|
US1349418A
(en)
*
|
1919-08-05 |
1920-08-10 |
George F Flynn |
Motor-support
|
|
US3590036A
(en)
*
|
1968-11-18 |
1971-06-29 |
George Y Lesher |
Naphthyridine-3-carboxylic acids,their derivatives and preparation thereof
|
|
DE2011970A1
(en)
|
1970-03-13 |
1971-11-18 |
CH. Boehringer Sohn, 6507 Ingelheim |
Imidazo-(1, 2-a)- pyrimidines prepn
|
|
US3635667A
(en)
|
1970-07-23 |
1972-01-18 |
Fmc Corp |
Drycleaning with hydrogen peroxide
|
|
GB1322318A
(en)
*
|
1971-05-19 |
1973-07-04 |
Sterling Drug Inc |
1-alkyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids and esters
|
|
BE786028A
(fr)
|
1971-07-08 |
1973-01-08 |
Boehringer Sohn Ingelheim |
2,3-dihydro-oxo-imidazo(1,2-a)-pyrimidines, leurs sels d'addition avec des acides et procedes pour les fabriquer
|
|
DE2356005A1
(de)
|
1973-11-09 |
1975-05-22 |
Boehringer Sohn Ingelheim |
Neue 7-amino-imidazo eckige klammer auf 1,2-a eckige klammer zu pyrimidine, diese enthaltende arzneimittel sowie verfahren zu deren herstellung
|
|
AU577105B2
(en)
|
1985-04-02 |
1988-09-15 |
T.P.O. :Pharmachim: |
Acylaminic penicillin derivatives
|
|
US6117940A
(en)
|
1997-10-17 |
2000-09-12 |
Mjalli; Adnan M. M. |
Amino-ketone solid support templates
|
|
HU229553B1
(en)
*
|
2000-06-12 |
2014-01-28 |
Eisai R & D Man Co |
1,2-dihydropyridine compound, process for preparation of the same and use thereof
|
|
GB0129260D0
(en)
*
|
2001-12-06 |
2002-01-23 |
Eisai London Res Lab Ltd |
Pharmaceutical compositions and their uses
|
|
EP1556381B1
(en)
|
2002-09-26 |
2008-02-20 |
Pfizer Limited |
Pyrazole amides for treating hiv infections
|
|
JP2005089352A
(ja)
|
2003-09-16 |
2005-04-07 |
Kissei Pharmaceut Co Ltd |
新規なイミダゾ［１，５−ａ］ピラジン誘導体、それを含有する医薬組成物およびそれらの用途
|
|
JP4824563B2
(ja)
*
|
2003-09-23 |
2011-11-30 |
メルク・シャープ・エンド・ドーム・コーポレイション |
イソキノリンカリウムチャネル阻害剤
|
|
EP1667982B1
(en)
|
2003-09-23 |
2013-07-31 |
Merck Sharp & Dohme Corp. |
Isoquinolinone potassium channel inhibitors
|
|
KR100703068B1
(ko)
|
2003-12-30 |
2007-04-05 |
에스케이케미칼주식회사 |
피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물
|
|
TW200536830A
(en)
*
|
2004-02-06 |
2005-11-16 |
Chugai Pharmaceutical Co Ltd |
1-(2H)-isoquinolone derivative
|
|
WO2005095384A1
(en)
|
2004-04-01 |
2005-10-13 |
Astellas Pharma Inc. |
Pyrazine derivatives and pharmaceutical use thereof as adenosine antagonists
|
|
GB0420722D0
(en)
|
2004-09-17 |
2004-10-20 |
Addex Pharmaceuticals Sa |
Novel allosteric modulators
|
|
KR100781704B1
(ko)
|
2005-04-20 |
2007-12-03 |
에스케이케미칼주식회사 |
피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물
|
|
US7452892B2
(en)
|
2005-06-17 |
2008-11-18 |
Bristol-Myers Squibb Company |
Triazolopyrimidine cannabinoid receptor 1 antagonists
|
|
EP2385047B1
(en)
|
2005-07-26 |
2013-05-29 |
Sanofi |
Piperidinyl-substituted isoquinolone derivatives
|
|
ES2372067T3
(es)
|
2005-07-26 |
2012-01-13 |
Sanofi |
Derivados de ciclohexilamina isoquinolona como inhibidores de la rho-quinasa.
