JP2018510851A5 - - Google Patents
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- JP2018510851A5 JP2018510851A5 JP2017544916A JP2017544916A JP2018510851A5 JP 2018510851 A5 JP2018510851 A5 JP 2018510851A5 JP 2017544916 A JP2017544916 A JP 2017544916A JP 2017544916 A JP2017544916 A JP 2017544916A JP 2018510851 A5 JP2018510851 A5 JP 2018510851A5
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- JP
- Japan
- Prior art keywords
- cancer
- composition
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- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *c1c(*)nnc(*)c1 Chemical compound *c1c(*)nnc(*)c1 0.000 description 16
- VUKHQPGJNTXTPY-NSCUHMNNSA-N C/C=C/Cc1ccccc1 Chemical compound C/C=C/Cc1ccccc1 VUKHQPGJNTXTPY-NSCUHMNNSA-N 0.000 description 1
- VJNJUWJHKJQYIF-UHFFFAOYSA-N CC(C)(CN(C)CC1)N1C(C)=O Chemical compound CC(C)(CN(C)CC1)N1C(C)=O VJNJUWJHKJQYIF-UHFFFAOYSA-N 0.000 description 1
- MSZXDTUUUMSSQS-UHFFFAOYSA-N CC(C)(CN(C)CC1)N1S(C)(=O)=O Chemical compound CC(C)(CN(C)CC1)N1S(C)(=O)=O MSZXDTUUUMSSQS-UHFFFAOYSA-N 0.000 description 1
- UFUZCUFUKAHDSB-IYBDPMFKSA-N CC(C)N1C[C@H](CN(Cc2ccccc2)C2)[C@H]2C1 Chemical compound CC(C)N1C[C@H](CN(Cc2ccccc2)C2)[C@H]2C1 UFUZCUFUKAHDSB-IYBDPMFKSA-N 0.000 description 1
- YGUJCUMSQULQEU-UHFFFAOYSA-N CC(C)[n]1ncc(CN2CCNCC2)c1 Chemical compound CC(C)[n]1ncc(CN2CCNCC2)c1 YGUJCUMSQULQEU-UHFFFAOYSA-N 0.000 description 1
- HNNHJSSSTNIYHO-UHFFFAOYSA-N CC(CCc1ccccc1)C(N1C(C)CN(C)CC1)=O Chemical compound CC(CCc1ccccc1)C(N1C(C)CN(C)CC1)=O HNNHJSSSTNIYHO-UHFFFAOYSA-N 0.000 description 1
- SNORQMCMXKTQSU-UHFFFAOYSA-N CC(CN(C)CC1)N1C(C1(C)COC1)=O Chemical compound CC(CN(C)CC1)N1C(C1(C)COC1)=O SNORQMCMXKTQSU-UHFFFAOYSA-N 0.000 description 1
- RKMLMSGVPZXOTA-UHFFFAOYSA-N CC(CN(C)CC1)N1C(c1cnccc1)=O Chemical compound CC(CN(C)CC1)N1C(c1cnccc1)=O RKMLMSGVPZXOTA-UHFFFAOYSA-N 0.000 description 1
- PYJUEKVBNIROGK-UHFFFAOYSA-N CC(CN(C)CC1)N1S(C1CC1)(=O)=O Chemical compound CC(CN(C)CC1)N1S(C1CC1)(=O)=O PYJUEKVBNIROGK-UHFFFAOYSA-N 0.000 description 1
- BZTWODHNEMLJEI-UHFFFAOYSA-N CC(CN(CC1)N)N1C(C(C)(C)O)=O Chemical compound CC(CN(CC1)N)N1C(C(C)(C)O)=O BZTWODHNEMLJEI-UHFFFAOYSA-N 0.000 description 1
- GCFFVKUNULPIKW-UHFFFAOYSA-N CC(N)N(CC1)CC(C)N1S(c1ccccc1)(=O)=O Chemical compound CC(N)N(CC1)CC(C)N1S(c1ccccc1)(=O)=O GCFFVKUNULPIKW-UHFFFAOYSA-N 0.000 description 1
- UESXDJWPFOVOSR-UHFFFAOYSA-N CC(N1C(Cc2ccccc2)CN(C)CC1)=O Chemical compound CC(N1C(Cc2ccccc2)CN(C)CC1)=O UESXDJWPFOVOSR-UHFFFAOYSA-N 0.000 description 1
- UZJLYRRDVFWSGA-UHFFFAOYSA-N CC(NCc1ccccc1)=O Chemical compound CC(NCc1ccccc1)=O UZJLYRRDVFWSGA-UHFFFAOYSA-N 0.000 description 1
- OKNYZIGDRLPEEJ-WDEREUQCSA-N CC(N[C@H](C1)[C@@H]1c1ccccc1)=O Chemical compound CC(N[C@H](C1)[C@@H]1c1ccccc1)=O OKNYZIGDRLPEEJ-WDEREUQCSA-N 0.000 description 1
- FZLJNEILFLTBCP-UHFFFAOYSA-N CC1N(Cc2ccccc2)CCN(C)C1 Chemical compound CC1N(Cc2ccccc2)CCN(C)C1 FZLJNEILFLTBCP-UHFFFAOYSA-N 0.000 description 1
- ROBUKNKOVCATJT-UHFFFAOYSA-N CCN1CCN(Cc2c[n](C)nc2)CC1 Chemical compound CCN1CCN(Cc2c[n](C)nc2)CC1 ROBUKNKOVCATJT-UHFFFAOYSA-N 0.000 description 1
