JP2018510639A5 - - Google Patents
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- Publication number
- JP2018510639A5 JP2018510639A5 JP2017549766A JP2017549766A JP2018510639A5 JP 2018510639 A5 JP2018510639 A5 JP 2018510639A5 JP 2017549766 A JP2017549766 A JP 2017549766A JP 2017549766 A JP2017549766 A JP 2017549766A JP 2018510639 A5 JP2018510639 A5 JP 2018510639A5
- Authority
- JP
- Japan
- Prior art keywords
- car
- item
- polypeptide
- nucleic acid
- multimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1504840.8 | 2015-03-23 | ||
| GBGB1504840.8A GB201504840D0 (en) | 2015-03-23 | 2015-03-23 | Chimeric antigen receptor |
| PCT/GB2016/050795 WO2016151315A1 (en) | 2015-03-23 | 2016-03-22 | Chimeric antigen receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020001971A Division JP2020048588A (ja) | 2015-03-23 | 2020-01-09 | キメラ抗原受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510639A JP2018510639A (ja) | 2018-04-19 |
| JP2018510639A5 true JP2018510639A5 (enExample) | 2019-12-05 |
| JP6675417B2 JP6675417B2 (ja) | 2020-04-01 |
Family
ID=53052211
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549766A Expired - Fee Related JP6675417B2 (ja) | 2015-03-23 | 2016-03-22 | キメラ抗原受容体 |
| JP2020001971A Withdrawn JP2020048588A (ja) | 2015-03-23 | 2020-01-09 | キメラ抗原受容体 |
| JP2022201192A Withdrawn JP2023021396A (ja) | 2015-03-23 | 2022-12-16 | キメラ抗原受容体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020001971A Withdrawn JP2020048588A (ja) | 2015-03-23 | 2020-01-09 | キメラ抗原受容体 |
| JP2022201192A Withdrawn JP2023021396A (ja) | 2015-03-23 | 2022-12-16 | キメラ抗原受容体 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11058722B2 (enExample) |
| EP (1) | EP3274366B8 (enExample) |
| JP (3) | JP6675417B2 (enExample) |
| KR (1) | KR102174280B1 (enExample) |
| CN (1) | CN107406518B (enExample) |
| AU (1) | AU2016238583B2 (enExample) |
| BR (1) | BR112017018252A2 (enExample) |
| CA (1) | CA2978852C (enExample) |
| CL (1) | CL2017002413A1 (enExample) |
| DK (1) | DK3274366T3 (enExample) |
| ES (1) | ES2773527T3 (enExample) |
| GB (1) | GB201504840D0 (enExample) |
| HU (1) | HUE047929T2 (enExample) |
| IL (1) | IL254254B (enExample) |
| MX (1) | MX371384B (enExample) |
| PL (1) | PL3274366T3 (enExample) |
| PT (1) | PT3274366T (enExample) |
| RU (1) | RU2752880C2 (enExample) |
| SG (1) | SG11201706940QA (enExample) |
| WO (1) | WO2016151315A1 (enExample) |
| ZA (1) | ZA201705682B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9511092B2 (en) | 2013-01-28 | 2016-12-06 | St. Jude Children's Research Hospital, Inc. | Chimeric receptor with NKG2D specificity for use in cell therapy against cancer and infectious disease |
| US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
| US20230027993A1 (en) | 2014-03-05 | 2023-01-26 | Autolus Limited | Methods |
| GB201403972D0 (en) | 2014-03-06 | 2014-04-23 | Ucl Business Plc | Chimeric antigen receptor |
| GB201405845D0 (en) | 2014-04-01 | 2014-05-14 | Ucl Business Plc | Signalling system |
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| GB201415347D0 (en) | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Signalling system |
| GB201501936D0 (en) * | 2015-02-05 | 2015-03-25 | Ucl Business Plc | Signalling system |
| EP3466967A1 (en) | 2015-05-18 | 2019-04-10 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| GB201610512D0 (en) | 2016-06-16 | 2016-08-03 | Autolus Ltd | Chimeric antigen receptor |
