JP2018513135A5 - - Google Patents
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- JP2018513135A5 JP2018513135A5 JP2017549815A JP2017549815A JP2018513135A5 JP 2018513135 A5 JP2018513135 A5 JP 2018513135A5 JP 2017549815 A JP2017549815 A JP 2017549815A JP 2017549815 A JP2017549815 A JP 2017549815A JP 2018513135 A5 JP2018513135 A5 JP 2018513135A5
- Authority
- JP
- Japan
- Prior art keywords
- molecule
- variable region
- scfv
- antibody variable
- fab
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 39
- 108091008874 T cell receptors Proteins 0.000 claims description 34
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 34
- 102000027450 oncoproteins Human genes 0.000 claims description 30
- 108091008819 oncoproteins Proteins 0.000 claims description 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 30
- 102000004169 proteins and genes Human genes 0.000 claims description 22
- 108090000623 proteins and genes Proteins 0.000 claims description 22
- 230000035772 mutation Effects 0.000 claims description 20
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims description 10
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims description 7
- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 102000037865 fusion proteins Human genes 0.000 claims description 6
- 108020001507 fusion proteins Proteins 0.000 claims description 6
- 230000003834 intracellular effect Effects 0.000 claims description 6
- 210000000265 leukocyte Anatomy 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 4
- 102000001301 EGF receptor Human genes 0.000 claims description 4
- 108060006698 EGF receptor Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 102000015735 Beta-catenin Human genes 0.000 claims description 2
- 108060000903 Beta-catenin Proteins 0.000 claims description 2
- 102100030708 GTPase KRas Human genes 0.000 claims description 2
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims description 2
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims description 2
- 108010086377 HLA-A3 Antigen Proteins 0.000 claims description 2
- 108091034117 Oligonucleotide Proteins 0.000 claims description 2
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 claims description 2
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 claims description 2
- 239000000178 monomer Substances 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 238000002823 phage display Methods 0.000 claims description 2
- 238000002818 protein evolution Methods 0.000 claims description 2
- 102200044886 rs121913409 Human genes 0.000 claims description 2
- 102200006531 rs121913529 Human genes 0.000 claims description 2
- 102200006539 rs121913529 Human genes 0.000 claims description 2
- 102200006538 rs121913530 Human genes 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002702 ribosome display Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021072976A JP7304911B2 (ja) | 2015-03-23 | 2021-04-23 | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
| JP2023063966A JP2023085528A (ja) | 2015-03-23 | 2023-04-11 | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562136843P | 2015-03-23 | 2015-03-23 | |
| US62/136,843 | 2015-03-23 | ||
| US201562186455P | 2015-06-30 | 2015-06-30 | |
| US62/186,455 | 2015-06-30 | ||
| PCT/US2016/023673 WO2016154246A1 (en) | 2015-03-23 | 2016-03-23 | Hla-restricted epitopes encoded by somatically mutated genes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021072976A Division JP7304911B2 (ja) | 2015-03-23 | 2021-04-23 | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513135A JP2018513135A (ja) | 2018-05-24 |
