|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5374548A
(en)
|
1986-05-02 |
1994-12-20 |
Genentech, Inc. |
Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
|
|
MX9203291A
(es)
|
1985-06-26 |
1992-08-01 |
Liposome Co Inc |
Metodo para acoplamiento de liposomas.
|
|
US5101827A
(en)
|
1985-07-05 |
1992-04-07 |
Immunomedics, Inc. |
Lymphographic and organ imaging method and kit
|
|
US4735210A
(en)
|
1985-07-05 |
1988-04-05 |
Immunomedics, Inc. |
Lymphographic and organ imaging method and kit
|
|
US5776093A
(en)
|
1985-07-05 |
1998-07-07 |
Immunomedics, Inc. |
Method for imaging and treating organs and tissues
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5128119A
(en)
|
1989-06-12 |
1992-07-07 |
Immunomedics, Inc. |
Methods for technetium/rhenium labeling of f(ab1)2 fragments
|
|
US5328679A
(en)
|
1988-04-01 |
1994-07-12 |
Immunomedics, Inc. |
Methods for technetium/rhenium labeling of proteins
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
|
JP3051145B2
(ja)
|
1990-08-28 |
2000-06-12 |
住友製薬株式会社 |
新規なポリエチレングリコール誘導体修飾ペプチド
|
|
US5746996A
(en)
|
1994-06-03 |
1998-05-05 |
Immunomedics, Inc. |
Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
|
|
IL113610A0
(en)
|
1994-06-03 |
1995-08-31 |
Immunomedics Inc |
A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US5753206A
(en)
|
1995-06-07 |
1998-05-19 |
Immunomedics, Inc. |
Radiometal-binding analogues of luteinizing hormone releasing hormone
|
|
AU717020B2
(en)
|
1996-05-03 |
2000-03-16 |
Immunomedics Inc. |
Targeted combination immunotherapy of cancer
|
|
EP0975374B1
(en)
|
1996-07-12 |
2007-12-05 |
Immunomedics, Inc. |
Radiometal-binding peptide analogues
|
|
US6261804B1
(en)
|
1997-01-21 |
2001-07-17 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
|
DK1712623T3
(da)
|
1997-01-21 |
2012-02-06 |
Gen Hospital Corp |
Udvælgelse af proteiner ved anvendelse af RNA-proteinfusioner
|
|
US6187284B1
(en)
|
1997-09-03 |
2001-02-13 |
Immunomedics, Inc. |
Fluorination of proteins and peptides for F-18 positron emission tomography
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US20050287153A1
(en)
|
2002-06-28 |
2005-12-29 |
Genentech, Inc. |
Serum albumin binding peptides for tumor targeting
|
|
JP2003528632A
(ja)
|
2000-03-31 |
2003-09-30 |
インスティティ・パスツール |
血管内皮成長因子(vegf)−媒介性脈管形成を阻害するペプチド、該ペプチドをエンコードするポリヌクレオチド及びその使用方法
|
|
CA2416219C
(en)
|
2000-07-11 |
2016-10-11 |
Research Corporation Technologies, Inc. |
Artificial antibody polypeptides
|
|
CA2443332A1
(en)
|
2001-04-04 |
2002-10-17 |
University Of Rochester |
.alpha..nu..beta.3 integrin-binding polypeptide monobodies and their use
|
|
US7129261B2
(en)
|
2001-05-31 |
2006-10-31 |
Medarex, Inc. |
Cytotoxic agents
|
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
|
CN1946417A
(zh)
|
2003-12-05 |
2007-04-11 |
阿德内克休斯治疗公司 |
2型血管内皮生长因子受体的抑制剂
|
|
ES2567634T3
(es)
|
2004-02-09 |
2016-04-25 |
Human Genome Sciences, Inc. |
Proteínas de fusión de albúmina
|
|
JP4806680B2
(ja)
|
2004-05-19 |
2011-11-02 |
メダレックス インコーポレイテッド |
自己犠牲リンカー及び薬剤複合体
|
|
RU2402548C2
(ru)
|
2004-05-19 |
2010-10-27 |
Медарекс, Инк. |
Химические линкеры и их конъюгаты
|
|
US7714016B2
(en)
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
RU2494107C2
(ru)
|
2005-05-09 |
2013-09-27 |
Оно Фармасьютикал Ко., Лтд. |
Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами
|
|
CN104356236B
(zh)
|
2005-07-01 |
2020-07-03 |
E.R.施贵宝&圣斯有限责任公司 |
抗程序性死亡配体1(pd-l1)的人单克隆抗体
|
|
BRPI0617546A2
(pt)
|
2005-09-26 |
2011-07-26 |
Medarex Inc |
conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto
|
|
SI1940789T1
(sl)
|
2005-10-26 |
2012-03-30 |
Medarex Inc |
Postopki in spojine za pripravo cc analogov
|
|
CA2627190A1
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
CA2670471A1
(en)
|
