HK1245254A1 - 甲酰胺卤化的卟啉的低分子量衍生物、即二氢卟酚和菌绿素及其应用 - Google Patents

甲酰胺卤化的卟啉的低分子量衍生物、即二氢卟酚和菌绿素及其应用 Download PDF

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Publication number
HK1245254A1
HK1245254A1 HK18104533.6A HK18104533A HK1245254A1 HK 1245254 A1 HK1245254 A1 HK 1245254A1 HK 18104533 A HK18104533 A HK 18104533A HK 1245254 A1 HK1245254 A1 HK 1245254A1
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HK
Hong Kong
Prior art keywords
hydrogen
formula
carboxamide
independently selected
porphyrin derivatives
Prior art date
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HK18104533.6A
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English (en)
Chinese (zh)
Inventor
‧佩雷拉 纳西门托 科斯塔 G
‧佩雷拉 納西門托 科斯塔 G
贡萨尔维斯 N‧P‧佩雷拉
蒙泰罗 C‧J‧佩雷拉
貢薩爾維斯 N‧P‧佩雷拉
德 阿布雷乌 A‧C‧雷斯
卡多佐 苏亚雷斯 H‧T‧费拉斯
蒙泰羅 C‧J‧佩雷拉
罗沙 L‧G‧博尔热斯
F‧A‧沙伯勒
德 阿布雷烏 A‧C‧雷斯
佩雷拉 M‧米根斯
席尔瓦 阿尔瑙特 莫雷拉 L‧G‧达
卡多佐 蘇亞雷斯 H‧T‧費拉斯
羅沙 L‧G‧博爾熱斯
席爾瓦 阿爾瑙特 莫雷拉 L‧G‧達
Original Assignee
卢西蒂恩股份有限公司
科英布拉大学
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Application filed by 卢西蒂恩股份有限公司, 科英布拉大学 filed Critical 卢西蒂恩股份有限公司
Publication of HK1245254A1 publication Critical patent/HK1245254A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
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    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
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    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
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    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/04—Antibacterial agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Acoustics & Sound (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK18104533.6A 2015-05-07 2016-05-06 甲酰胺卤化的卟啉的低分子量衍生物、即二氢卟酚和菌绿素及其应用 HK1245254A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT108447 2015-05-07
PT10844715 2015-05-07
PCT/IB2016/052606 WO2016178191A1 (en) 2015-05-07 2016-05-06 Low molecular weight derivatives of carboxamide halogenated porphyrins, namely chlorins and bacteriochlorins, and their applications thereof

Publications (1)

Publication Number Publication Date
HK1245254A1 true HK1245254A1 (zh) 2018-08-24

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US (1) US10450322B2 (https=)
EP (1) EP3292129B1 (https=)
JP (1) JP6730319B2 (https=)
CN (1) CN107624114B (https=)
AU (1) AU2016259188B2 (https=)
BR (1) BR112017023948A2 (https=)
CA (1) CA2985187C (https=)
HK (1) HK1245254A1 (https=)
RU (1) RU2718923C2 (https=)
WO (1) WO2016178191A1 (https=)
ZA (1) ZA201707533B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017214637A1 (en) 2016-06-10 2017-12-14 Nirvana Sciences Inc. Hydroporphyrin beads with narrow fluorescence emissions
CN110662748A (zh) * 2017-02-03 2020-01-07 尼尔瓦纳科学股份有限公司 用于光声成像的氢卟啉
US11904026B2 (en) 2017-02-03 2024-02-20 Nirvana Sciences Inc. Metallohydroporphyrins for photoacoustic imaging
CN109912607B (zh) * 2018-12-11 2021-01-22 南华大学 一类卟啉-白杨素复合物及其抗肿瘤活性
SG10201811547RA (en) * 2018-12-21 2020-07-29 Oreal Cosmetic use of a short chain fatty acid (scfa) for preventing and/or treating dry skin and/or aged skin
CN109651383B (zh) * 2019-01-25 2021-11-16 华东理工大学 用于光敏剂的化合物及其应用
WO2020236828A1 (en) * 2019-05-20 2020-11-26 Nirvana Sciences Inc. Narrow emission dyes, compositions comprising same, and methods for making and using same
US12570665B2 (en) 2019-06-10 2026-03-10 University Of Massachusetts Compositions comprising fullerenyl mesochlorin nano-photosensitizers with covalently bound antibiotics and their uses in combination therapy
CN116354970B (zh) * 2023-03-28 2024-06-18 大连理工大学 一种卟啉类一氧化碳前药的制备方法及气体-声动力联合治疗应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1480638A2 (en) * 2002-01-08 2004-12-01 Emory University Porphyrins with virucidal activity
FR2877943B1 (fr) * 2004-11-16 2008-09-05 Univ De Coimbra Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorine, et leurs applications en therapie photodynamique
GB0819594D0 (en) * 2008-10-24 2008-12-03 Univ Coimbrra Process
JP2013503895A (ja) * 2009-09-02 2013-02-04 ザ リージェンツ オブ ザ ユニバーシティー オブ コロラド，ア ボディー コーポレート 金属ポルフィリン類を使用するミトコンドリア病の処置法
WO2011099602A1 (ja) * 2010-02-12 2011-08-18 学校法人日本大学 ポルフィリン誘導体および放射線力学療法におけるその使用
BR112013001576A2 (pt) * 2010-07-22 2016-07-19 Ceramoptec Gmbh composto tetrapirrólico e composição farmacêutica derivado farmacêuticamente aceitável da mesma e respectivos usos e métodos de terapia fotodinâmica e de diagnóstico e tratamento da artrite e de doenças inflamatórias semelhantes.
CN102166182A (zh) * 2011-01-24 2011-08-31 上海交通大学 纳米探针及其在肿瘤诊断组合物和光动力疗法中的应用
US10456375B2 (en) * 2014-09-30 2019-10-29 Biolitec Unternehmensbeteiligungs Ii Ag Specifically meso-substituted porphyrins and chlorins for photodynamic therapy

Also Published As

Publication number Publication date
AU2016259188A1 (en) 2017-11-30
WO2016178191A1 (en) 2016-11-10
CN107624114A (zh) 2018-01-23
RU2017138871A3 (https=) 2019-06-11
BR112017023948A2 (en) 2018-07-24
JP6730319B2 (ja) 2020-07-29
JP2018515498A (ja) 2018-06-14
US10450322B2 (en) 2019-10-22
EP3292129A1 (en) 2018-03-14
CN107624114B (zh) 2021-03-23
RU2718923C2 (ru) 2020-04-15
AU2016259188B2 (en) 2019-10-31
ZA201707533B (en) 2019-04-24
RU2017138871A (ru) 2019-06-10
US20180282344A1 (en) 2018-10-04
CA2985187C (en) 2024-01-02
EP3292129B1 (en) 2019-03-27
CA2985187A1 (en) 2016-11-10

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