| JP2018513135A5 true JP2018513135A5 (OSRAM) | 2019-05-09 |
| JP6944877B2 JP6944877B2 (ja) | 2021-10-06 |
Family
ID=56977729
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549815A Active JP6944877B2 (ja) | 2015-03-23 | 2016-03-23 | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
| JP2021072976A Active JP7304911B2 (ja) | 2015-03-23 | 2021-04-23 | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
| JP2023063966A Pending JP2023085528A (ja) | 2015-03-23 | 2023-04-11 | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021072976A Active JP7304911B2 (ja) | 2015-03-23 | 2021-04-23 | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
| JP2023063966A Pending JP2023085528A (ja) | 2015-03-23 | 2023-04-11 | 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20180086832A1 (OSRAM) |
| EP (1) | EP3286222A4 (OSRAM) |
| JP (3) | JP6944877B2 (OSRAM) |
| CN (2) | CN115873129A (OSRAM) |
| AU (3) | AU2016235251B2 (OSRAM) |
| CA (1) | CA2980292A1 (OSRAM) |
| WO (1) | WO2016154246A1 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016154047A2 (en) * | 2015-03-20 | 2016-09-29 | Memorial Sloan-Kettering Cancer Center | Monoclonal antigen-binding proteins to intracellular oncogene products |
| KR102760578B1 (ko) | 2016-12-22 | 2025-02-03 | 큐 바이오파마, 인크. | T-세포 조절 다량체 폴리펩타이드 및 이의 사용 방법 |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| CN110603267A (zh) * | 2017-03-08 | 2019-12-20 | 新加坡科技研究局 | 与p53-MHC I类复合物结合的T细胞受体样抗体 |
| IL269000B2 (en) | 2017-03-15 | 2024-06-01 | Cue Biopharma Inc | Methods for modulating an immune response |
| TW201907937A (zh) | 2017-05-08 | 2019-03-01 | 美商葛利史東腫瘤科技公司 | 阿爾法病毒新抗原載體 |
| AU2018269370B2 (en) * | 2017-05-16 | 2025-06-05 | The Johns Hopkins University | Manabodies and methods of using |
| TW201920249A (zh) | 2017-09-07 | 2019-06-01 | 美商信號生物製藥公司 | 具有結合位點之t細胞調節多聚體多肽及其使用方法 |
| CN111886241A (zh) | 2018-01-09 | 2020-11-03 | 库尔生物制药有限公司 | 多聚体t细胞调节多肽及其使用方法 |
| WO2020037239A1 (en) | 2018-08-16 | 2020-02-20 | Neon Therapeutics, Inc. | T cell receptor constructs and uses thereof |
| CN111116754A (zh) * | 2018-10-30 | 2020-05-08 | 天津亨佳生物科技发展有限公司 | 一种针对egfr l858r基因突变的特异性tcr及其应用 |
| CN111116732A (zh) * | 2018-10-30 | 2020-05-08 | 天津亨佳生物科技发展有限公司 | 针对egfr l858r基因突变的特异性tcr及其应用 |
| GB2596461B (en) * | 2019-02-20 | 2023-09-27 | Fred Hutchinson Cancer Center | Binding proteins specific for RAS neoantigens and uses thereof |
| CN111748026A (zh) * | 2019-03-29 | 2020-10-09 | 天津亨佳生物科技发展有限公司 | 一种针对egfr l858r基因突变的特异性t细胞受体及其应用 |
| CN111777678A (zh) * | 2019-04-04 | 2020-10-16 | 天津亨佳生物科技发展有限公司 | 一种egfr l858r 新抗原表位肽及其在治疗肿瘤中的应用 |
| CN111848781A (zh) * | 2019-04-25 | 2020-10-30 | 天津亨佳生物科技发展有限公司 | 一种针对egfr l858r基因突变的特异性t细胞受体及其应用 |
| MX2021014525A (es) | 2019-05-30 | 2022-03-17 | Gritstone Bio Inc | Adenovirus modificados. |
| CN110172089B (zh) * | 2019-06-11 | 2020-01-07 | 北京鼎成肽源生物技术有限公司 | 一种kras突变多抗原组合、靶向kras突变肿瘤ctl及其应用 |
| WO2021055594A1 (en) * | 2019-09-20 | 2021-03-25 | Cue Biopharma, Inc. | T-cell modulatory polypeptides and methods of use thereof |
| US20220378890A1 (en) * | 2019-09-26 | 2022-12-01 | Board Of Regents, The University Of Texas System | Immunogenic egfr peptide compositions and their use in the treatment of cancer |
| WO2021087840A1 (zh) * | 2019-11-07 | 2021-05-14 | 武汉华大吉诺因生物科技有限公司 | 肿瘤免疫治疗多肽及其应用 |
| JP2023502625A (ja) * | 2019-11-15 | 2023-01-25 | グリットストーン バイオ インコーポレイテッド | 共有新抗原を標的にする抗原結合タンパク質 |