2006-11-22 |
2008-06-05 |
Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) |
Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
|
|
WO2008073458A2
(en)
|
2006-12-11 |
2008-06-19 |
Bracco Imaging S.P.A. |
Fibrin-binding peptides and conjugates thereof
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
梅達雷克斯有限責任公司 |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
US8398956B2
(en)
|
2007-01-11 |
2013-03-19 |
Immunomedics, Inc. |
In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
|
|
CA2678514A1
(en)
|
2007-02-21 |
2008-08-28 |
Medarex, Inc. |
Chemical linkers with single amino acids and conjugates thereof
|
|
US20090176654A1
(en)
|
2007-08-10 |
2009-07-09 |
Protelix, Inc. |
Universal fibronectin type III binding-domain libraries
|
|
EP2036576A1
(en)
|
2007-09-17 |
2009-03-18 |
Bayer Schering Pharma Aktiengesellschaft |
ED-B fibronectin as stratification marker for antitumor drugs
|
|
EP2215246B1
(en)
|
2007-10-31 |
2015-01-07 |
MedImmune, LLC |
Protein scaffolds
|
|
WO2009086116A2
(en)
|
2007-12-19 |
2009-07-09 |
Centocor, Inc. |
Alternative scaffold protein fusions phage display via fusion to plx of m13 phage
|
|
EP2072525A1
(en)
|
2007-12-21 |
2009-06-24 |
Affibody AB |
New polypeptides having affinity for HER2
|
|
JP2011507543A
(ja)
|
2007-12-27 |
2011-03-10 |
ノバルティス アーゲー |
改善されたフィブロネクチンベースの結合分子およびそれらの使用
|
|
CN102007145A
(zh)
|
2008-02-14 |
2011-04-06 |
百时美施贵宝公司 |
基于结合egfr的工程化蛋白质的靶向治疗剂
|
|
PL2274331T3
(pl)
|
2008-05-02 |
2014-04-30 |
Novartis Ag |
Ulepszone cząsteczki wiążące oparte na fibronektynie i ich zastosowanie
|
|
PE20091931A1
(es)
|
2008-05-22 |
2009-12-31 |
Bristol Myers Squibb Co |
Proteinas de dominio de armazon basadas en fibronectina multivalentes
|
|
BRPI0919881B1
(pt)
|
2008-10-31 |
2021-09-08 |
Centocor Ortho Biotech Inc |
Proteína de arcabouço e seu método de geração, biblioteca e seu método de construção, molécula de ácido nucleico, vetor de ácido nucleico, célula hospedeira, composição, dispositivo médico e artigo de fabricação
|
|
US8415291B2
(en)
|
2008-10-31 |
2013-04-09 |
Centocor Ortho Biotech Inc. |
Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
|
|
TWI496582B
(zh)
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之egfr/igfir結合分子
|
|
BRPI1008532B1
(pt)
|
2009-02-12 |
2021-12-14 |
Janssen Biotech, Inc |
Arcabouço de proteína isolada, método para construção de uma biblioteca de arcabouço de proteína isolada, molécula de ácido nucleico isolada, vetor de ácido nucleico isolado, célula hospedeira de bactéria ou fungo, composição, dispositivo médico e artigo de manufatura para uso farmacêutico ou de diagnóstico em seres humanos
|
|
US9217210B2
(en)
|
2009-03-24 |
2015-12-22 |
North Carolina State University |
Process of making composite inorganic/polymer nanofibers
|
|
EP2464663A4
(en)
|
2009-08-13 |
2013-05-29 |
Massachusetts Inst Technology |
MANIPULATED PROTEINS WITH MUTANT FIBRONECTIN DOMAINS
|
|
EP2494046B1
(en)
|
2009-10-30 |
2018-09-12 |
Novartis AG |
Universal fibronectin type iii bottom-side binding domain libraries
|
|
WO2011051466A1
(en)
|
2009-11-02 |
2011-05-05 |
Novartis Ag |
Anti-idiotypic fibronectin-based binding molecules and uses thereof
|
|
WO2011092233A1
(en)
|
2010-01-29 |
2011-08-04 |
Novartis Ag |
Yeast mating to produce high-affinity combinations of fibronectin-based binders
|
|
WO2011100700A2
(en)
|
2010-02-12 |
2011-08-18 |
University Of Rochester |
Antigenic mimics of discontinuous epitopes of pathogen recognized by broadly neutralizing antibodies
|
|
CA2795325A1
(en)
|
2010-04-13 |
2011-10-20 |
Medimmune, Llc |
Fibronectin type iii domain-based multimeric scaffolds
|
|
EP3569256B1
(en)
|
2010-04-30 |
2022-06-15 |
Janssen Biotech, Inc. |
Stabilized fibronectin domain compositions, methods and uses
