CN107624114B - 甲酰胺卤化的卟啉的低分子量衍生物、即二氢卟酚和菌绿素及其应用 - Google Patents

甲酰胺卤化的卟啉的低分子量衍生物、即二氢卟酚和菌绿素及其应用 Download PDF

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CN107624114B
CN107624114B CN201680026500.XA CN201680026500A CN107624114B CN 107624114 B CN107624114 B CN 107624114B CN 201680026500 A CN201680026500 A CN 201680026500A CN 107624114 B CN107624114 B CN 107624114B
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hydrogen
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halogenated
independently selected
carboxamide
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CN107624114A (zh
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纳西门托 科斯塔 G·佩雷拉
贡萨尔维斯 N·P·佩雷拉
蒙泰罗 C·J·佩雷拉
德 阿布雷乌 A·C·雷斯
卡多佐 苏亚雷斯 H·T·费拉斯
罗沙 L·G·博尔热斯
F·A·沙伯勒
佩雷拉 M·米根斯
席尔瓦 阿尔瑙特 莫雷拉 L·G·达
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Luzitin SA
Universidade de Coimbra
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Universidade de Coimbra
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CN201680026500.XA 2015-05-07 2016-05-06 甲酰胺卤化的卟啉的低分子量衍生物、即二氢卟酚和菌绿素及其应用 Active CN107624114B (zh)

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PT108447 2015-05-07
PT10844715 2015-05-07
PCT/IB2016/052606 WO2016178191A1 (en) 2015-05-07 2016-05-06 Low molecular weight derivatives of carboxamide halogenated porphyrins, namely chlorins and bacteriochlorins, and their applications thereof

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JP (1) JP6730319B2 (https=)
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AU (1) AU2016259188B2 (https=)
BR (1) BR112017023948A2 (https=)
CA (1) CA2985187C (https=)
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Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
WO2017214637A1 (en) 2016-06-10 2017-12-14 Nirvana Sciences Inc. Hydroporphyrin beads with narrow fluorescence emissions
CN110662748A (zh) * 2017-02-03 2020-01-07 尼尔瓦纳科学股份有限公司 用于光声成像的氢卟啉
US11904026B2 (en) 2017-02-03 2024-02-20 Nirvana Sciences Inc. Metallohydroporphyrins for photoacoustic imaging
CN109912607B (zh) * 2018-12-11 2021-01-22 南华大学 一类卟啉-白杨素复合物及其抗肿瘤活性
SG10201811547RA (en) * 2018-12-21 2020-07-29 Oreal Cosmetic use of a short chain fatty acid (scfa) for preventing and/or treating dry skin and/or aged skin
CN109651383B (zh) * 2019-01-25 2021-11-16 华东理工大学 用于光敏剂的化合物及其应用
WO2020236828A1 (en) * 2019-05-20 2020-11-26 Nirvana Sciences Inc. Narrow emission dyes, compositions comprising same, and methods for making and using same
US12570665B2 (en) 2019-06-10 2026-03-10 University Of Massachusetts Compositions comprising fullerenyl mesochlorin nano-photosensitizers with covalently bound antibiotics and their uses in combination therapy
CN116354970B (zh) * 2023-03-28 2024-06-18 大连理工大学 一种卟啉类一氧化碳前药的制备方法及气体-声动力联合治疗应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011099602A1 (ja) * 2010-02-12 2011-08-18 学校法人日本大学 ポルフィリン誘導体および放射線力学療法におけるその使用
CN102166182A (zh) * 2011-01-24 2011-08-31 上海交通大学 纳米探针及其在肿瘤诊断组合物和光动力疗法中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1480638A2 (en) * 2002-01-08 2004-12-01 Emory University Porphyrins with virucidal activity
FR2877943B1 (fr) * 2004-11-16 2008-09-05 Univ De Coimbra Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorine, et leurs applications en therapie photodynamique
GB0819594D0 (en) * 2008-10-24 2008-12-03 Univ Coimbrra Process
JP2013503895A (ja) * 2009-09-02 2013-02-04 ザ リージェンツ オブ ザ ユニバーシティー オブ コロラド,ア ボディー コーポレート 金属ポルフィリン類を使用するミトコンドリア病の処置法
BR112013001576A2 (pt) * 2010-07-22 2016-07-19 Ceramoptec Gmbh composto tetrapirrólico e composição farmacêutica derivado farmacêuticamente aceitável da mesma e respectivos usos e métodos de terapia fotodinâmica e de diagnóstico e tratamento da artrite e de doenças inflamatórias semelhantes.
US10456375B2 (en) * 2014-09-30 2019-10-29 Biolitec Unternehmensbeteiligungs Ii Ag Specifically meso-substituted porphyrins and chlorins for photodynamic therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011099602A1 (ja) * 2010-02-12 2011-08-18 学校法人日本大学 ポルフィリン誘導体および放射線力学療法におけるその使用
CN102166182A (zh) * 2011-01-24 2011-08-31 上海交通大学 纳米探针及其在肿瘤诊断组合物和光动力疗法中的应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
An efficient one-pot procedure for asymmetric bifunctionalization of 5,15-disubstituted prophyrins: a simple preparation of meso acyl-, alkoxycarbonyl-, and carbamoyl-substituted meso-formylporphyrins;Toshikatsu Takanami;《Chemical Communications》;20081119;101-103 *
Gang Zheng.Synthesis, Photophysical Properties, Tumor Uptake, and Preliminary in Vivo Photosensitizing Efficacy of a Homologous Series of 3-(1¢-Alkyloxy)ethyl-3-devinylpurpurin-18-N-alkylimides with Variable Lipophilicity.《Journal of Medicinal Chemistry》.2000,第44卷(第10期),1540-1559. *

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AU2016259188A1 (en) 2017-11-30
WO2016178191A1 (en) 2016-11-10
CN107624114A (zh) 2018-01-23
RU2017138871A3 (https=) 2019-06-11
BR112017023948A2 (en) 2018-07-24
JP6730319B2 (ja) 2020-07-29
JP2018515498A (ja) 2018-06-14
HK1245254A1 (zh) 2018-08-24
US10450322B2 (en) 2019-10-22
EP3292129A1 (en) 2018-03-14
RU2718923C2 (ru) 2020-04-15
AU2016259188B2 (en) 2019-10-31
ZA201707533B (en) 2019-04-24
RU2017138871A (ru) 2019-06-10
US20180282344A1 (en) 2018-10-04
CA2985187C (en) 2024-01-02
EP3292129B1 (en) 2019-03-27
CA2985187A1 (en) 2016-11-10

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