-10-05 | SNIPR Biome ApS. | Treating & preventing microbial infections |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12227776B2 (en) | 2018-06-13 | 2025-02-18 | Caribou Biosciences, Inc. | Engineered cascade components and cascade complexes |
| US10227576B1 (en) | 2018-06-13 | 2019-03-12 | Caribou Biosciences, Inc. | Engineered cascade components and cascade complexes |
| KR102142474B1 (ko) * | 2019-04-08 | 2020-08-07 | 한국식품연구원 | Lactobacillus acidophilus YT1 균주 판별용 조성물 및 이를 이용한 판별방법 |
| KR102142473B1 (ko) * | 2019-04-08 | 2020-08-07 | 한국식품연구원 | 락토바실러스 속 중에서 특정 종을 특이적으로 판별하기 위한 프라이머 조성물 및 이를 이용한 판별방법 |
| US12264330B2 (en) | 2018-10-01 | 2025-04-01 | North Carolina State University | Recombinant type I CRISPR-Cas system and uses thereof for killing target cells |
| EP3861120A4 (en) | 2018-10-01 | 2023-08-16 | North Carolina State University | Recombinant type i crispr-cas system |
| WO2020072250A1 (en) | 2018-10-01 | 2020-04-09 | North Carolina State University | Recombinant type i crispr-cas system and uses thereof for genome modification and alteration of expression |
| US12203123B2 (en) | 2018-10-01 | 2025-01-21 | North Carolina State University | Recombinant type I CRISPR-Cas system and uses thereof for screening for variant cells |
| US11851663B2 (en) | 2018-10-14 | 2023-12-26 | Snipr Biome Aps | Single-vector type I vectors |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020181264A1 (en) | 2019-03-07 | 2020-09-10 | The Trustees Of Columbia University In The City Of New York | Rna-guided dna integration using tn7-like transposons |
| DE112020001306T5 (de) | 2019-03-19 | 2022-01-27 | Massachusetts Institute Of Technology | Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| GB201907733D0 (en) * | 2019-05-31 | 2019-07-17 | Governing Council Of The Univ Of Toronto | Methods and compositions for multiplex gene editing |
| EP3979832A4 (en) * | 2019-06-06 | 2023-06-21 | Tata Consultancy Services Limited | METHOD AND SYSTEM FOR IDENTIFICATION OF CANDIDATE TARGET SITE FOR PATHOGENS COMBAT |
| WO2020245783A2 (en) * | 2019-06-06 | 2020-12-10 | Tata Consultancy Services Limited | Method and system for identification of target sites in protein coding regions for combating pathogens |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN110791578B (zh) * | 2019-11-28 | 2022-12-16 | 广州微远医疗器械有限公司 | 用于百日咳博德特氏杆菌的crispr检测引物组及其用途 |
| US20230087228A1 (en) * | 2020-02-24 | 2023-03-23 | The Broad Institute, Inc. | Novel type iv and type i crispr-cas systems and methods of use thereof |
| US20230136613A1 (en) * | 2020-03-26 | 2023-05-04 | San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation | Compositions and methods for treating or ameliorating infections |
| US20230218684A1 (en) * | 2020-03-30 | 2023-07-13 | North Carolina State University | Engineered bacteria for use in vaccine compositions |
| AU2021267940A1 (en) | 2020-05-08 | 2022-12-08 | President And Fellows Of Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| GB202007943D0 (en) | 2020-05-27 | 2020-07-08 | Snipr Biome Aps | Products & methods |
| CN112080571B (zh) * | 2020-09-22 | 2022-11-11 | 扬州大学 | 基于CRISPR-Cas12b系统的空肠弯曲菌检测试剂盒和方法 |
| CN112646902A (zh) * | 2020-12-24 | 2021-04-13 | 山西大学 | 一种古菌快速检测的试剂盒及方法 |
| EP4294933A4 (en) * | 2021-02-19 | 2025-10-15 | Nuclear Rna Networks Inc | COMPOSITIONS AND METHODS FOR MODULATING GENE TRANSCRIPTION NETWORKS BASED ON SHARED HIGH-IDENTITY TRANSPOSABLE ELEMENT SEQUENCES AND NON-PROCESSIVE PROMOTER TRANSCRIPTS AND PROMOTER-PROXIMAL TRANSCRIPTS |
| US20240376461A1 (en) * | 2021-09-13 | 2024-11-14 | North Carolina State University | Novel type i-b crispr-cas system from clostridia |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4723202A (en) | 1987-04-02 | 1988-02-02 | The Garrett Corporation | Converter-fed AC machine without damper winding |
