JP2018515479A5 - - Google Patents
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- JP2018515479A5 JP2018515479A5 JP2017556986A JP2017556986A JP2018515479A5 JP 2018515479 A5 JP2018515479 A5 JP 2018515479A5 JP 2017556986 A JP2017556986 A JP 2017556986A JP 2017556986 A JP2017556986 A JP 2017556986A JP 2018515479 A5 JP2018515479 A5 JP 2018515479A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- carbohydrate
- cationic polymer
- composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001720 carbohydrates Chemical class 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 229920006317 cationic polymer Polymers 0.000 claims 13
- 229920002873 Polyethylenimine Polymers 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 125000000647 trehalose group Chemical group 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021079039A JP2021130671A (ja) | 2015-05-05 | 2021-05-07 | 核酸−カチオン性ポリマー組成物、並びにその作製方法及び使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL23864315 | 2015-05-05 | ||
| IL238643 | 2015-05-05 | ||
| PCT/IL2016/050477 WO2016178233A1 (en) | 2015-05-05 | 2016-05-05 | Nucleic acid-cationic polymer compositions and methods of making and using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021079039A Division JP2021130671A (ja) | 2015-05-05 | 2021-05-07 | 核酸−カチオン性ポリマー組成物、並びにその作製方法及び使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018515479A JP2018515479A (ja) | 2018-06-14 |
| JP2018515479A5 true JP2018515479A5 (enExample) | 2019-04-25 |
Family
ID=56134418
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556986A Pending JP2018515479A (ja) | 2015-05-05 | 2016-05-05 | 核酸−カチオン性ポリマー組成物、並びにその作製方法及び使用方法 |
| JP2021079039A Pending JP2021130671A (ja) | 2015-05-05 | 2021-05-07 | 核酸−カチオン性ポリマー組成物、並びにその作製方法及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021079039A Pending JP2021130671A (ja) | 2015-05-05 | 2021-05-07 | 核酸−カチオン性ポリマー組成物、並びにその作製方法及び使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20180154023A1 (enExample) |
| EP (1) | EP3291799A1 (enExample) |
| JP (2) | JP2018515479A (enExample) |
| KR (1) | KR20180015145A (enExample) |
| CN (1) | CN107735079A (enExample) |
| AU (1) | AU2016258326A1 (enExample) |
| BR (1) | BR112017023788A2 (enExample) |
| CA (1) | CA2984879A1 (enExample) |
| IL (1) | IL255254A0 (enExample) |
| MX (1) | MX2017014060A (enExample) |
| PH (1) | PH12017502216A1 (enExample) |
| RU (1) | RU2017140065A (enExample) |
| SG (2) | SG11201708760PA (enExample) |
| WO (1) | WO2016178233A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018515479A (ja) * | 2015-05-05 | 2018-06-14 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム リミテッドＹｉｓｓｕｍ Ｒｅｓｅａｒｃｈ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏｍｐａｎｙ Ｏｆ Ｔｈｅ Ｈｅｂｒｅｗ Ｕｎｉｖｅｒｓｔｙ Ｏｆ Ｊｅｒｕｓａｌｅｍ Ｌｔｄ． | 核酸−カチオン性ポリマー組成物、並びにその作製方法及び使用方法 |
| DE102017003004A1 (de) | 2017-03-23 | 2018-09-27 | Friedrich-Schiller-Universität Jena | Kationische Polymere mit D-Fructose-Substituenten |
| US10849921B2 (en) * | 2017-05-17 | 2020-12-01 | Bioncotech Therapeutics Sl | Pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine |
| EP3924463A1 (en) | 2019-02-11 | 2021-12-22 | Excellgene SA | Novel eukaryotic cell transfection systems and related methods |
| CN111363761A (zh) * | 2020-03-17 | 2020-07-03 | 苏州吉恒基因科技有限公司 | 利用阳离子多聚体dna复合物促进aav介导的基因表达方法 |
| CA3181339A1 (en) * | 2020-04-27 | 2021-11-04 | Juno Therapeutics, Inc. | Stabilization of polyethyleneimine-deoxyribonucleic acid complex size and activity |
| TW202228727A (zh) * | 2020-10-01 | 2022-08-01 | 德商拜恩迪克公司 | 適用於治療之微脂體ｒｎａ調配物之製備及儲存 |
| WO2022249180A1 (en) | 2021-05-25 | 2022-12-01 | Ramot At Tel-Aviv University Ltd. | Compositions comprising extracellular vesicles and an active agent and uses thereof |
