JP2018515107A5 - - Google Patents
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- JP2018515107A5 JP2018515107A5 JP2017559449A JP2017559449A JP2018515107A5 JP 2018515107 A5 JP2018515107 A5 JP 2018515107A5 JP 2017559449 A JP2017559449 A JP 2017559449A JP 2017559449 A JP2017559449 A JP 2017559449A JP 2018515107 A5 JP2018515107 A5 JP 2018515107A5
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- Japan
- Prior art keywords
- cells
- host
- strains
- expression
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021034586A JP7465833B2 (ja) | 2015-05-13 | 2021-03-04 | Cd3反応性に基づくt細胞リクルートポリペプチド |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562160794P | 2015-05-13 | 2015-05-13 | |
| US62/160,794 | 2015-05-13 | ||
| PCT/EP2016/060919 WO2016180982A1 (en) | 2015-05-13 | 2016-05-13 | T cell recruiting polypeptides based on cd3 reactivity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021034586A Division JP7465833B2 (ja) | 2015-05-13 | 2021-03-04 | Cd3反応性に基づくt細胞リクルートポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515107A JP2018515107A (ja) | 2018-06-14 |
| JP2018515107A5 true JP2018515107A5 (OSRAM) | 2021-04-30 |
| JP7163028B2 JP7163028B2 (ja) | 2022-10-31 |
Family
ID=55971009
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559449A Active JP7163028B2 (ja) | 2015-05-13 | 2016-05-13 | Cd3反応性に基づくt細胞リクルートポリペプチド |
| JP2021034586A Active JP7465833B2 (ja) | 2015-05-13 | 2021-03-04 | Cd3反応性に基づくt細胞リクルートポリペプチド |
| JP2023068151A Active JP7763804B2 (ja) | 2015-05-13 | 2023-04-18 | Cd3反応性に基づくt細胞リクルートポリペプチド |
| JP2025151363A Pending JP2025186357A (ja) | 2015-05-13 | 2025-09-11 | Cd3反応性に基づくt細胞リクルートポリペプチド |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021034586A Active JP7465833B2 (ja) | 2015-05-13 | 2021-03-04 | Cd3反応性に基づくt細胞リクルートポリペプチド |
| JP2023068151A Active JP7763804B2 (ja) | 2015-05-13 | 2023-04-18 | Cd3反応性に基づくt細胞リクルートポリペプチド |
| JP2025151363A Pending JP2025186357A (ja) | 2015-05-13 | 2025-09-11 | Cd3反応性に基づくt細胞リクルートポリペプチド |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US11046767B2 (OSRAM) |
| EP (2) | EP4345112A3 (OSRAM) |
| JP (4) | JP7163028B2 (OSRAM) |
| CN (4) | CN107847559B (OSRAM) |
| AU (1) | AU2016260909B2 (OSRAM) |
| CA (2) | CA2985700C (OSRAM) |
| DK (1) | DK3294319T3 (OSRAM) |
| ES (1) | ES2984656T3 (OSRAM) |
| FI (1) | FI3294319T3 (OSRAM) |
| HR (1) | HRP20240971T1 (OSRAM) |
| HU (1) | HUE067423T2 (OSRAM) |
| LT (1) | LT3294319T (OSRAM) |
| PL (1) | PL3294319T3 (OSRAM) |
| PT (1) | PT3294319T (OSRAM) |
| RS (1) | RS65904B1 (OSRAM) |
| SI (1) | SI3294319T1 (OSRAM) |
| WO (1) | WO2016180982A1 (OSRAM) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11046767B2 (en) | 2015-05-13 | 2021-06-29 | Ablynx N.V. | T cell recruiting polypeptides based on CD3 reactivity |
| MX383614B (es) | 2015-05-21 | 2025-03-14 | Harpoon Therapeutics Inc | Proteinas de union triespecificas y metodos de uso. |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| US10100106B2 (en) | 2016-05-20 | 2018-10-16 | Harpoon Therapeutics, Inc. | Single domain serum albumin binding protein |
| WO2018191438A1 (en) | 2017-04-11 | 2018-10-18 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same |
| AU2018265856B2 (en) | 2017-05-12 | 2023-04-27 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
| WO2019000223A1 (en) | 2017-06-27 | 2019-01-03 | Nanjing Legend Biotech Co., Ltd. | ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF |
| SI3694529T1 (sl) | 2017-10-13 | 2024-10-30 | Harpoon Therapeutics, Inc. | Trispecifične beljakovine in načini uporabe |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| GB201721802D0 (en) * | 2017-12-22 | 2018-02-07 | Almac Discovery Ltd | Ror1-specific antigen binding molecules |
