JP2019511212A5 - - Google Patents
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- JP2019511212A5 JP2019511212A5 JP2018544355A JP2018544355A JP2019511212A5 JP 2019511212 A5 JP2019511212 A5 JP 2019511212A5 JP 2018544355 A JP2018544355 A JP 2018544355A JP 2018544355 A JP2018544355 A JP 2018544355A JP 2019511212 A5 JP2019511212 A5 JP 2019511212A5
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- Prior art keywords
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- pharmaceutical composition
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- cancer
- monoclonal antibody
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- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 6
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 6
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 4
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 4
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 108010048507 poliovirus receptor Proteins 0.000 claims 4
- 102100029740 Poliovirus receptor Human genes 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 2
- 102000002698 KIR Receptors Human genes 0.000 claims 2
- 108010043610 KIR Receptors Proteins 0.000 claims 2
- 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 claims 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 102100038078 CD276 antigen Human genes 0.000 claims 1
- 101710185679 CD276 antigen Proteins 0.000 claims 1
- 108010062802 CD66 antigens Proteins 0.000 claims 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 101100463133 Caenorhabditis elegans pdl-1 gene Proteins 0.000 claims 1
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 101001102797 Homo sapiens Transmembrane protein PVRIG Proteins 0.000 claims 1
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 1
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 1
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 1
- 101150069255 KLRC1 gene Proteins 0.000 claims 1
- 101100404845 Macaca mulatta NKG2A gene Proteins 0.000 claims 1
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 claims 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 102100039630 Transmembrane protein PVRIG Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 108010079206 V-Set Domain-Containing T-Cell Activation Inhibitor 1 Proteins 0.000 claims 1
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 claims 1
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 229940126546 immune checkpoint molecule Drugs 0.000 claims 1
- 102000027596 immune receptors Human genes 0.000 claims 1
- 108091008915 immune receptors Proteins 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 229940127084 other anti-cancer agent Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662301727P | 2016-03-01 | 2016-03-01 | |
| US62/301,727 | 2016-03-01 | ||
| US201662364924P | 2016-07-21 | 2016-07-21 | |
| US62/364,924 | 2016-07-21 | ||
| PCT/IL2017/050256 WO2017149538A1 (en) | 2016-03-01 | 2017-02-28 | Antibodies specific to human poliovirus receptor (pvr) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019511212A JP2019511212A (ja) | 2019-04-25 |
| JP2019511212A5 true JP2019511212A5 (cg-RX-API-DMAC7.html) | 2020-04-09 |
| JP6966176B2 JP6966176B2 (ja) | 2021-11-10 |
Family
ID=58410405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544355A Active JP6966176B2 (ja) | 2016-03-01 | 2017-02-28 | ヒトポリオウイルス受容体（ｐｖｒ）に特異的な抗体 |
Country Status (15)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11098130B1 (en) | 2015-08-03 | 2021-08-24 | Tasrif Pharmaceutical, LLC | Antibodies and antibody fragments against the CD155 receptor and methods of use thereof |
| CA3015619A1 (en) | 2016-03-01 | 2017-09-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies specific to human poliovirus receptor (pvr) |
| WO2018229163A1 (en) * | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| WO2019102456A1 (en) | 2017-11-27 | 2019-05-31 | University Of Rijeka Faculty Of Medicine | Immunotoxins for treating cancer |
| JP2021522801A (ja) | 2018-05-09 | 2021-09-02 | イッサム リサーチ デベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド | ヒトネクチン４に特異的な抗体 |
| US11401339B2 (en) | 2018-08-23 | 2022-08-02 | Seagen Inc. | Anti-TIGIT antibodies |
