ES2796504T3 - Aptámeros de EpCAM y conjugados de los mismos - Google Patents

Aptámeros de EpCAM y conjugados de los mismos Download PDF

Info

Publication number
ES2796504T3
ES2796504T3 ES16748486T ES16748486T ES2796504T3 ES 2796504 T3 ES2796504 T3 ES 2796504T3 ES 16748486 T ES16748486 T ES 16748486T ES 16748486 T ES16748486 T ES 16748486T ES 2796504 T3 ES2796504 T3 ES 2796504T3
Authority
ES
Spain
Prior art keywords
aptamer
cells
aptamers
epcam
brain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES16748486T
Other languages
English (en)
Spanish (es)
Inventor
Sarah Shigdar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deakin University
Original Assignee
Deakin University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2015900437A external-priority patent/AU2015900437A0/en
Application filed by Deakin University filed Critical Deakin University
Application granted granted Critical
Publication of ES2796504T3 publication Critical patent/ES2796504T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/51—Physical structure in polymeric form, e.g. multimers, concatemers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES16748486T 2015-02-11 2016-02-11 Aptámeros de EpCAM y conjugados de los mismos Active ES2796504T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2015900437A AU2015900437A0 (en) 2015-02-11 Aptamer conjugate
PCT/AU2016/050085 WO2016127216A1 (en) 2015-02-11 2016-02-11 Epcam aptamers and conjugates thereof

Publications (1)

Publication Number Publication Date
ES2796504T3 true ES2796504T3 (es) 2020-11-27

Family

ID=56613973

Family Applications (1)

Application Number Title Priority Date Filing Date
ES16748486T Active ES2796504T3 (es) 2015-02-11 2016-02-11 Aptámeros de EpCAM y conjugados de los mismos

Country Status (7)

Country Link
US (1) US10577610B2 (enExample)
EP (1) EP3256593B1 (enExample)
JP (1) JP6978317B2 (enExample)
AU (1) AU2016218945B2 (enExample)
CA (1) CA2975190C (enExample)
ES (1) ES2796504T3 (enExample)
WO (1) WO2016127216A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2985036T3 (es) * 2014-08-29 2024-11-04 Childrens Medical Ct Corp Métodos y composiciones para el tratamiento del cáncer
CN107249644A (zh) 2014-10-15 2017-10-13 希望之城 针对转铁蛋白受体(TfR)的RNA适体
US11219635B2 (en) 2016-02-19 2022-01-11 City Of Hope Bi-specific aptamer
US11332747B2 (en) * 2017-02-24 2022-05-17 Augusta University Research Institute, Inc. Bispecific aptamer for treating cancer
US11427826B2 (en) 2017-08-11 2022-08-30 City of Hopw RNA aptamers against transferrin receptor (TfR)
AU2019309328B2 (en) * 2018-07-26 2026-02-19 Ixaka France SAS Aptamer-based CAR T-cell switch
EP3827083A2 (en) * 2018-07-26 2021-06-02 aratinga. bio TNP Aptamer-based car t-cell switch
CA3143996A1 (en) 2019-06-21 2020-12-24 The Children's Medical Center Corporation Methods and compositions for the treatment of cancer
KR102294694B1 (ko) * 2019-07-18 2021-08-30 국립암센터 신규한 dna 앱타머 및 이의 용도
CN110592093B (zh) * 2019-09-10 2023-08-25 上海交通大学医学院附属仁济医院 一种能够识别EpCAM蛋白的核酸适体及其制备方法与应用
CN112843261B (zh) * 2021-03-10 2022-11-01 中国人民解放军空军军医大学 靶向EpCAM的放射性配合物及其制备方法
JP7359457B2 (ja) * 2021-10-11 2023-10-11 タグシクス・バイオ株式会社 自己免疫性疾患治療薬

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070178451A1 (en) * 2001-08-02 2007-08-02 Molian Deng Nucleic acid sequences from Chlorella sarokiniana and uses thereof
JP2008512098A (ja) 2004-09-07 2008-04-24 アーケミックス コーポレイション フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用
WO2007137117A2 (en) 2006-05-17 2007-11-29 Massachusetts Institute Of Technology Aptamer-directed drug delivery
EP2159286A1 (en) 2008-09-01 2010-03-03 Consiglio Nazionale Delle Ricerche Method for obtaining oligonucleotide aptamers and uses thereof
WO2013003898A1 (en) 2011-07-07 2013-01-10 Clinical Genomics Pty. Ltd Method for detection of cancer in a patient
US9439973B2 (en) 2012-04-25 2016-09-13 Albert Einstein College Of Medicine, Inc. Transferrin receptor aptamers and aptamer-targeted delivery
CN104781417B (zh) 2012-08-02 2017-12-12 迪肯大学 用于检测癌症干细胞的cd133适配子
CA2880590C (en) * 2012-08-02 2020-10-06 Deakin University Epcam aptamer for detection of cancer stem cells
CN103387988B (zh) 2012-09-24 2016-01-06 厦门大学 上皮细胞粘附分子的核酸适体EpCAM Ccut及其制备方法
KR20150090072A (ko) 2012-10-23 2015-08-05 카리스 라이프 사이언스 스위스 홀딩스 게엠베하 압타머 및 이의 용도
WO2014197455A1 (en) * 2013-06-03 2014-12-11 University Of Florida Research Foundation, Incorporated Devices and methods for isolating cells

Also Published As

Publication number Publication date
AU2016218945A1 (en) 2017-08-03
JP6978317B2 (ja) 2021-12-08
EP3256593A4 (en) 2018-12-05
AU2016218945B2 (en) 2021-08-26
WO2016127216A1 (en) 2016-08-18
EP3256593A1 (en) 2017-12-20
CA2975190C (en) 2023-06-06
JP2018506284A (ja) 2018-03-08
EP3256593B1 (en) 2020-03-25
US20180037892A1 (en) 2018-02-08
US10577610B2 (en) 2020-03-03
CA2975190A1 (en) 2016-08-18

Similar Documents

Publication Publication Date Title
US10577610B2 (en) EpCAM aptamers and conjugates thereof
ES2741949T3 (es) Aptámeros CD133 para la detección de células madre cancerosas
CA2880590C (en) Epcam aptamer for detection of cancer stem cells
ES2851924T3 (es) Estructura artificial de aptámero
EP3901263A1 (en) Compositions and methods for inhibiting gene expression of hepatitis b virus
WO2015117206A1 (en) Improved aptamers
ES2373047T3 (es) Aptámeros estabilizados para factor de crecimiento derivado de plaquetas y su uso como agentes terapéuticos oncológicos.
HK1231933B (en) Aptamer construct