JP2018508183A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018508183A5 JP2018508183A5 JP2017534208A JP2017534208A JP2018508183A5 JP 2018508183 A5 JP2018508183 A5 JP 2018508183A5 JP 2017534208 A JP2017534208 A JP 2017534208A JP 2017534208 A JP2017534208 A JP 2017534208A JP 2018508183 A5 JP2018508183 A5 JP 2018508183A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- patient
- postn
- signature genes
- stromal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 63
- 206010028980 Neoplasm Diseases 0.000 claims 61
- 201000011510 cancer Diseases 0.000 claims 57
- 101001095308 Homo sapiens Periostin Proteins 0.000 claims 41
- 102100037765 Periostin Human genes 0.000 claims 41
- 108090000623 proteins and genes Proteins 0.000 claims 39
- 101710088083 Glomulin Proteins 0.000 claims 24
- 101710159002 L-lactate oxidase Proteins 0.000 claims 24
- 102100026858 Protein-lysine 6-oxidase Human genes 0.000 claims 24
- 239000003814 drug Substances 0.000 claims 21
- 102100026261 Metalloproteinase inhibitor 3 Human genes 0.000 claims 20
- 108010031429 Tissue Inhibitor of Metalloproteinase-3 Proteins 0.000 claims 20
- 238000002512 chemotherapy Methods 0.000 claims 18
- 239000000523 sample Substances 0.000 claims 16
- 239000005557 antagonist Substances 0.000 claims 12
- 206010033128 Ovarian cancer Diseases 0.000 claims 10
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 10
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 9
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 9
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 8
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 8
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 8
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 claims 7
- 102000049320 CD36 Human genes 0.000 claims 7
- 108010045374 CD36 Antigens Proteins 0.000 claims 7
- 102100038395 Granzyme K Human genes 0.000 claims 7
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims 7
- 101001033007 Homo sapiens Granzyme K Proteins 0.000 claims 7
- 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 claims 7
- 101000716124 Homo sapiens T-cell surface glycoprotein CD1c Proteins 0.000 claims 7
- 101000738335 Homo sapiens T-cell surface glycoprotein CD3 zeta chain Proteins 0.000 claims 7
- 101000892398 Homo sapiens Tryptophan 2,3-dioxygenase Proteins 0.000 claims 7
- 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 claims 7
- 206010038389 Renal cancer Diseases 0.000 claims 7
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 7
- 102100036014 T-cell surface glycoprotein CD1c Human genes 0.000 claims 7
- 102100037906 T-cell surface glycoprotein CD3 zeta chain Human genes 0.000 claims 7
- 102100040653 Tryptophan 2,3-dioxygenase Human genes 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 238000009104 chemotherapy regimen Methods 0.000 claims 7
- 229960001592 paclitaxel Drugs 0.000 claims 7
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 7
- WAVYAFBQOXCGSZ-UHFFFAOYSA-N 2-fluoropyrimidine Chemical compound FC1=NC=CC=N1 WAVYAFBQOXCGSZ-UHFFFAOYSA-N 0.000 claims 6
- 229930012538 Paclitaxel Natural products 0.000 claims 6
- 201000010174 renal carcinoma Diseases 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 229940127089 cytotoxic agent Drugs 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 102100024642 ATP-binding cassette sub-family C member 9 Human genes 0.000 claims 4
- 102100036732 Actin, aortic smooth muscle Human genes 0.000 claims 4
- 102100025672 Angiopoietin-related protein 2 Human genes 0.000 claims 4
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 4