- XQLBXAYDYAWRNK-UHFFFAOYSA-N CCS(N1C(C)CN(C)CC1)(=O)=O Chemical compound CCS(N1C(C)CN(C)CC1)(=O)=O XQLBXAYDYAWRNK-UHFFFAOYSA-N 0.000 description 1
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N CCc1ccccc1 Chemical compound CCc1ccccc1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 1
- COJMYCSMNZBNCW-UHFFFAOYSA-N CN(C1)CC1OCc1ccccc1 Chemical compound CN(C1)CC1OCc1ccccc1 COJMYCSMNZBNCW-UHFFFAOYSA-N 0.000 description 1
- PJGCYUIHITYYHT-UHFFFAOYSA-N CN(CC1)CC(Cc2ccccc2)N1S(C)(=O)=O Chemical compound CN(CC1)CC(Cc2ccccc2)N1S(C)(=O)=O PJGCYUIHITYYHT-UHFFFAOYSA-N 0.000 description 1
- BRIWHPAJCKTPIP-UHFFFAOYSA-N CN(CC1)CC1(Cc1ccccc1)O Chemical compound CN(CC1)CC1(Cc1ccccc1)O BRIWHPAJCKTPIP-UHFFFAOYSA-N 0.000 description 1
- FLVFPAIGVBQGET-UHFFFAOYSA-N CN(CC1)CC1O Chemical compound CN(CC1)CC1O FLVFPAIGVBQGET-UHFFFAOYSA-N 0.000 description 1
- QRYWRVHZEBEZDQ-UHFFFAOYSA-N CN(CC1)CCN1C(c1ccccc1)=O Chemical compound CN(CC1)CCN1C(c1ccccc1)=O QRYWRVHZEBEZDQ-UHFFFAOYSA-N 0.000 description 1
- NCKYKYNYJREWCI-UHFFFAOYSA-N CN(CC1)CCN1S(c1ccccc1)(=O)=O Chemical compound CN(CC1)CCN1S(c1ccccc1)(=O)=O NCKYKYNYJREWCI-UHFFFAOYSA-N 0.000 description 1
- WQDDXVGJRSTLED-UHFFFAOYSA-N CN(CC1)CCN1c1ccccc1 Chemical compound CN(CC1)CCN1c1ccccc1 WQDDXVGJRSTLED-UHFFFAOYSA-N 0.000 description 1
- AWYQDNIZEIQOKM-UHFFFAOYSA-N CN(CCN1Cc2ccccc2)CC1=O Chemical compound CN(CCN1Cc2ccccc2)CC1=O AWYQDNIZEIQOKM-UHFFFAOYSA-N 0.000 description 1
- PZNQMJBVNDWXDY-UHFFFAOYSA-N CN(CCN1c2ccccc2)CC1=O Chemical compound CN(CCN1c2ccccc2)CC1=O PZNQMJBVNDWXDY-UHFFFAOYSA-N 0.000 description 1
- QSDUADMNMGNPLU-UHFFFAOYSA-N CN1CC(CC2)N(Cc3ccccc3)C2C1 Chemical compound CN1CC(CC2)N(Cc3ccccc3)C2C1 QSDUADMNMGNPLU-UHFFFAOYSA-N 0.000 description 1
- NJHPPXZJEYFKMD-UHFFFAOYSA-N CN1CC(Cc2ccccc2)NCC1 Chemical compound CN1CC(Cc2ccccc2)NCC1 NJHPPXZJEYFKMD-UHFFFAOYSA-N 0.000 description 1
- NNYDAONDPGWBRI-UHFFFAOYSA-N CN1CCN(Cc2cc(C#N)ccc2)CC1 Chemical compound CN1CCN(Cc2cc(C#N)ccc2)CC1 NNYDAONDPGWBRI-UHFFFAOYSA-N 0.000 description 1
- UFRQXKOKLIMLBO-UHFFFAOYSA-N CN1CCN(Cc2ccncc2)CC1 Chemical compound CN1CCN(Cc2ccncc2)CC1 UFRQXKOKLIMLBO-UHFFFAOYSA-N 0.000 description 1
- TVKCKGFYMZDMBA-STQMWFEESA-N CN1[C@@H](C2)CN(Cc3ccccc3)[C@@H]2C1 Chemical compound CN1[C@@H](C2)CN(Cc3ccccc3)[C@@H]2C1 TVKCKGFYMZDMBA-STQMWFEESA-N 0.000 description 1
- CQTKDGNXBCFBTR-LBPRGKRZSA-N C[C@@H](c1ccccc1)N1CCN(C)CC1 Chemical compound C[C@@H](c1ccccc1)N1CCN(C)CC1 CQTKDGNXBCFBTR-LBPRGKRZSA-N 0.000 description 1
- CGGBSNOQTQFSIN-UHFFFAOYSA-N C[n]1nc(CN2CCN(C)CC2)cc1 Chemical compound C[n]1nc(CN2CCN(C)CC2)cc1 CGGBSNOQTQFSIN-UHFFFAOYSA-N 0.000 description 1
- VAVNNDTVDOJAFD-UHFFFAOYSA-N Cc1nc(CN2CCN(C)CC2)c[o]1 Chemical compound Cc1nc(CN2CCN(C)CC2)c[o]1 VAVNNDTVDOJAFD-UHFFFAOYSA-N 0.000 description 1
- XBEALJJZQWXEDH-UHFFFAOYSA-N NCCN(CC1C2)C2CN1c1ncccc1 Chemical compound NCCN(CC1C2)C2CN1c1ncccc1 XBEALJJZQWXEDH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562120732P | 2015-02-25 | 2015-02-25 | |
