NZ734292A - Imidazolyl tricyclic enones as antioxidant inflammation modulators - Google Patents

Info

Publication number

NZ734292A

NZ734292A NZ734292A NZ73429216A NZ734292A NZ 734292 A NZ734292 A NZ 734292A NZ 734292 A NZ734292 A NZ 734292A NZ 73429216 A NZ73429216 A NZ 73429216A NZ 734292 A NZ734292 A NZ 734292A

Authority

NZ

New Zealand

Prior art keywords

compound

alkyl

groups

acyl

substituted

Prior art date

2015-02-12

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• 230000004054 inflammatory process Effects 0.000 title claims abstract description 35
• 206010061218 Inflammation Diseases 0.000 title claims abstract description 30
• 230000003078 antioxidant effect Effects 0.000 title abstract description 10
• 239000003963 antioxidant agent Substances 0.000 title abstract description 9
• 125000002883 imidazolyl group Chemical group 0.000 title description 4
• 150000001875 compounds Chemical class 0.000 claims abstract description 376
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• 238000000034 method Methods 0.000 claims abstract description 34
• 238000011282 treatment Methods 0.000 claims abstract description 23
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
• -1 hydroxy, amino Chemical group 0.000 claims description 123
• 125000000217 alkyl group Chemical group 0.000 claims description 112
• 125000003118 aryl group Chemical group 0.000 claims description 108
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 108
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 96
• 125000002252 acyl group Chemical group 0.000 claims description 92
• 229910052739 hydrogen Inorganic materials 0.000 claims description 89
• 125000003545 alkoxy group Chemical group 0.000 claims description 88
• 125000001072 heteroaryl group Chemical group 0.000 claims description 86
• 239000001257 hydrogen Substances 0.000 claims description 84
• 125000004104 aryloxy group Chemical group 0.000 claims description 77
• 125000004423 acyloxy group Chemical group 0.000 claims description 75
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 74
• 125000005553 heteroaryloxy group Chemical group 0.000 claims description 70
• 125000004429 atom Chemical group 0.000 claims description 68
• 125000005843 halogen group Chemical group 0.000 claims description 66
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• 125000000753 cycloalkyl group Chemical group 0.000 claims description 49
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• 125000004663 dialkyl amino group Chemical group 0.000 claims description 40
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• 125000001769 aryl amino group Chemical group 0.000 claims description 38
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