JP2018509907A5 - - Google Patents
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- JP2018509907A5 JP2018509907A5 JP2017548919A JP2017548919A JP2018509907A5 JP 2018509907 A5 JP2018509907 A5 JP 2018509907A5 JP 2017548919 A JP2017548919 A JP 2017548919A JP 2017548919 A JP2017548919 A JP 2017548919A JP 2018509907 A5 JP2018509907 A5 JP 2018509907A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 982
- 230000027455 binding Effects 0.000 claims description 377
- 239000000427 antigen Substances 0.000 claims description 321
- 102000036639 antigens Human genes 0.000 claims description 321
- 108091007433 antigens Proteins 0.000 claims description 321
- 239000012634 fragment Substances 0.000 claims description 246
- 210000004027 cell Anatomy 0.000 claims description 197
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 83
- 102100023123 Mucin-16 Human genes 0.000 claims description 83
- 238000000338 in vitro Methods 0.000 claims description 52
- 108010082117 matrigel Proteins 0.000 claims description 52
- 230000009545 invasion Effects 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 49
- 229910052757 nitrogen Inorganic materials 0.000 claims description 32
- 230000013595 glycosylation Effects 0.000 claims description 31
- 238000006206 glycosylation reaction Methods 0.000 claims description 31
- 108091033319 polynucleotide Proteins 0.000 claims description 24
- 102000040430 polynucleotide Human genes 0.000 claims description 24
- 239000002157 polynucleotide Substances 0.000 claims description 24
- 125000000539 amino acid group Chemical group 0.000 claims description 22
- QLTSDROPCWIKKY-PMCTYKHCSA-N beta-D-glucosaminyl-(1->4)-beta-D-glucosamine Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O)[C@@H](CO)O1 QLTSDROPCWIKKY-PMCTYKHCSA-N 0.000 claims description 19
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 14
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 14
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 11
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 10
- 150000007523 nucleic acids Chemical group 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 229910052698 phosphorus Inorganic materials 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 229940127089 cytotoxic agent Drugs 0.000 claims description 7
- 239000002254 cytotoxic agent Substances 0.000 claims description 7
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 239000012216 imaging agent Substances 0.000 claims description 7
- 108060003951 Immunoglobulin Proteins 0.000 claims description 6
- 102000018358 immunoglobulin Human genes 0.000 claims description 6
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 210000003101 oviduct Anatomy 0.000 claims description 2
- 210000000496 pancreas Anatomy 0.000 claims description 2
- 210000004291 uterus Anatomy 0.000 claims description 2
- 201000005296 lung carcinoma Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000004303 peritoneum Anatomy 0.000 claims 1
- 230000002163 immunogen Effects 0.000 description 54
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 description 53
- 108010015899 Glycopeptides Proteins 0.000 description 53
- 102000002068 Glycopeptides Human genes 0.000 description 53
- 150000001720 carbohydrates Chemical class 0.000 description 14
- 108020001507 fusion proteins Proteins 0.000 description 7
- 102000037865 fusion proteins Human genes 0.000 description 7
- 150000002016 disaccharides Chemical class 0.000 description 6
- 229940127121 immunoconjugate Drugs 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 102000014914 Carrier Proteins Human genes 0.000 description 4
- 108010078791 Carrier Proteins Proteins 0.000 description 4
- 108090000288 Glycoproteins Proteins 0.000 description 4
- 102000003886 Glycoproteins Human genes 0.000 description 4
