JP2005507635A5 - - Google Patents
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- JP2005507635A5 JP2005507635A5 JP2002564963A JP2002564963A JP2005507635A5 JP 2005507635 A5 JP2005507635 A5 JP 2005507635A5 JP 2002564963 A JP2002564963 A JP 2002564963A JP 2002564963 A JP2002564963 A JP 2002564963A JP 2005507635 A5 JP2005507635 A5 JP 2005507635A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- human
- antigen
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims 23
- 108091007433 antigens Proteins 0.000 claims 23
- 102000036639 antigens Human genes 0.000 claims 23
- 101000878602 Homo sapiens Immunoglobulin alpha Fc receptor Proteins 0.000 claims 13
- 102100038005 Immunoglobulin alpha Fc receptor Human genes 0.000 claims 13
- 125000000539 amino acid group Chemical group 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 108700019146 Transgenes Proteins 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 102000001301 EGF receptor Human genes 0.000 claims 7
- 108060006698 EGF receptor Proteins 0.000 claims 7
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 6
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 6
- 230000009261 transgenic effect Effects 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims 5
- 210000004408 hybridoma Anatomy 0.000 claims 5
- 238000012986 modification Methods 0.000 claims 5
- 230000004048 modification Effects 0.000 claims 5
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 4
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 4
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims 4
- 102000009109 Fc receptors Human genes 0.000 claims 4
- 108010087819 Fc receptors Proteins 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 3
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 3
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 3
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 3
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 3
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 3
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 3
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 3
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 3
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims 3
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims 3
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108010073466 Bombesin Receptors Proteins 0.000 claims 2
- 102000047481 Gastrin-releasing peptide receptors Human genes 0.000 claims 2
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 2
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 2
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims 2
- 102000000440 Melanoma-associated antigen Human genes 0.000 claims 2
- 108050008953 Melanoma-associated antigen Proteins 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 102100034256 Mucin-1 Human genes 0.000 claims 2
- 108010063954 Mucins Proteins 0.000 claims 2
- 102000015728 Mucins Human genes 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 2
- 230000008021 deposition Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 208000015446 immunoglobulin a vasculitis Diseases 0.000 claims 2
- 238000012737 microarray-based gene expression Methods 0.000 claims 2
- 238000012243 multiplex automated genomic engineering Methods 0.000 claims 2
- 101150047061 tag-72 gene Proteins 0.000 claims 2
- 206010008909 Chronic Hepatitis Diseases 0.000 claims 1
- 206010021263 IgA nephropathy Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000002637 immunotoxin Effects 0.000 claims 1
- 229940051026 immunotoxin Drugs 0.000 claims 1
- 239000002596 immunotoxin Substances 0.000 claims 1
- 231100000608 immunotoxin Toxicity 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000006166 lysate Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26807501P | 2001-02-12 | 2001-02-12 | |
| US33895601P | 2001-11-05 | 2001-11-05 | |
| PCT/US2002/004024 WO2002064634A2 (en) | 2001-02-12 | 2002-02-11 | Human monoclonal antibodies to fc alpha receptor (cd89) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009187733A Division JP2010004888A (ja) | 2001-02-12 | 2009-08-13 | Ｆｃα受容体（ＣＤ８９）に対するヒトモノクローナル抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005507635A JP2005507635A (ja) | 2005-03-24 |
| JP2005507635A5 true JP2005507635A5 (enExample) | 2005-12-22 |
Family
ID=26952868
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002564963A Pending JP2005507635A (ja) | 2001-02-12 | 2002-02-11 | Ｆｃα受容体（ＣＤ８９）に対するヒトモノクローナル抗体 |