- 102100030401 Biglycan Human genes 0.000 claims 4
- 208000003174 Brain Neoplasms Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 102100027207 CD27 antigen Human genes 0.000 claims 4
- 102100032912 CD44 antigen Human genes 0.000 claims 4
- -1 COX inhibitors Substances 0.000 claims 4
- 101001110283 Canis lupus familiaris Ras-related C3 botulinum toxin substrate 1 Proteins 0.000 claims 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims 4
- 102100022145 Collagen alpha-1(IV) chain Human genes 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 4
- 102100027641 DNA-binding protein inhibitor ID-1 Human genes 0.000 claims 4
- 206010014733 Endometrial cancer Diseases 0.000 claims 4
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 4
- 201000001342 Fallopian tube cancer Diseases 0.000 claims 4
- 208000013452 Fallopian tube neoplasm Diseases 0.000 claims 4
- 102100031507 Fc receptor-like protein 5 Human genes 0.000 claims 4
- 101150032879 Fcrl5 gene Proteins 0.000 claims 4
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims 4
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 4
- 102100037362 Fibronectin Human genes 0.000 claims 4
- 102100031812 Fibulin-1 Human genes 0.000 claims 4
- 102100033423 GDNF family receptor alpha-1 Human genes 0.000 claims 4
- 101000760581 Homo sapiens ATP-binding cassette sub-family C member 9 Proteins 0.000 claims 4
- 101000929319 Homo sapiens Actin, aortic smooth muscle Proteins 0.000 claims 4
- 101000693081 Homo sapiens Angiopoietin-related protein 2 Proteins 0.000 claims 4
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 4
- 101001126865 Homo sapiens Biglycan Proteins 0.000 claims 4
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 4
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 4
- 101000901150 Homo sapiens Collagen alpha-1(IV) chain Proteins 0.000 claims 4
- 101001081590 Homo sapiens DNA-binding protein inhibitor ID-1 Proteins 0.000 claims 4
- 101001027128 Homo sapiens Fibronectin Proteins 0.000 claims 4
- 101001065276 Homo sapiens Fibulin-1 Proteins 0.000 claims 4
- 101000997961 Homo sapiens GDNF family receptor alpha-1 Proteins 0.000 claims 4
- 101000958390 Homo sapiens Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA Proteins 0.000 claims 4
- 101000970023 Homo sapiens NUAK family SNF1-like kinase 1 Proteins 0.000 claims 4
- 101000603202 Homo sapiens Nicotinamide N-methyltransferase Proteins 0.000 claims 4
- 101000652382 Homo sapiens O-phosphoseryl-tRNA(Sec) selenium transferase Proteins 0.000 claims 4
- 101000620348 Homo sapiens Plasmalemma vesicle-associated protein Proteins 0.000 claims 4
- 101001116302 Homo sapiens Platelet endothelial cell adhesion molecule Proteins 0.000 claims 4
- 101000612134 Homo sapiens Procollagen C-endopeptidase enhancer 1 Proteins 0.000 claims 4
- 101001057166 Homo sapiens Protein EVI2A Proteins 0.000 claims 4
- 101000620365 Homo sapiens Protein TMEPAI Proteins 0.000 claims 4
- 101001110313 Homo sapiens Ras-related C3 botulinum toxin substrate 2 Proteins 0.000 claims 4
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 4
- 101000665882 Homo sapiens Retinol-binding protein 4 Proteins 0.000 claims 4
- 101000689199 Homo sapiens Src-like-adapter Proteins 0.000 claims 4
- 101000577877 Homo sapiens Stromelysin-3 Proteins 0.000 claims 4
- 102100038245 Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA Human genes 0.000 claims 4
- 102100021732 NUAK family SNF1-like kinase 1 Human genes 0.000 claims 4
- 102100038951 Nicotinamide N-methyltransferase Human genes 0.000 claims 4