| IL277863B2 (en) | 2018-04-11 | 2026-02-01 | Inhibrx Inc | Multispecific polypeptide constructs with forced CD3 binding and related methods and uses |
| AU2019283639A1 (en) * | 2018-06-04 | 2021-01-07 | Apo-T B.V. | Methods and means for attracting immune effector cells to tumor cells |
| CN113195544A (zh) * | 2018-06-07 | 2021-07-30 | 库利南肿瘤股份有限公司 | 多特异性结合蛋白及其使用方法 |
| US20210269525A1 (en) * | 2018-06-29 | 2021-09-02 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | ANTI-CD3e ANTIBODIES AND USES THEREOF |
| CA3105891A1 (en) | 2018-07-24 | 2020-01-30 | Inhibrx, Inc. | Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same |
| WO2020052542A1 (en) | 2018-09-10 | 2020-03-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies against cll1 and constructs thereof |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| EP3856771A4 (en) | 2018-09-25 | 2022-06-29 | Harpoon Therapeutics, Inc. | Dll3 binding proteins and methods of use |
| CN113518647A (zh) | 2018-10-11 | 2021-10-19 | 印希比股份有限公司 | 5t4单域抗体及其治疗性组合物 |
| EP3864045A2 (en) | 2018-10-11 | 2021-08-18 | Inhibrx, Inc. | Dll3 single domain antibodies and therapeutic compositions thereof |
| CN116333141B (zh) | 2019-01-15 | 2025-10-03 | 浙江道尔生物科技有限公司 | 抗cld18a2纳米抗体及其应用 |
| CN121971599A (zh) | 2019-02-25 | 2026-05-05 | 芝加哥大学 | 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物 |
| KR20220008866A (ko) | 2019-05-14 | 2022-01-21 | 하푼 테라퓨틱스, 인크. | EpCAM 결합 단백질 및 사용 방법 |
| NL2024375B1 (en) * | 2019-12-04 | 2021-08-31 | Apo T B V | Methods and means for attracting immune effector cells to tumor cells. |
| EP4073122A4 (en) | 2019-12-11 | 2024-03-27 | Cullinan Oncology, Inc. | Anti-cd19 antibodies and multi-specific binding proteins |
| IL294879A (en) | 2020-01-29 | 2022-09-01 | Inhibrx Inc | Monodomain antibodies of cd28 and their multivalent and multispecific constructs |
| CN113527496B (zh) * | 2020-04-16 | 2022-03-04 | 上海洛启生物医药技术有限公司 | 抗Trop2纳米抗体及其应用 |
| CN111548390B (zh) * | 2020-06-17 | 2022-09-06 | 清华大学深圳国际研究生院 | 一种cd133拮抗多肽及其衍生物与应用 |
| WO2024133935A1 (en) | 2022-12-23 | 2024-06-27 | Ablynx Nv | Protein-based conjugation carriers |
| WO2022109611A1 (en) | 2020-11-20 | 2022-05-27 | Simcere Innovation, Inc. | Armed dual car-t compositions and methods for cancer immunotherapy |
| US11795224B2 (en) * | 2021-03-24 | 2023-10-24 | China Medical University Hospital | Anti-T-cell nanobody and nucleic acid encoding sequence thereof, and uses of the same |
| US11795227B2 (en) * | 2021-03-24 | 2023-10-24 | Shine-On Biomedical Co., Ltd. | Immunomodulation and anti-tumor-related nanobody and nucleic acid encoding sequence thereof, and uses of the same |
| BR112023022975A2 (pt) | 2021-05-05 | 2024-01-23 | Immatics Biotechnologies Gmbh | Polipeptídeos de ligação ao antígeno bma031 melhorados |
| WO2023079524A2 (en) * | 2021-11-08 | 2023-05-11 | Life Technologies As | Polymer-interaction molecule conjugates and methods of use |
| WO2023141856A1 (zh) * | 2022-01-27 | 2023-08-03 | 岩唐生物科技(杭州)有限责任公司 | 靶向cd3的多特异性抗体及其应用 |
| AR131869A1 (es) | 2023-02-17 | 2025-05-07 | Ablynx Nv | POLIPÉPTIDOS QUE SE UNEN AL RECEPTOR DE Fc NEONATAL |
| WO2025251924A1 (zh) * | 2024-06-07 | 2025-12-11 | 广东菲鹏制药股份有限公司 | 特异性结合cd3/tcr复合物的纳米抗体或其抗原结合片段及其应用 |
| WO2026021698A1 (en) | 2024-07-23 | 2026-01-29 | BioNTech SE | Nucleic acid particle |
| WO2026078159A1 (en) | 2024-10-10 | 2026-04-16 | Ablynx Nv | Immune cell engagers and methods comprising the same |
| EP4729542A1 (en) | 2024-10-16 | 2026-04-22 | Universitätsklinikum Hamburg-Eppendorf | Antigen-binding polypeptides against cd229 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| AU687010B2 (en) | 1992-07-17 | 1998-02-19 | Dana-Farber Cancer Institute | Method of intracellular binding of target molecules |
