JP2018510169A - カチオン性ヒドロキシエチルセルロースを含有する組成物 - Google Patents
カチオン性ヒドロキシエチルセルロースを含有する組成物 Download PDFInfo
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- JP2018510169A JP2018510169A JP2017550256A JP2017550256A JP2018510169A JP 2018510169 A JP2018510169 A JP 2018510169A JP 2017550256 A JP2017550256 A JP 2017550256A JP 2017550256 A JP2017550256 A JP 2017550256A JP 2018510169 A JP2018510169 A JP 2018510169A
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- Prior art keywords
- aqueous solution
- mucosal surface
- polymer
- group
- cationic polymer
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- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 description 1
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- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
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- BJORNXNYWNIWEY-UHFFFAOYSA-N tetrahydrozoline hydrochloride Chemical compound Cl.N1CCN=C1C1C2=CC=CC=C2CCC1 BJORNXNYWNIWEY-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B11/00—Preparation of cellulose ethers
- C08B11/02—Alkyl or cycloalkyl ethers
- C08B11/04—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals
- C08B11/14—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals with nitrogen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B11/00—Preparation of cellulose ethers
- C08B11/193—Mixed ethers, i.e. ethers with two or more different etherifying groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/26—Cellulose ethers
- C08L1/28—Alkyl ethers
- C08L1/288—Alkyl ethers substituted with nitrogen-containing radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Peff=(TSS)/[(MA)*(DC)*(PT)]
によって計算した。
TSS=透過におけるSSの総量(mgの単位)
MA=膜面積(0.6cm2と等しい)
DC=ドナー濃度(mg/cm3の単位)
PT=透過時間(14400秒と等しい)
TEER試験は、上記の実施例2に報告されるサンプルに対して行った。抵抗は、透過前の初期値から透過試験の最後の最終値へ落下し、より大きい落下は、より高い透過性を示す。結果は以下の通りである。
上述のように透過試験を行った後、組織に上述の通りに生存試験を行った。サンプルは、SSを含有した。1つのサンプルは、0.2重量%のレベルでTriton(商標)X−100界面活性剤を有した。結果は以下の通りである。:
サンプルは、また、TEER法での回復に対して試験した。サンプルは、2mg/LのSSを有した。結果は以下の通りである。
透過試験は、比較例1の通りに行った。P7−1及びP7−2のラベルが付いた、実施例ポリマーP7の2つの異なるバッチを使用した。結果は以下の通りである。
Claims (7)
- (a)水中に溶解されるカチオン性ポリマーであって、ヒドロキシエチルセルロースポリマー骨格に共有結合している疎水性第4級アンモニウム基を含む、カチオン性ポリマーと、
(b)1つ以上の生理活性薬剤と、
を含む、水溶液。 - 前記カチオン性ポリマーの量は、前記水溶液の重量に基づいて0.01重量%〜10重量%である、請求項1に記載の水溶液。
- 前記カチオン性ポリマーは、構造IIの繰り返し単位を有し、
請求項1に記載の水溶液。 - −Rd−は、−CH2−であり、−Re−は、−OHであり、−R2及び−R3は、それぞれがメチルであり、−R4は、12個以上の炭素原子を有するアルキル基である、請求項3に記載の水溶液。
- 薬物を生体の粘膜面に送達する方法であって、前記方法は、請求項1に記載の水溶液を前記粘膜面に適用することを含み、請求項1に記載の水溶液は、前記薬物を含む、方法。
- 前記粘膜面は、膣、口、眼、耳、食道、胃、腸、または鼻腔内にある、請求項5に記載の方法。
- 前記粘膜面は、鼻腔内にある、請求項5に記載の方法。
Applications Claiming Priority (3)
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US201562142045P | 2015-04-02 | 2015-04-02 | |
US62/142,045 | 2015-04-02 | ||
PCT/US2016/024491 WO2016160688A1 (en) | 2015-04-02 | 2016-03-28 | Composition containing cationic hydroxyethyl cellulose |
Publications (2)
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JP6703997B2 JP6703997B2 (ja) | 2020-06-03 |
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Country | Link |
