JP2019513410A5 - - Google Patents

Info

Publication number

JP2019513410A5

JP2019513410A5 JP2018562399A JP2018562399A JP2019513410A5 JP 2019513410 A5 JP2019513410 A5 JP 2019513410A5 JP 2018562399 A JP2018562399 A JP 2018562399A JP 2018562399 A JP2018562399 A JP 2018562399A JP 2019513410 A5 JP2019513410 A5 JP 2019513410A5

Authority

JP

Japan

Prior art keywords

seq

hvr

cells

acid sequence

antibody

Prior art date

2017-02-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000004027 cell Anatomy 0.000 claims 20
• 125000003275 alpha amino acid group Chemical group 0.000 claims 8
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 7
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 5
• 210000004969 inflammatory cell Anatomy 0.000 claims 5
• OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 4
• OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 4
• MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 4
• OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 4
• MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 4
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
• 229950006780 n-acetylglucosamine Drugs 0.000 claims 4
• 150000007523 nucleic acids Chemical group 0.000 claims 4
• 108091033319 polynucleotide Proteins 0.000 claims 4
• 102000040430 polynucleotide Human genes 0.000 claims 4
• 239000002157 polynucleotide Substances 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000036764 Adenocarcinoma of the esophagus Diseases 0.000 claims 1
• 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims 1
• 241000321096 Adenoides Species 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 201000009030 Carcinoma Diseases 0.000 claims 1
• 206010008342 Cervix carcinoma Diseases 0.000 claims 1
• 201000008808 Fibrosarcoma Diseases 0.000 claims 1
• 208000005577 Gastroenteritis Diseases 0.000 claims 1
• 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
• 208000032612 Glial tumor Diseases 0.000 claims 1
• 206010018338 Glioma Diseases 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 206010030137 Oesophageal adenocarcinoma Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010038019 Rectal adenocarcinoma Diseases 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
• 210000002534 adenoid Anatomy 0.000 claims 1
• 239000012472 biological sample Substances 0.000 claims 1
• 201000010881 cervical cancer Diseases 0.000 claims 1
• 206010009887 colitis Diseases 0.000 claims 1
• 201000010897 colon adenocarcinoma Diseases 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 208000010643 digestive system disease Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 208000018529 duodenal adenocarcinoma Diseases 0.000 claims 1
• 201000005839 duodenum adenocarcinoma Diseases 0.000 claims 1
• 208000028653 esophageal adenocarcinoma Diseases 0.000 claims 1
• 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
• 208000005017 glioblastoma Diseases 0.000 claims 1
• 230000000968 intestinal effect Effects 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 201000007270 liver cancer Diseases 0.000 claims 1
• 208000014018 liver neoplasm Diseases 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims 1
• 201000001281 rectum adenocarcinoma Diseases 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1