- 102100022427 Plasmalemma vesicle-associated protein Human genes 0.000 claims 4
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 4
- 102100041026 Procollagen C-endopeptidase enhancer 1 Human genes 0.000 claims 4
- 102100027246 Protein EVI2A Human genes 0.000 claims 4
- 102100022429 Protein TMEPAI Human genes 0.000 claims 4
- 102100022129 Ras-related C3 botulinum toxin substrate 2 Human genes 0.000 claims 4
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 4
- 102100038246 Retinol-binding protein 4 Human genes 0.000 claims 4
- 102100024519 Src-like-adapter Human genes 0.000 claims 4
- 102100028847 Stromelysin-3 Human genes 0.000 claims 4
- 102000006280 Twist-Related Protein 1 Human genes 0.000 claims 4
- 108010083162 Twist-Related Protein 1 Proteins 0.000 claims 4
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 4
- 206010047741 Vulval cancer Diseases 0.000 claims 4
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 4
- 201000010881 cervical cancer Diseases 0.000 claims 4
- 208000005017 glioblastoma Diseases 0.000 claims 4
- 230000002519 immonomodulatory effect Effects 0.000 claims 4
- 239000002955 immunomodulating agent Substances 0.000 claims 4
- 229960004768 irinotecan Drugs 0.000 claims 4
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 4
- NJHLGKJQFKUSEA-UHFFFAOYSA-N n-[2-(4-hydroxyphenyl)ethyl]-n-methylnitrous amide Chemical compound O=NN(C)CCC1=CC=C(O)C=C1 NJHLGKJQFKUSEA-UHFFFAOYSA-N 0.000 claims 4
- 201000002628 peritoneum cancer Diseases 0.000 claims 4
- 230000000750 progressive effect Effects 0.000 claims 4
- 229960000303 topotecan Drugs 0.000 claims 4
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 4
- 206010046885 vaginal cancer Diseases 0.000 claims 4
- 208000013139 vaginal neoplasm Diseases 0.000 claims 4
- 201000005102 vulva cancer Diseases 0.000 claims 4
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 3
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 3
- 101001037256 Homo sapiens Indoleamine 2,3-dioxygenase 1 Proteins 0.000 claims 3
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 3
- 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 claims 3
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 3
- 229960000397 bevacizumab Drugs 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 229960004117 capecitabine Drugs 0.000 claims 3
- 229960004562 carboplatin Drugs 0.000 claims 3
- 190000008236 carboplatin Chemical compound 0.000 claims 3
- 230000002584 immunomodulator Effects 0.000 claims 3
- 229940121354 immunomodulator Drugs 0.000 claims 3
- 238000002483 medication Methods 0.000 claims 3
- 229960001756 oxaliplatin Drugs 0.000 claims 3
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 3
- 239000013610 patient sample Substances 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 230000008685 targeting Effects 0.000 claims 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 2
- 108010047761 Interferon-alpha Proteins 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 2
- 229960004316 cisplatin Drugs 0.000 claims 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 2
- 229960003668 docetaxel Drugs 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- 229960005277 gemcitabine Drugs 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 229940046159 pegylated liposomal doxorubicin Drugs 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 229960004964 temozolomide Drugs 0.000 claims 2