| PT1621554E (pt) | 1992-08-21 | 2009-07-13 | Univ Bruxelles | Imunoglobtainas desprovidas de cadeias leves |
| ES2155854T3 (es) | 1993-06-09 | 2001-06-01 | Unilever Nv | Procedimiento de produccion de proteinas de fusion que comprende fragmentos de scfv con la ayuda de un molde transformado. |
| EP0745134A1 (en) | 1994-02-22 | 1996-12-04 | Danafarber Cancer Institute | Nucleic acid delivery system, method of synthesis and uses thereof |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| WO1999023221A2 (en) | 1997-10-27 | 1999-05-14 | Unilever Plc | Multivalent antigen-binding proteins |
| CN1316910A (zh) * | 1998-02-19 | 2001-10-10 | 埃克斯西特治疗公司 | 用于调节淋巴细胞活化的组合物及方法 |
| KR100508289B1 (ko) | 1998-04-21 | 2005-08-17 | 마이크로메트 에이지 | Cd19×cd3 특이 폴리펩티드 및 그의 용도 |
| US7608681B2 (en) | 1999-12-24 | 2009-10-27 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| EP1377306A1 (en) | 2001-03-09 | 2004-01-07 | Dyax Corp. | Serum albumin binding moieties |
| CN1195779C (zh) * | 2001-05-24 | 2005-04-06 | 中国科学院遗传与发育生物学研究所 | 抗人卵巢癌抗人cd3双特异性抗体 |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| WO2003014960A2 (en) | 2001-08-03 | 2003-02-20 | Medical Research Council | Method of identifying a consensus sequence for intracellular antibodies |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| US7958021B2 (en) | 2002-09-10 | 2011-06-07 | Igt | Method and device for collecting and reporting data |
| US7004940B2 (en) | 2002-10-10 | 2006-02-28 | Ethicon, Inc. | Devices for performing thermal ablation having movable ultrasound transducers |
| EP1558647B1 (en) | 2002-11-08 | 2015-06-10 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| EP2284192A3 (en) | 2002-11-08 | 2011-07-20 | Ablynx N.V. | Camelidae antibodies for sublingual administration |
| SI1639011T1 (sl) | 2003-06-30 | 2009-04-30 | Domantis Ltd | Pegilirana protitelesa z enojno domeno (dAb) |
| PT1687338E (pt) | 2003-11-07 | 2011-01-20 | Ablynx Nv | Anticorpos de domínio único vhh de camelídeos direccionados para o receptor do factor de crescimento epidérmico e suas utilizações |
| US7235641B2 (en) | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| AU2006249144B2 (en) | 2005-05-18 | 2011-11-17 | Ablynx Nv | Improved NanobodiesTM against Tumor Necrosis Factor-alpha |
| MX2007014564A (es) | 2005-05-20 | 2008-02-07 | Ablynx Nv | Anticuerpos de vhh de dominio unico contra el factor de von willebrand. |
| JP5686953B2 (ja) | 2005-10-11 | 2015-03-18 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハー | 交差種特異的(cross−species−specific)抗体を含む組成物および該組成物の使用 |
| EP2010568A1 (en) | 2006-04-14 | 2009-01-07 | Ablynx N.V. | Dp-78-like nanobodies |
| CA2666599A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| WO2008068280A1 (en) | 2006-12-05 | 2008-06-12 | Ablynx N.V. | Peptides capable of binding to serum proteins |
| WO2009068631A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
| CN102089325A (zh) | 2008-04-17 | 2011-06-08 | 埃博灵克斯股份有限公司 | 能够结合血清白蛋白的肽,以及包含其的化合物、构建体和多肽 |
| HUE053480T2 (hu) | 2009-04-30 | 2021-06-28 | Ablynx Nv | Eljárás domén ellenanyagok elõállítására |
| US9150640B2 (en) | 2009-07-10 | 2015-10-06 | Ablynx N.V. | Method for the production of variable domains |
| CN102481348A (zh) * | 2009-08-31 | 2012-05-30 | Ibc药品公司 | 双特异性免疫细胞因子停靠-和-加锁(dnl)复合物及其治疗性用途 |
| CN102781959A (zh) | 2010-02-05 | 2012-11-14 | 埃博灵克斯股份有限公司 | 能够结合血清白蛋白的肽和包含所述肽的化合物、构建体和多肽 |
| WO2011119484A1 (en) * | 2010-03-23 | 2011-09-29 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
| ES2660895T3 (es) | 2010-10-29 | 2018-03-26 | Ablynx N.V. | Método para la producción de dominios variables individuales de inmunoglobulina |