- 241000283984 Rodentia Species 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 description 2
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 2
- ATHHXGZTWNVVOU-UHFFFAOYSA-N N-methylformamide Chemical class CNC=O ATHHXGZTWNVVOU-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 150000004044 tetrasaccharides Chemical class 0.000 description 2
- 150000004043 trisaccharides Chemical class 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 201000001342 Fallopian tube cancer Diseases 0.000 description 1
- 208000013452 Fallopian tube neoplasm Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 150000001508 asparagines Chemical class 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562134402P | 2015-03-17 | 2015-03-17 | |
| US62/134,402 | 2015-03-17 | ||
| PCT/US2016/022643 WO2016149368A1 (en) | 2015-03-17 | 2016-03-16 | Anti-muc16 antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020162274A Division JP2021000132A (ja) | 2015-03-17 | 2020-09-28 | 抗ｍｕｃ１６抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018509907A JP2018509907A (ja) | 2018-04-12 |
| JP2018509907A5 true JP2018509907A5 (enExample) | 2019-04-25 |
| JP6968698B2 JP6968698B2 (ja) | 2021-11-24 |
Family
ID=55755670
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017548919A Active JP6968698B2 (ja) | 2015-03-17 | 2016-03-16 | 抗ｍｕｃ１６抗体及びその使用 |
| JP2020162274A Withdrawn JP2021000132A (ja) | 2015-03-17 | 2020-09-28 | 抗ｍｕｃ１６抗体及びその使用 |
| JP2022091593A Withdrawn JP2022116314A (ja) | 2015-03-17 | 2022-06-06 | 抗ｍｕｃ１６抗体及びその使用 |
| JP2024232825A Pending JP2025061682A (ja) | 2015-03-17 | 2024-12-27 | 抗ｍｕｃ１６抗体及びその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020162274A Withdrawn JP2021000132A (ja) | 2015-03-17 | 2020-09-28 | 抗ｍｕｃ１６抗体及びその使用 |
| JP2022091593A Withdrawn JP2022116314A (ja) | 2015-03-17 | 2022-06-06 | 抗ｍｕｃ１６抗体及びその使用 |
| JP2024232825A Pending JP2025061682A (ja) | 2015-03-17 | 2024-12-27 | 抗ｍｕｃ１６抗体及びその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11066480B2 (enExample) |
| EP (2) | EP4190817A1 (enExample) |
| JP (4) | JP6968698B2 (enExample) |
| KR (1) | KR102618312B1 (enExample) |
| CN (2) | CN115368460A (enExample) |
| AU (3) | AU2016233309B2 (enExample) |
| CA (1) | CA2979976A1 (enExample) |
| ES (1) | ES2929614T3 (enExample) |
| IL (3) | IL296062A (enExample) |
| MX (2) | MX391249B (enExample) |
| RU (1) | RU2758113C2 (enExample) |
| SG (1) | SG11201707538XA (enExample) |
| WO (1) | WO2016149368A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3255551A1 (en) | 2010-03-26 | 2025-04-15 | Memorial Sloan-Kettering Cancer Center | MUC16 ANTIBODIES AND METHODS OF USE |
| FI3218005T3 (fi) | 2014-11-12 | 2023-03-31 | Seagen Inc | Glykaanin kanssa vuorovaikutteisia yhdisteitä ja käyttömenetelmiä |
| SG11201707538XA (en) | 2015-03-17 | 2017-10-30 | Memorial Sloan Kettering Cancer Center | Anti-muc16 antibodies and uses thereof |
| MX2018004721A (es) | 2015-10-23 | 2018-07-06 | Eureka Therapeutics Inc | Construcciones quimericas anticuerpo/receptor de celulas t y usos de las mismas. |
| CA3002097A1 (en) | 2015-11-12 | 2017-05-18 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| JP7066690B2 (ja) * | 2016-09-23 | 2022-05-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ｍｕｃ１６（ムチン１６）抗体 |
| WO2018094143A1 (en) * | 2016-11-17 | 2018-05-24 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| JP7516047B2 (ja) | 2016-11-23 | 2024-07-16 | アセチロン ファーマシューティカルズ インコーポレイテッド | ヒストン脱アセチル化酵素阻害剤とｃｄ３８阻害剤とを含む医薬組み合わせ物及びその使用方法 |
| WO2018160909A1 (en) | 2017-03-03 | 2018-09-07 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| JP7538601B2 (ja) | 2017-04-26 | 2024-08-22 | ユーリカ セラピューティックス， インコーポレイテッド | キメラ活性化受容体及びキメラ刺激受容体を発現する細胞並びにその使用 |
| EA201990784A1 (ru) * | 2017-09-14 | 2019-09-30 | Ридженерон Фармасьютикалз, Инк. | Анти-muc16 (mucin16) антитела |
