JP2018505196A5 - - Google Patents
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- Publication number
- JP2018505196A5 JP2018505196A5 JP2017542001A JP2017542001A JP2018505196A5 JP 2018505196 A5 JP2018505196 A5 JP 2018505196A5 JP 2017542001 A JP2017542001 A JP 2017542001A JP 2017542001 A JP2017542001 A JP 2017542001A JP 2018505196 A5 JP2018505196 A5 JP 2018505196A5
- Authority
- JP
- Japan
- Prior art keywords
- groups
- alkyl
- acyl
- aryl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C(CC1)C(*)(*)C2=O)(C=C2C#N)C2=C1N(*)C(*)N2* Chemical compound CC(C(CC1)C(*)(*)C2=O)(C=C2C#N)C2=C1N(*)C(*)N2* 0.000 description 2
- CQCQJTLAFJFRRY-LCMPSIMXSA-N C[C@@H]([C@@H]([C@]1(C)C=C2C#N)C=Cc3c1nc(-c1ccccc1)[nH]3)C2=O Chemical compound C[C@@H]([C@@H]([C@]1(C)C=C2C#N)C=Cc3c1nc(-c1ccccc1)[nH]3)C2=O CQCQJTLAFJFRRY-LCMPSIMXSA-N 0.000 description 1
- WPSDBDOIRYODBP-CAASOKRLSA-N C[C@@H]([C@H](CC1)[C@](C)(C=C2C#N)C(N(C)C3)=C1N3c(cc1)ccc1-c1ccccc1)C2=O Chemical compound C[C@@H]([C@H](CC1)[C@](C)(C=C2C#N)C(N(C)C3)=C1N3c(cc1)ccc1-c1ccccc1)C2=O WPSDBDOIRYODBP-CAASOKRLSA-N 0.000 description 1
- LWJLVUSSTVDXDT-AKUOWQNMSA-N C[C@@H]([C@H](CC1)[C@](C)(C=C2C#N)C(N=C(C3)c4ccccc4)=C1N3c1cccc(CCCOC(C)=O)c1)C2=O Chemical compound C[C@@H]([C@H](CC1)[C@](C)(C=C2C#N)C(N=C(C3)c4ccccc4)=C1N3c1cccc(CCCOC(C)=O)c1)C2=O LWJLVUSSTVDXDT-AKUOWQNMSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562115247P | 2015-02-12 | 2015-02-12 | |
| US62/115,247 | 2015-02-12 | ||
| PCT/US2016/017769 WO2016130927A1 (en) | 2015-02-12 | 2016-02-12 | Imidazolyl tricyclic enones as antioxidant iflammation modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018505196A JP2018505196A (ja) | 2018-02-22 |
| JP2018505196A5 true JP2018505196A5 (https=) | 2019-03-22 |
| JP6748652B2 JP6748652B2 (ja) | 2020-09-02 |
Family
ID=55442884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017542001A Active JP6748652B2 (ja) | 2015-02-12 | 2016-02-12 | 抗酸化性炎症調節剤としてのイミダゾリル三環式エノン |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11059792B2 (https=) |
| EP (1) | EP3256451B1 (https=) |
| JP (1) | JP6748652B2 (https=) |
| KR (2) | KR102686868B1 (https=) |
| CN (1) | CN107428698B (https=) |
| AU (1) | AU2016219109B2 (https=) |
| CA (1) | CA2974726C (https=) |
| EA (1) | EA038328B1 (https=) |
| IL (1) | IL253923B (https=) |
| MX (1) | MX370586B (https=) |
| NZ (1) | NZ734292A (https=) |
| WO (1) | WO2016130927A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009129546A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17 |
| JP6410710B2 (ja) | 2012-04-27 | 2018-10-24 | リアタ ファーマシューティカルズ インコーポレイテッド | バルドキソロンメチルの２，２−ジフルオロプロピオンアミド誘導体、その多形体および使用方法 |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| TWI649330B (zh) | 2013-04-24 | 2019-02-01 | 艾伯維有限公司 | 甲基巴多索龍之２，２－二氟丙醯胺衍生物、其多晶形及其使用方法 |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| IL279348B2 (en) * | 2018-06-15 | 2026-01-01 | Reata Pharmaceuticals Inc | Decahydro-2h-naphth[1,2-d]imidazole compounds for inhibition of IL-17 and ROR-gamma |
| WO2019246461A1 (en) * | 2018-06-20 | 2019-12-26 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| US7435755B2 (en) | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| CA2430454A1 (en) | 2000-11-28 | 2002-06-20 | Board Of Regents, The University Of Texas System | Cddo-compounds and combination therapies thereof |
| DK1465615T3 (da) | 2002-01-15 | 2012-11-12 | Dartmouth College | Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf |
| AU2003303128A1 (en) | 2002-05-13 | 2004-08-13 | Trustees Of Dartmouth College | Inhibitors and methods of use thereof |
| WO2006089406A1 (en) | 2005-02-22 | 2006-08-31 | Gemin X Biotechnologies Inc. | Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents |
| US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
| US7714012B2 (en) | 2006-11-17 | 2010-05-11 | Trustees Of Dartmouth University | Synthesis and biological activities of new tricyclic-bis-enones (TBEs) |