| JP7407822B2 (ja) | 2018-08-30 | 2024-01-04 | エイチシーダブリュー バイオロジックス インコーポレイテッド | 単鎖キメラポリペプチドおよびその使用 |
| EP4659757A2 (en) | 2018-08-30 | 2025-12-10 | ImmunityBio, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| CN112888445B (zh) | 2018-08-30 | 2025-06-10 | 免疫生物公司 | 治疗老年化相关病症的方法 |
| KR20210117277A (ko) * | 2019-01-13 | 2021-09-28 | 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. | 인간 넥틴-2에 특이적인 항체 |
| WO2020257639A1 (en) | 2019-06-21 | 2020-12-24 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| CN114502595B (zh) | 2019-10-08 | 2025-05-23 | 奈克汀治疗有限公司 | 针对脊髓灰质炎病毒受体(pvr)的抗体及其用途 |
| KR102370915B1 (ko) | 2019-10-22 | 2022-03-08 | 단국대학교 천안캠퍼스 산학협력단 | 폴리오바이러스를 검출하기 위한 등온증폭 반응용 프라이머 세트 및 이의 용도 |
| JP2023519107A (ja) | 2020-02-11 | 2023-05-10 | エイチシーダブリュー バイオロジックス インコーポレイテッド | 制御性ｔ細胞を活性化する方法 |
| WO2021163369A2 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of treating age-related and inflammatory diseases |
| CN115362169A (zh) | 2020-02-11 | 2022-11-18 | Hcw生物科技公司 | 色谱树脂以及其用途 |
| JP7734693B2 (ja) | 2020-04-29 | 2025-09-05 | イミュニティーバイオ インコーポレイテッド | 抗ｃｄ２６タンパク質及びそれらの使用法 |
| JP2023527869A (ja) | 2020-06-01 | 2023-06-30 | エイチシーダブリュー バイオロジックス インコーポレイテッド | 加齢関連障害の治療法 |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| WO2021247003A1 (en) | 2020-06-01 | 2021-12-09 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| CN112538108B (zh) * | 2020-12-24 | 2022-06-28 | 郑州大学 | 高亲和pvr突变体 |
| WO2023022729A1 (en) * | 2021-08-20 | 2023-02-23 | Tasrif Pharmaceutical, LLC | Antibodies and antigen binding fragments against cd155 methods of use thereof |
| CN114005538B (zh) * | 2021-11-30 | 2025-10-28 | 中国医科大学附属第一医院 | Nectin家族和类nectin分子在低级别胶质瘤预后模型中的应用 |
| JP2025508939A (ja) | 2022-03-02 | 2025-04-10 | イミュニティーバイオ インコーポレイテッド | 膵臓癌の治療方法 |
| EP4493195A1 (en) | 2022-03-15 | 2025-01-22 | Compugen Ltd. | Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer |
| WO2024047654A1 (en) | 2022-09-04 | 2024-03-07 | Nectin Therapeutics Ltd. | Drug conjugates of humanized anti pvr antibodies |
| CN116284395B (zh) * | 2022-12-12 | 2024-11-08 | 合肥天港免疫药物有限公司 | 抗cd155的抗体及其应用 |
| WO2024233945A1 (en) * | 2023-05-10 | 2024-11-14 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Combination therapy of polio virus receptor inhibitors and fucose |
| TW202515608A (zh) | 2023-06-26 | 2025-04-16 | 以色列商坎布根有限公司 | Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途 |
| KR102669477B1 (ko) * | 2023-09-04 | 2024-06-10 | 재단법인 아산사회복지재단 | 신규 항-pvr 항체 또는 이의 항원 결합 단편, 및 이의 용도 |
| CN118359711B (zh) * | 2024-06-20 | 2024-10-15 | 华淞(上海)生物医药科技有限公司 | 一种抗脊髓灰质炎病毒1型抗体及其制备方法和用途 |
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-
2017
- 2017-02-28 CA CA3015619A patent/CA3015619A1/en active Pending
- 2017-02-28 EP EP17713469.9A patent/EP3423495B1/en active Active
- 2017-02-28 AU AU2017228055A patent/AU2017228055B2/en active Active
- 2017-02-28 US US16/081,667 patent/US10906987B2/en active Active
- 2017-02-28 EP EP21200696.9A patent/EP4043492A1/en active Pending
- 2017-02-28 WO PCT/IL2017/050256 patent/WO2017149538A1/en not_active Ceased
- 2017-02-28 KR KR1020257014225A patent/KR20250065434A/ko active Pending
- 2017-02-28 SG SG11201807437XA patent/SG11201807437XA/en unknown
- 2017-02-28 CN CN201780027236.6A patent/CN109071666B/zh active Active
- 2017-02-28 BR BR112018067522A patent/BR112018067522A2/pt active Search and Examination
- 2017-02-28 MX MX2018010445A patent/MX2018010445A/es unknown
- 2017-02-28 IL IL296874A patent/IL296874A/en unknown
- 2017-02-28 IL IL261200A patent/IL261200B2/en unknown
- 2017-02-28 RU RU2018134065A patent/RU2756275C2/ru active
- 2017-02-28 JP JP2018544355A patent/JP6966176B2/ja active Active
- 2017-02-28 ES ES17713469T patent/ES2903280T3/es active Active
- 2017-02-28 KR KR1020187028157A patent/KR102812377B1/ko active Active
-
2018
- 2018-08-29 MX MX2022014867A patent/MX2022014867A/es unknown
- 2018-10-01 CO CONC2018/0010538A patent/CO2018010538A2/es unknown
-
2020
- 2020-12-10 US US17/118,062 patent/US20210115150A1/en not_active Abandoned
-
2023
- 2023-08-15 US US18/450,022 patent/US20240018257A1/en active Pending
-
2024
- 2024-03-25 AU AU2024201912A patent/AU2024201912A1/en active Pending
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