| AU2019215202B2 (en) * | 2018-02-01 | 2025-11-13 | Memorial Sloan Kettering Cancer Center | Antibodies to Galectin-3 and methods of use thereof |
| CA3095457A1 (en) | 2018-05-09 | 2019-11-14 | Quest Pharmatech Inc. | Muc16 monoclonal antibody and uses thereof |
| CN110526988A (zh) * | 2018-05-25 | 2019-12-03 | 深圳宾德生物技术有限公司 | 一种靶向muc1的嵌合抗原受体和嵌合抗原受体t细胞及其制备方法和应用 |
| CN110527667A (zh) * | 2018-05-25 | 2019-12-03 | 深圳宾德生物技术有限公司 | 一种靶向muc16的嵌合抗原受体和嵌合抗原受体t细胞及其制备方法和应用 |
| CN110526974A (zh) * | 2018-05-25 | 2019-12-03 | 深圳宾德生物技术有限公司 | 一种靶向muc16的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
| CN110526977A (zh) * | 2018-05-25 | 2019-12-03 | 深圳宾德生物技术有限公司 | 一种靶向muc1的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
| CN113366022B (zh) | 2018-11-16 | 2025-11-21 | 纪念斯隆凯特琳癌症中心 | 针对粘蛋白-16的抗体及其使用方法 |
| EP3966248A4 (en) * | 2019-05-08 | 2023-04-12 | Memorial Sloan Kettering Cancer Center | HUMAN ANTIBODIES TO FEL MUCIN-16 AND THEIR METHODS OF USE |
| EP3986934A1 (en) | 2019-06-21 | 2022-04-27 | Regeneron Pharmaceuticals, Inc. | Use of bispecific antigen-binding molecules that bind muc16 and cd3 in combination with 4-1bb co-stimulation |
| US12516096B2 (en) * | 2019-08-08 | 2026-01-06 | Navrogen, Inc. | Composition and use of humoral immune suppressor antagonists for the treatment of humoral immune suppressed diseases |
| EP4171608A1 (en) * | 2020-06-30 | 2023-05-03 | Universiteit Antwerpen | Mucins and isoforms thereof in diseases characterized by barrier dysfunction |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| KR20230122618A (ko) | 2020-12-21 | 2023-08-22 | 알로젠 테라퓨틱스 인코포레이티드 | 프로테아제 활성화 cd45-게이트 car |
| CA3204417A1 (en) | 2021-01-29 | 2022-08-04 | Allogene Therapeutics, Inc. | Knockdown or knockout of one or more of tap2, nlrc5, ?2m, trac, rfx5, rfxap and rfxank to mitigate t cell recognition of allogeneic cell products |
| JP2024513755A (ja) * | 2021-03-23 | 2024-03-27 | グリコエラ アーゲー | マンノース３グリカン媒介タンパク質分解 |
| WO2022204249A1 (en) * | 2021-03-24 | 2022-09-29 | Memorial Sloan-Kettering Cancer Center | Variants of humanized anti-muc16 ectodomain antibodies for treatment of muc16 overexpressing tumors |
| CN113061186B (zh) * | 2021-04-09 | 2022-05-13 | 福州迈新生物技术开发有限公司 | 抗ca125蛋白的单克隆抗体及其细胞株、制备方法和应用 |
| CN115260305B (zh) * | 2021-04-29 | 2025-02-28 | 郑州大学 | 抗SARS-CoV-2 RBD单克隆抗体和应用 |
| CN114835805B (zh) * | 2022-06-10 | 2023-06-06 | 郑州大学 | 抗SARS-CoV-2 spike蛋白的单克隆抗体及应用 |
| CA3261440A1 (en) | 2022-07-29 | 2024-02-01 | Allogene Therapeutics, Inc. | MODIFIED CELLS WITH REDUCED GENE EXPRESSION TO MITIGATE RECOGNITION BY IMMUNE CELLS |
| US20240262929A1 (en) * | 2023-02-06 | 2024-08-08 | Ibio, Inc. | Anti-muc16 antibodies |
| AU2024372734A1 (en) | 2023-10-30 | 2026-04-16 | Allogene Therapeutics, Inc. | Engineered cells |
| CN118684782A (zh) * | 2024-07-17 | 2024-09-24 | 武汉科技大学 | 一种muc16和folr1双靶点嵌合抗原受体dcar-16-r1及应用 |
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-
2016
- 2016-03-16 SG SG11201707538XA patent/SG11201707538XA/en unknown
- 2016-03-16 MX MX2017011822A patent/MX391249B/es unknown
- 2016-03-16 EP EP22192814.6A patent/EP4190817A1/en active Pending
- 2016-03-16 ES ES16716959T patent/ES2929614T3/es active Active
- 2016-03-16 EP EP16716959.8A patent/EP3271398B1/en active Active
- 2016-03-16 IL IL296062A patent/IL296062A/en unknown
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- 2016-03-16 JP JP2017548919A patent/JP6968698B2/ja active Active
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- 2016-03-16 KR KR1020177029700A patent/KR102618312B1/ko active Active
- 2016-03-16 WO PCT/US2016/022643 patent/WO2016149368A1/en not_active Ceased
- 2016-03-16 CN CN202210174122.7A patent/CN115368460A/zh active Pending
- 2016-03-16 RU RU2017134592A patent/RU2758113C2/ru active
- 2016-03-16 CN CN201680028517.9A patent/CN107667120B/zh active Active
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