JP2018513883A5 - - Google Patents

Info

Publication number

JP2018513883A5

JP2018513883A5 JP2017546793A JP2017546793A JP2018513883A5 JP 2018513883 A5 JP2018513883 A5 JP 2018513883A5 JP 2017546793 A JP2017546793 A JP 2017546793A JP 2017546793 A JP2017546793 A JP 2017546793A JP 2018513883 A5 JP2018513883 A5 JP 2018513883A5

Authority

JP

Japan

Prior art keywords

nanoparticle

cargo

outer membrane

lipid

lipid outer

Prior art date

2016-03-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000002105 nanoparticle Substances 0.000 claims 18
• 150000002632 lipids Chemical class 0.000 claims 8
• 239000012528 membrane Substances 0.000 claims 8
• 239000000203 mixture Substances 0.000 claims 4
• 229920000642 polymer Polymers 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229920002674 hyaluronan Polymers 0.000 claims 2
• 229960003160 hyaluronic acid Drugs 0.000 claims 2
• XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 2
• 229960003105 metformin Drugs 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• KSXTUUUQYQYKCR-LQDDAWAPSA-M 2,3-bis[[(z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC KSXTUUUQYQYKCR-LQDDAWAPSA-M 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 108020004459 Small interfering RNA Proteins 0.000 claims 1
• 229930182558 Sterol Natural products 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 229940041181 antineoplastic drug Drugs 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• -1 cationic lipid Chemical class 0.000 claims 1
• 235000012000 cholesterol Nutrition 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 229910052739 hydrogen Inorganic materials 0.000 claims 1
• 239000001257 hydrogen Substances 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 150000003432 sterols Chemical class 0.000 claims 1
• 235000003702 sterols Nutrition 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1