| US7919277B2 (en) | 2004-04-28 | 2011-04-05 | Danisco A/S | Detection and typing of bacterial strains |
| EP1874110A4 (en) | 2005-04-15 | 2009-06-10 | Del Monte Fresh Produce Compan | VEGETABLE PROMOTERS, TERMINATORS, GENES, VECTORS AND RELATED TRANSFORMED PLANTS |
| ES2719789T3 (es) | 2007-03-02 | 2019-07-16 | Dupont Nutrition Biosci Aps | Cultivos con resistencia mejorada a fagos |
| RU2570562C2 (ru) | 2008-11-07 | 2015-12-10 | ДюПон НЬЮТРИШН БАЙОСАЙЕНСИЗ АпС | Последовательности crispr бифидобактерий |
| WO2010075424A2 (en) | 2008-12-22 | 2010-07-01 | The Regents Of University Of California | Compositions and methods for downregulating prokaryotic genes |
| WO2012054726A1 (en) | 2010-10-20 | 2012-04-26 | Danisco A/S | Lactococcus crispr-cas sequences |
| WO2012164565A1 (en) | 2011-06-01 | 2012-12-06 | Yeda Research And Development Co. Ltd. | Compositions and methods for downregulating prokaryotic genes |
| GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
| US9637739B2 (en) | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
| WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
| WO2013176772A1 (en) | 2012-05-25 | 2013-11-28 | The Regents Of The University Of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| MX2014015204A (es) | 2012-06-12 | 2015-08-07 | Genentech Inc | Metodos y composiciones para generar alelos con inactivacion condicional. |
| WO2013188638A2 (en) | 2012-06-15 | 2013-12-19 | The Regents Of The University Of California | Endoribonucleases and methods of use thereof |
| EP2880171B1 (en) | 2012-08-03 | 2018-10-03 | The Regents of The University of California | Methods and compositions for controlling gene expression by rna processing |
| CN110643600A (zh) | 2012-10-23 | 2020-01-03 | 基因工具股份有限公司 | 用于切割靶dna的系统及其用途 |
| US20150315576A1 (en) * | 2012-11-01 | 2015-11-05 | Massachusetts Institute Of Technology | Genetic device for the controlled destruction of dna |
| LT3138910T (lt) | 2012-12-06 | 2017-11-10 | Sigma-Aldrich Co. Llc | Crispr pagrįstas genomo modifikavimas ir reguliavimas |
| WO2014093479A1 (en) | 2012-12-11 | 2014-06-19 | Montana State University | Crispr (clustered regularly interspaced short palindromic repeats) rna-guided control of gene regulation |
| EP2840140B2 (en) * | 2012-12-12 | 2023-02-22 | The Broad Institute, Inc. | Crispr-Cas based method for mutation of prokaryotic cells |
| WO2014093655A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| SG10201704932UA (en) | 2012-12-17 | 2017-07-28 | Harvard College | Rna-guided human genome engineering |
| CA2897390A1 (en) | 2013-01-10 | 2014-07-17 | Ge Healthcare Dharmacon, Inc. | Templates, libraries, kits and methods for generating molecules |
| EP2946015B1 (en) | 2013-01-16 | 2021-05-26 | Emory University | Cas9-nucleic acid complexes and uses related thereto |
| WO2014124226A1 (en) * | 2013-02-07 | 2014-08-14 | The Rockefeller University | Sequence specific antimicrobials |
| NZ712727A (en) | 2013-03-14 | 2017-05-26 | Caribou Biosciences Inc | Compositions and methods of nucleic acid-targeting nucleic acids |
| KR102271292B1 (ko) | 2013-03-15 | 2021-07-02 | 더 제너럴 하스피탈 코포레이션 | Rna-안내 게놈 편집의 특이성을 증가시키기 위한 rna-안내 foki 뉴클레아제(rfn)의 용도 |
| US20140273230A1 (en) | 2013-03-15 | 2014-09-18 | Sigma-Aldrich Co., Llc | Crispr-based genome modification and regulation |
| JP2016512048A (ja) | 2013-03-15 | 2016-04-25 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ＣＲＩＳＰＲ／Ｃａｓシステムを使用した植物ゲノム操作 |
| WO2014186686A2 (en) | 2013-05-17 | 2014-11-20 | Two Blades Foundation | Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases |
| JP6608807B2 (ja) | 2013-05-29 | 2019-11-20 | セレクティス | Ｒｎａガイドｃａｓヌクレアーゼ系を用いることによって免疫療法のためにｔ細胞を操作するための方法 |