- NECZZOFFLFZNHL-XVGZVFJZSA-N (2s)-2-amino-5-[[(2r)-3-[2-[bis[bis(2-chloroethyl)amino]-oxidophosphaniumyl]oxyethylsulfonyl]-1-[[(r)-carboxy(phenyl)methyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;hydron;chloride Chemical compound Cl.ClCCN(CCCl)P(=O)(N(CCCl)CCCl)OCCS(=O)(=O)C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)N[C@@H](C(O)=O)C1=CC=CC=C1 NECZZOFFLFZNHL-XVGZVFJZSA-N 0.000 claims 1
- 108010058566 130-nm albumin-bound paclitaxel Proteins 0.000 claims 1
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 229940124638 COX inhibitor Drugs 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 206010070907 Ovarian cancer stage III Diseases 0.000 claims 1
- 206010070908 Ovarian cancer stage IV Diseases 0.000 claims 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 1
- 229940078123 Ras inhibitor Drugs 0.000 claims 1
- 108700011582 TER 286 Proteins 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 230000003388 anti-hormonal effect Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229950000772 canfosfamide Drugs 0.000 claims 1
- 229940045200 cardioprotective agent Drugs 0.000 claims 1
- 239000012659 cardioprotective agent Substances 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims 1
- 235000008191 folinic acid Nutrition 0.000 claims 1
- 239000011672 folinic acid Substances 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 230000002631 hypothermal effect Effects 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 229960001691 leucovorin Drugs 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 239000000559 sulfotransferase inhibitor Substances 0.000 claims 1
- 238000002626 targeted therapy Methods 0.000 claims 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462096355P | 2014-12-23 | 2014-12-23 | |
| US62/096,355 | 2014-12-23 | ||
| US201562200340P | 2015-08-03 | 2015-08-03 | |
| US62/200,340 | 2015-08-03 | ||
| PCT/US2015/067427 WO2016106340A2 (en) | 2014-12-23 | 2015-12-22 | Compositions and methods for treating and diagnosing chemotherapy-resistant cancers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018508183A JP2018508183A (ja) | 2018-03-29 |
| JP2018508183A5 true JP2018508183A5 (OSRAM) | 2019-02-07 |
Family
ID=55275162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017534208A Pending JP2018508183A (ja) | 2014-12-23 | 2015-12-22 | 化学療法耐性癌を治療及び診断する組成物及び方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20170253933A1 (OSRAM) |
| EP (1) | EP3237639A2 (OSRAM) |
| JP (1) | JP2018508183A (OSRAM) |
| KR (1) | KR20170094165A (OSRAM) |
| CN (1) | CN107109491A (OSRAM) |
| AU (1) | AU2015369624A1 (OSRAM) |
| BR (1) | BR112017010788A2 (OSRAM) |
| CA (1) | CA2968359A1 (OSRAM) |
| HK (1) | HK1243141A1 (OSRAM) |
| IL (1) | IL252361A0 (OSRAM) |
| MX (1) | MX2017006864A (OSRAM) |
| RU (1) | RU2710735C2 (OSRAM) |
| SG (1) | SG11201704707PA (OSRAM) |
| WO (1) | WO2016106340A2 (OSRAM) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3548035A4 (en) | 2016-11-30 | 2020-07-22 | Case Western Reserve University | COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES |
| CN110573154A (zh) | 2017-02-06 | 2019-12-13 | 卡斯西部储备大学 | 调节短链脱氢酶活性的组合物和方法 |
| EP3714069A1 (en) * | 2017-11-20 | 2020-09-30 | Tolremo Therapeutics AG | Diagnostic method |
| WO2019103456A2 (ko) * | 2017-11-22 | 2019-05-31 | 울산대학교 산학협력단 | Pmvk를 유효성분으로 포함하는 방사선 저항성 암 진단용 또는 방사선 치료 예후 예측용 바이오마커 조성물 |
| KR102141997B1 (ko) | 2017-11-22 | 2020-08-06 | (주)인핸스드바이오 | Pmvk를 유효성분으로 포함하는 방사선 저항성 암 진단용 또는 방사선 치료 예후 예측용 바이오마커 조성물 |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法 |
| CN118325839A (zh) * | 2018-03-27 | 2024-07-12 | 宾夕法尼亚大学董事会 | 具有增强功能的修饰的免疫细胞及其筛选方法 |
| CN112739716B (zh) | 2018-05-07 | 2025-05-27 | 展马博联合股份有限公司 | 使用抗pd-1抗体与抗组织因子抗体-药物偶联物的组合治疗癌症的方法 |