| US62/120,732 | 2015-02-25 | ||
| PCT/US2016/019328 WO2016138114A1 (en) | 2015-02-25 | 2016-02-24 | Therapeutic pyridazine compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510851A JP2018510851A (ja) | 2018-04-19 |
| JP2018510851A5 true JP2018510851A5 (OSRAM) | 2019-03-07 |
| JP6847844B2 JP6847844B2 (ja) | 2021-03-24 |
Family
ID=55456970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544916A Active JP6847844B2 (ja) | 2015-02-25 | 2016-02-24 | 治療用ピリダジン化合物およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10308614B2 (OSRAM) |
| EP (1) | EP3262036B1 (OSRAM) |
| JP (1) | JP6847844B2 (OSRAM) |
| CN (1) | CN107531668B (OSRAM) |
| MA (1) | MA41598A (OSRAM) |
| WO (1) | WO2016138114A1 (OSRAM) |
Families Citing this family (57)
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| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| WO2017087885A1 (en) | 2015-11-19 | 2017-05-26 | Dana-Farber Cancer Institute, Inc. | Methods of identifying compounds that interfere with erg-driven misguidance of baf complexes in tmprss2-erg driven prostate cancers |
| CN106674127A (zh) * | 2016-11-18 | 2017-05-17 | 山东友帮生化科技有限公司 | 一种n‑(6‑氯‑3‑哒嗪基)乙酰胺的合成方法 |
| JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
| SG10202109335TA (en) * | 2017-02-28 | 2021-10-28 | Epizyme Inc | Inhibition of smarca2 for treatment of cancer |
| WO2019084026A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HETEROCYCLIC COMPOUNDS AND METHODS OF USE |
| WO2019084030A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HYDROXAMATE COMPOUNDS AND METHODS OF USE |
| MX387232B (es) * | 2017-10-27 | 2025-03-18 | Boehringer Ingelheim Int | Derivados de piridincarbonilo y usos terapéuticos de los mismos como inhibidores de trpc6. |
| WO2019152437A1 (en) | 2018-01-30 | 2019-08-08 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| WO2019183523A1 (en) | 2018-03-23 | 2019-09-26 | Genentech, Inc. | Hetero-bifunctional degrader compounds and their use as modulators of targeted ubiquination (vhl) |
| DK3774789T3 (da) * | 2018-04-01 | 2025-06-10 | Arvinas Operations Inc | BRM-målrettede forbindelser og tilhørende fremgangsmåder til anvendelse |
| SG11202104495YA (en) | 2018-04-26 | 2021-05-28 | Aurigene Discovery Tech Ltd | Pyridazine derivatives as smarca2/4 degraders |
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| EP3817822A4 (en) | 2018-07-06 | 2022-07-27 | Kymera Therapeutics, Inc. | PROTEIN DEGRADANTS AND USES THEREOF |
| SG11202100137TA (en) * | 2018-07-09 | 2021-02-25 | Lieber Institute Inc | PYRIDAZINE COMPOUNDS FOR INHIBITING Nav1.8 |
| PL3837256T3 (pl) | 2018-08-17 | 2023-07-10 | Novartis Ag | Związki i kompozycje mocznika jako inhibitory smarca2/brm-atpazy |
| WO2020078933A1 (en) | 2018-10-16 | 2020-04-23 | Boehringer Ingelheim International Gmbh | Proteolysis targeting chimera (protacs) as degraders of smarca2 and/or smarca4 |
| WO2020081588A1 (en) | 2018-10-17 | 2020-04-23 | Dana-Farber Cancer Institute, Inc. | Swi/snf family chromatin remodeling complexes and uses thereof |