| JP2009187733A Withdrawn JP2010004888A (ja) | 2001-02-12 | 2009-08-13 | Ｆｃα受容体（ＣＤ８９）に対するヒトモノクローナル抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009187733A Withdrawn JP2010004888A (ja) | 2001-02-12 | 2009-08-13 | Ｆｃα受容体（ＣＤ８９）に対するヒトモノクローナル抗体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7192582B2 (enExample) |
| EP (1) | EP1370588A2 (enExample) |
| JP (2) | JP2005507635A (enExample) |
| KR (1) | KR100890088B1 (enExample) |
| CN (1) | CN1312181C (enExample) |
| AU (1) | AU2002240338C1 (enExample) |
| CA (1) | CA2437814C (enExample) |
| IL (2) | IL157274A0 (enExample) |
| MX (1) | MXPA03007144A (enExample) |
| NZ (1) | NZ527977A (enExample) |
| WO (1) | WO2002064634A2 (enExample) |
| ZA (1) | ZA200305996B (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192584B2 (en) * | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| AU2002252456A1 (en) * | 2001-03-23 | 2002-10-08 | Aphton Corporation | Combination treatment of pancreatic cancer |
| US20090191232A1 (en) * | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
| CN1525868A (zh) * | 2001-07-09 | 2004-09-01 | 埃弗顿有限公司 | 治疗和预防肝脏、肺脏和食道的癌症和癌症前期症状 |
| US20060165675A1 (en) * | 2002-08-02 | 2006-07-27 | Richman-Eisenstat Janice Beth | Modulation of mesenchymal cells via iga-receptors |
| KR20050118690A (ko) * | 2003-03-28 | 2005-12-19 | 애프톤 코포레이션 | 가스트린 호르몬 면역어세이 |
| AR045563A1 (es) * | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| EP1570858A1 (en) * | 2004-03-05 | 2005-09-07 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Monovalent ligand of the FCalphaRi receptor as an anti-inflammatory agent |
| AU2005228897B2 (en) * | 2004-03-29 | 2009-12-10 | Cancer Advances, Inc. | Monoclonal antibodies to gastrin hormone |
| EP1794586B1 (en) | 2004-09-22 | 2013-01-30 | Cancer Advances, Inc., | Monoclonal antibodies to progastrin |
| DK1874821T3 (da) | 2005-04-26 | 2013-07-08 | Trion Pharma Gmbh | Kombination af antistoffer med glykokortikoider til behandling af kræft |
| NZ606294A (en) | 2005-07-25 | 2014-09-26 | Emergent Product Dev Seattle | B-cell reduction using cd37-specific and cd20-specific binding molecules |
| AU2007257692B2 (en) | 2006-06-12 | 2013-11-14 | Aptevo Research And Development Llc | Single-chain multivalent binding proteins with effector function |
| JP5189098B2 (ja) | 2007-08-23 | 2013-04-24 | 三菱化学メディエンス株式会社 | 非特異反応抑制剤 |
| MX340204B (es) | 2008-04-11 | 2016-06-30 | Emergent Product Dev Seattle | Inmunoterapeutico de cd37 y combinacion con quimioterapeutico bifuncional del mismo. |
| EP2127666A1 (en) * | 2008-05-28 | 2009-12-02 | Drug Discovery Factory B.V. | Method for the treatment or prophylaxis of chronic inflammatory diseases |
| US20130195840A1 (en) * | 2010-01-13 | 2013-08-01 | Robert P. Kimberly | Therapeutics and processes for treatment of immune disorders |
| AU2011239706B2 (en) * | 2010-04-13 | 2015-08-20 | Celldex Therapeutics Inc. | Antibodies that bind human CD27 and uses thereof |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| CN108117586A (zh) | 2010-08-10 | 2018-06-05 | 洛桑聚合联合学院 | 红细胞结合性治疗剂 |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| EP2465536A1 (en) * | 2010-12-14 | 2012-06-20 | CSL Behring AG | CD89 activation in therapy |
| AU2013216863B2 (en) * | 2012-02-10 | 2018-09-06 | Seagen Inc. | Detection and treatment of CD30+ cancers |
| EP2636681A1 (en) | 2012-03-09 | 2013-09-11 | CSL Behring AG | Process for enriching IgA |
| CN104254542A (zh) | 2012-03-09 | 2014-12-31 | 瑞士杰特贝林生物制品有限公司 | 包含分泌-样免疫球蛋白的组合物 |
| EP2636684A1 (en) | 2012-03-09 | 2013-09-11 | CSL Behring AG | Prevention of infection |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| SG11201606761RA (en) | 2014-02-21 | 2016-09-29 | Ecole Polytecnique Federale De Lausanne Epfl Epfl Tto | Glycotargeting therapeutics |
| CA2980642C (en) * | 2015-03-25 | 2022-09-20 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Anti-cd89 cytotoxic complex |
| JOP20200312A1 (ar) | 2015-06-26 | 2017-06-16 | Novartis Ag | الأجسام المضادة للعامل xi وطرق الاستخدام |
| HK1251480A1 (zh) | 2015-09-21 | 2019-02-01 | Aptevo Research And Development Llc | Cd3结合多肽 |
| TW201802121A (zh) | 2016-05-25 | 2018-01-16 | 諾華公司 | 抗因子XI/XIa抗體之逆轉結合劑及其用途 |
| JP7083820B2 (ja) * | 2016-09-30 | 2022-06-13 | セントレ ナショナル デ ラ レセルシュ シャンティフィク | 膜マーカー |