| JP2021529784A (ja) * | 2018-06-27 | 2021-11-04 | メドパクト，インコーポレーテッド | 高レベルのＴＧＦ−β応答シグネチャーを発現しているがん患者を診断及び処置する方法 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| TWI844571B (zh) * | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
| US12325879B2 (en) | 2018-10-31 | 2025-06-10 | Regents Of The University Of Minnesota | Methods for predicting a response to bevacizumab or platinum-based chemotherapy or both in patients with ovarian cancer |
| EA202191422A1 (ru) | 2018-11-21 | 2021-10-21 | Кейс Вестерн Ризерв Юниверсити | Композиции и способы модулирования активности короткоцепочечной дегидрогеназы |
| WO2020140927A1 (en) * | 2019-01-02 | 2020-07-09 | Crownmab Biotech Inc. | Cancer treatment using multi-targeted kinase inhibitor in combination of protein kinase biomarkers |
| CN110563830B (zh) * | 2019-09-16 | 2021-01-29 | 中南大学湘雅医院 | Anxa1衍生多肽及其应用 |
| TW202128174A (zh) * | 2019-10-09 | 2021-08-01 | 美商G1治療公司 | 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療 |
| CN110950960B (zh) * | 2019-11-26 | 2021-05-14 | 中国农业大学 | 基于高通量测序和杂合杂交瘤技术的小分子化合物抗体的制备方法 |
| JP2023520286A (ja) * | 2020-02-20 | 2023-05-17 | ヴェルシテック リミテッド | Ｐｄ１ベースワクチン接種組成物およびその方法 |
| CN111440871A (zh) * | 2020-04-26 | 2020-07-24 | 至本医疗科技（上海）有限公司 | 基因标记物在肺癌预后判断中的应用 |
| RU2738167C1 (ru) * | 2020-06-08 | 2020-12-09 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии" Министерства здравоохранения Российской Федерации | Способ определения эффективности химиотерапии препаратами платины при раке яичников III-IV стадии |
| WO2022187092A1 (en) * | 2021-03-01 | 2022-09-09 | Genentech, Inc. | Diagnostic methods and methods of treatment of ovarian cancer |
| CN114230655B (zh) * | 2021-03-24 | 2025-02-25 | 深圳市新靶向生物科技有限公司 | 一种与食道癌驱动基因突变相关的抗原肽组合及其应用 |
| CN113174439B (zh) * | 2021-03-30 | 2022-06-28 | 中国医学科学院肿瘤医院 | 一种基于免疫基因对评分体系在预测非小细胞肺癌患者免疫治疗效果中的应用 |
| KR20230001587A (ko) * | 2021-06-28 | 2023-01-05 | 연세대학교 산학협력단 | 암의 예방 또는 치료용 약학 조성물 |
| CN113876753A (zh) * | 2021-10-20 | 2022-01-04 | 复旦大学附属中山医院 | 重组人半乳糖凝集素1抑制剂的制药用途 |
| KR102842785B1 (ko) * | 2022-09-07 | 2025-08-07 | 재단법인 아산사회복지재단 | 선행화학요법 내성의 고형암 환자 진단용 바이오마커 및 이를 이용한 선행화학요법 내성 진단을 위한 정보제공방법 |
| CN117248022A (zh) * | 2023-10-24 | 2023-12-19 | 郑州大学第一附属医院 | 双硫死亡相关基因及风险模型预测肾上腺皮质癌预后及治疗中的应用 |
| CN119224306A (zh) * | 2024-09-26 | 2024-12-31 | 上海交通大学医学院附属仁济医院 | Gprc5a的新用途 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| WO1991003489A1 (en) | 1989-09-08 | 1991-03-21 | The Johns Hopkins University | Structural alterations of the egf receptor gene in human gliomas |
| US20030206899A1 (en) | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| US6582959B2 (en) | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| EP0646178A1 (en) | 1992-06-04 | 1995-04-05 | The Regents Of The University Of California | expression cassette with regularoty regions functional in the mammmlian host |
| ATE348110T1 (de) | 1992-10-28 | 2007-01-15 | Genentech Inc | Hvegf rezeptor als vegf antagonist |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| ES2166368T3 (es) | 1993-12-24 | 2002-04-16 | Merck Patent Gmbh | Inmunoconjugados. |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| US5679683A (en) | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US5635388A (en) | 1994-04-04 | 1997-06-03 | Genentech, Inc. | Agonist antibodies against the flk2/flt3 receptor and uses thereof |
| MX9700535A (es) | 1994-07-21 | 1997-04-30 | Akzo Nobel Nv | Formulaciones de peroxido de cetona ciclico. |