| BR112022011177A2 (pt) | 2019-12-11 | 2022-09-27 | Molecular Partners Ag | Domínios de repetição de anquirina projetados com resíduos de superfície alterados |
| WO2021127184A1 (en) * | 2019-12-17 | 2021-06-24 | The Johns Hopkins University | MANAbodies TARGETING TUMOR ANTIGENS AND METHODS OF USING |
| WO2021231376A2 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| EP4192496A4 (en) | 2020-08-06 | 2025-01-01 | Gritstone bio, Inc. | MULTIEPITOP VACCINE CASSETTES |
| EP4211149A4 (en) | 2020-09-09 | 2024-10-09 | Cue Biopharma, Inc. | MULTIMERIC POLYPEPTIDES MODULATING MHC CLASS II T CELLS FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS (T1D) AND METHODS OF USE THEREOF |
| CN112300269B (zh) * | 2020-09-29 | 2022-12-09 | 中国科学院微生物研究所 | Kras突变特异性t细胞受体筛选及抗肿瘤用途 |
| WO2022099157A1 (en) * | 2020-11-06 | 2022-05-12 | Cue Biopharma, Inc. | Antigen presenting polypeptide complexes and methods of use thereof |
| CA3209741A1 (en) | 2021-02-26 | 2022-09-01 | Shohei Koide | Compositions and methods comprising antibodies that bind to covalent peptide conjugates |
| CN114085281A (zh) * | 2021-10-15 | 2022-02-25 | 北京臻知医学科技有限责任公司 | 一种肿瘤抗原表位肽及其多聚体和应用 |
| WO2025217204A1 (en) * | 2024-04-08 | 2025-10-16 | The Johns Hopkins University | Methods and materials for treating p53+ cancers |
| WO2026062579A1 (en) | 2024-09-19 | 2026-03-26 | Comed Therapeutics Ltd. | Compositions and methods for protein delivery to cells |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6630584B1 (en) * | 2000-03-16 | 2003-10-07 | Ramot At Tel-Aviv University Ltd. | Single chain antibody against mutant p53 |
| EP1485075A4 (en) * | 2002-02-20 | 2006-04-26 | Dyax Corp | MHC-PEPTIDE COMPLEX BINDING LIGANDS |
| JP3738308B2 (ja) * | 2002-11-29 | 2006-01-25 | 篤 村口 | 抗原特異的リンパ球抗原受容体遺伝子のクローニング方法 |
| US7736644B2 (en) * | 2003-06-27 | 2010-06-15 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
| AU2005247950B2 (en) * | 2004-05-27 | 2012-02-02 | Receptor Logic, Inc. | Antibodies as T cell receptor mimics, methods of production and uses thereof |
| CN101228187A (zh) * | 2005-03-25 | 2008-07-23 | 特拉维夫大学拉莫特有限公司 | 针对突变p53的共同表位的人合成单链抗体及其用途 |
| US8039594B2 (en) * | 2005-03-25 | 2011-10-18 | Ramot At Tel-Aviv University Ltd. | Human synthetic single-chain antibodies directed against the common epitope of mutant P53 and their uses |
| KR101944557B1 (ko) * | 2011-02-11 | 2019-01-30 | 메모리얼 슬로안 케터링 캔서 센터 | 에이치엘에이 제한된, 펩타이드특이성 항원 결합 단백질 |
-
2016
- 2016-03-23 EP EP16769561.8A patent/EP3286222A4/en active Pending
- 2016-03-23 CN CN202211294036.6A patent/CN115873129A/zh active Pending
- 2016-03-23 CA CA2980292A patent/CA2980292A1/en active Pending
- 2016-03-23 US US15/560,241 patent/US20180086832A1/en not_active Abandoned
- 2016-03-23 JP JP2017549815A patent/JP6944877B2/ja active Active
- 2016-03-23 CN CN201680028347.4A patent/CN108137685B/zh active Active
- 2016-03-23 AU AU2016235251A patent/AU2016235251B2/en active Active
- 2016-03-23 WO PCT/US2016/023673 patent/WO2016154246A1/en not_active Ceased
-
2021
- 2021-04-23 JP JP2021072976A patent/JP7304911B2/ja active Active
-
2022
- 2022-03-02 AU AU2022201421A patent/AU2022201421A1/en not_active Abandoned
-
2023
- 2023-04-11 JP JP2023063966A patent/JP2023085528A/ja active Pending
- 2023-07-12 US US18/351,087 patent/US20240166751A1/en active Pending
-
2025
- 2025-03-24 AU AU2025202102A patent/AU2025202102A1/en active Pending
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