JP2018503680A5 - - Google Patents
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- Publication number
- JP2018503680A5 JP2018503680A5 JP2017547068A JP2017547068A JP2018503680A5 JP 2018503680 A5 JP2018503680 A5 JP 2018503680A5 JP 2017547068 A JP2017547068 A JP 2017547068A JP 2017547068 A JP2017547068 A JP 2017547068A JP 2018503680 A5 JP2018503680 A5 JP 2018503680A5
- Authority
- JP
- Japan
- Prior art keywords
- haloalkyl
- alkyl
- group
- formula
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 50
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 40
- 229910052736 halogen Inorganic materials 0.000 claims description 38
- 150000002367 halogens Chemical class 0.000 claims description 38
- 150000001875 compounds Chemical class 0.000 claims description 35
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- 125000004770 (C1-C4) haloalkylsulfanyl group Chemical group 0.000 claims description 22
- 125000004771 (C1-C4) haloalkylsulfinyl group Chemical group 0.000 claims description 22
- 125000001424 substituent group Chemical group 0.000 claims description 22
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims description 18
- 239000001257 hydrogen Substances 0.000 claims description 18
- 150000002431 hydrogen Chemical class 0.000 claims description 16
- -1 C 1 -C 4 alkyl Chemical group 0.000 claims description 15
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 14
- 125000004122 cyclic group Chemical group 0.000 claims description 14
- 125000003545 alkoxy group Chemical group 0.000 claims description 13
- 125000001188 haloalkyl group Chemical group 0.000 claims description 13
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims description 13
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims description 12
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 125000000623 heterocyclic group Chemical group 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 229910052717 sulfur Chemical group 0.000 claims description 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 7
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 6
- 241000607479 Yersinia pestis Species 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 229920006395 saturated elastomer Polymers 0.000 claims description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
- 239000001301 oxygen Chemical group 0.000 claims description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000011593 sulfur Chemical group 0.000 claims description 4
- 125000004434 sulfur atom Chemical group 0.000 claims description 4
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical group [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 3
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 2
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 2
- 125000004740 (C1-C6) haloalkylsulfanyl group Chemical group 0.000 claims description 2
- 125000004749 (C1-C6) haloalkylsulfinyl group Chemical group 0.000 claims description 2
- 125000004741 (C1-C6) haloalkylsulfonyl group Chemical group 0.000 claims description 2
- UCFSYHMCKWNKAH-UHFFFAOYSA-N 4,4,5,5-tetramethyl-1,3,2-dioxaborolane Chemical group CC1(C)OBOC1(C)C UCFSYHMCKWNKAH-UHFFFAOYSA-N 0.000 claims description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 150000001204 N-oxides Chemical class 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 238000002405 diagnostic procedure Methods 0.000 claims description 2
- 125000004439 haloalkylsulfanyl group Chemical group 0.000 claims description 2
- 125000002950 monocyclic group Chemical group 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims description 2
- 230000000361 pesticidal effect Effects 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 description 8
- 0 CC1(*)C=*C(C(N=C(*C(*)=*)N(C)*)=*)=C(**)C=C1 Chemical compound CC1(*)C=*C(C(N=C(*C(*)=*)N(C)*)=*)=C(**)C=C1 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 description 1
- 125000006643 (C2-C6) haloalkenyl group Chemical group 0.000 description 1
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14195573 | 2014-12-01 | ||
| EP14195573.2 | 2014-12-01 | ||
| PCT/EP2015/077417 WO2016087257A1 (en) | 2014-12-01 | 2015-11-24 | Pesticidally active amide heterocyclic derivatives with sulphur containing substituents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503680A JP2018503680A (ja) | 2018-02-08 |
