JP2018502165A - エフィナコナゾールの結晶形態 - Google Patents

エフィナコナゾールの結晶形態 Download PDF

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Publication number
JP2018502165A
JP2018502165A JP2017555872A JP2017555872A JP2018502165A JP 2018502165 A JP2018502165 A JP 2018502165A JP 2017555872 A JP2017555872 A JP 2017555872A JP 2017555872 A JP2017555872 A JP 2017555872A JP 2018502165 A JP2018502165 A JP 2018502165A
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JP
Japan
Prior art keywords
efinaconazole
crystalline
ray diffraction
degrees
powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017555872A
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English (en)
Japanese (ja)
Other versions
JP2018502165A5 (enExample
Inventor
イタイ・アディン
ヒラ・エラザリ−シャローム
オリ・ロリルク
ヤナ・セリー
Original Assignee
ペリゴ・エーピーアイ・リミテッド
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Application filed by ペリゴ・エーピーアイ・リミテッド filed Critical ペリゴ・エーピーアイ・リミテッド
Publication of JP2018502165A publication Critical patent/JP2018502165A/ja
Publication of JP2018502165A5 publication Critical patent/JP2018502165A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2017555872A 2015-01-20 2015-12-02 エフィナコナゾールの結晶形態 Pending JP2018502165A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562105390P 2015-01-20 2015-01-20
US62/105,390 2015-01-20
PCT/IL2015/051171 WO2016116919A1 (en) 2015-01-20 2015-12-02 Crystalline forms of efinaconazole

Publications (2)

Publication Number Publication Date
JP2018502165A true JP2018502165A (ja) 2018-01-25
JP2018502165A5 JP2018502165A5 (enExample) 2019-01-17

Family

ID=56416514

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017555872A Pending JP2018502165A (ja) 2015-01-20 2015-12-02 エフィナコナゾールの結晶形態

Country Status (8)

Country Link
US (1) US20180002310A1 (enExample)
EP (1) EP3247399A4 (enExample)
JP (1) JP2018502165A (enExample)
CN (1) CN107427585A (enExample)
AU (1) AU2015379251A1 (enExample)
CA (1) CA2974180A1 (enExample)
IL (1) IL253479A0 (enExample)
WO (1) WO2016116919A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021054781A (ja) * 2019-09-26 2021-04-08 デボン エルエス，リミテッド 共結晶形エフィナコナゾール、及びその製造方法
KR20210090225A (ko) * 2018-12-29 2021-07-19 비위트 파마슈티컬 컴퍼니 리미티드 에피나코나졸의 제조 방법

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106995434A (zh) * 2016-01-25 2017-08-01 广东东阳光药业有限公司 一种三唑类抗真菌药的晶型及其制备方法
CN110770220B (zh) * 2017-05-19 2022-08-12 科研制药株式会社 艾菲康唑的制备及提纯方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0959272A (ja) * 1993-05-10 1997-03-04 Kaken Pharmaceut Co Ltd アゾリルアミン誘導体
WO2008081940A1 (ja) * 2006-12-28 2008-07-10 Kaken Pharmaceutical Co., Ltd. 真菌症治療用ゲル組成物
US20100298394A1 (en) * 2007-04-05 2010-11-25 The Johns Hopkins University Antifungal agents as neuroprotectants
JP2011508774A (ja) * 2008-01-03 2011-03-17 ドウ ファーマシューティカル サイエンシーズ、インク． 爪の疾患を治療するための組成物及び方法
WO2012029836A1 (ja) * 2010-08-31 2012-03-08 科研製薬株式会社 １－トリアゾール－２－ブタノール誘導体の製造法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1046278C (zh) * 1993-05-10 1999-11-10 科研制药株式会社 吡咯胺衍生物
PT1205559E (pt) * 1999-07-28 2009-08-04 Kaken Pharma Co Ltd Método para detectar microrganismos patogénicos e agentes antimicrobianos, método para avaliar o efeito medicamentoso de agentes antimicrobianos e agentes antimicrobianos
FR2938066B1 (fr) * 2008-11-06 2010-12-17 Centre Nat Rech Scient Systeme et procede d'analyse quantitative de la composition elementaire de la matiere par spectroscopie du plasma induit par laser (libs)
CN104292214B (zh) * 2014-09-24 2017-04-05 南京华威医药科技开发有限公司 艾氟康唑及其中间体的合成方法
CN104327047B (zh) * 2014-10-17 2016-04-06 苏州明锐医药科技有限公司 艾菲康唑的制备方法
AU2016261273A1 (en) * 2015-05-12 2017-12-07 Lupin Limited Process for the preparation of efinaconazole
US10125115B2 (en) * 2015-06-04 2018-11-13 Glenmark Pharmaceuticals Limited Process for the preparation of efinaconazole

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0959272A (ja) * 1993-05-10 1997-03-04 Kaken Pharmaceut Co Ltd アゾリルアミン誘導体
WO2008081940A1 (ja) * 2006-12-28 2008-07-10 Kaken Pharmaceutical Co., Ltd. 真菌症治療用ゲル組成物
US20100298394A1 (en) * 2007-04-05 2010-11-25 The Johns Hopkins University Antifungal agents as neuroprotectants
JP2011508774A (ja) * 2008-01-03 2011-03-17 ドウ ファーマシューティカル サイエンシーズ、インク． 爪の疾患を治療するための組成物及び方法
WO2012029836A1 (ja) * 2010-08-31 2012-03-08 科研製薬株式会社 １－トリアゾール－２－ブタノール誘導体の製造法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEM. PHARM. BULL., vol. 47(10), JPN6019032917, 1999, pages 1417 - 1425, ISSN: 0004103562 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210090225A (ko) * 2018-12-29 2021-07-19 비위트 파마슈티컬 컴퍼니 리미티드 에피나코나졸의 제조 방법
JP2022515696A (ja) * 2018-12-29 2022-02-22 威智医薬有限公司 エフィナコナゾールの調製方法
KR102622061B1 (ko) * 2018-12-29 2024-01-08 비위트 파마슈티컬 컴퍼니 리미티드 에피나코나졸의 제조 방법
JP2021054781A (ja) * 2019-09-26 2021-04-08 デボン エルエス，リミテッド 共結晶形エフィナコナゾール、及びその製造方法

Also Published As

Publication number Publication date
EP3247399A1 (en) 2017-11-29
AU2015379251A1 (en) 2017-07-27
WO2016116919A1 (en) 2016-07-28
CA2974180A1 (en) 2016-07-28
US20180002310A1 (en) 2018-01-04
EP3247399A4 (en) 2018-09-05
CN107427585A (zh) 2017-12-01
IL253479A0 (en) 2017-09-28

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