|
|
US20070099911A1
(en)
|
2005-10-28 |
2007-05-03 |
Wyeth |
Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands
|
|
EP1998620B1
(en)
|
2006-03-10 |
2011-01-12 |
Neurogen Corporation |
Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues
|
|
GB0612428D0
(en)
*
|
2006-06-22 |
2006-08-02 |
Prolysis Ltd |
Antibacterial agents
|
|
HRP20100705T1
(hr)
|
2006-12-27 |
2011-01-31 |
Sanofi-Aventis |
Cikloalkilaminski supstituirani izokinolinski i izokinolinonski derivati
|
|
RU2455302C2
(ru)
|
2006-12-27 |
2012-07-10 |
Санофи-Авентис |
ЗАМЕЩЕННЫЕ ИЗОХИНОЛИНОВЫЕ И ИЗОХИНОЛИНОНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ
|
|
CN101595094B
(zh)
|
2006-12-27 |
2013-02-20 |
塞诺菲-安万特股份有限公司 |
环烷基胺取代的异喹诺酮衍生物
|
|
WO2009029214A1
(en)
*
|
2007-08-23 |
2009-03-05 |
Amgen Inc. |
Isoquinolone derivatives as phosphodiesterase 10 inhibitors
|
|
EP2250176B1
(en)
|
2008-01-30 |
2012-08-01 |
Cephalon, Inc. |
Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands
|
|
ES2389478T3
(es)
|
2008-06-25 |
2012-10-26 |
Bristol-Myers Squibb Company |
Derivados de dicetopiperidina como inhibidores de la fijación del VIH
|
|
WO2010039186A2
(en)
*
|
2008-09-23 |
2010-04-08 |
Renovis, Inc. |
Compounds useful as faah modulators and uses thereof
|
|
EP2196465A1
(en)
|
2008-12-15 |
2010-06-16 |
Almirall, S.A. |
(3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
|
|
WO2010071819A1
(en)
*
|
2008-12-19 |
2010-06-24 |
Schering Corporation |
Bicyclic heterocyclic derivatives and methods of use thereof
|
|
RU2615130C2
(ru)
|
2009-10-06 |
2017-04-04 |
Милленниум Фармасьютикалз, Инк |
Гетероциклические соединения, используемые в качестве ингибиторов pdk1
|
|
KR20120123325A
(ko)
|
2009-12-15 |
2012-11-08 |
시오노기세야쿠 가부시키가이샤 |
혈관 내피 리파아제 저해 활성을 갖는 옥사디아졸 유도체
|
|
ES2792799T3
(es)
|
2010-06-28 |
2020-11-12 |
Merck Patent Gmbh |
[1,8]naftiridinas 2,4-diaril-sustituidas como inhibidores de quinasas para su uso contra el cáncer
|
|
JPWO2012086735A1
(ja)
*
|
2010-12-22 |
2014-06-05 |
大正製薬株式会社 |
縮合複素環化合物
|
|
KR20140041583A
(ko)
|
2011-05-23 |
2014-04-04 |
엘란 파마슈티컬스, 엘엘씨 |
Ｌｒｒｋ2 키나제 활성의 억제제
|
|
RU2477723C2
(ru)
*
|
2011-06-16 |
2013-03-20 |
Общество С Ограниченной Ответственностью "Фьюжн Фарма" |
Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
|
|
CN102827073A
(zh)
|
2011-06-17 |
2012-12-19 |
安吉奥斯医药品有限公司 |
治疗活性组合物和它们的使用方法
|
|
CN104093716B
(zh)
|
2011-10-31 |
2017-06-23 |
克赛农制药股份有限公司 |
联芳醚磺酰胺化合物及其作为治疗剂的用途
|
|
CN103183675A
(zh)
|
2011-12-27 |
2013-07-03 |
山东轩竹医药科技有限公司 |
磷酸二酯酶-4抑制剂
|
|
US9434743B2
(en)
*
|
2012-03-02 |
2016-09-06 |
Takeda Pharmaceutical Company Limited |
Indazole derivatives
|
|
BR112014030940B1
(pt)
|
2012-06-11 |
2022-09-06 |
UCB Biopharma SRL |
Benzimidazóis que modulam tnf-alfa e composição farmacêutica compreendendo os mesmos