| JP2018503680A5 true JP2018503680A5 (enExample) | 2019-01-10 |
| JP6665196B2 JP6665196B2 (ja) | 2020-03-13 |
Family
ID=52002775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547068A Expired - Fee Related JP6665196B2 (ja) | 2014-12-01 | 2015-11-24 | 硫黄含有置換基を有する殺有害生物的に活性なアミド複素環式誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10494366B2 (enExample) |
| EP (1) | EP3227285B1 (enExample) |
| JP (1) | JP6665196B2 (enExample) |
| CN (1) | CN107108568B (enExample) |
| AR (1) | AR102825A1 (enExample) |
| BR (1) | BR112017011306B1 (enExample) |
| WO (1) | WO2016087257A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102551157B1 (ko) * | 2014-11-07 | 2023-07-03 | 신젠타 파티서페이션즈 아게 | 황 함유 치환기를 가지는 살충 활성 폴리사이클릭 유도체 |
| CN107001352B (zh) * | 2014-12-01 | 2021-06-04 | 先正达参股股份有限公司 | 具有含硫取代基的杀有害生物活性酰胺杂环衍生物 |
| US10357493B2 (en) | 2017-03-10 | 2019-07-23 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
| CN109456902B (zh) * | 2018-12-25 | 2020-07-07 | 广西大学 | 一株白及内生真菌1-n2及其应用 |
| CN114727974A (zh) | 2019-07-30 | 2022-07-08 | 艾科尼佐治疗股份有限公司 | Hdac6抑制剂及其用途 |
| BR112022010313A2 (pt) | 2019-11-27 | 2022-08-16 | Syngenta Crop Protection Ag | Processo para a preparação de ácidos 5-cloro-piridina-2-carboxílicos e carboxilatos com substituintes contendo 3-enxofre |
| WO2022169985A1 (en) | 2021-02-03 | 2022-08-11 | Eikonizo Therapeutics, Inc. | Hdac6 inhibitors and uses thereof |
| AU2023250964A1 (en) | 2022-04-08 | 2024-11-07 | Eikonizo Therapeutics, Inc. | Oxadiazole hdac6 inhibitors and uses thereof |
| WO2024189139A1 (en) | 2023-03-14 | 2024-09-19 | Syngenta Crop Protection Ag | Control of pests resistant to insecticides |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002092584A1 (en) | 2001-05-14 | 2002-11-21 | Nihon Nohyaku Co., Ltd. | Thiadiazole derivatives, pesticides for agricultural and horticultural use and usage thereof |
| EP1820504A1 (en) | 2004-11-15 | 2007-08-22 | Taisho Pharmaceutical Co., Ltd | Imine compound |
| US9247745B2 (en) | 2010-07-22 | 2016-02-02 | Basf Se | Substituted pyridazines for controlling invertebrate pests |
| EP2611785B1 (de) | 2010-09-01 | 2014-06-04 | Bayer Intellectual Property GmbH | N-(tetrazol-5-yl)- und n-(triazol-5-yl)arylcarbonsäureamide und ihre verwendung als herbizide |
| CN102367240B (zh) | 2011-01-25 | 2014-06-18 | 华东理工大学 | 含1,2,3-噻二唑母环的酰亚胺基噻唑酮化合物、中间体及其应用 |
| AR085469A1 (es) * | 2011-03-22 | 2013-10-02 | Bayer Cropscience Ag | Amidas del acido n-(1,3,4-oxadiazol-2-il)arilcarboxilico y su uso como herbicidas |
| TWI545119B (zh) | 2011-08-04 | 2016-08-11 | 住友化學股份有限公司 | 稠合雜環化合物及其在病蟲害防制上之用途 |
| EP2865667B1 (en) * | 2012-06-26 | 2019-12-18 | Sumitomo Chemical Company, Limited | Amide compound and use thereof for pest control |
| BR112015002017B1 (pt) | 2012-07-31 | 2020-10-27 | Sumitomo Chemical Company, Limited | compostos do tipo amida, composição e método para o controle de pragas |
| US9758494B2 (en) * | 2012-12-06 | 2017-09-12 | Bayer Cropscience Ag | N-(oxazol-2-yl)-aryl-carboxylic acid amides and use thereof as herbicides |
| WO2015177063A1 (en) | 2014-05-19 | 2015-11-26 | Syngenta Participations Ag | Insecticidally active amide derivatives with sulfur-substituted phenyl or pyridine groups |
| BR112017003168B1 (pt) * | 2014-08-21 | 2021-03-02 | Syngenta Participations Ag | compostos derivados de heterocíclicos, composição pesticida, método para controle de pragas e método para a proteção de material de propagação de plantas do ataque por pragas |
| CN107001352B (zh) * | 2014-12-01 | 2021-06-04 | 先正达参股股份有限公司 | 具有含硫取代基的杀有害生物活性酰胺杂环衍生物 |
-
2015
- 2015-11-24 EP EP15804347.1A patent/EP3227285B1/en not_active Not-in-force
- 2015-11-24 CN CN201580065193.1A patent/CN107108568B/zh not_active Expired - Fee Related
- 2015-11-24 JP JP2017547068A patent/JP6665196B2/ja not_active Expired - Fee Related
- 2015-11-24 US US15/531,638 patent/US10494366B2/en not_active Expired - Fee Related
- 2015-11-24 BR BR112017011306-6A patent/BR112017011306B1/pt not_active IP Right Cessation
- 2015-11-24 WO PCT/EP2015/077417 patent/WO2016087257A1/en not_active Ceased
- 2015-11-26 AR ARP150103873A patent/AR102825A1/es unknown
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