| JP2022508155A (ja) * | 2018-11-21 | 2022-01-19 | フォグホーン セラピューティクス インコーポレイテッド | がんを治療する方法 |
| ES3032327T3 (en) * | 2019-01-29 | 2025-07-17 | Foghorn Therapeutics Inc | Compounds and uses thereof |
| EP3917529A4 (en) | 2019-01-29 | 2022-11-02 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| AR119731A1 (es) | 2019-05-17 | 2022-01-05 | Novartis Ag | Inhibidores del inflamasoma nlrp3 |
| US20220324880A1 (en) * | 2019-06-10 | 2022-10-13 | Kymara Therapeutics, Inc. | Smarca inhibitors and uses thereof |
| US20230087825A1 (en) * | 2019-06-10 | 2023-03-23 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| MX2022002244A (es) | 2019-09-12 | 2022-03-22 | Aurigene Discovery Tech Ltd | Metodo para identificar respondedores a degradantes de smarca2/4. |
| EP4038066A1 (en) | 2019-10-01 | 2022-08-10 | Arvinas Operations, Inc. | Brm targeting compounds and associated methods of use |
| CN114728936A (zh) * | 2019-10-29 | 2022-07-08 | 豪夫迈·罗氏有限公司 | 用于治疗癌症的双功能化合物 |
| CA3162502A1 (en) | 2019-12-23 | 2021-07-01 | Yi Zhang | Smarca degraders and uses thereof |
| JP7561195B2 (ja) | 2020-01-29 | 2024-10-03 | フォグホーン セラピューティクス インコーポレイテッド | 化合物及びその使用 |
| MX2022012474A (es) * | 2020-04-06 | 2023-01-04 | Foghorn Therapeutics Inc | Compuestos y usos de estos. |
| US12383555B2 (en) | 2020-05-20 | 2025-08-12 | Foghorn Therapeutics Inc. | Methods of treating cancers |
| PL4161935T3 (pl) | 2020-06-09 | 2025-09-08 | Prelude Therapeutics Incorporated | Związki celowane brm i powiązane sposoby zastosowania |
| BR112023002089A2 (pt) * | 2020-08-04 | 2023-02-28 | Aurigene Oncology Ltd | Compostos de piridazina 6-substituídos como degradadores de smarca2 e/ou smarca4 |
| US12059408B2 (en) | 2020-08-13 | 2024-08-13 | Boehringer Ingelheim International Gmbh | Treatment of cognitive impairment associated with schizophrenia |
| WO2022078927A1 (en) | 2020-10-13 | 2022-04-21 | Boehringer Ingelheim International Gmbh | Process of reworking |
| CA3196965A1 (en) * | 2020-11-20 | 2022-05-27 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| US20250109138A1 (en) * | 2020-12-09 | 2025-04-03 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| US20240166610A1 (en) * | 2021-02-08 | 2024-05-23 | Medshine Discovery Inc. | Substituted pyridazine phenol derivatives |
| US20240425479A1 (en) * | 2021-04-30 | 2024-12-26 | Ontario Institute For Cancer Research (Oicr) | Halo-substituted amino aza-heteroaryl compounds as inhibitors of the haematopoietic progenitor kinase 1 (hpk1) |
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| EP4408846A1 (en) | 2021-09-29 | 2024-08-07 | Boehringer Ingelheim International GmbH | Novel tetrahydroquinolines and proteolysis targeting chimera (protacs) comprising them as degraders of smarca |
| JP2024541480A (ja) | 2021-11-24 | 2024-11-08 | アルビナス・オペレーションズ・インコーポレイテッド | Ｂｒｍ標的化化合物及び関連使用方法 |
| EP4436965A1 (en) | 2021-11-24 | 2024-10-02 | Arvinas Operations, Inc. | Brm targeting compounds and associated methods of use |
