CN109071668B - 抗n-乙酰基葡萄糖胺和n-乙酰基-半乳糖胺的抗体 - Google Patents
抗n-乙酰基葡萄糖胺和n-乙酰基-半乳糖胺的抗体 Download PDFInfo
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- CN109071668B CN109071668B CN201780008964.2A CN201780008964A CN109071668B CN 109071668 B CN109071668 B CN 109071668B CN 201780008964 A CN201780008964 A CN 201780008964A CN 109071668 B CN109071668 B CN 109071668B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
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- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
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- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2016/074146 WO2017139975A1 (en) | 2016-02-19 | 2016-02-19 | Antibodies against n-acetylglucosamine and n-acetyl-galactosamine |
| CNPCT/CN2016/074146 | 2016-02-19 | ||
| PCT/CN2017/073890 WO2017140256A1 (en) | 2016-02-19 | 2017-02-17 | Antibodies against n-acetylglucosamine and n-acetyl-galactosamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109071668A CN109071668A (zh) | 2018-12-21 |
| CN109071668B true CN109071668B (zh) | 2022-09-02 |
Family
ID=59624718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780008964.2A Active CN109071668B (zh) | 2016-02-19 | 2017-02-17 | 抗n-乙酰基葡萄糖胺和n-乙酰基-半乳糖胺的抗体 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US11446328B2 (https=) |
| JP (1) | JP6972030B2 (https=) |
| CN (1) | CN109071668B (https=) |
| WO (2) | WO2017139975A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014151526A1 (en) | 2013-03-15 | 2014-09-25 | Huiru Wang | Biological therapeutics for infection-relating disorders or conditions |
| WO2016026143A1 (en) | 2014-08-22 | 2016-02-25 | Huiru Wang | Saccharide-based biomarkers and therapeutics |
| WO2017139975A1 (en) | 2016-02-19 | 2017-08-24 | Huiru Wang | Antibodies against n-acetylglucosamine and n-acetyl-galactosamine |
| EP3870614A1 (en) * | 2018-10-23 | 2021-09-01 | GlyCardial Diagnostics, S.L. | Antibodies specific for glycosylated apoj and uses thereof |
| WO2020171020A1 (ja) * | 2019-02-18 | 2020-08-27 | 株式会社エヌビィー健康研究所 | 細胞の選抜方法、核酸の製造方法、組換え細胞の製造方法、目的物質の製造方法、医薬組成物の製造方法、及び試薬 |
| CN111234022B (zh) * | 2019-12-16 | 2024-03-22 | 江苏省药物研究所有限公司 | 抗n-乙酰氨基葡萄糖转移酶修饰的蛋白质单克隆抗体及杂交瘤细胞株和其制备方法与应用 |
| WO2025090749A1 (en) * | 2023-10-25 | 2025-05-01 | St. Jude Children's Research Hospital, Inc. | Chimeric antigen receptors targeting leucine rich repeat containing 15 (lrrc15) |
| CN118891290A (zh) * | 2024-04-12 | 2024-11-01 | 科济生物医药(上海)有限公司 | 细胞免疫疗法的组合物和方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0390115A1 (en) * | 1989-03-29 | 1990-10-03 | Ikuo Yamashina | Monoclonal antibody NNY128 |
| WO2011054359A2 (en) * | 2009-11-06 | 2011-05-12 | University Of Copenhagen | Method for early detection of cancer |
| CN102178686A (zh) * | 2010-01-07 | 2011-09-14 | 王慧茹 | 多糖相关疾病的药物和疫苗及免疫测定产品 |
| CN107074960A (zh) * | 2014-08-22 | 2017-08-18 | 王慧茹 | 基于糖类的生物标记物和治疗剂 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| EP0407586A4 (en) | 1988-09-14 | 1991-01-30 | Teijin Limited | Human monoclonal antibody and process for its preparation |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| DE69232137T2 (de) | 1991-11-25 | 2002-05-29 | Enzon Inc | Multivalente antigen-bindende proteine |
| JP2005535723A (ja) * | 2002-08-20 | 2005-11-24 | バイオティ セラピィーズ コープ | 腫瘍特異的オリゴ糖エピトープおよびその用途 |