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US (3) | US20180369393A1 (ja) |
EP (1) | EP3277728B1 (ja) |
JP (1) | JP6703997B2 (ja) |
KR (1) | KR102647534B1 (ja) |
CN (1) | CN107428846B (ja) |
BR (1) | BR112017020454A2 (ja) |
WO (1) | WO2016160688A1 (ja) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61181801A (ja) * | 1985-02-01 | 1986-08-14 | ユニオン、カーバイト、コーポレーシヨン | ハイドロフオーブ置換した水溶性カチオン多糖類 |
JPH09503763A (ja) * | 1993-09-29 | 1997-04-15 | ザ・メディカル・カレッジ・オブ・ハンプトン・ローズ・オン・ビハーフ・オブ・ザ・コンラッド・プログラム | 避妊用組成物 |
JP2003513897A (ja) * | 1999-11-09 | 2003-04-15 | ザ、プロクター、エンド、ギャンブル、カンパニー | 疎水変性カチオン系セルロースを含むヘアコンディショニング組成物 |
JP2006526029A (ja) * | 2003-06-06 | 2006-11-16 | ザ プロクター アンド ギャンブル カンパニー | 疎水変性カチオン性増粘ポリマーを含む毛髪又は皮膚コンディショニング組成物 |
JP2010504992A (ja) * | 2006-09-29 | 2010-02-18 | ユニオン カーバイド ケミカルズ アンド プラスティックス テクノロジー エルエルシー | パーソナルケア製品用の4級化セルロースエーテル |
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US3472840A (en) * | 1965-09-14 | 1969-10-14 | Union Carbide Corp | Quaternary nitrogen-containing cellulose ethers |
US5645827A (en) * | 1992-09-30 | 1997-07-08 | Union Carbide Chemicals & Plastics Technology Corporation | Muco-adhesive polymers |
US5358706A (en) * | 1992-09-30 | 1994-10-25 | Union Carbide Chemicals & Plastics Technology Corporation | Muco-adhesive polymers |
ZA947572B (en) * | 1993-09-29 | 1995-09-28 | Hampton Roads Medical College | Contraceptive compositions |
US5407919A (en) * | 1993-09-29 | 1995-04-18 | Brode; George L. | Double-substituted cationic cellulose ethers |
CN1259860A (zh) * | 1997-07-09 | 2000-07-12 | 普罗克特和甘保尔公司 | 包括疏水改性的阳离子纤维素的护发组合物 |
RU2342953C2 (ru) * | 2003-02-24 | 2009-01-10 | Фармасьютикал Продакшенз, Инк. | Трансмукозная система доставки лекарственных средств |
JP6039861B2 (ja) | 2013-07-17 | 2016-12-07 | ダウ グローバル テクノロジーズ エルエルシー | ヒドロキシアルキルメチルセルロースを含む粘膜適用組成物 |
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2016
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JPS61181801A (ja) * | 1985-02-01 | 1986-08-14 | ユニオン、カーバイト、コーポレーシヨン | ハイドロフオーブ置換した水溶性カチオン多糖類 |
JPH09503763A (ja) * | 1993-09-29 | 1997-04-15 | ザ・メディカル・カレッジ・オブ・ハンプトン・ローズ・オン・ビハーフ・オブ・ザ・コンラッド・プログラム | 避妊用組成物 |
JP2003513897A (ja) * | 1999-11-09 | 2003-04-15 | ザ、プロクター、エンド、ギャンブル、カンパニー | 疎水変性カチオン系セルロースを含むヘアコンディショニング組成物 |
JP2006526029A (ja) * | 2003-06-06 | 2006-11-16 | ザ プロクター アンド ギャンブル カンパニー | 疎水変性カチオン性増粘ポリマーを含む毛髪又は皮膚コンディショニング組成物 |
JP2010504992A (ja) * | 2006-09-29 | 2010-02-18 | ユニオン カーバイド ケミカルズ アンド プラスティックス テクノロジー エルエルシー | パーソナルケア製品用の4級化セルロースエーテル |
Also Published As
Publication number | Publication date |
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CN107428846B (zh) | 2021-12-14 |
CN107428846A (zh) | 2017-12-01 |
KR20170133389A (ko) | 2017-12-05 |
EP3277728A1 (en) | 2018-02-07 |
US20200147224A1 (en) | 2020-05-14 |
WO2016160688A1 (en) | 2016-10-06 |
BR112017020454A2 (pt) | 2018-07-03 |
US20180369393A1 (en) | 2018-12-27 |
KR102647534B1 (ko) | 2024-03-13 |
US20230055279A1 (en) | 2023-02-23 |
EP3277728B1 (en) | 2023-10-04 |
JP6703997B2 (ja) | 2020-06-03 |
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