JP2018513141A5 - - Google Patents
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- Publication number
- JP2018513141A5 JP2018513141A5 JP2017551169A JP2017551169A JP2018513141A5 JP 2018513141 A5 JP2018513141 A5 JP 2018513141A5 JP 2017551169 A JP2017551169 A JP 2017551169A JP 2017551169 A JP2017551169 A JP 2017551169A JP 2018513141 A5 JP2018513141 A5 JP 2018513141A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- cdr
- seq
- residues
- epitope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims 21
- 201000011510 cancer Diseases 0.000 claims 21
- 108010056045 K cadherin Proteins 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 18
- 108010018828 cadherin 5 Proteins 0.000 claims 18
- 101710196881 Cadherin-17 Proteins 0.000 claims 17
- 102100024152 Cadherin-17 Human genes 0.000 claims 17
- 101710196906 Cadherin-20 Proteins 0.000 claims 17
- 102100022480 Cadherin-20 Human genes 0.000 claims 17
- 102100029761 Cadherin-5 Human genes 0.000 claims 17
- 102100029756 Cadherin-6 Human genes 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 8
- 239000003550 marker Substances 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 101000762247 Homo sapiens Cadherin-17 Proteins 0.000 claims 6
- 101000899459 Homo sapiens Cadherin-20 Proteins 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 102000051456 human CDH17 Human genes 0.000 claims 6
- 102000043623 human CDH20 Human genes 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 101000794587 Homo sapiens Cadherin-5 Proteins 0.000 claims 5
- 101000794604 Homo sapiens Cadherin-6 Proteins 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 208000017897 Carcinoma of esophagus Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 201000005619 esophageal carcinoma Diseases 0.000 claims 4
- 206010017758 gastric cancer Diseases 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 4
- 208000014018 liver neoplasm Diseases 0.000 claims 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 210000004798 organs belonging to the digestive system Anatomy 0.000 claims 4
- 201000002528 pancreatic cancer Diseases 0.000 claims 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 3
- 201000011549 stomach cancer Diseases 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 241000282836 Camelus dromedarius Species 0.000 claims 1
- 108010069514 Cyclic Peptides Proteins 0.000 claims 1
- 102000001189 Cyclic Peptides Human genes 0.000 claims 1
- 108700022150 Designed Ankyrin Repeat Proteins Proteins 0.000 claims 1
- 108010079855 Peptide Aptamers Proteins 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000010749 gastric carcinoma Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 108091008104 nucleic acid aptamers Proteins 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 201000000498 stomach carcinoma Diseases 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2015/058527 WO2016169581A1 (en) | 2015-04-20 | 2015-04-20 | Agents binding specifically to human cadherin-17, human cadherin-5, human cadherin-6 and human cadherin-20 rgd motif |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018513141A JP2018513141A (ja) | 2018-05-24 |
| JP2018513141A5 true JP2018513141A5 (https=) | 2018-07-05 |
Family
ID=52875715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551169A Pending JP2018513141A (ja) | 2015-04-20 | 2015-04-20 | ヒトカドヘリン−１７、ヒトカドヘリン−５、ヒトカドヘリン−６およびヒトカドヘリン−２０のｒｇｄモチーフに特異的に結合する薬剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10829560B2 (https=) |
| EP (1) | EP3286218B1 (https=) |
| JP (1) | JP2018513141A (https=) |
| AU (1) | AU2015392603B2 (https=) |
| ES (1) | ES2939013T3 (https=) |
| WO (1) | WO2016169581A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2703949C1 (ru) * | 2018-04-27 | 2019-10-22 | Открытое акционерное общество "Всероссийский научный Центр молекулярной диагностики и лечения" (ОАО ВНЦМДЛ) | Вариабельные домены лёгкой и тяжёлой цепи мышиного моноклонального антитела против кадгерина-17 человека, антигенсвязывающий фрагмент (Fab) против кадгерина-17 человека, содержащий указанные домены |
| US20210116456A1 (en) * | 2018-05-16 | 2021-04-22 | Arbele Limited | Compositions and methods for diagnosis and treatment of cancer |
| CN111349157B (zh) * | 2018-12-21 | 2023-06-23 | 艾比玛特医药科技（上海）有限公司 | 钙粘附蛋白6的单克隆抗体及其应用 |
| JP7249579B2 (ja) * | 2019-02-20 | 2023-03-31 | 日本電信電話株式会社 | 細胞接着基板及びその製造方法 |
| AU2022406708A1 (en) * | 2021-12-10 | 2024-06-27 | Multitude Therapeutics Inc. | Anti-cdh6 antibodies and antibody-drug conjugates thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2003038096A1 (ja) | 2001-10-30 | 2005-02-24 | 俊一郎 久保田 | 血管新生阻害因子に対する受容体および血管新生阻害因子のスクリーニング方法 |
| CA2566257A1 (en) | 2004-05-07 | 2005-11-24 | Applera Corporation | Genetic polymorphisms associated with vascular diseases, methods of detection and uses thereof |
| DE102004023187A1 (de) * | 2004-05-11 | 2005-12-01 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
| DK2421898T3 (en) | 2009-04-20 | 2016-05-30 | Oxford Biotherapeutics Ltd | Cadherin-17 SPECIFIC ANTIBODIES |
| KR101809761B1 (ko) | 2009-09-24 | 2017-12-15 | 가부시키가이샤 진 테크노 사이언스 | 세포 외 기질 단백질의 아미노산 서열 ｒｇｄ에 특이적인 인간화된 항체 및 그의 용도 |
| KR101398079B1 (ko) | 2011-10-10 | 2014-05-27 | 재단법인 의약바이오컨버젼스연구단 | 글리실-티알엔에이 합성효소 및 캐드헤린을 이용한 암 예방 또는 치료제의 스크리닝 방법 |
| HK1214652A1 (zh) * | 2013-03-13 | 2016-07-29 | 克里蒂科斯有限责任公司 | 用於检测胰腺癌的方法和组合物 |
-
2015
- 2015-04-20 WO PCT/EP2015/058527 patent/WO2016169581A1/en not_active Ceased
- 2015-04-20 ES ES15716831T patent/ES2939013T3/es active Active
- 2015-04-20 JP JP2017551169A patent/JP2018513141A/ja active Pending
- 2015-04-20 AU AU2015392603A patent/AU2015392603B2/en active Active
- 2015-04-20 US US15/565,937 patent/US10829560B2/en active Active
- 2015-04-20 EP EP15716831.1A patent/EP3286218B1/en active Active
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