|
|
JP2014024838A
(ja)
*
|
2012-06-21 |
2014-02-06 |
Taisho Pharmaceutical Co Ltd |
縮合複素環化合物を有効成分として含有する血糖低下作用薬
|
|
US8987314B2
(en)
*
|
2012-07-19 |
2015-03-24 |
Bristol-Myers Squibb Company |
Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase
|
|
US9765039B2
(en)
*
|
2012-11-21 |
2017-09-19 |
Zenith Epigenetics Ltd. |
Biaryl derivatives as bromodomain inhibitors
|
|
CN104903320B
(zh)
*
|
2013-01-11 |
2018-11-13 |
富士胶片株式会社 |
含氮杂环化合物或其盐
|
|
CN105377851B
(zh)
*
|
2013-03-11 |
2018-07-20 |
密执安州立大学董事会 |
Bet布罗莫结构域抑制剂和使用这些抑制剂的治疗方法
|
|
PT2970265T
(pt)
*
|
2013-03-15 |
2018-10-23 |
Plexxikon Inc |
Compostos heterocíclicos e suas utilizações
|
|
CN105209467B
(zh)
*
|
2013-05-27 |
2018-06-08 |
诺华股份有限公司 |
咪唑并吡咯烷酮衍生物及其在治疗疾病中的用途
|
|
US9636328B2
(en)
|
2013-06-21 |
2017-05-02 |
Zenith Epigenetics Ltd. |
Substituted bicyclic compounds as bromodomain inhibitors
|
|
WO2014205594A1
(en)
*
|
2013-06-24 |
2014-12-31 |
Merck Sharp & Dohme Corp. |
Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases
|
|
MX355943B
(es)
*
|
2013-06-26 |
2018-05-07 |
Abbvie Inc |
Carboxamidas primarias como inhibidores de btk.
|
|
EP3640241B1
(en)
*
|
2013-10-18 |
2022-09-28 |
Celgene Quanticel Research, Inc. |
Bromodomain inhibitors
|
|
US9315501B2
(en)
*
|
2013-11-26 |
2016-04-19 |
Incyte Corporation |
Bicyclic heterocycles as BET protein inhibitors
|
|
US9920052B2
(en)
|
2013-12-09 |
2018-03-20 |
Ucb Biopharma Sprl |
Imidazopyridine derivatives as modulators of TNF activity
|
|
US10173991B2
(en)
*
|
2014-01-07 |
2019-01-08 |
Bristol-Myers Squibb Company |
Sulfone amide linked benzothiazole inhibitors of endothelial lipase
|
|
EP3096761A1
(en)
|
2014-01-24 |
2016-11-30 |
Confluence Life Sciences, Inc. |
Substituted pyroolopyridines and pyrrolopyrazines for treating cancer or inflammatory diseases
|
|
EA034972B1
(ru)
*
|
2014-04-23 |
2020-04-13 |
Инсайт Корпорейшн |
1h-пирроло[2,3-c]пиридин-7(6h)-оны в качестве ингибиторов белков bet
|
|
MA40943A
(fr)
*
|
2014-11-10 |
2017-09-19 |
Constellation Pharmaceuticals Inc |
Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
|
|
MA40940A
(fr)
|
2014-11-10 |
2017-09-19 |
Constellation Pharmaceuticals Inc |
Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
|
|
JP6771464B2
(ja)
*
|
2014-11-27 |
2020-10-21 |
ジェネンテック， インコーポレイテッド |
Ｃｂｐおよび／またはｅｐ３００インヒビターとしての、４，５，６，７−テトラヒドロ−１ｈ−ピラゾロ［４，３−ｃ］ピリジン−３−アミン化合物
|
|
EP3265453B1
(en)
*
|
2015-03-05 |
2022-06-29 |
Boehringer Ingelheim International GmbH |
New pyridinones and isoquinolinones as inhibitors of the bromodomain brd9
|
|
AR104259A1
(es)
*
|
2015-04-15 |
2017-07-05 |
Celgene Quanticel Res Inc |
Inhibidores de bromodominio
|
|
TW201642860A
(zh)
*
|
2015-04-22 |
2016-12-16 |
塞爾基因定量細胞研究公司 |
布羅莫結構域抑制劑
|