| AU2017306432A1 (en) | 2016-08-02 | 2019-03-21 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| BR112019007100A2 (pt) | 2016-10-07 | 2019-06-25 | Tcr2 Therapeutics Inc | composições e métodos para reprogramação de receptores de célula t com o uso de proteínas de fusão |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| WO2018182511A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| CN110678551A (zh) * | 2017-03-29 | 2020-01-10 | 阳光溪流研究所 | 经改造的t-细胞调节分子及其使用方法 |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| JP7356354B2 (ja) | 2017-05-12 | 2023-10-04 | クリスパー セラピューティクス アクチェンゲゼルシャフト | 細胞の操作のための材料及び方法並びに免疫腫瘍学におけるその使用 |
| EP3662055A1 (en) * | 2017-08-02 | 2020-06-10 | Autolus Limited | Cells expressing a chimeric antigen receptor or engineered tcr and comprising a nucleotide sequence which is selectively expressed |
| WO2019086394A1 (en) | 2017-11-01 | 2019-05-09 | F. Hoffmann-La Roche Ag | The compbody - a multivalent target binder |
| GB201801831D0 (en) * | 2018-02-05 | 2018-03-21 | Autolus Ltd | Chimeric receptor |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| SG11202008976YA (en) | 2018-04-02 | 2020-10-29 | Nat Univ Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| EP3790629A1 (en) | 2018-05-11 | 2021-03-17 | CRISPR Therapeutics AG | Methods and compositions for treating cancer |
| GB201807870D0 (en) | 2018-05-15 | 2018-06-27 | Autolus Ltd | A CD79-specific chimeric antigen receptor |
| CN112119096B (zh) | 2018-05-15 | 2024-04-30 | 奥托路斯有限公司 | 嵌合抗原受体 |
| EP3836944A4 (en) * | 2018-08-16 | 2022-05-11 | Memorial Sloan Kettering Cancer Center | LEUCINE ZIPPER BASED COMPOSITIONS AND METHODS OF USE |
| JP7560882B2 (ja) | 2018-08-29 | 2024-10-03 | ナショナル ユニヴァーシティー オブ シンガポール | 遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法 |
| CN109265550B (zh) * | 2018-09-25 | 2020-09-15 | 华东师范大学 | Bcma抗体、嵌合抗原受体和药物 |
| HUE069503T2 (hu) | 2018-09-27 | 2025-03-28 | Autolus Ltd | Kiméra antigénreceptor |
| CA3109747A1 (en) * | 2018-10-05 | 2020-04-09 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
| EP3860642A1 (en) * | 2018-10-05 | 2021-08-11 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
| GB201817822D0 (en) | 2018-10-31 | 2018-12-19 | Autolus Ltd | Binding domain |
| AU2020224160A1 (en) * | 2019-02-21 | 2021-08-26 | John M. LUK | Artificial immunosurveillance chimeric antigen receptor (AI-CAR) and cells expressing the same |
| CN118546959A (zh) | 2019-03-05 | 2024-08-27 | 恩卡尔塔公司 | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 |
| PH12021552123A1 (en) | 2019-03-21 | 2022-08-22 | Regeneron Pharma | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
| CN113939319A (zh) | 2019-04-30 | 2022-01-14 | 克里斯珀医疗股份公司 | 靶向cd19的基因工程化t细胞针对b细胞恶性肿瘤的同种异体细胞疗法 |
| GB201919017D0 (en) | 2019-12-20 | 2020-02-05 | Autolus Ltd | Cell |
| CN111234033B (zh) * | 2020-01-21 | 2021-05-11 | 南京北恒生物科技有限公司 | 多链嵌合抗原受体及其用途 |
| GB202004263D0 (en) | 2020-03-24 | 2020-05-06 | Autolus Ltd | Antibody conjugate |
| GB202005216D0 (en) | 2020-04-08 | 2020-05-20 | Autolus Ltd | Cell |
| GB202006820D0 (en) | 2020-05-07 | 2020-06-24 | Autolus Ltd | Cell |
| GB202017649D0 (en) | 2020-11-09 | 2020-12-23 | Autolus Ltd | Polypeptide |
| US12144827B2 (en) | 2021-02-25 | 2024-11-19 | Lyell Immunopharma, Inc. | ROR1 targeting chimeric antigen receptor |
| WO2022204326A1 (en) * | 2021-03-24 | 2022-09-29 | The Regents Of The University Of California | Humanized synthetic notch receptors with augmented transactivation domains and uses thereof |
| GB202115329D0 (en) * | 2021-10-25 | 2021-12-08 | Autolus Ltd | Chimeric cytokine receptor |
| WO2024019961A1 (en) * | 2022-07-18 | 2024-01-25 | Cargo Therapeutics, Inc. | Cd2 recruiting chimeric antigen receptors and fusion proteins |
