JP2018515498A5 - - Google Patents
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- Publication number
- JP2018515498A5 JP2018515498A5 JP2017557940A JP2017557940A JP2018515498A5 JP 2018515498 A5 JP2018515498 A5 JP 2018515498A5 JP 2017557940 A JP2017557940 A JP 2017557940A JP 2017557940 A JP2017557940 A JP 2017557940A JP 2018515498 A5 JP2018515498 A5 JP 2018515498A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- carboxamide
- alkyl
- formula
- derivative according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 7
- 230000003463 hyperproliferative effect Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000002595 magnetic resonance imaging Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 18
- -1 cycloalkyl halides Chemical class 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 229910052794 bromium Inorganic materials 0.000 claims 7
- 229910052801 chlorine Inorganic materials 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- 125000003277 amino group Chemical group 0.000 claims 5
- 150000001735 carboxylic acids Chemical group 0.000 claims 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 5
- 150000002148 esters Chemical group 0.000 claims 5
- 150000002170 ethers Chemical group 0.000 claims 5
- 150000003141 primary amines Chemical class 0.000 claims 5
- 150000003335 secondary amines Chemical class 0.000 claims 5
- 150000003512 tertiary amines Chemical class 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 208000012641 Pigmentation disease Diseases 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 230000006698 induction Effects 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 150000001350 alkyl halides Chemical class 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241000204031 Mycoplasma Species 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 208000031481 Pathologic Constriction Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 241000606701 Rickettsia Species 0.000 claims 1
- 206010040829 Skin discolouration Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 150000004036 bacteriochlorins Chemical class 0.000 claims 1
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 claims 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 1
- SURLGNKAQXKNSP-DBLYXWCISA-N chlorin Chemical compound C\1=C/2\N/C(=C\C3=N/C(=C\C=4NC(/C=C\5/C=CC/1=N/5)=CC=4)/C=C3)/CC\2 SURLGNKAQXKNSP-DBLYXWCISA-N 0.000 claims 1
- 150000004035 chlorins Chemical class 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 208000000069 hyperpigmentation Diseases 0.000 claims 1
- 230000003810 hyperpigmentation Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 238000002428 photodynamic therapy Methods 0.000 claims 1
- 150000004032 porphyrins Chemical class 0.000 claims 1
- 230000003716 rejuvenation Effects 0.000 claims 1
- 208000031019 skin pigmentation disease Diseases 0.000 claims 1
- 230000036262 stenosis Effects 0.000 claims 1
- 208000037804 stenosis Diseases 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 230000002087 whitening effect Effects 0.000 claims 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT108447 | 2015-05-07 | ||
| PT10844715 | 2015-05-07 | ||
| PCT/IB2016/052606 WO2016178191A1 (en) | 2015-05-07 | 2016-05-06 | Low molecular weight derivatives of carboxamide halogenated porphyrins, namely chlorins and bacteriochlorins, and their applications thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515498A JP2018515498A (ja) | 2018-06-14 |
| JP2018515498A5 true JP2018515498A5 (https=) | 2020-06-18 |
| JP6730319B2 JP6730319B2 (ja) | 2020-07-29 |
Family
