|
US4199574A
(en)
|
1974-09-02 |
1980-04-22 |
Burroughs Wellcome Co. |
Methods and compositions for treating viral infections and guanine acyclic nucleosides
|
|
US4968686A
(en)
|
1988-04-08 |
1990-11-06 |
The Regents Of The University Of Michigan |
Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents
|
|
US5786359A
(en)
|
1994-05-27 |
1998-07-28 |
The Scripps Research Institute |
N9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines
|
|
US6608035B1
(en)
|
1994-10-25 |
2003-08-19 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
GB9505025D0
(en)
|
1995-03-13 |
1995-05-03 |
Medical Res Council |
Chemical compounds
|
|
US20080119427A1
(en)
|
1996-06-06 |
2008-05-22 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US6069132A
(en)
|
1996-08-14 |
2000-05-30 |
Revanker; Ganapathi R. |
Phosphazole compounds
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
|
US6037176A
(en)
|
1999-06-25 |
2000-03-14 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of integrin beta 3 expression
|
|
GB9925459D0
(en)
|
1999-10-27 |
1999-12-29 |
Plant Bioscience Ltd |
Gene silencing
|
|
US7829693B2
(en)
|
1999-11-24 |
2010-11-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
|
WO2003070918A2
(en)
|
2002-02-20 |
2003-08-28 |
Ribozyme Pharmaceuticals, Incorporated |
Rna interference by modified short interfering nucleic acid
|
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
KR20080023768A
(ko)
|
2000-03-30 |
2008-03-14 |
화이트헤드 인스티튜트 포 바이오메디칼 리서치 |
Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체
|
|
CN100523215C
(zh)
|
2000-12-01 |
2009-08-05 |
马普科技促进协会 |
介导rna干涉的小rna分子
|
|
US8546143B2
(en)
|
2001-01-09 |
2013-10-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
|
EP1386004A4
(en)
|
2001-04-05 |
2005-02-16 |
Ribozyme Pharm Inc |
MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID
|
|
JP2005504020A
(ja)
|
2001-07-03 |
2005-02-10 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
ヌクレアーゼ耐性キメラオリゴヌクレオチド
|
|
BR0211111A
(pt)
|
2001-07-12 |
2004-06-22 |
Univ Massachusetts |
Molécula de ácido nucleico isolada, vetor, célula hospedeira, transgene, precursor de rna engenheirado, animal transgênico não humano, e, método de induzir a interferência de ácido ribonucleico de um gene alvo em uma célula
|
|
JP2005508634A
(ja)
|
2001-10-29 |
2005-04-07 |
マクギル・ユニヴァーシティ |
非環式リンカー含有オリゴヌクレオチド及びその用途
|
|
US7388002B2
(en)
|
2001-11-14 |
2008-06-17 |
Biocryst Pharmaceuticals, Inc. |
Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
|
|
US7897753B2
(en)
|
2002-02-20 |
2011-03-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of XIAP gene expression using short interfering nucleic acid (siNA)
|
|
WO2003106477A1
(en)
|
2002-06-01 |
2003-12-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds that include carbocyclic nucleosides and their use in gene modulation
|
|
US7923547B2
(en)
|
2002-09-05 |
2011-04-12 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
CA2504694C
(en)
|
2002-11-05 |
2013-10-01 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
US20040261149A1
(en)
|
2003-02-24 |
2004-12-23 |
Fauquet Claude M. |
siRNA-mediated inhibition of gene expression in plant cells
|
|
CA2518475C
(en)
|
2003-03-07 |
2014-12-23 |
Alnylam Pharmaceuticals, Inc. |
Irna agents comprising asymmetrical modifications
|
|
EP1608733B1
(en)
|
2003-04-02 |
2011-12-07 |
Dharmacon, Inc. |
Modified polynucleotides for use in rna interference
|
|
US20070167384A1
(en)
|
2003-04-02 |
2007-07-19 |
Dharmacon, Inc. |
Modified polynucleotides for use in rna interference
|
|
JP2006522158A
(ja)
|
2003-04-03 |
2006-09-28 |
アルナイラム ファーマシューティカルズ インコーポレイテッド |
ｉＲＮＡ複合体
|
|
EP2669377A3
(en)
|
2003-04-17 |
2015-10-14 |
Alnylam Pharmaceuticals Inc. |
Modified iRNA agents
|
|
CA2528012C
(en)
|
2003-06-02 |
2015-11-24 |
University Of Massachusetts |
Methods and compositions for controlling efficacy of rna silencing
|
|
US7750144B2
(en)
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
|
WO2004108897A2
(en)
|
2003-06-02 |
2004-12-16 |
Cytokinetics, Inc. |
Sirna libraries
|
|
ES2905724T3
(es)
|
2003-06-13 |
2022-04-11 |
Alnylam Europe Ag |
Acido ribonucleico bicatenario con elevada eficacia en un organismo
|
|
EP1651192A1
(en)
|
2003-08-06 |