| CN113501889A (zh) * | 2021-07-06 | 2021-10-15 | 郑州大学 | 一种三七多糖阳离子衍生物的制备方法及其应用 |
| CN116549626A (zh) * | 2022-01-27 | 2023-08-08 | 深圳瑞吉生物科技有限公司 | 一种载核酸脂质纳米颗粒冻干制剂及其制备方法与应用 |
| CN114762731B (zh) * | 2022-05-16 | 2024-08-23 | 常州大学 | 一种延长基因药物在温和条件下储存时间的方法 |
| CN116036043A (zh) * | 2023-01-10 | 2023-05-02 | 深圳市乐土生物医药有限公司 | 一种核酸药物制剂、冻干粉及制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| FR2722506B1 (fr) | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| US6087164A (en) * | 1997-10-03 | 2000-07-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods and compositions for inducing tumor-specific cytotoxicity |
| US20040142474A1 (en) * | 2000-09-14 | 2004-07-22 | Expression Genetics, Inc. | Novel cationic lipopolymer as a biocompatible gene delivery agent |
| WO2007007317A1 (en) | 2005-07-07 | 2007-01-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acid agents for downregulating h19, and methods of using same |
| JP2009508516A (ja) | 2005-09-22 | 2009-03-05 | イッサム リサーチ ディベロプメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム | 核酸構築物、薬剤組成物、及び癌治療のためのその使用方法 |
| CA2675967A1 (en) | 2007-01-16 | 2008-07-24 | Yissum Research Development Company Of The Hebrew University Of Jerusale M | Nucleic acid constructs and methods for specific silencing of h19 |
| US20090042825A1 (en) * | 2007-08-06 | 2009-02-12 | Majed Matar | Composition, method of preparation & application of concentrated formulations of condensed nucleic acids with a cationic lipopolymer |
| CN101820864A (zh) * | 2007-08-06 | 2010-09-01 | 艾根股份有限公司 | 核酸-脂聚合物组合物 |
| BRPI0818937B8 (pt) | 2007-10-25 | 2021-05-25 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | constructos contendo múltiplos cassetes de expressão para terapia de câncer |
| WO2010028093A2 (en) * | 2008-09-03 | 2010-03-11 | Senesco Technologies, Inc. | Use of a truncated elf-5a1 polynucleotide to induce apoptosis in cancer cells |
| DE102009006606A1 (de) * | 2009-01-29 | 2010-08-05 | Philipps-Universität Marburg | Nicht-virales Transfektionsmittel |
| JP2018515479A (ja) * | 2015-05-05 | 2018-06-14 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム リミテッドＹｉｓｓｕｍ Ｒｅｓｅａｒｃｈ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏｍｐａｎｙ Ｏｆ Ｔｈｅ Ｈｅｂｒｅｗ Ｕｎｉｖｅｒｓｔｙ Ｏｆ Ｊｅｒｕｓａｌｅｍ Ｌｔｄ． | 核酸−カチオン性ポリマー組成物、並びにその作製方法及び使用方法 |
-
2016
- 2016-05-05 JP JP2017556986A patent/JP2018515479A/ja active Pending
- 2016-05-05 KR KR1020177034664A patent/KR20180015145A/ko not_active Ceased
- 2016-05-05 CN CN201680039770.4A patent/CN107735079A/zh active Pending
- 2016-05-05 RU RU2017140065A patent/RU2017140065A/ru not_active Application Discontinuation
- 2016-05-05 BR BR112017023788A patent/BR112017023788A2/pt not_active Application Discontinuation
- 2016-05-05 CA CA2984879A patent/CA2984879A1/en not_active Abandoned
- 2016-05-05 WO PCT/IL2016/050477 patent/WO2016178233A1/en not_active Ceased
- 2016-05-05 MX MX2017014060A patent/MX2017014060A/es unknown
- 2016-05-05 US US15/571,699 patent/US20180154023A1/en not_active Abandoned
- 2016-05-05 AU AU2016258326A patent/AU2016258326A1/en not_active Abandoned
- 2016-05-05 EP EP16730012.8A patent/EP3291799A1/en not_active Withdrawn
- 2016-05-05 SG SG11201708760PA patent/SG11201708760PA/en unknown
- 2016-05-05 SG SG10201909209R patent/SG10201909209RA/en unknown
-
2017
- 2017-10-25 IL IL255254A patent/IL255254A0/en unknown
- 2017-12-05 PH PH12017502216A patent/PH12017502216A1/en unknown
-
2020
- 2020-01-02 US US16/732,770 patent/US20200138977A1/en not_active Abandoned
-
2021
- 2021-05-07 JP JP2021079039A patent/JP2021130671A/ja active Pending
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