| WO2023152666A1 (en) * | 2022-02-09 | 2023-08-17 | Aurigene Oncology Limited | 3-substituted pyridazine compounds as smarca2 and/or smarca4 degraders |
| KR20250036812A (ko) * | 2022-06-16 | 2025-03-14 | 플렉시움 인코포레이티드 | Swi/snf-관련 매트릭스-연관 액틴 의존성 크로마틴 조절인자 하위계열 a를 분해하는 화합물 및 약학적 조성물 |
| CN119384414A (zh) | 2022-06-30 | 2025-01-28 | 甘李药业股份有限公司 | 一种用作smarca2/4抑制剂的化合物及其应用 |
| UY40374A (es) | 2022-08-03 | 2024-02-15 | Novartis Ag | Inhibidores de inflamasoma nlrp3 |
| CN120752233A (zh) * | 2023-02-28 | 2025-10-03 | 上海海雁医药科技有限公司 | 取代的三环衍生物及其药物组合物和用途 |
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| WO2024256988A1 (en) * | 2023-06-14 | 2024-12-19 | Astrazeneca Ab | Smarca2 degraders and uses thereof |
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| WO2025054356A1 (en) * | 2023-09-07 | 2025-03-13 | Leapfrog Bio, Inc. | Bet inhibitors for the treatment of cancer |
| WO2025094065A1 (en) | 2023-11-01 | 2025-05-08 | Aurigene Oncology Limited | Amino-substituted pyridazine compounds as smarca2 and/or smarca4 degraders |
| WO2025196686A1 (en) | 2024-03-20 | 2025-09-25 | Aurigene Oncology Limited | Fused bicyclic compounds as smarca2 and/or smarca4 degraders |
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| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| PT980244E (pt) | 1997-05-06 | 2003-10-31 | Wyeth Corp | Utilizacao de compostos de quinazolina para o tratamento da doenca policistica renal |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| IL135622A0 (en) | 1997-11-06 | 2001-05-20 | American Cyanamid Co | Use of quinazoline derivatives as tyrosine kinase inhibitors for treating colonic polyps |
| PT1131304E (pt) | 1998-11-19 | 2003-04-30 | Warner Lambert Co | N-¬4-(3-cloro-4-fluoro-fenilamino)-7-(3-morfolin-4-il-propoxi)-quinazolin-6-il|-acrilamida um inibidor irreversivel de tirosino quinases |
| WO2004076412A2 (en) * | 2003-02-26 | 2004-09-10 | Sugen, Inc. | Aminoheteroaryl compounds as protein kinase inhibitors |
| DE602005002357T2 (de) | 2004-03-26 | 2008-05-29 | Smithkline Beecham Corp. | Als antivirale mittel geeignete 4-carboxypyrazolderivate |
| RU2008141761A (ru) * | 2006-03-22 | 2010-04-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | ИНГИБИТОРЫ с-МЕТ ПРОТЕИНКИНАЗЫ |
| EP2477976A4 (en) | 2009-09-18 | 2013-03-13 | Boehringer Ingelheim Int | QUINAZOLINONE DERIVATIVES AS VIRAL POLYMERASE INHIBITORS |
| WO2011138751A2 (en) * | 2010-05-04 | 2011-11-10 | Pfizer Inc. | Heterocyclic derivatives as alk inhibitors |
| WO2012161877A1 (en) * | 2011-05-23 | 2012-11-29 | Merck Patent Gmbh | Pyridine-and pyrazine derivatives |
-
2016
- 2016-02-23 MA MA041598A patent/MA41598A/fr unknown
- 2016-02-24 CN CN201680023840.7A patent/CN107531668B/zh active Active
- 2016-02-24 EP EP16708332.8A patent/EP3262036B1/en active Active
- 2016-02-24 WO PCT/US2016/019328 patent/WO2016138114A1/en not_active Ceased
- 2016-02-24 JP JP2017544916A patent/JP6847844B2/ja active Active
-
2017
- 2017-08-24 US US15/686,028 patent/US10308614B2/en active Active
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