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
ES2573108T3
(es)
|
2010-05-26 |
2016-06-06 |
Bristol-Myers Squibb Company |
Proteínas de armazón a base de fibronectina que tienen estabilidad mejorada
|
|
CN107903321A
(zh)
|
2010-07-30 |
2018-04-13 |
诺华有限公司 |
纤连蛋白摇篮分子和其库
|
|
RS55609B1
(sr)
|
2011-04-13 |
2017-06-30 |
Bristol Myers Squibb Co |
Fc fuzioni proteini koji sadrže nove linkere ili aranžmane
|
|
WO2013010573A1
(en)
|
2011-07-18 |
2013-01-24 |
Universitaet Muenster |
Compounds with matrix-metalloproteinase inhibitory activity
|
|
EP2773659A2
(en)
|
2011-10-31 |
2014-09-10 |
Bristol-Myers Squibb Company |
Fibronectin binding domains with reduced immunogenicity
|
|
CN113967253A
(zh)
|
2012-05-15 |
2022-01-25 |
百时美施贵宝公司 |
通过破坏pd-1/pd-l1信号传输的免疫治疗
|
|
HK1204557A1
(en)
|
2012-05-31 |
2015-11-27 |
Sorrento Therapeutics, Inc. |
Antigen binding proteins that bind pd-l1
|
|
TWI633117B
(zh)
|
2012-09-13 |
2018-08-21 |
必治妥美雅史谷比公司 |
結合至肌肉生長抑制素(myostatin)以纖維連接蛋白爲主之支架結構域蛋白質
|
|
CA3221851A1
(en)
|
2012-12-03 |
2014-06-12 |
Curasight A/S |
Positron emitting radionuclide labeled peptides for human upar pet imaging
|
|
EP2951206A2
(en)
|
2013-02-01 |
2015-12-09 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold proteins
|
|
ES2689372T3
(es)
|
2013-02-06 |
2018-11-13 |
Bristol-Myers Squibb Company |
Proteínas de dominio de fibronectina tipo III con solubilidad mejorada
|
|
JP2016510342A
(ja)
|
2013-02-15 |
2016-04-07 |
トーマス・ジェファーソン・ユニバーシティThomas Jefferson University |
腫瘍画像化のためのキット
|
|
US9433689B2
(en)
|
2013-03-12 |
2016-09-06 |
The Board Of Trustees Of The Leland Stanford Junio |
Probes and methods of imaging non-Hodgkins lymphoma
|
|
US10556024B2
(en)
|
2013-11-13 |
2020-02-11 |
Whitehead Institute For Biomedical Research |
18F labeling of proteins using sortases
|
|
CN106795214B
(zh)
|
2014-03-20 |
2022-09-02 |
百时美施贵宝公司 |
稳定化的基于纤连蛋白的支架分子
|
|
EP3129401B1
(en)
|
2014-03-20 |
2019-06-12 |
Bristol-Myers Squibb Company |
Serum albumin-binding fibronectin type iii domains
|
|
EP3152198B1
(en)
|
2014-06-09 |
2019-02-27 |
Takeda Pharmaceutical Company Limited |
Radiolabeled compounds
|
|
US9546206B2
(en)
|
2014-08-08 |
2017-01-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
High affinity PD-1 agents and methods of use
|
|
US9856292B2
(en)
|
2014-11-14 |
2018-01-02 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
MX385081B
(es)
|
2014-11-25 |
2025-03-14 |
Bristol Myers Squibb Co |
Métodos y composiciones para radioetiquetado con 18f de productos biológicos.
|
|
ES2981335T3
(es)
|
2014-11-25 |
2024-10-08 |
Bristol Myers Squibb Co |
Novedosos polipéptidos de unión a PD-L1 para obtención de imágenes
|
|
WO2016162368A1
(en)
|
2015-04-07 |
2016-10-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Non-invasive imaging of tumor pd-l1 expression
|
|
ES2809125T3
(es)
|
2015-09-23 |
2021-03-03 |
Bristol Myers Squibb Co |
Moléculas de armazón a base de fibronectina de unión a glipicano-3
|
|
EP3708580B1
(en)
|
2015-09-23 |
2023-11-01 |
Bristol-Myers Squibb Company |
Fast-off rate serum albumin binding fibronectin type iii domains
|
|
WO2017072273A1
(en)
|
2015-10-30 |
2017-05-04 |
Affibody Ab |
New polypeptide
|
|
WO2017072280A1
(en)
|
2015-10-30 |
2017-05-04 |
Affibody Ab |
New polypeptide having affinity to pd-l1
|
|
ES2856968T3
(es)
|
2016-01-15 |
2021-09-28 |
Rigshospitalet |
Adquisición de imágenes de TEP cuantitativas de la expresión de factor tisular usando factor VII inhibido en el punto activo y marcado con 18F
|
|
US10994033B2
(en)
|
2016-06-01 |
2021-05-04 |
Bristol-Myers Squibb Company |
Imaging methods using 18F-radiolabeled biologics
|
|
US11344639B2
(en)
|
2016-06-01 |
2022-05-31 |
Bristol-Myers Squibb Company |
PET imaging with PD-L1 binding polypeptides
|