| US5910486A (en) | 1994-09-06 | 1999-06-08 | Uab Research Foundation | Methods for modulating protein function in cells using, intracellular antibody homologues |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| ATE205483T1 (de) | 1995-03-30 | 2001-09-15 | Pfizer | Chinazolinderivate |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| EP0831880A4 (en) | 1995-06-07 | 2004-12-01 | Imclone Systems Inc | ANTIBODIES AND FRAGMENTS OF ANTIBODIES INHIBITING TUMOR GROWTH |
| JP4146514B2 (ja) | 1995-07-06 | 2008-09-10 | ノバルティス アクチエンゲゼルシャフト | ピロロピリミジン類およびその製造方法 |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| ES2174250T5 (es) | 1996-04-12 | 2010-04-21 | Warner-Lambert Company Llc | Inhibidores irreversibles de tirosina quinasas. |
| EP0912559B1 (en) | 1996-07-13 | 2002-11-06 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| WO1998045331A2 (en) | 1997-04-07 | 1998-10-15 | Genentech, Inc. | Anti-vegf antibodies |
| US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
| SI1695985T1 (sl) | 1997-04-07 | 2011-06-30 | Genentech Inc | Postopki za tvorbo humaniziranih protiteles z naključno mutagenezo |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| EP0980244B1 (en) | 1997-05-06 | 2003-06-04 | Wyeth Holdings Corporation | Use of quinazoline compounds for the treatment of polycystic kidney disease |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| CA2306155A1 (en) | 1997-11-06 | 1999-05-20 | Philip Frost | Use of quinazoline derivatives as tyrosine kinase inhibitors for treating colonic polyps |
| ATE229008T1 (de) | 1998-11-19 | 2002-12-15 | Warner Lambert Co | N- 4-(3-chloro-4-fluoro-phenylamino)-7-(3- morfolin-4-yl-propoxy)-chinazolin-6-yl -akrylamid,ein irreversibler tyrosin-kinasen hemmer |
| US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| WO2003086467A1 (en) | 2002-04-08 | 2003-10-23 | Smithkline Beecham Corporation | Cancer treatment method comprising administering an erb-family inhibitor and a raf and/or ras inhibitor |
| RS20050885A (sr) | 2003-05-30 | 2008-04-04 | Genentech | Lečenje sa anti-vegf antitelima |
| US20050106667A1 (en) | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
| US20060009360A1 (en) | 2004-06-25 | 2006-01-12 | Robert Pifer | New adjuvant composition |
| US20110178154A1 (en) * | 2007-02-06 | 2011-07-21 | Birrer Michael J | gene expression profile that predicts ovarian cancer subject response to chemotherapy |
| WO2009074968A2 (en) * | 2007-12-12 | 2009-06-18 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method for predicting the efficacy of cancer therapy |
| WO2011153345A2 (en) * | 2010-06-03 | 2011-12-08 | Beth Israel Deaconess Medical Center, Inc. | A gene expression profile of brca-ness that correlates with responsiveness to chemotherapy and with outcome in cancer patients |
| WO2012083132A2 (en) | 2010-12-16 | 2012-06-21 | Genentech, Inc. | Diagnosis and treatments relating to th2 inhibition |
| KR20140142719A (ko) * | 2012-03-30 | 2014-12-12 | 제넨테크, 인크. | 암의 치료를 위한 진단 방법 및 조성물 |
| WO2013180274A1 (ja) * | 2012-06-01 | 2013-12-05 | 大鵬薬品工業株式会社 | 胃癌患者に対する化学療法の選択方法 |
| AU2013331154B2 (en) * | 2012-10-17 | 2018-02-01 | Cedars-Sinai Medical Center | Molecular signatures of ovarian cancer |
| AU2013353839A1 (en) * | 2012-12-03 | 2015-06-18 | Almac Diagnostics Limited | Molecular diagnostic test for cancer |
-
2015
- 2015-12-22 EP EP15831106.8A patent/EP3237639A2/en not_active Withdrawn
- 2015-12-22 SG SG11201704707PA patent/SG11201704707PA/en unknown
- 2015-12-22 RU RU2017125054A patent/RU2710735C2/ru active
- 2015-12-22 JP JP2017534208A patent/JP2018508183A/ja active Pending
- 2015-12-22 CN CN201580070095.7A patent/CN107109491A/zh active Pending
