JP2018505674A5 - - Google Patents
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- JP2018505674A5 JP2018505674A5 JP2017540834A JP2017540834A JP2018505674A5 JP 2018505674 A5 JP2018505674 A5 JP 2018505674A5 JP 2017540834 A JP2017540834 A JP 2017540834A JP 2017540834 A JP2017540834 A JP 2017540834A JP 2018505674 A5 JP2018505674 A5 JP 2018505674A5
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- Prior art keywords
- lag
- binding agent
- cancer
- sequence
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 27
- 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 claims 27
- 239000011230 binding agent Substances 0.000 claims 25
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229940127121 immunoconjugate Drugs 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 2
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims 2
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 206010023825 Laryngeal cancer Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 206010023841 laryngeal neoplasm Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562111486P | 2015-02-03 | 2015-02-03 | |
| US62/111,486 | 2015-02-03 | ||
| PCT/US2016/016424 WO2016126858A2 (en) | 2015-02-03 | 2016-02-03 | Antibodies directed against lymphocyte activation gene 3 (lag-3) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018505674A JP2018505674A (ja) | 2018-03-01 |
| JP2018505674A5 true JP2018505674A5 (cg-RX-API-DMAC7.html) | 2019-03-14 |
| JP6949713B2 JP6949713B2 (ja) | 2021-10-13 |
Family
ID=56564868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540834A Active JP6949713B2 (ja) | 2015-02-03 | 2016-02-03 | 抗リンパ球活性化遺伝子３（ｌａｇ−３）抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10836824B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP4011914A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6949713B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102759268B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN114634573A (cg-RX-API-DMAC7.html) |
| BR (1) | BR112017016638B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2975753A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201791742A1 (cg-RX-API-DMAC7.html) |
| HK (2) | HK1246814A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL253718B (cg-RX-API-DMAC7.html) |
| MA (1) | MA41463A (cg-RX-API-DMAC7.html) |
| MX (2) | MX391124B (cg-RX-API-DMAC7.html) |
| SG (2) | SG10201907161YA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016126858A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201705303B (cg-RX-API-DMAC7.html) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| MA41463A (fr) | 2015-02-03 | 2017-12-12 | Anaptysbio Inc | Anticorps dirigés contre le gène d'activation 3 des lymphocytes (lag-3) |
| FI3277321T3 (fi) | 2015-04-01 | 2024-10-31 | Anaptysbio Inc | T-soluimmunoglobuliinia ja musiiniproteiini 3:a (tim-3) vastaan suunnattuja vasta-aineita |
| IL257110B (en) | 2015-10-02 | 2022-09-01 | Hoffmann La Roche | Bispecific antibodies specific against pd1 and tim3 |
| KR20180086502A (ko) | 2015-12-16 | 2018-07-31 | 머크 샤프 앤드 돔 코포레이션 | 항-lag3 항체 및 항원-결합 단편 |
| CN116903741A (zh) | 2016-06-20 | 2023-10-20 | 科马布有限公司 | 特异性结合于pd-l1的抗体或其抗原结合片段及其用途 |
| CN109689870B (zh) | 2016-09-08 | 2022-11-29 | 第一三共株式会社 | 用于治疗自身免疫疾病的抗体 |
| WO2018071500A1 (en) | 2016-10-11 | 2018-04-19 | Agenus Inc. | Anti-lag-3 antibodies and methods of use thereof |
| EP3526255A2 (en) | 2016-10-13 | 2019-08-21 | Symphogen A/S | Anti-lag-3 antibodies and compositions |
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| BR112019008861A2 (pt) | 2016-11-01 | 2019-07-09 | Tesaro, Inc. | anticorpos direcionados contra imunoglobulina de células t e proteína de mucina 3 (tim-3) |
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2016
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- 2016-02-03 KR KR1020177024728A patent/KR102759268B1/ko active Active
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- 2016-02-03 WO PCT/US2016/016424 patent/WO2016126858A2/en not_active Ceased
- 2016-02-03 EP EP16747220.8A patent/EP3253798A4/en not_active Ceased
- 2016-02-03 JP JP2017540834A patent/JP6949713B2/ja active Active
- 2016-02-03 US US15/548,405 patent/US10836824B2/en active Active
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2017
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2019
- 2019-05-01 US US16/400,198 patent/US20190256596A1/en not_active Abandoned
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2020
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