ID=56084187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557940A Active JP6730319B2 (ja) | 2015-05-07 | 2016-05-06 | カルボキサミドハロゲン化ポルフィリン、即ちクロリン及びバクテリオクロリンの低分子量誘導体と、それらの応用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10450322B2 (https=) |
| EP (1) | EP3292129B1 (https=) |
| JP (1) | JP6730319B2 (https=) |
| CN (1) | CN107624114B (https=) |
| AU (1) | AU2016259188B2 (https=) |
| BR (1) | BR112017023948A2 (https=) |
| CA (1) | CA2985187C (https=) |
| HK (1) | HK1245254A1 (https=) |
| RU (1) | RU2718923C2 (https=) |
| WO (1) | WO2016178191A1 (https=) |
| ZA (1) | ZA201707533B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017214637A1 (en) | 2016-06-10 | 2017-12-14 | Nirvana Sciences Inc. | Hydroporphyrin beads with narrow fluorescence emissions |
| CN110662748A (zh) * | 2017-02-03 | 2020-01-07 | 尼尔瓦纳科学股份有限公司 | 用于光声成像的氢卟啉 |
| US11904026B2 (en) | 2017-02-03 | 2024-02-20 | Nirvana Sciences Inc. | Metallohydroporphyrins for photoacoustic imaging |
| CN109912607B (zh) * | 2018-12-11 | 2021-01-22 | 南华大学 | 一类卟啉-白杨素复合物及其抗肿瘤活性 |
| SG10201811547RA (en) * | 2018-12-21 | 2020-07-29 | Oreal | Cosmetic use of a short chain fatty acid (scfa) for preventing and/or treating dry skin and/or aged skin |
| CN109651383B (zh) * | 2019-01-25 | 2021-11-16 | 华东理工大学 | 用于光敏剂的化合物及其应用 |
| WO2020236828A1 (en) * | 2019-05-20 | 2020-11-26 | Nirvana Sciences Inc. | Narrow emission dyes, compositions comprising same, and methods for making and using same |
| US12570665B2 (en) | 2019-06-10 | 2026-03-10 | University Of Massachusetts | Compositions comprising fullerenyl mesochlorin nano-photosensitizers with covalently bound antibiotics and their uses in combination therapy |
| CN116354970B (zh) * | 2023-03-28 | 2024-06-18 | 大连理工大学 | 一种卟啉类一氧化碳前药的制备方法及气体-声动力联合治疗应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1480638A2 (en) * | 2002-01-08 | 2004-12-01 | Emory University | Porphyrins with virucidal activity |
| FR2877943B1 (fr) * | 2004-11-16 | 2008-09-05 | Univ De Coimbra | Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorine, et leurs applications en therapie photodynamique |
| GB0819594D0 (en) * | 2008-10-24 | 2008-12-03 | Univ Coimbrra | Process |
| JP2013503895A (ja) * | 2009-09-02 | 2013-02-04 | ザ リージェンツ オブ ザ ユニバーシティー オブ コロラド，ア ボディー コーポレート | 金属ポルフィリン類を使用するミトコンドリア病の処置法 |
| WO2011099602A1 (ja) * | 2010-02-12 | 2011-08-18 | 学校法人日本大学 | ポルフィリン誘導体および放射線力学療法におけるその使用 |
| BR112013001576A2 (pt) * | 2010-07-22 | 2016-07-19 | Ceramoptec Gmbh | composto tetrapirrólico e composição farmacêutica derivado farmacêuticamente aceitável da mesma e respectivos usos e métodos de terapia fotodinâmica e de diagnóstico e tratamento da artrite e de doenças inflamatórias semelhantes. |
| CN102166182A (zh) * | 2011-01-24 | 2011-08-31 | 上海交通大学 | 纳米探针及其在肿瘤诊断组合物和光动力疗法中的应用 |
| US10456375B2 (en) * | 2014-09-30 | 2019-10-29 | Biolitec Unternehmensbeteiligungs Ii Ag | Specifically meso-substituted porphyrins and chlorins for photodynamic therapy |
-
2016
- 2016-05-06 BR BR112017023948-5A patent/BR112017023948A2/en not_active IP Right Cessation
- 2016-05-06 CA CA2985187A patent/CA2985187C/en active Active
- 2016-05-06 EP EP16725584.3A patent/EP3292129B1/en active Active
- 2016-05-06 RU RU2017138871A patent/RU2718923C2/ru active
- 2016-05-06 CN CN201680026500.XA patent/CN107624114B/zh active Active
- 2016-05-06 JP JP2017557940A patent/JP6730319B2/ja active Active
- 2016-05-06 AU AU2016259188A patent/AU2016259188B2/en active Active
- 2016-05-06 WO PCT/IB2016/052606 patent/WO2016178191A1/en not_active Ceased
- 2016-05-06 US US15/570,956 patent/US10450322B2/en active Active
- 2016-05-06 HK HK18104533.6A patent/HK1245254A1/zh unknown
-
2017
- 2017-11-07 ZA ZA2017/07533A patent/ZA201707533B/en unknown
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