| US11414695B2 (en) | 2013-05-29 | 2022-08-16 | Agilent Technologies, Inc. | Nucleic acid enrichment using Cas9 |
| AU2014273082B2 (en) | 2013-05-29 | 2018-11-08 | Cellectis | A method for producing precise DNA cleavage using Cas9 nickase activity |
| US20140356956A1 (en) | 2013-06-04 | 2014-12-04 | President And Fellows Of Harvard College | RNA-Guided Transcriptional Regulation |
| EP3008181B1 (en) | 2013-06-11 | 2019-11-06 | The Regents of The University of California | Methods and compositions for target dna modification |
| EP3725885A1 (en) | 2013-06-17 | 2020-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
| ES2777217T3 (es) | 2013-06-17 | 2020-08-04 | Broad Inst Inc | Suministro, modificación y optimización de sistemas de guía en tándem, métodos y composiciones para la manipulación de secuencias |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| CA3221516A1 (en) | 2013-08-22 | 2015-02-26 | E. I. Du Pont De Nemours And Company | Plant genome modification using guide rna/cas endonuclease systems and methods of use |
| EP3041498B1 (en) | 2013-09-05 | 2022-02-16 | Massachusetts Institute of Technology | Tuning microbial populations with programmable nucleases |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| DE202014010413U1 (de) | 2013-09-18 | 2015-12-08 | Kymab Limited | Zellen und Organismen |
| US20150098954A1 (en) | 2013-10-08 | 2015-04-09 | Elwha Llc | Compositions and Methods Related to CRISPR Targeting |
| WO2015066119A1 (en) | 2013-10-30 | 2015-05-07 | North Carolina State University | Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri |
| WO2015070193A1 (en) | 2013-11-11 | 2015-05-14 | Liu Oliver | Compositions and methods for targeted gene disruption in prokaryotes |
| AU2014350051A1 (en) | 2013-11-18 | 2016-07-07 | Crispr Therapeutics Ag | CRISPR-Cas system materials and methods |
| US10787684B2 (en) | 2013-11-19 | 2020-09-29 | President And Fellows Of Harvard College | Large gene excision and insertion |
| EP3080271B1 (en) | 2013-12-12 | 2020-02-12 | The Broad Institute, Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
| US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
| EP3080266B1 (en) | 2013-12-12 | 2021-02-03 | The Regents of The University of California | Methods and compositions for modifying a single stranded target nucleic acid |
| CA2936646C (en) | 2014-01-24 | 2024-04-30 | North Carolina State University | Methods and compositions for sequences guiding cas9 targeting |
| US10787654B2 (en) | 2014-01-24 | 2020-09-29 | North Carolina State University | Methods and compositions for sequence guiding Cas9 targeting |
| WO2015116686A1 (en) | 2014-01-29 | 2015-08-06 | Agilent Technologies, Inc. | Cas9-based isothermal method of detection of specific dna sequence |
| PL3102722T3 (pl) | 2014-02-04 | 2021-03-08 | Jumpcode Genomics, Inc. | Frakcjonowanie genomu |
| WO2015139139A1 (en) | 2014-03-20 | 2015-09-24 | UNIVERSITé LAVAL | Crispr-based methods and products for increasing frataxin levels and uses thereof |
| AU2015236045B2 (en) | 2014-03-25 | 2021-09-23 | Ginkgo Bioworks, Inc. | Methods and genetic systems for cell engineering |
| WO2015153791A1 (en) | 2014-04-01 | 2015-10-08 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating herpes simplex virus type 2 (hsv-2) |
| WO2015153889A2 (en) | 2014-04-02 | 2015-10-08 | University Of Florida Research Foundation, Incorporated | Materials and methods for the treatment of latent viral infection |
| EP3126503A1 (en) | 2014-04-03 | 2017-02-08 | Massachusetts Institute Of Technology | Methods and compositions for the production of guide rna |
| CN106460003A (zh) | 2014-04-08 | 2017-02-22 | 北卡罗来纳州立大学 | 用于使用crispr相关基因rna引导阻遏转录的方法和组合物 |
| WO2015160683A1 (en) | 2014-04-14 | 2015-10-22 | Maxcyte, Inc. | Methods and compositions for modifying genomic dna |
