JP2018509908A5 - - Google Patents
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- JP2018509908A5 JP2018509908A5 JP2017548953A JP2017548953A JP2018509908A5 JP 2018509908 A5 JP2018509908 A5 JP 2018509908A5 JP 2017548953 A JP2017548953 A JP 2017548953A JP 2017548953 A JP2017548953 A JP 2017548953A JP 2018509908 A5 JP2018509908 A5 JP 2018509908A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- drug
- host cell
- seq
- following formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562134981P | 2015-03-18 | 2015-03-18 | |
| US62/134,981 | 2015-03-18 | ||
| PCT/US2016/022943 WO2016149535A1 (en) | 2015-03-18 | 2016-03-17 | Cd48 antibodies and conjugates thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020091335A Division JP2020141700A (ja) | 2015-03-18 | 2020-05-26 | Ｃｄ４８抗体及びその複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018509908A JP2018509908A (ja) | 2018-04-12 |
| JP2018509908A5 true JP2018509908A5 (enExample) | 2019-03-07 |
| JP6892826B2 JP6892826B2 (ja) | 2021-06-23 |
Family
ID=56919489
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017548953A Expired - Fee Related JP6892826B2 (ja) | 2015-03-18 | 2016-03-17 | Ｃｄ４８抗体及びその複合体 |
| JP2020091335A Pending JP2020141700A (ja) | 2015-03-18 | 2020-05-26 | Ｃｄ４８抗体及びその複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020091335A Pending JP2020141700A (ja) | 2015-03-18 | 2020-05-26 | Ｃｄ４８抗体及びその複合体 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10722592B2 (enExample) |
| EP (2) | EP3662933A1 (enExample) |
| JP (2) | JP6892826B2 (enExample) |
| KR (1) | KR20170128256A (enExample) |
| CN (1) | CN107530422B (enExample) |
| AU (1) | AU2016232839B2 (enExample) |
| BR (1) | BR112017019617A2 (enExample) |
| CA (1) | CA2976740A1 (enExample) |
| DK (1) | DK3270965T3 (enExample) |
| EA (2) | EA201992756A3 (enExample) |
| ES (1) | ES2795818T3 (enExample) |
| IL (1) | IL254027B (enExample) |
| MX (1) | MX382582B (enExample) |
| SG (1) | SG11201706786UA (enExample) |
| WO (1) | WO2016149535A1 (enExample) |
| ZA (1) | ZA201705935B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109843919A (zh) | 2016-03-25 | 2019-06-04 | 西雅图基因公司 | 用于制备聚乙二醇化的药物-接头及其中间体的方法 |
| KR102648564B1 (ko) | 2017-03-24 | 2024-03-19 | 씨젠 인크. | 글루쿠로니드 약물-링커의 제조 공정 및 그 중간물 |
| MX2020012718A (es) | 2018-05-29 | 2021-02-16 | Intocell Inc | Derivados de benzodiazepinas novedosos y usos de los mismos. |
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| CN112930350A (zh) | 2018-10-31 | 2021-06-08 | 尹图赛利有限公司 | 稠合杂环苯并二氮杂䓬衍生物及其用途 |
| WO2020163225A1 (en) * | 2019-02-05 | 2020-08-13 | Seattle Genetics, Inc. | Anti-cd228 antibodies and antibody-drug conjugates |
| JP7706210B2 (ja) | 2019-06-10 | 2025-07-11 | ストロ バイオファーマ インコーポレーテッド | ５Ｈ－ピロロ［３，２－ｄ］ピリミジン－２，４－ジアミノ化合物およびその抗体コンジュゲート |
| CN114929284A (zh) | 2019-10-04 | 2022-08-19 | 西根公司 | 喜树碱肽缀合物 |
| WO2021067820A1 (en) | 2019-10-04 | 2021-04-08 | Seagen Inc. | Formulation of antibody-drug conjugate |
| EP4038101A2 (en) | 2019-10-04 | 2022-08-10 | Seagen Inc. | Anti-pd-l1 antibodies and antibody-drug conjugates |
| AU2021251875A1 (en) | 2020-04-10 | 2022-11-03 | Seagen Inc. | Charge variant linkers |
| PE20240225A1 (es) | 2020-11-24 | 2024-02-16 | Novartis Ag | Anticuerpos anti-cd48, conjugados de anticuerpo-farmaco, y usos de los mismos |
| IL303079A (en) * | 2020-11-24 | 2023-07-01 | Novartis Ag | Mcl-1 inhibitor antibody-drug conjugates and methods of use |
| BR112023018676A2 (pt) | 2021-03-18 | 2023-10-10 | Seagen Inc | Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco |
| AU2022283467A1 (en) | 2021-05-28 | 2023-12-07 | Seagen Inc. | Anthracycline antibody conjugates |
| WO2023178289A2 (en) | 2022-03-17 | 2023-09-21 | Seagen Inc. | Camptothecin conjugates |
| WO2024129756A1 (en) | 2022-12-13 | 2024-06-20 | Seagen Inc. | Site-specific engineered cysteine antibody drug conjugates |
| KR20250169306A (ko) | 2023-04-18 | 2025-12-02 | 아스트라제네카 아베 | 절단가능한 링커를 포함하는 접합체 |
| TW202525344A (zh) | 2023-08-15 | 2025-07-01 | 瑞典商阿斯特捷利康公司 | 包含可切割連接子的軛合物 |
| AR134171A1 (es) | 2023-10-24 | 2025-12-10 | Seagen Inc | Compuestos quimioterapéuticos y métodos de uso |
| WO2025149947A1 (en) | 2024-01-12 | 2025-07-17 | Seagen Inc. | Antibody-drug conjugates |