| US20130273055A1 (en) * | 2010-11-16 | 2013-10-17 | Eric Borges | Agents and methods for treating diseases that correlate with bcma expression |
| AU2012245116A1 (en) * | 2011-04-20 | 2013-11-07 | Genmab A/S | Bispecific antibodies against HER2 and CD3 |
| HUE031828T2 (en) | 2011-06-23 | 2017-08-28 | Ablynx Nv | Procedures for Predicting, Detecting, and Reducing Aspiration Protein Interference in Assays Containing Immunoglobulin Variable Single Domain |
| TWI679212B (zh) * | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對bcma之e3以及cd3的結合分子 |
| ES2680151T3 (es) | 2012-03-01 | 2018-09-04 | Amgen Research (Munich) Gmbh | Moléculas de unión de polipéptidos de larga duración |
| US20140154253A1 (en) * | 2012-07-13 | 2014-06-05 | Zymeworks Inc. | Bispecific Asymmetric Heterodimers Comprising Anti-CD3 Constructs |
| WO2014028560A2 (en) * | 2012-08-14 | 2014-02-20 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| EP2887960A2 (en) * | 2012-08-21 | 2015-07-01 | Glaxo Group Limited | Compositions comprising a single variable domain and camostat mesylate (cm) |
| JO3519B1 (ar) * | 2013-01-25 | 2020-07-05 | Amgen Inc | تركيبات أجسام مضادة لأجل cdh19 و cd3 |
| EP2769989A1 (en) * | 2013-02-21 | 2014-08-27 | Universitätsklinikum Freiburg | Recombinant bispecific antibody that binds to the CD133 antigen on tumor cells and to the human CD3 T cell receptor |
| CA2899577C (en) * | 2013-04-03 | 2023-10-17 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| PT3049439T (pt) * | 2013-09-26 | 2020-03-31 | Ablynx Nv | Nanocorpos biespecíficos |
| KR102093343B1 (ko) | 2013-10-23 | 2020-03-25 | 삼성전자주식회사 | 이미지 센서 및 이미지 센서를 구동하는 방법 |
| WO2015095412A1 (en) * | 2013-12-19 | 2015-06-25 | Zhong Wang | Bispecific antibody with two single-domain antigen-binding fragments |
| US11046767B2 (en) | 2015-05-13 | 2021-06-29 | Ablynx N.V. | T cell recruiting polypeptides based on CD3 reactivity |
-
2016
- 2016-05-13 US US15/573,298 patent/US11046767B2/en active Active
- 2016-05-13 PT PT167228915T patent/PT3294319T/pt unknown
- 2016-05-13 JP JP2017559449A patent/JP7163028B2/ja active Active
- 2016-05-13 ES ES16722891T patent/ES2984656T3/es active Active
- 2016-05-13 EP EP24155492.2A patent/EP4345112A3/en active Pending
- 2016-05-13 CN CN201680040586.1A patent/CN107847559B/zh active Active
- 2016-05-13 CN CN202210664220.9A patent/CN114920848B/zh active Active
- 2016-05-13 RS RS20240804A patent/RS65904B1/sr unknown
- 2016-05-13 FI FIEP16722891.5T patent/FI3294319T3/fi active
- 2016-05-13 AU AU2016260909A patent/AU2016260909B2/en active Active
- 2016-05-13 CA CA2985700A patent/CA2985700C/en active Active
- 2016-05-13 CA CA3155409A patent/CA3155409A1/en active Pending
- 2016-05-13 DK DK16722891.5T patent/DK3294319T3/da active
- 2016-05-13 CN CN202210164018.XA patent/CN114920847A/zh active Pending
- 2016-05-13 HU HUE16722891A patent/HUE067423T2/hu unknown
- 2016-05-13 LT LTEPPCT/EP2016/060919T patent/LT3294319T/lt unknown
- 2016-05-13 HR HRP20240971TT patent/HRP20240971T1/hr unknown
- 2016-05-13 EP EP16722891.5A patent/EP3294319B1/en active Active
- 2016-05-13 CN CN202411292391.9A patent/CN119219778A/zh active Pending
- 2016-05-13 PL PL16722891.5T patent/PL3294319T3/pl unknown
- 2016-05-13 WO PCT/EP2016/060919 patent/WO2016180982A1/en not_active Ceased
- 2016-05-13 SI SI201631835T patent/SI3294319T1/sl unknown
-
2021
- 2021-03-04 JP JP2021034586A patent/JP7465833B2/ja active Active
- 2021-05-03 US US17/246,771 patent/US12371496B2/en active Active
-
2023
- 2023-04-18 JP JP2023068151A patent/JP7763804B2/ja active Active
-
2025
- 2025-06-03 US US19/226,314 patent/US20250388672A1/en active Pending
- 2025-09-11 JP JP2025151363A patent/JP2025186357A/ja active Pending
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