JP2018513150A5 - - Google Patents
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- JP2018513150A5 JP2018513150A5 JP2017553109A JP2017553109A JP2018513150A5 JP 2018513150 A5 JP2018513150 A5 JP 2018513150A5 JP 2017553109 A JP2017553109 A JP 2017553109A JP 2017553109 A JP2017553109 A JP 2017553109A JP 2018513150 A5 JP2018513150 A5 JP 2018513150A5
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- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- enantiomer
- solvate
- diastereoisomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 C*c1cc2nccc(OC3CICCC(*)C3)c2cc1C(N)=O Chemical compound C*c1cc2nccc(OC3CICCC(*)C3)c2cc1C(N)=O 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019203698A JP6928774B2 (ja) | 2015-04-07 | 2019-11-11 | チロシンキナーゼ阻害剤およびそれを含む医薬組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510161674.4 | 2015-04-07 | ||
| CN201510161674 | 2015-04-07 | ||
| PCT/CN2016/078703 WO2016161952A1 (zh) | 2015-04-07 | 2016-04-07 | 酪氨酸激酶抑制剂及包含该酪氨酸激酶抑制剂的药物组合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019203698A Division JP6928774B2 (ja) | 2015-04-07 | 2019-11-11 | チロシンキナーゼ阻害剤およびそれを含む医薬組成物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2018513150A JP2018513150A (ja) | 2018-05-24 |
| JP2018513150A5 true JP2018513150A5 (https=) | 2018-08-02 |
| JP6617155B2 JP6617155B2 (ja) | 2019-12-11 |
| JP6617155B6 JP6617155B6 (ja) | 2020-01-22 |
Family
ID=57072288
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553109A Active JP6617155B6 (ja) | 2015-04-07 | 2016-04-07 | チロシンキナーゼ阻害剤およびそれを含む医薬組成物 |
| JP2019203698A Active JP6928774B2 (ja) | 2015-04-07 | 2019-11-11 | チロシンキナーゼ阻害剤およびそれを含む医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019203698A Active JP6928774B2 (ja) | 2015-04-07 | 2019-11-11 | チロシンキナーゼ阻害剤およびそれを含む医薬組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10654808B2 (https=) |
| EP (1) | EP3293177B1 (https=) |
| JP (2) | JP6617155B6 (https=) |
| CN (3) | CN106046007B (https=) |
| WO (1) | WO2016161952A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108430977B (zh) * | 2015-12-25 | 2021-06-08 | 株式会社大塚制药工场 | 苯基咪唑化合物 |
| EP3521276B1 (en) * | 2016-09-30 | 2021-03-10 | Guangdong Raynovent Biotech Co., Ltd. | Crystal form and salt form of and preparation method for tyrosine kinase inhibitor |
| CN110049969A (zh) * | 2017-02-07 | 2019-07-23 | 恩瑞生物医药科技（上海）有限公司 | 喹啉类化合物、其制备方法及其医药用途 |
| CN107115344B (zh) * | 2017-03-23 | 2019-06-14 | 广东众生睿创生物科技有限公司 | 酪氨酸激酶抑制剂在制备用于预防和/或治疗纤维化疾病的药物中的用途 |
| KR102327054B1 (ko) * | 2017-08-29 | 2021-11-17 | 기초과학연구원 | 퀴놀린 유도체 및 alk와 변이된 alk의 저해제로서의 용도 |
| TW201920104A (zh) * | 2017-08-31 | 2019-06-01 | 美商馬愈法瑪公司 | 外核苷酸焦磷酸酶-磷酸二酯酶1(enpp-1)抑制劑及其用途 |
| ES2932805T3 (es) * | 2017-09-28 | 2023-01-26 | Chongqing Pharmaceutical Industrial Res Institute Co Ltd | Derivado de quinolina y aplicación del mismo como inhibidor de la tirosina quinasa |
| CN108623521B (zh) * | 2018-03-22 | 2020-09-04 | 盐城师范学院 | 一种乐伐替尼的制备方法 |
| CN110483482A (zh) * | 2018-05-15 | 2019-11-22 | 北京诺诚健华医药科技有限公司 | 吲哚啉-1-甲酰胺类化合物、其制备方法及其在医药学上的应用 |
| CN110590839B (zh) * | 2018-06-13 | 2022-04-05 | 四川海思科制药有限公司 | 一种乐伐替尼衍生物及制备方法和用途 |
| CN110862397A (zh) * | 2018-08-27 | 2020-03-06 | 北京赛特明强医药科技有限公司 | 二噁烷并喹唑啉与二噁烷并喹啉类化合物及其制备方法与应用 |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| US12522583B2 (en) | 2018-11-07 | 2026-01-13 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof |
| EP3877371A4 (en) | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| CN109485620A (zh) * | 2018-12-26 | 2019-03-19 | 安徽工大化工科技有限公司 | 一种2-甲氧基-6-甲氧基苯并噻唑的制备方法 |
| JP7777332B2 (ja) * | 2019-02-01 | 2025-11-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 免疫応答をモジュレートするｅｎｐｐ１阻害剤および方法 |
| US20220213064A1 (en) * | 2019-04-12 | 2022-07-07 | National Health Research Institutes | Heterocyclic compounds as kinase inhibitors for therapeutic uses |
| CN111892536B (zh) * | 2019-05-05 | 2022-06-28 | 北京福元医药股份有限公司 | 取代的喹啉甲酰胺类化合物及其用途 |