- 2015-12-22 BR BR112017010788A patent/BR112017010788A2/pt not_active Application Discontinuation
- 2015-12-22 MX MX2017006864A patent/MX2017006864A/es unknown
- 2015-12-22 AU AU2015369624A patent/AU2015369624A1/en not_active Abandoned
- 2015-12-22 CA CA2968359A patent/CA2968359A1/en not_active Abandoned
- 2015-12-22 HK HK18102602.6A patent/HK1243141A1/zh unknown
- 2015-12-22 KR KR1020177014690A patent/KR20170094165A/ko not_active Withdrawn
- 2015-12-22 WO PCT/US2015/067427 patent/WO2016106340A2/en not_active Ceased
-
2017
- 2017-05-17 US US15/597,789 patent/US20170253933A1/en not_active Abandoned
- 2017-05-18 IL IL252361A patent/IL252361A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018508183A5 (OSRAM) | ||
| RU2017125054A (ru) | Композиции и способы лечения и диагностики резистентного к химиотерапии рака | |
| Singh et al. | TNBC: potential targeting of multiple receptors for a therapeutic breakthrough, nanomedicine, and immunotherapy | |
| Miyauchi et al. | Immune modulation of head and neck squamous cell carcinoma and the tumor microenvironment by conventional therapeutics | |
| Huyghe et al. | Immunotherapy with immune checkpoint inhibitors in colorectal cancer: what is the future beyond deficient mismatch-repair tumours? | |
| Røsland et al. | Novel points of attack for targeted cancer therapy | |
| Farley et al. | Phase II study of cisplatin plus cetuximab in advanced, recurrent, and previously treated cancers of the cervix and evaluation of epidermal growth factor receptor immunohistochemical expression: a Gynecologic Oncology Group study | |
| Liu et al. | The BRAF and MEK inhibitors dabrafenib and trametinib: effects on immune function and in combination with immunomodulatory antibodies targeting PD-1, PD-L1, and CTLA-4 | |
| Santin et al. | Phase II trial of cetuximab in the treatment of persistent or recurrent squamous or non-squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study | |
| Ferté et al. | IGF-1R targeting increases the antitumor effects of DNA-damaging agents in SCLC model: an opportunity to increase the efficacy of standard therapy | |
| JP2018508469A5 (OSRAM) | ||
| Kim et al. | Preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with locally advanced resectable rectal cancer: a multicenter Phase II study | |
| Cornista et al. | Colorectal cancer immunotherapy: state of the art and future directions | |
| Kim et al. | Geographic differences in approach to advanced gastric cancer: Is there a standard approach? | |
| RU2016141385A (ru) | Лечение рака антагонистами с-мет и их корреляция с экспрессией hgf | |
| Petrillo et al. | Biomarkers for precision treatment in gastric cancer | |
| Ishii et al. | Dawn of precision medicine on gastric cancer | |
| Duenas-Gonzalez et al. | Emerging drugs for cervical cancer | |
| Zhang et al. | Management of castrate resistant prostate cancer—recent advances and optimal sequence of treatments | |
| JP2017535548A5 (OSRAM) | ||
| Alsaafeen et al. | Combinational therapeutic strategies to overcome resistance to immune checkpoint inhibitors | |
| Yao et al. | It’s high-time to re-evaluate the value of induced-chemotherapy for reinforcing immunotherapy in colorectal cancer | |
| RU2017120388A (ru) | Прогнозирование ответа на антагонист vegf | |
| Qi et al. | The co-inhibitory immune checkpoint proteins B7-H1 (PD-L1) and B7-H4 in high grade glioma: from bench to bedside | |
| Gui et al. | Tislelizumab plus nab-paclitaxel and cisplatin as induction immunochemotherapy for organ preservation of locally advanced hypopharyngeal squamous cell carcinoma: a single-arm phase II trial |