| US20250242056A1 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for using plasma cell depleting agents and/or b cell depleting agents to suppress host anti-aav antibody response and enable aav transduction and re-dosing |
| WO2025160340A2 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration |
| WO2025184567A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7081443B2 (en) | 2002-05-21 | 2006-07-25 | Korea Advanced Institutes Of Science And Technology (Kaist) | Chimeric comp-ang1 molecule |
| WO2010102518A1 (zh) * | 2009-03-13 | 2010-09-16 | 北京表源生物技术有限公司 | 一种融合蛋白多聚体 |
| KR101156085B1 (ko) * | 2010-01-29 | 2012-06-20 | 국립암센터 | ４－１ｂｂ리간드（４－１ｂｂｌ）오중합체 및 이의 용도 |
| US10745467B2 (en) * | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
| JP6053688B2 (ja) * | 2011-10-07 | 2016-12-27 | 国立大学法人三重大学 | キメラ抗原受容体 |
| DK3473707T3 (da) * | 2012-05-25 | 2025-03-17 | Cellectis | Fremgangsmåder til engineering af allogen og immunsuppressiv resistent t-celle til immunoterapi |
| WO2014039523A1 (en) * | 2012-09-04 | 2014-03-13 | Cellectis | Multi-chain chimeric antigen receptor and uses thereof |
| DK2956175T3 (da) * | 2013-02-15 | 2017-11-27 | Univ California | Kimærisk antigenreceptor og fremgangsmåder til anvendelse deraf |
| CN103145849B (zh) * | 2013-02-18 | 2014-06-11 | 冯振卿 | 嵌合抗原受体及其用途 |
| MX386422B (es) * | 2013-12-20 | 2025-03-18 | Fred Hutchinson Cancer Center | Moléculas efectoras químericas etiquetadas y receptores de las mismas. |
| ES2767423T3 (es) | 2014-01-13 | 2020-06-17 | Hope City | Receptores de antígenos quiméricos (CARS) con mutaciones en la región del espaciador Fc y métodos para su uso |
| GB201415347D0 (en) | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Signalling system |
| GB201610512D0 (en) | 2016-06-16 | 2016-08-03 | Autolus Ltd | Chimeric antigen receptor |
-
2015
- 2015-03-23 GB GBGB1504840.8A patent/GB201504840D0/en not_active Ceased
-
2016
- 2016-03-22 CA CA2978852A patent/CA2978852C/en active Active
- 2016-03-22 EP EP16712424.7A patent/EP3274366B8/en active Active
- 2016-03-22 SG SG11201706940QA patent/SG11201706940QA/en unknown
- 2016-03-22 KR KR1020177030391A patent/KR102174280B1/ko active Active
- 2016-03-22 RU RU2017132978A patent/RU2752880C2/ru active
- 2016-03-22 WO PCT/GB2016/050795 patent/WO2016151315A1/en not_active Ceased
- 2016-03-22 BR BR112017018252-1A patent/BR112017018252A2/pt active Search and Examination
- 2016-03-22 JP JP2017549766A patent/JP6675417B2/ja not_active Expired - Fee Related
- 2016-03-22 AU AU2016238583A patent/AU2016238583B2/en not_active Ceased
- 2016-03-22 ES ES16712424T patent/ES2773527T3/es active Active
- 2016-03-22 PT PT167124247T patent/PT3274366T/pt unknown
- 2016-03-22 HU HUE16712424A patent/HUE047929T2/hu unknown
- 2016-03-22 CN CN201680017370.3A patent/CN107406518B/zh active Active
- 2016-03-22 PL PL16712424T patent/PL3274366T3/pl unknown
- 2016-03-22 DK DK16712424.7T patent/DK3274366T3/da active
- 2016-03-22 US US15/560,558 patent/US11058722B2/en active Active
- 2016-03-22 MX MX2017010552A patent/MX371384B/es active IP Right Grant
-
2017
- 2017-08-21 ZA ZA2017/05682A patent/ZA201705682B/en unknown
- 2017-08-31 IL IL254254A patent/IL254254B/en active IP Right Grant
- 2017-09-25 CL CL2017002413A patent/CL2017002413A1/es unknown
-
2020
- 2020-01-09 JP JP2020001971A patent/JP2020048588A/ja not_active Withdrawn
-
2022
- 2022-12-16 JP JP2022201192A patent/JP2023021396A/ja not_active Withdrawn
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