| WO2025185617A1 (en) * | 2024-03-05 | 2025-09-12 | Hutchmed Limited | Linker, antibody-drug conjugate and use thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| WO1997035614A1 (en) * | 1996-03-27 | 1997-10-02 | Crc For Biopharmaceutical Research Pty. Ltd. | The use of antibodies against cd48 for the treatment of t and b cell lymphomas and leukemias |
| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| MXPA05000511A (es) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| DK1545613T3 (da) | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom |
| EP2478912B1 (en) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy |
| EP1749538A4 (en) * | 2004-03-31 | 2009-11-11 | Kirin Pharma Kk | METHOD FOR DETERMINING THE DIFFERENTIATION OF REGULATORY T CELLS AND THEIR PROLIFERATION WITH GPI ANCHOR PROTEIN AGONISTS AND MEDICINAL COMPOSITION THEREFOR |
| JP5367982B2 (ja) * | 2004-04-16 | 2013-12-11 | マクロジェニクス，インコーポレーテッド | ＦｃγＲＩＩＢ特異的抗体とその利用法 |
| WO2007008848A2 (en) | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus |
| ES2708763T3 (es) | 2005-07-07 | 2019-04-11 | Seattle Genetics Inc | Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C |
| DK3248613T3 (da) * | 2005-07-18 | 2022-03-14 | Seagen Inc | Beta-glucuronid-lægemiddel-linkerkonjugater |
| NZ616992A (en) * | 2005-12-20 | 2015-07-31 | Sbi Biotech Co Ltd | Anti-ilt7 antibody |
| DK2211904T3 (en) | 2007-10-19 | 2016-10-24 | Seattle Genetics Inc | Cd19-binding agents and uses thereof |
| UA104132C2 (en) | 2007-11-13 | 2014-01-10 | Тева Биофармасьютикалз Юесей, Инк. | Humanized antibodies against tl1a |
| US9029636B2 (en) * | 2008-02-05 | 2015-05-12 | Monsanto Technology Llc | Isolated novel nucleic acid and protein molecules from soy and methods of using those molecules to generate transgenic plants with enhanced agronomic traits |
| EP2418222B1 (en) * | 2009-04-10 | 2016-11-02 | Osaka University | Therapeutic agent for treating diseases in which neoplastic proliferation of plasma cells occurs |
| EP2287197A1 (en) * | 2009-08-21 | 2011-02-23 | Pierre Fabre Medicament | Anti-cMET antibody and its use for the detection and the diagnosis of cancer |
| AR083044A1 (es) | 2010-09-27 | 2013-01-30 | Regeneron Pharma | Anticuerpos anti-cd48 y usos de los mismos |
| NZ713461A (en) * | 2011-04-15 | 2017-02-24 | Compugen Ltd | Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer |
| AU2013229786B2 (en) * | 2012-03-08 | 2017-06-22 | Halozyme, Inc. | Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof |
| WO2013173337A2 (en) * | 2012-05-15 | 2013-11-21 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| NZ758049A (en) * | 2013-10-15 | 2024-03-22 | Seagen Inc | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
-
2016
- 2016-03-17 DK DK16765773.3T patent/DK3270965T3/da active
- 2016-03-17 ES ES16765773T patent/ES2795818T3/es active Active
- 2016-03-17 KR KR1020177024226A patent/KR20170128256A/ko not_active Withdrawn
- 2016-03-17 JP JP2017548953A patent/JP6892826B2/ja not_active Expired - Fee Related
- 2016-03-17 EP EP19219476.9A patent/EP3662933A1/en not_active Withdrawn
- 2016-03-17 US US15/557,910 patent/US10722592B2/en active Active
- 2016-03-17 CN CN201680013161.1A patent/CN107530422B/zh not_active Expired - Fee Related
- 2016-03-17 EP EP16765773.3A patent/EP3270965B1/en active Active
- 2016-03-17 WO PCT/US2016/022943 patent/WO2016149535A1/en not_active Ceased
- 2016-03-17 CA CA2976740A patent/CA2976740A1/en not_active Abandoned
- 2016-03-17 BR BR112017019617-4A patent/BR112017019617A2/pt not_active IP Right Cessation
- 2016-03-17 EA EA201992756A patent/EA201992756A3/ru unknown
- 2016-03-17 MX MX2017011432A patent/MX382582B/es unknown
- 2016-03-17 AU AU2016232839A patent/AU2016232839B2/en not_active Ceased
- 2016-03-17 EA EA201792055A patent/EA035374B1/ru unknown
- 2016-03-17 SG SG11201706786UA patent/SG11201706786UA/en unknown
-
2017
- 2017-08-16 IL IL254027A patent/IL254027B/en active IP Right Grant
- 2017-08-31 ZA ZA2017/05935A patent/ZA201705935B/en unknown
-
2020
- 2020-05-26 JP JP2020091335A patent/JP2020141700A/ja active Pending
- 2020-06-04 US US16/892,529 patent/US20200289661A1/en not_active Abandoned
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