JP2018514523A - リボシクリブ錠剤 - Google Patents

リボシクリブ錠剤 Download PDF

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Publication number
JP2018514523A
JP2018514523A JP2017553915A JP2017553915A JP2018514523A JP 2018514523 A JP2018514523 A JP 2018514523A JP 2017553915 A JP2017553915 A JP 2017553915A JP 2017553915 A JP2017553915 A JP 2017553915A JP 2018514523 A JP2018514523 A JP 2018514523A
Authority
JP
Japan
Prior art keywords
ribocyclib
tablet
tablets
core
succinate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017553915A
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English (en)
Japanese (ja)
Other versions
JP2018514523A5 (cg-RX-API-DMAC7.html
Inventor
グルラジャン，ビンドゥーマドハーヴァン
グランドゥリ，アルノー
コスタ，ルイ
Original Assignee
ノバルティス アーゲー
ノバルティス アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55806565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2018514523(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ノバルティス アーゲー, ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2018514523A publication Critical patent/JP2018514523A/ja
Publication of JP2018514523A5 publication Critical patent/JP2018514523A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017553915A 2015-04-16 2016-04-14 リボシクリブ錠剤 Pending JP2018514523A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562148240P 2015-04-16 2015-04-16
US62/148,240 2015-04-16
PCT/IB2016/052136 WO2016166703A1 (en) 2015-04-16 2016-04-14 Ribociclib tablet

Publications (2)

Publication Number Publication Date
JP2018514523A true JP2018514523A (ja) 2018-06-07
JP2018514523A5 JP2018514523A5 (cg-RX-API-DMAC7.html) 2019-05-23

Family

ID=55806565

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017553915A Pending JP2018514523A (ja) 2015-04-16 2016-04-14 リボシクリブ錠剤

Country Status (29)

Country Link
US (6) US10799506B2 (cg-RX-API-DMAC7.html)
EP (3) EP4620458A3 (cg-RX-API-DMAC7.html)
JP (1) JP2018514523A (cg-RX-API-DMAC7.html)
KR (2) KR20250009572A (cg-RX-API-DMAC7.html)
CN (2) CN107530292B (cg-RX-API-DMAC7.html)
AR (1) AR104257A1 (cg-RX-API-DMAC7.html)
AU (5) AU2016248017A1 (cg-RX-API-DMAC7.html)
BR (1) BR112017021283A2 (cg-RX-API-DMAC7.html)
CA (1) CA2982425C (cg-RX-API-DMAC7.html)
CL (1) CL2017002593A1 (cg-RX-API-DMAC7.html)
CO (1) CO2017010510A2 (cg-RX-API-DMAC7.html)
DK (1) DK3283058T3 (cg-RX-API-DMAC7.html)
EA (1) EA201792290A1 (cg-RX-API-DMAC7.html)
EC (1) ECSP17075052A (cg-RX-API-DMAC7.html)
ES (1) ES2938261T3 (cg-RX-API-DMAC7.html)
FI (1) FI3283058T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20230053T1 (cg-RX-API-DMAC7.html)
HU (1) HUE061213T2 (cg-RX-API-DMAC7.html)
IL (1) IL254818A0 (cg-RX-API-DMAC7.html)
MX (1) MX2017013350A (cg-RX-API-DMAC7.html)
PE (1) PE20180035A1 (cg-RX-API-DMAC7.html)
PH (1) PH12017501820A1 (cg-RX-API-DMAC7.html)
PL (1) PL3283058T3 (cg-RX-API-DMAC7.html)
PT (1) PT3283058T (cg-RX-API-DMAC7.html)
SG (1) SG11201708084PA (cg-RX-API-DMAC7.html)
SI (1) SI3283058T1 (cg-RX-API-DMAC7.html)
TN (1) TN2017000422A1 (cg-RX-API-DMAC7.html)
TW (1) TW201642864A (cg-RX-API-DMAC7.html)
WO (1) WO2016166703A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023543565A (ja) * 2020-09-29 2023-10-17 ラボラトリオス シラネス、エセ．ア．デ セ．べ． 脂質異常症及び心血管疾患の処置及び予防のためのスタチン類及びフィブラート類の薬学的配合物

