JP2018502165A5 - - Google Patents
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- Publication number
- JP2018502165A5 JP2018502165A5 JP2017555872A JP2017555872A JP2018502165A5 JP 2018502165 A5 JP2018502165 A5 JP 2018502165A5 JP 2017555872 A JP2017555872 A JP 2017555872A JP 2017555872 A JP2017555872 A JP 2017555872A JP 2018502165 A5 JP2018502165 A5 JP 2018502165A5
- Authority
- JP
- Japan
- Prior art keywords
- efinaconazole
- crystals
- solvent
- crystalline
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NFEZZTICAUWDHU-RDTXWAMCSA-N efinaconazole Chemical compound N1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)CCC(=C)CC1 NFEZZTICAUWDHU-RDTXWAMCSA-N 0.000 claims 17
- 229960003937 efinaconazole Drugs 0.000 claims 14
- 239000013078 crystal Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 3
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims 3
- 238000002844 melting Methods 0.000 claims 3
- 230000008018 melting Effects 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000012296 anti-solvent Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105390P | 2015-01-20 | 2015-01-20 | |
| US62/105,390 | 2015-01-20 | ||
| PCT/IL2015/051171 WO2016116919A1 (en) | 2015-01-20 | 2015-12-02 | Crystalline forms of efinaconazole |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018502165A JP2018502165A (ja) | 2018-01-25 |
| JP2018502165A5 true JP2018502165A5 (enExample) | 2019-01-17 |
Family
ID=56416514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555872A Pending JP2018502165A (ja) | 2015-01-20 | 2015-12-02 | エフィナコナゾールの結晶形態 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20180002310A1 (enExample) |
| EP (1) | EP3247399A4 (enExample) |
| JP (1) | JP2018502165A (enExample) |
| CN (1) | CN107427585A (enExample) |
| AU (1) | AU2015379251A1 (enExample) |
| CA (1) | CA2974180A1 (enExample) |
| IL (1) | IL253479A0 (enExample) |
| WO (1) | WO2016116919A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106995434A (zh) * | 2016-01-25 | 2017-08-01 | 广东东阳光药业有限公司 | 一种三唑类抗真菌药的晶型及其制备方法 |
| CA3063341C (en) | 2017-05-19 | 2025-02-04 | Kaken Pharmaceutical Co., Ltd. | PRODUCTION AND PURIFICATION PROCESSES OF EFINACONAZOLE |
| WO2020133411A1 (zh) * | 2018-12-29 | 2020-07-02 | 山东威智医药工业有限公司 | 一种艾氟康唑的制备方法 |
| JP2021054781A (ja) * | 2019-09-26 | 2021-04-08 | デボン エルエス，リミテッド | 共結晶形エフィナコナゾール、及びその製造方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU225416B1 (en) * | 1993-05-10 | 2006-11-28 | Kaken Pharma Co Ltd | Azolylamine derivatives and pharmaceutical compositions of antifungal effect |
| JP3437695B2 (ja) * | 1993-05-10 | 2003-08-18 | 科研製薬株式会社 | アゾリルアミン誘導体 |
| PT1205559E (pt) * | 1999-07-28 | 2009-08-04 | Kaken Pharma Co Ltd | Método para detectar microrganismos patogénicos e agentes antimicrobianos, método para avaliar o efeito medicamentoso de agentes antimicrobianos e agentes antimicrobianos |
| DE602007009574D1 (de) * | 2006-12-28 | 2010-11-11 | Kaken Pharma Co Ltd | Gelzusammensetzung zur behandlung von mykose |
| WO2008124131A1 (en) * | 2007-04-05 | 2008-10-16 | The John Hopkins University | Antifungal agents as neuroprotectants |
| US20090175810A1 (en) * | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
| FR2938066B1 (fr) * | 2008-11-06 | 2010-12-17 | Centre Nat Rech Scient | Systeme et procede d'analyse quantitative de la composition elementaire de la matiere par spectroscopie du plasma induit par laser (libs) |
| WO2012029836A1 (ja) * | 2010-08-31 | 2012-03-08 | 科研製薬株式会社 | １－トリアゾール－２－ブタノール誘導体の製造法 |
| CN104292214B (zh) * | 2014-09-24 | 2017-04-05 | 南京华威医药科技开发有限公司 | 艾氟康唑及其中间体的合成方法 |
| CN104327047B (zh) * | 2014-10-17 | 2016-04-06 | 苏州明锐医药科技有限公司 | 艾菲康唑的制备方法 |
| WO2016181306A1 (en) * | 2015-05-12 | 2016-11-17 | Lupin Limited | Process for the preparation of efinaconazole |
| US10125115B2 (en) * | 2015-06-04 | 2018-11-13 | Glenmark Pharmaceuticals Limited | Process for the preparation of efinaconazole |
-
2015
- 2015-12-02 US US15/544,173 patent/US20180002310A1/en not_active Abandoned
- 2015-12-02 JP JP2017555872A patent/JP2018502165A/ja active Pending
- 2015-12-02 WO PCT/IL2015/051171 patent/WO2016116919A1/en not_active Ceased
- 2015-12-02 CN CN201580073938.9A patent/CN107427585A/zh active Pending
- 2015-12-02 AU AU2015379251A patent/AU2015379251A1/en not_active Abandoned
- 2015-12-02 EP EP15878656.6A patent/EP3247399A4/en not_active Withdrawn
- 2015-12-02 CA CA2974180A patent/CA2974180A1/en not_active Abandoned
-
2017
- 2017-07-13 IL IL253479A patent/IL253479A0/en unknown
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