JP2018506284A5 - - Google Patents
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- Publication number
- JP2018506284A5 JP2018506284A5 JP2017542477A JP2017542477A JP2018506284A5 JP 2018506284 A5 JP2018506284 A5 JP 2018506284A5 JP 2017542477 A JP2017542477 A JP 2017542477A JP 2017542477 A JP2017542477 A JP 2017542477A JP 2018506284 A5 JP2018506284 A5 JP 2018506284A5
- Authority
- JP
- Japan
- Prior art keywords
- aptamer conjugate
- aptamer
- conjugate according
- epcam
- brain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108091023037 Aptamer Proteins 0.000 claims 23
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 7
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 7
- 208000003174 Brain Neoplasms Diseases 0.000 claims 6
- 102000007238 Transferrin Receptors Human genes 0.000 claims 5
- 108010033576 Transferrin Receptors Proteins 0.000 claims 5
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 4
- 206010027476 Metastases Diseases 0.000 claims 3
- 101000946068 Caenorhabditis elegans Ceramide glucosyltransferase 3 Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000001588 bifunctional effect Effects 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000001093 anti-cancer Effects 0.000 claims 1
- 230000008499 blood brain barrier function Effects 0.000 claims 1
- 210000001218 blood-brain barrier Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015900437 | 2015-02-11 | ||
| AU2015900437A AU2015900437A0 (en) | 2015-02-11 | Aptamer conjugate | |
| PCT/AU2016/050085 WO2016127216A1 (en) | 2015-02-11 | 2016-02-11 | Epcam aptamers and conjugates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018506284A JP2018506284A (ja) | 2018-03-08 |
| JP2018506284A5 true JP2018506284A5 (enExample) | 2019-03-28 |
| JP6978317B2 JP6978317B2 (ja) | 2021-12-08 |
Family
ID=56613973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017542477A Active JP6978317B2 (ja) | 2015-02-11 | 2016-02-11 | ＥｐＣＡＭアプタマー及びそのコンジュゲート |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10577610B2 (enExample) |
| EP (1) | EP3256593B1 (enExample) |
| JP (1) | JP6978317B2 (enExample) |
| AU (1) | AU2016218945B2 (enExample) |
| CA (1) | CA2975190C (enExample) |
| ES (1) | ES2796504T3 (enExample) |
| WO (1) | WO2016127216A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120591279A (zh) * | 2014-08-29 | 2025-09-05 | 儿童医疗中心有限公司 | 用于治疗癌症的方法和组合物 |
| EP3206719B1 (en) | 2014-10-15 | 2020-04-08 | City of Hope | Rna aptamers against transferrin receptor (tfr) |
| WO2017143150A1 (en) * | 2016-02-19 | 2017-08-24 | City Of Hope | Bi-specific aptamer |
| US11332747B2 (en) * | 2017-02-24 | 2022-05-17 | Augusta University Research Institute, Inc. | Bispecific aptamer for treating cancer |
| CN118931907A (zh) * | 2017-08-11 | 2024-11-12 | 希望之城 | 转铁蛋白受体(TfR)的RNA适体 |
| EP3827083A2 (en) * | 2018-07-26 | 2021-06-02 | aratinga. bio TNP | Aptamer-based car t-cell switch |
| JP7642236B2 (ja) * | 2018-07-26 | 2025-03-10 | イグザカ フランス | アプタマーベースのｃａｒ ｔ－細胞スイッチ |
| KR102294694B1 (ko) * | 2019-07-18 | 2021-08-30 | 국립암센터 | 신규한 dna 앱타머 및 이의 용도 |
| CN110592093B (zh) * | 2019-09-10 | 2023-08-25 | 上海交通大学医学院附属仁济医院 | 一种能够识别EpCAM蛋白的核酸适体及其制备方法与应用 |
| CN112843261B (zh) * | 2021-03-10 | 2022-11-01 | 中国人民解放军空军军医大学 | 靶向EpCAM的放射性配合物及其制备方法 |
| JP7359457B2 (ja) * | 2021-10-11 | 2023-10-11 | タグシクス・バイオ株式会社 | 自己免疫性疾患治療薬 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070178451A1 (en) * | 2001-08-02 | 2007-08-02 | Molian Deng | Nucleic acid sequences from Chlorella sarokiniana and uses thereof |
| CA2579374A1 (en) | 2004-09-07 | 2006-03-30 | Archemix Corp. | Aptamers to von willebrand factor and their use as thrombotic disease therapeutics |
| US20110052697A1 (en) | 2006-05-17 | 2011-03-03 | Gwangju Institute Of Science & Technology | Aptamer-Directed Drug Delivery |
| EP2159286A1 (en) | 2008-09-01 | 2010-03-03 | Consiglio Nazionale Delle Ricerche | Method for obtaining oligonucleotide aptamers and uses thereof |
| WO2013003898A1 (en) | 2011-07-07 | 2013-01-10 | Clinical Genomics Pty. Ltd | Method for detection of cancer in a patient |
| WO2013163303A2 (en) * | 2012-04-25 | 2013-10-31 | Albert Einstein College Of Medicine Of Yeshiva University | Transferrin receptor aptamers and aptamer-targeted delivery |
| SG11201500666TA (en) | 2012-08-02 | 2015-02-27 | Univ Deakin | Cd133 aptamers for detection of cancer stem cells |
| EP2880163B1 (en) * | 2012-08-02 | 2018-11-21 | Deakin University | Epcam aptamer for detection of cancer stem cells |
| CN103387989B (zh) | 2012-09-24 | 2016-05-18 | 厦门大学 | 上皮细胞粘附分子的核酸适体EpCAM D及其制备方法 |
| EP2912182B1 (en) * | 2012-10-23 | 2021-12-08 | Caris Science, Inc. | Aptamers and uses thereof |
| WO2014197455A1 (en) | 2013-06-03 | 2014-12-11 | University Of Florida Research Foundation, Incorporated | Devices and methods for isolating cells |
-
2016
- 2016-02-11 JP JP2017542477A patent/JP6978317B2/ja active Active
- 2016-02-11 ES ES16748486T patent/ES2796504T3/es active Active
- 2016-02-11 AU AU2016218945A patent/AU2016218945B2/en active Active
- 2016-02-11 US US15/550,671 patent/US10577610B2/en active Active
- 2016-02-11 WO PCT/AU2016/050085 patent/WO2016127216A1/en not_active Ceased
- 2016-02-11 CA CA2975190A patent/CA2975190C/en active Active
- 2016-02-11 EP EP16748486.4A patent/EP3256593B1/en active Active
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