2006-05-03 |
Nirmal Mulye |
Pharmaceutical composition containing water soluble drug
|
|
CA2559955C
(en)
|
2004-03-15 |
2016-02-16 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded rna
|
|
WO2005089268A2
(en)
|
2004-03-15 |
2005-09-29 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for optimizing cleavage of rna by rnase h
|
|
AU2005323437B2
(en)
|
2004-04-30 |
2011-10-06 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a C5-modified pyrimidine
|
|
JP2008504840A
(ja)
|
2004-06-30 |
2008-02-21 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
非リン酸骨格結合を含むオリゴヌクレオチド
|
|
WO2006085987A2
(en)
|
2004-07-09 |
2006-08-17 |
University Of Iowa Research Foundation |
Rna interference in respiratory epitheial cells
|
|
AU2005328382C1
(en)
|
2004-07-21 |
2013-01-24 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a modified or non-natural nucleobase
|
|
EP1913011B1
(en)
|
2004-08-04 |
2016-11-02 |
Alnylam Pharmaceuticals Inc. |
Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
|
|
KR20080036650A
(ko)
|
2005-08-17 |
2008-04-28 |
시르나 쎄러퓨틱스 인코퍼레이티드 |
Ｒｎａ 간섭을 매개하는 화학적으로 변형된 짧은 간섭 핵산분자
|
|
EP1948674A4
(en)
|
2005-11-02 |
2009-02-04 |
Protiva Biotherapeutics Inc |
MODIFIED SIRNA MOLECULES AND APPLICATIONS THEREOF
|
|
EP1951263A4
(en)
|
2005-11-21 |
2009-11-18 |
Johnson & Johnson Res Pty Ltd |
MULTITARGETING DISTURBING RNAS WITH TWO ACTIVE STRANDS AND DESIGN AND APPLICATION METHODS
|
|
US7915399B2
(en)
|
2006-06-09 |
2011-03-29 |
Protiva Biotherapeutics, Inc. |
Modified siRNA molecules and uses thereof
|
|
WO2008020435A2
(en)
|
2006-08-15 |
2008-02-21 |
Quark Pharmaceuticals, Inc |
Compositions and methods for treatment of mood disorders
|
|
NZ580712A
(en)
*
|
2007-05-22 |
2011-12-22 |
Marina Biotech Inc |
Hydroxymethyl substituted rna oligonucleotides and rna complexes containing acyclic monomers
|
|
JP2011530289A
(ja)
|
2008-08-05 |
2011-12-22 |
マリーナ バイオテック，インコーポレイテッド |
Ｐｌｋ１遺伝子の発現を抑制するための核酸化合物およびその使用
|
|
EP2937418B1
(en)
|
2008-10-20 |
2017-10-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of transthyretin
|
|
CA2744093A1
(en)
*
|
2008-12-03 |
2010-06-10 |
Marina Biotech, Inc. |
Una oligomer structures for therapeutic agents
|
|
US20130281510A1
(en)
*
|
2010-03-29 |
2013-10-24 |
Kumamoto University |
siRNA Therapy for Transthyretin (TTR) Related Ocular Amyloidosis
|
|
WO2011133584A2
(en)
|
2010-04-19 |
2011-10-27 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting hras gene expression and uses thereof
|
|
US20130190383A1
(en)
|
2010-04-26 |
2013-07-25 |
Marina Biotech, Inc. |
Nucleic acid compounds with conformationally restricted monomers and uses thereof
|
|
US8817723B2
(en)
|
2010-11-17 |
2014-08-26 |
Futurewei Technologies, Inc. |
Methods and apparatus for inter-cell interference coordination self-organized network
|
|
CA2839896A1
(en)
*
|
2011-06-21 |
2012-12-27 |
Alnylam Pharmaceuticals, Inc. |
Assays and methods for determining activity of a therapeutic agent in a subject
|
|
UA118649C2
(uk)
|
2011-11-18 |
2019-02-25 |
Елнілем Фармасьютікалз, Інк. |
ДВОЛАНЦЮГОВИЙ ЗАСІБ ДЛЯ PHKі ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ЕКСПРЕСІЇ ТРАНСТИРЕТИНУ (TTR)
|
|
GR1008018B
(el)
|
2012-09-06 |
2013-10-29 |
Ιδρυμα Ιατροβιολογικων Ερευνων Ακαδημιας Αθηνων, |
Λιπιδικα συμπλοκα αποτελουμενα απο ανιονικα λυσο-λιπιδια και η εφαρμογη αυτων
|
|
WO2015042564A1
(en)
*
|
2013-09-23 |
2015-03-26 |
Alnylam Pharmaceuticals, Inc. |
Methods for treating or preventing transthyretin (ttr) associated diseases
|
|
CN110003066B
(zh)
|
2013-11-18 |
2021-09-03 |
阿克丘勒斯治疗公司 |
用于rna递送的可电离的阳离子脂质
|
|
US9365610B2
(en)
|
2013-11-18 |
2016-06-14 |
Arcturus Therapeutics, Inc. |
Asymmetric ionizable cationic lipid for RNA delivery
|
|
JP6752151B2
(ja)
*
|
2014-03-25 |
2020-09-09 |
アークトゥラス・セラピューティクス・インコーポレイテッドＡｒｃｔｕｒｕｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． |
遺伝子サイレンシングにおいて低下したｏｆｆ−ｔａｒｇｅｔ効果を有するｕｎａオリゴマー
|
|
JP6771387B2
(ja)
|
2014-03-25 |
2020-10-21 |
アークトゥラス・セラピューティクス・インコーポレイテッドＡｒｃｔｕｒｕｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． |
遺伝子サイレンシング用トランスサイレチン対立遺伝子選択的ｕｎａオリゴマー
|
|
US9856475B2
(en)
*
|
2014-03-25 |
2018-01-02 |
Arcturus Therapeutics, Inc. |
Formulations for treating amyloidosis
|