JP2018501251A5 - - Google Patents
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- Publication number
- JP2018501251A5 JP2018501251A5 JP2017533376A JP2017533376A JP2018501251A5 JP 2018501251 A5 JP2018501251 A5 JP 2018501251A5 JP 2017533376 A JP2017533376 A JP 2017533376A JP 2017533376 A JP2017533376 A JP 2017533376A JP 2018501251 A5 JP2018501251 A5 JP 2018501251A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- cycloalkyl
- haloalkyl
- alkylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 136
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 85
- -1 heterocyclylo Xy Chemical group 0.000 claims 82
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 67
- 125000000623 heterocyclic group Chemical group 0.000 claims 66
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 56
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 55
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 54
- 229910052736 halogen Inorganic materials 0.000 claims 52
- 150000002367 halogens Chemical class 0.000 claims 52
- 125000004093 cyano group Chemical group *C#N 0.000 claims 50
- 229910052739 hydrogen Inorganic materials 0.000 claims 44
- 125000004043 oxo group Chemical group O=* 0.000 claims 41
- 239000001257 hydrogen Substances 0.000 claims 39
- 229910052717 sulfur Inorganic materials 0.000 claims 35
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 33
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 30
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 30
- 229920006395 saturated elastomer Polymers 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 29
- 229910052760 oxygen Inorganic materials 0.000 claims 29
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 28
- 125000001072 heteroaryl group Chemical group 0.000 claims 28
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 27
- 229910052799 carbon Inorganic materials 0.000 claims 27
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 26
- 150000001721 carbon Chemical group 0.000 claims 24
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 22
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 21
- 125000003118 aryl group Chemical group 0.000 claims 21
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 18
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 16
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 15
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 14
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 14
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 10
- 125000006553 (C3-C8) cycloalkenyl group Chemical group 0.000 claims 10
- 125000006621 (C3-C8) cycloalkyl-(C1-C6) alkyl group Chemical group 0.000 claims 10
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 125000004434 sulfur atom Chemical group 0.000 claims 10
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 9
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 8
- 125000004641 (C1-C12) haloalkyl group Chemical group 0.000 claims 8
- 125000006643 (C2-C6) haloalkenyl group Chemical group 0.000 claims 8
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 7
- 125000006644 (C2-C6) haloalkynyl group Chemical group 0.000 claims 6
- UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical compound CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 claims 6
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 6
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims 5
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 5
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 5
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 4
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 4
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 4
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 4
- 125000006636 (C3-C8) cycloalkylcarbonyl group Chemical group 0.000 claims 4
- 125000006625 (C3-C8) cycloalkyloxy group Chemical group 0.000 claims 4
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 4