| EP3766971A1 (en) | 2014-04-14 | 2021-01-20 | Nemesis Bioscience Ltd. | Therapeutic |
| GB201406970D0 (en) | 2014-04-17 | 2014-06-04 | Green Biologics Ltd | Targeted mutations |
| GB201406968D0 (en) | 2014-04-17 | 2014-06-04 | Green Biologics Ltd | Deletion mutants |
| WO2015189693A1 (en) | 2014-06-12 | 2015-12-17 | King Abdullah University Of Science And Technology | Targeted viral-mediated plant genome editing using crispr/cas9 |
| WO2015200555A2 (en) | 2014-06-25 | 2015-12-30 | Caribou Biosciences, Inc. | Rna modification to engineer cas9 activity |
| US9726544B2 (en) * | 2014-07-30 | 2017-08-08 | Tyco Fire & Security Gmbh | Method and system for passive tracking of moving objects |
| EP3186375A4 (en) | 2014-08-28 | 2019-03-13 | North Carolina State University | Novel CAS9 PROTEINS AND CHARACTERISTICS FOR DNA TARGETING AND GENOME EDITING |
| WO2016084088A1 (en) | 2014-11-26 | 2016-06-02 | Ramot At Tel-Aviv University Ltd. | Targeted elimination of bacterial genes |
| US12129471B2 (en) | 2015-02-23 | 2024-10-29 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of human genetic diseases including hemoglobinopathies |
| EP3291679B1 (en) | 2015-05-06 | 2021-12-15 | SNIPR Technologies Limited | Altering microbial populations & modifying microbiota |
| HK1253712A1 (zh) | 2015-05-29 | 2019-06-28 | North Carolina State University | 使用crispr核酸筛选细菌、古细菌、藻类和酵母的方法 |
| CN107922918B (zh) | 2015-06-15 | 2022-10-21 | 北卡罗来纳州立大学 | 用于有效递送核酸和基于rna的抗微生物剂的方法和组合物 |
| US9580727B1 (en) | 2015-08-07 | 2017-02-28 | Caribou Biosciences, Inc. | Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides |
| EP3353309A4 (en) | 2015-09-25 | 2019-04-10 | Tarveda Therapeutics, Inc. | COMPOSITIONS AND METHOD FOR GENERIC EDITING |
| EP3356533A1 (en) | 2015-09-28 | 2018-08-08 | North Carolina State University | Methods and compositions for sequence specific antimicrobials |
| US11970710B2 (en) | 2015-10-13 | 2024-04-30 | Duke University | Genome engineering with Type I CRISPR systems in eukaryotic cells |
| WO2017112620A1 (en) | 2015-12-22 | 2017-06-29 | North Carolina State University | Methods and compositions for delivery of crispr based antimicrobials |
| US11504404B2 (en) | 2016-02-24 | 2022-11-22 | Crown Laboratories, Inc. | Skin probiotic formulation |
-
2016
- 2016-05-27 HK HK18112860.2A patent/HK1253712A1/zh unknown
- 2016-05-27 WO PCT/US2016/034812 patent/WO2016196361A1/en not_active Ceased
- 2016-05-27 US US15/167,727 patent/US10136649B2/en active Active
- 2016-05-27 AU AU2016270649A patent/AU2016270649B2/en active Active
- 2016-05-27 EP EP21214189.9A patent/EP4039816A1/en active Pending
- 2016-05-27 EP EP16804164.8A patent/EP3303607A4/en not_active Withdrawn
- 2016-05-27 JP JP2017559860A patent/JP2018516563A/ja active Pending
- 2016-05-27 CA CA2983023A patent/CA2983023A1/en active Pending
- 2016-05-27 EA EA201792663A patent/EA201792663A1/ru unknown
- 2016-05-27 KR KR1020177037797A patent/KR102451796B1/ko active Active
- 2016-05-27 CN CN201680030913.5A patent/CN108026536A/zh active Pending
- 2016-05-27 KR KR1020227034331A patent/KR20220139447A/ko active Pending
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2018
- 2018-10-05 US US16/153,052 patent/US11261451B2/en active Active
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2021
- 2021-11-02 JP JP2021179465A patent/JP2022031673A/ja active Pending
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2022
- 2022-01-14 US US17/575,948 patent/US20220228154A1/en active Pending
- 2022-06-28 AU AU2022204596A patent/AU2022204596B2/en active Active
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- 2023-07-04 JP JP2023109947A patent/JP2023126899A/ja active Pending
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