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017013350A (es) * 2015-04-16 2018-01-25 Novartis Ag Comprimido de ribociclib.
CA3048036A1 (en) 2018-07-02 2020-01-02 Apotex Inc Novel crystalline form of ribociclib succinate
AU2020336309A1 (en) 2019-08-26 2022-03-17 Arvinas Operations, Inc. Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders
CR20220342A (es) 2019-12-16 2023-01-23 Lunella Biotech Inc Agentes terapéuticos selectivos contra el cáncer inhibidores cdk4/6
US12358920B2 (en) 2019-12-16 2025-07-15 Lunella Biotech, Inc. Substituted pyrrolo[2,3-d]pyrimidines as selective CDK 4/6 inhibitors
BR112023001454A2 (pt) * 2020-08-03 2023-02-14 Natco Pharma Ltd Composição de comprimido de liberação imediata e processo para a preparação da composição
WO2022162122A1 (en) 2021-01-29 2022-08-04 Biotx.Ai Gmbh Genetically verified netosis inhibitor for use in the treatment of a sars-cov2 infection
AU2022311961A1 (en) 2021-07-16 2023-11-09 Dana-Farber Cancer Institute, Inc. Small molecule cyclin dependent kinase 4/6 (cdk4/6) and ikzf2 (helios) degraders and methods of use thereof
TWI848533B (zh) 2022-01-25 2024-07-11 瑞士商諾華公司 瑞博西尼藥物組成物
JP2025530742A (ja) 2022-08-31 2025-09-17 アルビナス・オペレーションズ・インコーポレイテッド エストロゲン受容体分解物質の投与計画
EP4626890A1 (en) 2022-12-01 2025-10-08 KRKA, d.d., Novo mesto Ribociclib salts and formulations thereof
KR20250163966A (ko) 2023-03-27 2025-11-21 노파르티스 아게 리보시클립과 아로마타제 저해제를 병용하여 초기 유방암을 치료하는 방법
WO2025219830A1 (en) 2024-04-15 2025-10-23 Novartis Ag Pharmaceutical compositions of ribociclib

Citations (7)

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JPS5428812A (en) * 1977-08-09 1979-03-03 Yoshitomi Pharmaceut Ind Ltd Preparation of coated tablet
JP2013542257A (ja) * 2010-11-10 2013-11-21 ノバルティス アーゲー ７−シクロペンチル−２−（５−ピペラジン−１−イル−ピリジン−２−イルアミノ）−７ｈ−ピロロ［２，３−ｄ］ピリミジン−６−カルボン酸ジメチルアミドの塩およびその製造方法
JP2014505095A (ja) * 2011-02-11 2014-02-27 ウィスタ ラボラトリーズ リミテッド フェノチアジンジアミニウム塩およびそれらの使用
EP2742940A1 (en) * 2012-12-13 2014-06-18 IP Gesellschaft für Management mbH Salts of aza-bicyclo-di-aryl ethers for adminstration once daily, twice daily or thrice daily
WO2014097125A1 (en) * 2012-12-20 2014-06-26 Novartis Ag Pharmaceutical combination comprising binimetinib
WO2014147573A2 (en) * 2013-03-21 2014-09-25 Novartis Ag Combination therapy
WO2014195421A1 (en) * 2013-06-06 2014-12-11 Ferrer Internacional, S.A. Oral formulation for the treatment of cardiovascular diseases