| US12188935B2 (en) | 2016-09-30 | 2025-01-07 | Centre National De La Recherche Scientifique | Method for the evaluation of antiretroviral therapy (ART) effectiveness in HIV-1 CD4+CD89+ cellular reservoirs |
| EP3551047A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CN110325550B (zh) | 2016-12-23 | 2024-03-08 | 诺华股份有限公司 | 因子xi抗体和使用方法 |
| CA3054632A1 (en) | 2017-03-30 | 2018-10-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| JP7469225B2 (ja) | 2017-06-15 | 2024-04-16 | キャンサー アドヴァンシーズ インク． | 腫瘍及び癌に対する体液性及び細胞性免疫を誘発するための組成物及び方法 |
| US12150978B2 (en) | 2017-06-15 | 2024-11-26 | Cancer Advances Inc. | Compositions and methods for preventing tumors and cancer |
| WO2018232176A1 (en) | 2017-06-16 | 2018-12-20 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| JP7009517B2 (ja) | 2017-06-21 | 2022-01-25 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖ ｇｐ１２０およびｃｄ３を標的とする多重特異性抗体 |
| JP7466459B2 (ja) | 2018-04-17 | 2024-04-12 | セルデックス セラピューティクス インコーポレイテッド | 抗ｃｄ２７および抗ｐｄ－ｌ１抗体ならびに二重特異性構築物 |
| IL278538B2 (en) | 2018-05-09 | 2024-01-01 | Univ Chicago | Compositions and methods concerning immune tolerance |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| US20230023414A1 (en) | 2018-11-19 | 2023-01-26 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| CN115698078A (zh) * | 2020-04-21 | 2023-02-03 | Jjp佰优罗机克斯有限公司 | 人源化抗人cd89抗体及其用途 |
| WO2022074206A1 (en) | 2020-10-08 | 2022-04-14 | Affimed Gmbh | Trispecific binders |
| KR102766045B1 (ko) * | 2020-11-06 | 2025-02-10 | 고려대학교 산학협력단 | Fc 알파 수용체 결합력이 향상된 항체 |
| KR102853685B1 (ko) * | 2020-11-06 | 2025-09-01 | 고려대학교 산학협력단 | Fc 알파 수용체 결합력이 증진된 항체 |
| US20230399407A1 (en) * | 2020-11-06 | 2023-12-14 | Korea University Research And Business Foundation | Fc alpha receptor binding antibody |
| KR102855679B1 (ko) * | 2020-11-06 | 2025-09-04 | 고려대학교 산학협력단 | Fc 알파 수용체 결합 항체 |
| IL308154A (en) | 2021-07-30 | 2023-12-01 | Affimed Gmbh | Double structure antibodies |
| WO2024218512A1 (en) | 2023-04-19 | 2024-10-24 | Centessa Pharmaceuticals (Uk) Limited | Activatable bispecific anti-cd89 and anti-pd-l1 proteins and uses thereof |
| CN117890576A (zh) * | 2023-12-12 | 2024-04-16 | 深圳市陆为生物技术有限公司 | 一种检测CD89-IgA免疫复合物的试剂、方法及其应用 |
| WO2025218725A1 (zh) * | 2024-04-18 | 2025-10-23 | 徕特康(苏州)生物制药有限公司 | 靶向cd20和cd89的髓细胞衔接子抗体及其用途 |
| WO2026002175A1 (zh) * | 2024-06-27 | 2026-01-02 | 无锡徕特康生物科技有限公司 | 靶向ilt7和cd89的髓细胞衔接子抗体及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6018031A (en) * | 1989-10-20 | 2000-01-25 | Trustees Of Dartmouth College | Binding agents specific for IgA receptor |
| DK0496818T3 (da) * | 1989-10-20 | 1999-11-22 | Dartmouth College | IgA-receptor-specifikt monoklonalt antistof |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5198342A (en) * | 1990-07-05 | 1993-03-30 | Immunex Corporation | DNA encoding IgA Fc receptors |
| WO1994025585A1 (en) | 1993-04-26 | 1994-11-10 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| DK0546073T3 (da) | 1990-08-29 | 1998-02-02 | Genpharm Int | Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer |
| US5922845A (en) * | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| CA2381565A1 (en) * | 1999-07-30 | 2001-02-08 | Medarex, Inc. | Therapeutic compounds comprised of anti-fc receptor binding agents |
| DK1282646T3 (da) | 2000-05-08 | 2012-05-14 | Celldex Res Corp | Humane monoklonale antistoffer mod dendritiske celler |
-
2002
- 2002-02-11 MX MXPA03007144A patent/MXPA03007144A/es active IP Right Grant
- 2002-02-11 EP EP02706236A patent/EP1370588A2/en not_active Withdrawn
- 2002-02-11 US US10/073,644 patent/US7192582B2/en not_active Expired - Fee Related
- 2002-02-11 JP JP2002564963A patent/JP2005507635A/ja active Pending
- 2002-02-11 CA CA002437814A patent/CA2437814C/en not_active Expired - Fee Related
- 2002-02-11 CN CNB028078381A patent/CN1312181C/zh not_active Expired - Fee Related
- 2002-02-11 WO PCT/US2002/004024 patent/WO2002064634A2/en not_active Ceased
- 2002-02-11 AU AU2002240338A patent/AU2002240338C1/en not_active Ceased
- 2002-02-11 NZ NZ527977A patent/NZ527977A/en unknown
- 2002-02-11 KR KR1020037010590A patent/KR100890088B1/ko not_active Expired - Fee Related
- 2002-02-11 IL IL15727402A patent/IL157274A0/xx unknown
-
2003
- 2003-08-04 ZA ZA2003/05996A patent/ZA200305996B/en unknown
- 2003-08-06 IL IL157274A patent/IL157274A/en not_active IP Right Cessation
-
2009
- 2009-08-13 JP JP2009187733A patent/JP2010004888A/ja not_active Withdrawn
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