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 claims 4
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 4
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 3
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 claims 3
- 241000233866 Fungi Species 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 229910052740 iodine Inorganic materials 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 3
- 125000006824 (C1-C6) dialkyl amine group Chemical group 0.000 claims 2
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 2
- 125000006766 (C2-C6) alkynyloxy group Chemical group 0.000 claims 2
- 125000006765 (C2-C6) haloalkenyloxy group Chemical group 0.000 claims 2
- 125000006767 (C2-C6) haloalkynyloxy group Chemical group 0.000 claims 2
- MJYFVDNMTKLGTH-UHFFFAOYSA-N 4-bromo-6-(3,4-dichlorophenyl)sulfanyl-1-[[4-(dimethylcarbamoyl)phenyl]methyl]indole-2-carboxylic acid Chemical compound BrC1=C2C=C(N(C2=CC(=C1)SC1=CC(=C(C=C1)Cl)Cl)CC1=CC=C(C=C1)C(N(C)C)=O)C(=O)O MJYFVDNMTKLGTH-UHFFFAOYSA-N 0.000 claims 2
- 241000277306 Esocidae Species 0.000 claims 2
- 150000003973 alkyl amines Chemical class 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000005332 alkyl sulfoxy group Chemical group 0.000 claims 2
- 125000005199 aryl carbonyloxy group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000005110 aryl thio group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000004678 hydrides Chemical class 0.000 claims 2
- 239000012948 isocyanate Substances 0.000 claims 2
- 150000002513 isocyanates Chemical class 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 150000002540 isothiocyanates Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000005023 xylyl group Chemical group 0.000 claims 2
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims 1
- 125000006593 (C2-C3) alkynyl group Chemical group 0.000 claims 1
- FKTXDTWDCPTPHK-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical group FC(F)(F)[C](F)C(F)(F)F FKTXDTWDCPTPHK-UHFFFAOYSA-N 0.000 claims 1
- OCYPFRDEUKBLNI-UHFFFAOYSA-N 1,2-thiazole-4-carbonitrile Chemical compound N#CC=1C=NSC=1 OCYPFRDEUKBLNI-UHFFFAOYSA-N 0.000 claims 1
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 230000000895 acaricidal effect Effects 0.000 claims 1
- 239000000642 acaricide Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 239000003337 fertilizer Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 244000000004 fungal plant pathogen Species 0.000 claims 1
- 239000000417 fungicide Substances 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 230000002363 herbicidal effect Effects 0.000 claims 1
- 239000004009 herbicide Substances 0.000 claims 1
- 239000002917 insecticide Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 239000005645 nematicide Substances 0.000 claims 1
- 230000000361 pesticidal effect Effects 0.000 claims 1
- 239000005648 plant growth regulator Substances 0.000 claims 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14199548 | 2014-12-22 | ||
| EP14199548.0 | 2014-12-22 | ||
| PCT/EP2015/080739 WO2016102435A2 (en) | 2014-12-22 | 2015-12-21 | Novel isothiazolamides, processes for their preparation and their use as fungicides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018501251A JP2018501251A (ja) | 2018-01-18 |
| JP2018501251A5 true JP2018501251A5 (enExample) | 2019-02-07 |
Family
ID=52130123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533376A Pending JP2018501251A (ja) | 2014-12-22 | 2015-12-21 | 新規イソチアゾールアミド、それらの調製方法および殺真菌剤としてのそれらの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20190110476A1 (enExample) |
| EP (1) | EP3236752A2 (enExample) |
| JP (1) | JP2018501251A (enExample) |
| CN (1) | CN107205394A (enExample) |
| BR (1) | BR112017013610A2 (enExample) |
| TW (1) | TW201632507A (enExample) |
| WO (1) | WO2016102435A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201638076A (zh) * | 2014-12-22 | 2016-11-01 | 拜耳作物科學股份有限公司 | 新穎之異噻唑醯胺類，其製備方法及其作為除草劑及／或植物生長調節劑之用途 |