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GB9414045D0 (en) 1994-07-12 1994-08-31 Berwind Pharma Service Moisture barrier film coating composition, method, and coated form
AU703933B2 (en) * 1994-07-12 1999-04-01 Berwind Pharmaceutical Services, Inc. Moisture barrier film coating composition, method, and coated form
US6448323B1 (en) * 1999-07-09 2002-09-10 Bpsi Holdings, Inc. Film coatings and film coating compositions based on polyvinyl alcohol
BRPI0917791B1 (pt) 2008-08-22 2022-03-22 Novartis Ag Compostos de pirrolopirimidina como inibidores de cdk, bem como composição farmacêutica e combinação
US8807979B2 (en) * 2009-09-24 2014-08-19 Mcneil-Ppc, Inc. Machine for the manufacture of dosage forms utilizing radiofrequency energy
LT2872482T (lt) * 2012-07-13 2020-12-28 Oncternal Therapeutics, Inc. Krūties vėžių gydymo būdas selektyviu androgeno receptoriaus moduliatoriumi
MX2017013350A (es) * 2015-04-16 2018-01-25 Novartis Ag Comprimido de ribociclib.
CN109953966A (zh) * 2017-12-26 2019-07-02 天津耀辰实业发展有限公司 一种含有瑞博西尼的药物组合物及其制备方法
JP7347388B2 (ja) 2020-09-25 2023-09-20 信越化学工業株式会社 紫外線硬化型有機変性シリコーン組成物および硬化物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5428812A (en) * 1977-08-09 1979-03-03 Yoshitomi Pharmaceut Ind Ltd Preparation of coated tablet
JP2013542257A (ja) * 2010-11-10 2013-11-21 ノバルティス アーゲー ７−シクロペンチル−２−（５−ピペラジン−１−イル−ピリジン−２−イルアミノ）−７ｈ−ピロロ［２，３−ｄ］ピリミジン−６−カルボン酸ジメチルアミドの塩およびその製造方法
JP2014505095A (ja) * 2011-02-11 2014-02-27 ウィスタ ラボラトリーズ リミテッド フェノチアジンジアミニウム塩およびそれらの使用
EP2742940A1 (en) * 2012-12-13 2014-06-18 IP Gesellschaft für Management mbH Salts of aza-bicyclo-di-aryl ethers for adminstration once daily, twice daily or thrice daily
WO2014097125A1 (en) * 2012-12-20 2014-06-26 Novartis Ag Pharmaceutical combination comprising binimetinib
WO2014147573A2 (en) * 2013-03-21 2014-09-25 Novartis Ag Combination therapy
WO2014195421A1 (en) * 2013-06-06 2014-12-11 Ferrer Internacional, S.A. Oral formulation for the treatment of cardiovascular diseases

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023543565A (ja) * 2020-09-29 2023-10-17 ラボラトリオス シラネス、エセ．ア．デ セ．べ． 脂質異常症及び心血管疾患の処置及び予防のためのスタチン類及びフィブラート類の薬学的配合物

Also Published As

Publication number Publication date
CL2017002593A1 (es) 2018-05-18
EP4197530A1 (en) 2023-06-21
AU2020250190A1 (en) 2020-11-05
CA2982425A1 (en) 2016-10-20
AU2022215155B2 (en) 2024-08-01
CN115554257A (zh) 2023-01-03
PE20180035A1 (es) 2018-01-09
HUE061213T2 (hu) 2023-05-28
TW201642864A (zh) 2016-12-16
BR112017021283A2 (pt) 2018-06-26
PH12017501820A1 (en) 2018-04-23
IL254818A0 (en) 2017-12-31
US12419894B2 (en) 2025-09-23
US20180071292A1 (en) 2018-03-15
EP4620458A3 (en) 2025-10-22
KR102750931B1 (ko) 2025-01-09
HRP20230053T1 (hr) 2023-03-03
PL3283058T3 (pl) 2023-03-20
US20250134893A1 (en) 2025-05-01
US20250090531A1 (en) 2025-03-20
CO2017010510A2 (es) 2018-03-20
SI3283058T1 (sl) 2023-03-31
AR104257A1 (es) 2017-07-05
EP3283058B1 (en) 2022-11-16
CN107530292B (zh) 2022-11-01
KR20170137101A (ko) 2017-12-12
ES2938261T3 (es) 2023-04-05
US12064434B2 (en) 2024-08-20
MX2017013350A (es) 2018-01-25
SG11201708084PA (en) 2017-10-30
EP4197530B1 (en) 2025-11-12
FI3283058T3 (fi) 2023-03-01
PT3283058T (pt) 2023-02-03
CA2982425C (en) 2023-10-31
AU2016248017A1 (en) 2017-10-19
US20230104792A1 (en) 2023-04-06
EP3283058A1 (en) 2018-02-21
AU2022215155A1 (en) 2022-09-01
US20200390771A1 (en) 2020-12-17
EA201792290A1 (ru) 2018-02-28
TN2017000422A1 (en) 2019-01-16
ECSP17075052A (es) 2018-02-28
KR20250009572A (ko) 2025-01-17
AU2019201929A1 (en) 2019-04-11
CN107530292A (zh) 2018-01-02
WO2016166703A1 (en) 2016-10-20
AU2019201929B2 (en) 2020-07-09
US20250127785A1 (en) 2025-04-24
DK3283058T3 (da) 2023-02-13
EP4620458A2 (en) 2025-09-24
AU2024227794A1 (en) 2024-11-21
US10799506B2 (en) 2020-10-13

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