JP6978317B2 - ＥｐＣＡＭアプタマー及びそのコンジュゲート - Google Patents

ＥｐＣＡＭアプタマー及びそのコンジュゲート Download PDF

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JP6978317B2
JP6978317B2 JP2017542477A JP2017542477A JP6978317B2 JP 6978317 B2 JP6978317 B2 JP 6978317B2 JP 2017542477 A JP2017542477 A JP 2017542477A JP 2017542477 A JP2017542477 A JP 2017542477A JP 6978317 B2 JP6978317 B2 JP 6978317B2
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aptamer
cells
epcam
aptamers
brain
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JP2018506284A (ja
JP2018506284A5 (enExample
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シグダー サラ
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ディーキン・ユニバーシティー
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/51—Physical structure in polymeric form, e.g. multimers, concatemers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2017542477A 2015-02-11 2016-02-11 ＥｐＣＡＭアプタマー及びそのコンジュゲート Active JP6978317B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015900437 2015-02-11
AU2015900437A AU2015900437A0 (en) 2015-02-11 Aptamer conjugate
PCT/AU2016/050085 WO2016127216A1 (en) 2015-02-11 2016-02-11 Epcam aptamers and conjugates thereof

Publications (3)

Publication Number Publication Date
JP2018506284A JP2018506284A (ja) 2018-03-08
JP2018506284A5 JP2018506284A5 (enExample) 2019-03-28
JP6978317B2 true JP6978317B2 (ja) 2021-12-08

Family

ID=56613973

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017542477A Active JP6978317B2 (ja) 2015-02-11 2016-02-11 ＥｐＣＡＭアプタマー及びそのコンジュゲート

Country Status (7)

Country Link
US (1) US10577610B2 (enExample)
EP (1) EP3256593B1 (enExample)
JP (1) JP6978317B2 (enExample)
AU (1) AU2016218945B2 (enExample)
CA (1) CA2975190C (enExample)
ES (1) ES2796504T3 (enExample)
WO (1) WO2016127216A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120591279A (zh) * 2014-08-29 2025-09-05 儿童医疗中心有限公司 用于治疗癌症的方法和组合物
EP3206719B1 (en) 2014-10-15 2020-04-08 City of Hope Rna aptamers against transferrin receptor (tfr)
WO2017143150A1 (en) * 2016-02-19 2017-08-24 City Of Hope Bi-specific aptamer
US11332747B2 (en) * 2017-02-24 2022-05-17 Augusta University Research Institute, Inc. Bispecific aptamer for treating cancer
CN118931907A (zh) * 2017-08-11 2024-11-12 希望之城 转铁蛋白受体(TfR)的RNA适体
EP3827083A2 (en) * 2018-07-26 2021-06-02 aratinga. bio TNP Aptamer-based car t-cell switch
JP7642236B2 (ja) * 2018-07-26 2025-03-10 イグザカ フランス アプタマーベースのｃａｒ ｔ－細胞スイッチ
KR102294694B1 (ko) * 2019-07-18 2021-08-30 국립암센터 신규한 dna 앱타머 및 이의 용도
CN110592093B (zh) * 2019-09-10 2023-08-25 上海交通大学医学院附属仁济医院 一种能够识别EpCAM蛋白的核酸适体及其制备方法与应用
CN112843261B (zh) * 2021-03-10 2022-11-01 中国人民解放军空军军医大学 靶向EpCAM的放射性配合物及其制备方法
JP7359457B2 (ja) * 2021-10-11 2023-10-11 タグシクス・バイオ株式会社 自己免疫性疾患治療薬

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070178451A1 (en) * 2001-08-02 2007-08-02 Molian Deng Nucleic acid sequences from Chlorella sarokiniana and uses thereof
CA2579374A1 (en) 2004-09-07 2006-03-30 Archemix Corp. Aptamers to von willebrand factor and their use as thrombotic disease therapeutics
US20110052697A1 (en) 2006-05-17 2011-03-03 Gwangju Institute Of Science & Technology Aptamer-Directed Drug Delivery
EP2159286A1 (en) 2008-09-01 2010-03-03 Consiglio Nazionale Delle Ricerche Method for obtaining oligonucleotide aptamers and uses thereof
WO2013003898A1 (en) 2011-07-07 2013-01-10 Clinical Genomics Pty. Ltd Method for detection of cancer in a patient
WO2013163303A2 (en) * 2012-04-25 2013-10-31 Albert Einstein College Of Medicine Of Yeshiva University Transferrin receptor aptamers and aptamer-targeted delivery
SG11201500666TA (en) 2012-08-02 2015-02-27 Univ Deakin Cd133 aptamers for detection of cancer stem cells
EP2880163B1 (en) * 2012-08-02 2018-11-21 Deakin University Epcam aptamer for detection of cancer stem cells
CN103387989B (zh) 2012-09-24 2016-05-18 厦门大学 上皮细胞粘附分子的核酸适体EpCAM D及其制备方法
EP2912182B1 (en) * 2012-10-23 2021-12-08 Caris Science, Inc. Aptamers and uses thereof
WO2014197455A1 (en) 2013-06-03 2014-12-11 University Of Florida Research Foundation, Incorporated Devices and methods for isolating cells

Also Published As

Publication number Publication date
EP3256593B1 (en) 2020-03-25
AU2016218945A1 (en) 2017-08-03
EP3256593A1 (en) 2017-12-20
ES2796504T3 (es) 2020-11-27
CA2975190A1 (en) 2016-08-18
JP2018506284A (ja) 2018-03-08
CA2975190C (en) 2023-06-06
US10577610B2 (en) 2020-03-03
AU2016218945B2 (en) 2021-08-26
EP3256593A4 (en) 2018-12-05
US20180037892A1 (en) 2018-02-08
WO2016127216A1 (en) 2016-08-18

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