| US8299046B2 (en) | 2006-11-17 | 2012-10-30 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
| WO2008136838A1 (en) | 2007-05-04 | 2008-11-13 | Trustees Of Dartmouth College | Novel amide derivatives of cddo and methods of use thereof |
| US20090048205A1 (en) | 2007-08-15 | 2009-02-19 | Colin Meyer | Combination therapy with synthetic triterpenoids and gemcitabine |
| US8088824B2 (en) | 2007-08-15 | 2012-01-03 | Reata Pharmaceuticals Inc. | Forms of CDDO methyl ester |
| PL2252283T3 (pl) | 2008-01-11 | 2019-09-30 | Reata Pharmaceuticals, Inc. | Syntetyczne triterpenoidy i sposoby zastosowania w leczeniu choroby |
| CA2721665C (en) | 2008-04-18 | 2017-01-24 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
| CN102164941B (zh) | 2008-04-18 | 2015-05-27 | 里亚塔医药公司 | 抗氧化剂炎症调节剂:具有饱和c环的齐墩果酸衍生物 |
| RS55631B1 (sr) | 2008-04-18 | 2017-06-30 | Reata Pharmaceuticals Inc | Antioksidansni modulatori upale: c-17 homologisani derivati oleanolinske kiseline |
| WO2009129546A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17 |
| WO2009146216A2 (en) | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals. Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| ES2449396T3 (es) | 2008-07-22 | 2014-03-19 | Trustees Of Dartmouth College | Cianoenonas monocíclicas y métodos de uso de las mismas |
| WO2010053817A1 (en) | 2008-11-04 | 2010-05-14 | Trustees Of Dartmouth College | Betulinic acid derivatives and methods of use thereof |
| SMT201900432T1 (it) | 2009-02-13 | 2019-09-09 | Reata Pharmaceuticals Inc | Composizioni di dosaggio orali, a rilascio ritardato contenenti cddo-me amorfo |
| MX357596B (es) | 2010-04-12 | 2018-07-16 | Reata Pharmaceuticals Inc | Método para tratar obesidad utilizando moduladores de inflamación con antioxidantes. |
| PL2651902T3 (pl) * | 2010-12-17 | 2018-04-30 | Reata Pharmaceuticals, Inc. | Pirazolilowe i pirymidynylowe tricykliczne enony jako modulatory zapalenia o działaniu przeciwutleniającym |
| SI2683731T1 (sl) | 2011-03-11 | 2019-07-31 | Reata Pharmaceuticals, Inc. | C4-monometil triterpenoidni derivati in postopki njihove uporabe |
| JP6410710B2 (ja) | 2012-04-27 | 2018-10-24 | リアタ ファーマシューティカルズ インコーポレイテッド | バルドキソロンメチルの２，２−ジフルオロプロピオンアミド誘導体、その多形体および使用方法 |
| WO2013188818A1 (en) | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| WO2014040060A1 (en) | 2012-09-10 | 2014-03-13 | Reata Pharmaceuticals, Inc. | C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof |
| US20140088163A1 (en) | 2012-09-10 | 2014-03-27 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| US9278912B2 (en) | 2012-09-10 | 2016-03-08 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| BR112016003454B1 (pt) | 2013-08-23 | 2023-02-14 | Reata Pharmaceuticals, Inc. | Uso de composto de metil bardoxolona |
| JP6530758B2 (ja) | 2014-01-24 | 2019-06-12 | リアタ ファーマシューティカルズ，インク | 抗酸化性炎症調節剤としてのアリールおよびアリールアルキル置換されたピラゾリルおよびピリミジニル三環式エノン類 |
| TWI831738B (zh) * | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
-
2016
- 2016-02-12 CN CN201680011160.3A patent/CN107428698B/zh active Active
- 2016-02-12 MX MX2017010422A patent/MX370586B/es active IP Right Grant
- 2016-02-12 AU AU2016219109A patent/AU2016219109B2/en active Active
- 2016-02-12 KR KR1020177023589A patent/KR102686868B1/ko active Active
- 2016-02-12 WO PCT/US2016/017769 patent/WO2016130927A1/en not_active Ceased
- 2016-02-12 KR KR1020247004058A patent/KR20240035818A/ko not_active Ceased
- 2016-02-12 JP JP2017542001A patent/JP6748652B2/ja active Active
- 2016-02-12 NZ NZ734292A patent/NZ734292A/en unknown
- 2016-02-12 EA EA201791814A patent/EA038328B1/ru unknown
- 2016-02-12 US US15/548,909 patent/US11059792B2/en active Active
- 2016-02-12 EP EP16706722.2A patent/EP3256451B1/en active Active
- 2016-02-12 CA CA2974726A patent/CA2974726C/en active Active
-
2017
- 2017-08-09 IL IL253923A patent/IL253923B/en active IP Right Grant
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