CA2984879A1 - Nucleic acid-cationic polymer compositions and methods of making and using the same - Google Patents
Nucleic acid-cationic polymer compositions and methods of making and using the same Download PDFInfo
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- CA2984879A1 CA2984879A1 CA2984879A CA2984879A CA2984879A1 CA 2984879 A1 CA2984879 A1 CA 2984879A1 CA 2984879 A CA2984879 A CA 2984879A CA 2984879 A CA2984879 A CA 2984879A CA 2984879 A1 CA2984879 A1 CA 2984879A1
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- Prior art keywords
- carbohydrate
- nucleic acid
- poly
- cationic polymer
- process according
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- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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| DE102017003004A1 (de) | 2017-03-23 | 2018-09-27 | Friedrich-Schiller-Universität Jena | Kationische Polymere mit D-Fructose-Substituenten |
| US10849921B2 (en) * | 2017-05-17 | 2020-12-01 | Bioncotech Therapeutics Sl | Pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine |
| EP3924463A1 (en) | 2019-02-11 | 2021-12-22 | Excellgene SA | Novel eukaryotic cell transfection systems and related methods |
| CN111363761A (zh) * | 2020-03-17 | 2020-07-03 | 苏州吉恒基因科技有限公司 | 利用阳离子多聚体dna复合物促进aav介导的基因表达方法 |
| CA3181339A1 (en) * | 2020-04-27 | 2021-11-04 | Juno Therapeutics, Inc. | Stabilization of polyethyleneimine-deoxyribonucleic acid complex size and activity |
| TW202228727A (zh) * | 2020-10-01 | 2022-08-01 | 德商拜恩迪克公司 | 適用於治療之微脂體ｒｎａ調配物之製備及儲存 |
| WO2022249180A1 (en) | 2021-05-25 | 2022-12-01 | Ramot At Tel-Aviv University Ltd. | Compositions comprising extracellular vesicles and an active agent and uses thereof |
| CN113501889A (zh) * | 2021-07-06 | 2021-10-15 | 郑州大学 | 一种三七多糖阳离子衍生物的制备方法及其应用 |
| CN116549626A (zh) * | 2022-01-27 | 2023-08-08 | 深圳瑞吉生物科技有限公司 | 一种载核酸脂质纳米颗粒冻干制剂及其制备方法与应用 |
| CN114762731B (zh) * | 2022-05-16 | 2024-08-23 | 常州大学 | 一种延长基因药物在温和条件下储存时间的方法 |
| CN116036043A (zh) * | 2023-01-10 | 2023-05-02 | 深圳市乐土生物医药有限公司 | 一种核酸药物制剂、冻干粉及制备方法 |
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| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| FR2722506B1 (fr) | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| US6087164A (en) * | 1997-10-03 | 2000-07-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods and compositions for inducing tumor-specific cytotoxicity |
| US20040142474A1 (en) * | 2000-09-14 | 2004-07-22 | Expression Genetics, Inc. | Novel cationic lipopolymer as a biocompatible gene delivery agent |
| WO2007007317A1 (en) | 2005-07-07 | 2007-01-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acid agents for downregulating h19, and methods of using same |
| JP2009508516A (ja) | 2005-09-22 | 2009-03-05 | イッサム リサーチ ディベロプメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム | 核酸構築物、薬剤組成物、及び癌治療のためのその使用方法 |
| CA2675967A1 (en) | 2007-01-16 | 2008-07-24 | Yissum Research Development Company Of The Hebrew University Of Jerusale M | Nucleic acid constructs and methods for specific silencing of h19 |
| US20090042825A1 (en) * | 2007-08-06 | 2009-02-12 | Majed Matar | Composition, method of preparation & application of concentrated formulations of condensed nucleic acids with a cationic lipopolymer |
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| BRPI0818937B8 (pt) | 2007-10-25 | 2021-05-25 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | constructos contendo múltiplos cassetes de expressão para terapia de câncer |
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| DE102009006606A1 (de) * | 2009-01-29 | 2010-08-05 | Philipps-Universität Marburg | Nicht-virales Transfektionsmittel |
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| RU2017140065A3 (enExample) | 2019-09-27 |
| SG11201708760PA (en) | 2017-11-29 |
| PH12017502216A1 (en) | 2018-06-11 |
| JP2018515479A (ja) | 2018-06-14 |
| SG10201909209RA (en) | 2019-11-28 |
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