| DE10303664A1 (de) | 2003-01-23 | 2004-08-12 | Nemod Immuntherapie Ag | Erkennungsmoleküle zur Behandlung und Detektion von Tumoren |
| EP1692519B1 (en) * | 2003-12-03 | 2010-06-02 | Glycominds Ltd. | Method for diagnosing diseases based on levels of anti-glycan antibodies |
| US9250248B2 (en) * | 2006-11-01 | 2016-02-02 | The Johns Hopkins University | Early detection of diabetes |
| US20090324617A1 (en) | 2008-01-24 | 2009-12-31 | Glykos Finland Ltd. | Cancer specific glycans and use thereof |
| US9119866B2 (en) * | 2008-04-08 | 2015-09-01 | Huiru Wang | Glycan-based drugs, therapies and biomarkers |
| JP5773352B2 (ja) * | 2008-10-28 | 2015-09-02 | 塩野義製薬株式会社 | 抗muc1抗体 |
| US8957188B2 (en) * | 2009-04-01 | 2015-02-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibodies that bind GalNAc1-3Gal, pharmaceutical compositions and methods of using same |
| EP2281844A1 (en) | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC 1 antibodies |
| EP2565268A4 (en) * | 2010-04-28 | 2013-10-09 | Shionogi & Co | NEW MUC1 ANTIBODY |
| CN102372773B (zh) * | 2010-08-11 | 2013-06-05 | 中国科学院生物物理研究所 | 人膀胱癌肿瘤标志物及其抗体和应用 |
| WO2012081701A1 (ja) * | 2010-12-16 | 2012-06-21 | 独立行政法人産業技術総合研究所 | 髄液型糖タンパク質の富化及び分離方法、並びにその方法を用いた中枢神経系疾患用マーカーの探索方法及び中枢神経系疾患用マーカー |
| AU2013204922B2 (en) * | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| US10317409B2 (en) * | 2013-03-01 | 2019-06-11 | Detroit R&D, Inc. | Glycosylation site-specific antibodies and anti-cancer compounds |
| RS58768B1 (sr) * | 2013-03-14 | 2019-06-28 | Merck Patent Gmbh | Inhibitori glikozidaze |
| WO2014159244A2 (en) * | 2013-03-14 | 2014-10-02 | Merck Patent Gmbh | O-GlcNAc TAU ANTIBODY AND USE THEREOF |
| JP6750148B2 (ja) * | 2014-04-25 | 2020-09-02 | 公益財団法人野口研究所 | 糖鎖切断抗体の製造方法及び均一糖鎖抗体 |
| CN104267185B (zh) | 2014-09-12 | 2016-05-18 | 范飞舟 | 检测肿瘤的试剂盒及其专用识别n-乙酰氨基葡萄糖的物质 |
| CN104198707B (zh) * | 2014-09-12 | 2016-09-14 | 范飞舟 | N-乙酰氨基葡萄糖在制备检测肿瘤的试剂盒中的应用 |
| CN105177031B (zh) * | 2015-06-12 | 2018-04-24 | 北京艺妙神州医疗科技有限公司 | 嵌合抗原受体修饰的t细胞及其用途 |
| WO2017139975A1 (en) | 2016-02-19 | 2017-08-24 | Huiru Wang | Antibodies against n-acetylglucosamine and n-acetyl-galactosamine |
-
2016
- 2016-02-19 WO PCT/CN2016/074146 patent/WO2017139975A1/en not_active Ceased
-
2017
- 2017-02-17 CN CN201780008964.2A patent/CN109071668B/zh active Active
- 2017-02-17 US US15/999,337 patent/US11446328B2/en active Active
- 2017-02-17 JP JP2018562399A patent/JP6972030B2/ja active Active
- 2017-02-17 WO PCT/CN2017/073890 patent/WO2017140256A1/en not_active Ceased
-
2022
- 2022-08-12 US US17/819,545 patent/US12391766B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0390115A1 (en) * | 1989-03-29 | 1990-10-03 | Ikuo Yamashina | Monoclonal antibody NNY128 |
| WO2011054359A2 (en) * | 2009-11-06 | 2011-05-12 | University Of Copenhagen | Method for early detection of cancer |
| CN102178686A (zh) * | 2010-01-07 | 2011-09-14 | 王慧茹 | 多糖相关疾病的药物和疫苗及免疫测定产品 |
| CN107074960A (zh) * | 2014-08-22 | 2017-08-18 | 王慧茹 | 基于糖类的生物标记物和治疗剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6972030B2 (ja) | 2021-11-24 |
| US20230065536A1 (en) | 2023-03-02 |
| WO2017139975A1 (en) | 2017-08-24 |
| CN109071668A (zh) | 2018-12-21 |
| WO2017140256A1 (en) | 2017-08-24 |
| JP2019513410A (ja) | 2019-05-30 |
| US20190038669A1 (en) | 2019-02-07 |
| US12391766B2 (en) | 2025-08-19 |
| US11446328B2 (en) | 2022-09-20 |
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