| EP3985005A4 (en) * | 2019-06-14 | 2023-07-19 | CGeneTech (Suzhou, China) Co., Ltd. | FUSED RING COMPOUND AS DUAL FGFR AND VEGFR INHIBITOR |
| ES3056661T3 (en) * | 2019-08-08 | 2026-02-23 | Hirundo Biosciences | Quinoline derivatives as protein kinase inhibitors |
| CN113321654B (zh) * | 2020-02-28 | 2022-05-03 | 上海济煜医药科技有限公司 | 作为激酶抑制剂的稠合吡啶酮类化合物 |
| US11691963B2 (en) | 2020-05-06 | 2023-07-04 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| US12043632B2 (en) | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| CN113582924A (zh) * | 2021-09-09 | 2021-11-02 | 四川国康药业有限公司 | 一种多靶点酪氨酸激酶抑制剂及其制备方法和用途 |
| WO2023086319A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
| CN114213404B (zh) * | 2021-12-27 | 2024-08-06 | 武汉九州钰民医药科技有限公司 | Vegfr抑制剂替沃扎尼的合成工艺 |
| CN118843617A (zh) * | 2022-03-29 | 2024-10-25 | 广东众生睿创生物科技有限公司 | 一种喹啉衍生物的晶型及其制备方法 |
| CN115215799B (zh) * | 2022-08-12 | 2024-05-31 | 上海爱博医药科技有限公司 | 脲类多靶点酪氨酸激酶抑制剂及其多种医药应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998013350A1 (en) * | 1996-09-25 | 1998-04-02 | Zeneca Limited | Qinoline derivatives inhibiting the effect of growth factors such as vegf |
| GB9904103D0 (en) * | 1999-02-24 | 1999-04-14 | Zeneca Ltd | Quinoline derivatives |
| WO2002012226A1 (en) * | 2000-08-09 | 2002-02-14 | Astrazeneca Ab | Quinoline derivatives having vegf inhibiting activity |
| AU9598601A (en) | 2000-10-20 | 2002-04-29 | Eisai Co Ltd | Nitrogenous aromatic ring compounds |
| ES2314444T3 (es) * | 2003-08-29 | 2009-03-16 | Pfizer Inc. | Tienopiridina-fenilacetaminasy sus derivados utiles como nuevos agentes antiangiogenicos. |
| AU2004309166B2 (en) * | 2003-12-23 | 2008-02-21 | Pfizer Inc. | Novel quinoline derivatives |
| JP2007518823A (ja) * | 2004-01-23 | 2007-07-12 | アムゲン インコーポレイテッド | キノリン、キナゾリン、ピリジン、及びピリミジン化合物と炎症、血管新生、及び癌に対する治療におけるそれら化合物の用途 |
| US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| CN1993130B (zh) * | 2004-06-28 | 2010-06-23 | 布里斯托尔-迈尔斯斯奎布公司 | 用于制备稠合杂环激酶抑制剂的方法和中间体 |
| WO2006125597A1 (en) * | 2005-05-24 | 2006-11-30 | Unilever N.V. | Toothbrush |
| EP1964837A4 (en) * | 2005-11-22 | 2010-12-22 | Eisai R&D Man Co Ltd | Antitumor agent against multiple myeloma |
| CA2649288C (en) * | 2006-04-19 | 2015-11-24 | Novartis Ag | 6-o-substituted benzoxazole and benzothiazole compounds and methods of inhibiting csf-1r signaling |
| JP4667537B2 (ja) * | 2008-04-10 | 2011-04-13 | 大鵬薬品工業株式会社 | アシルチオウレア化合物又はその塩、及びその用途 |
| US8957216B2 (en) * | 2010-03-24 | 2015-02-17 | Amitech Therapeutic Solutions, Inc. | Heterocyclic compounds useful for kinase inhibition |
| CN102958523B (zh) * | 2010-06-25 | 2014-11-19 | 卫材R&D管理有限公司 | 使用具有激酶抑制作用的组合的抗肿瘤剂 |
| RU2568258C2 (ru) * | 2011-02-28 | 2015-11-20 | Саншайн Лейк Фарма Ко., Лтд | Замещенные соединения хинолина и способы их использования |
| CN102816175B (zh) * | 2011-06-09 | 2015-12-16 | 上海汇伦生命科技有限公司 | 一种杂环并吡啶酮类化合物,其中间体、制备方法和用途 |
| SG11201402004YA (en) * | 2011-11-14 | 2014-05-29 | Cephalon Inc | Uracil derivatives as axl and c-met kinase inhibitors |
| WO2013180949A1 (en) * | 2012-05-27 | 2013-12-05 | Ning Xi | Substituted quinoline compounds and methods of use |
| KR20150098605A (ko) * | 2012-12-21 | 2015-08-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 퀴놀린 유도체의 비정질 형태 및 그의 제조방법 |
| EP3119476A1 (en) * | 2014-03-17 | 2017-01-25 | Exelixis, Inc. | Dosing of cabozantinib formulations |
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2016
- 2016-04-07 WO PCT/CN2016/078703 patent/WO2016161952A1/zh not_active Ceased
- 2016-04-07 CN CN201610211659.0A patent/CN106046007B/zh active Active
- 2016-04-07 CN CN201680019729.0A patent/CN107683279B/zh active Active
- 2016-04-07 CN CN202011033493.0A patent/CN112028825B/zh active Active
- 2016-04-07 JP JP2017553109A patent/JP6617155B6/ja active Active
- 2016-04-07 EP EP16776127.9A patent/EP3293177B1/en active Active
- 2016-04-07 US US15/562,825 patent/US10654808B2/en active Active
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2019
- 2019-11-11 JP JP2019203698A patent/JP6928774B2/ja active Active