| WO2017207395A1 (en) | 2016-06-02 | 2017-12-07 | Bayer Cropscience Aktiengesellschaft | Isothiazolopyridones, processes for their preparation and their use as fungicides |
| CN109195974A (zh) | 2016-06-02 | 2019-01-11 | 拜耳作物科学股份公司 | 异噻唑并吡啶酮、其制备方法及其用作除草剂和/或植物生长调节剂的用途 |
| EP3648605A1 (en) | 2017-07-03 | 2020-05-13 | Bayer CropScience Aktiengesellschaft | Novel isothiazolo-based bicycles, processes for their preparation and their use as herbicides and/or plant growth regulators |
| EP3648606A1 (en) | 2017-07-03 | 2020-05-13 | Bayer CropScience Aktiengesellschaft | Novel substituted isothiazolopyridones, processes for their preparation and their use as herbicides and/or plant growth regulators |
| CN111433214A (zh) * | 2017-11-29 | 2020-07-17 | 拜耳公司 | 新的异噻唑-氮杂*酮双环、其制备方法及其作为除草剂和/或植物生长调节剂的用途 |
| US20210032205A1 (en) * | 2018-02-27 | 2021-02-04 | Nippon Soda Co., Ltd. | Heteroaryl sulfonamide compound and formulation for controlling harmful organisms |
| EP3760627A4 (en) * | 2018-02-28 | 2022-03-02 | Hokko Chemical Industry Co., Ltd. | IMIDE DERIVATIVE AND BACTERICIDE WITH THIS AS AN ACTIVE SUBSTANCE |
| JP2021193068A (ja) * | 2018-09-14 | 2021-12-23 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 植物病害防除剤 |
| EP3878278B1 (en) * | 2018-10-31 | 2025-12-03 | Kumiai Chemical Industry Co., Ltd. | Method for controlling diseases in small grain cereals, seed of small grain cereals, and method for suppressing lodging damage in small grain cereals |
| WO2020161209A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| WO2020161208A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| JP2023527379A (ja) * | 2020-05-27 | 2023-06-28 | コンステレーション・ファーマシューティカルズ・インコーポレイテッド | Ｔｒｅｘ１のモジュレーターとしての置換ベンズアミド |
| KR20240136380A (ko) | 2022-01-14 | 2024-09-13 | 엔코 켐 인코포레이티드 | 프로토포르피리노겐 산화효소 억제제 |
| WO2024059559A1 (en) * | 2022-09-12 | 2024-03-21 | Hotspot Therapeutics, Inc. | Isothiazolylcarboxamide compounds and their use in therapy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US896623A (en) * | 1908-03-02 | 1908-08-18 | Jesse Childs | Pit-car. |
| DE1795344B2 (de) * | 1968-09-17 | 1976-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 3-aminoisothiazolen |
| GB1548397A (en) * | 1976-06-01 | 1979-07-11 | Lilly Industries Ltd | Acylated amino-isoxazoles and aminoisothiazoles |
| US4267341A (en) * | 1977-11-23 | 1981-05-12 | Merck & Co., Inc. | Process for preparing 2,3-substituted-1,2,-isothiazolium salt antimicrobials |
| US4292430A (en) * | 1977-11-23 | 1981-09-29 | Merck & Co., Inc. | 2,3-Substituted-1,2-isothiazolium salt antimicrobials |
| JPH07500116A (ja) * | 1992-03-26 | 1995-01-05 | ダウエランコ | 殺菌剤としてのｎ−複素環式ニトロアニリン |
| ATE243204T1 (de) * | 1995-08-24 | 2003-07-15 | Basf Ag | Isoxazole- und isothiazole-5-carboxamid derivate, deren herstellung und deren verwendung als herbizide |
| WO2003010143A1 (en) * | 2001-07-26 | 2003-02-06 | Samsung Electronics Co., Ltd. | Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses |
| WO2004092123A2 (en) * | 2003-04-10 | 2004-10-28 | Microbia, Inc. | Inhibitors of fungal invasion |
| TW200738701A (en) * | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| DK2319830T3 (en) * | 2008-08-13 | 2017-02-13 | Mitsui Chemicals Agro Inc | Amide derivative, pesticide containing the amide derivative and use of the pesticide |
| US8686044B2 (en) * | 2008-08-13 | 2014-04-01 | Mitsui Chemicals Agro, Inc. | Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative |
-
2015
- 2015-12-18 TW TW104142603A patent/TW201632507A/zh unknown
- 2015-12-21 EP EP15816178.6A patent/EP3236752A2/en not_active Withdrawn
- 2015-12-21 JP JP2017533376A patent/JP2018501251A/ja active Pending
- 2015-12-21 BR BR112017013610A patent/BR112017013610A2/pt not_active IP Right Cessation
- 2015-12-21 CN CN201580075870.8A patent/CN107205394A/zh active Pending
- 2015-12-21 US US15/537,261 patent/US20190110476A1/en not_active Abandoned
- 2015-12-21 WO PCT/EP2015/080739 patent/WO2016102435A2/en not_active Ceased
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