JP2018500336A5 - - Google Patents
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- Publication number
- JP2018500336A5 JP2018500336A5 JP2017532657A JP2017532657A JP2018500336A5 JP 2018500336 A5 JP2018500336 A5 JP 2018500336A5 JP 2017532657 A JP2017532657 A JP 2017532657A JP 2017532657 A JP2017532657 A JP 2017532657A JP 2018500336 A5 JP2018500336 A5 JP 2018500336A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- cantharidin
- iii
- formula
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462093396P | 2014-12-17 | 2014-12-17 | |
| US62/093,396 | 2014-12-17 | ||
| PCT/US2015/066487 WO2016100732A2 (en) | 2014-12-17 | 2015-12-17 | Commercially viable synthesis of cantharidin and bioactive cantharidin derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020206344A Division JP2021073173A (ja) | 2014-12-17 | 2020-12-11 | カンタリジンおよび生理活性カンタリジン誘導体の商業的に実現可能な合成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018500336A JP2018500336A (ja) | 2018-01-11 |
| JP2018500336A5 true JP2018500336A5 (enExample) | 2019-02-07 |
| JP6810693B2 JP6810693B2 (ja) | 2021-01-06 |
Family
ID=56127857
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017532657A Active JP6810693B2 (ja) | 2014-12-17 | 2015-12-17 | カンタリジンおよび生理活性カンタリジン誘導体の商業的に実現可能な合成 |
| JP2020206344A Pending JP2021073173A (ja) | 2014-12-17 | 2020-12-11 | カンタリジンおよび生理活性カンタリジン誘導体の商業的に実現可能な合成 |
| JP2023212697A Active JP7777726B2 (ja) | 2014-12-17 | 2023-12-18 | カンタリジンおよび生理活性カンタリジン誘導体の商業的に実現可能な合成 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020206344A Pending JP2021073173A (ja) | 2014-12-17 | 2020-12-11 | カンタリジンおよび生理活性カンタリジン誘導体の商業的に実現可能な合成 |
| JP2023212697A Active JP7777726B2 (ja) | 2014-12-17 | 2023-12-18 | カンタリジンおよび生理活性カンタリジン誘導体の商業的に実現可能な合成 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10745413B2 (enExample) |
| EP (1) | EP3233865A4 (enExample) |
| JP (3) | JP6810693B2 (enExample) |
| KR (1) | KR102528106B1 (enExample) |
| CN (2) | CN114106013A (enExample) |
| AU (2) | AU2015364524A1 (enExample) |
| BR (1) | BR112017013029B1 (enExample) |
| CA (1) | CA2971279C (enExample) |
| HK (1) | HK1246276A1 (enExample) |
| IL (2) | IL252907B2 (enExample) |
| MX (2) | MX385473B (enExample) |
| WO (1) | WO2016100732A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL283432B2 (en) | 2013-08-21 | 2025-02-01 | Verrica Pharmaceuticals Inc | Compositions, methods and systems for treating skin disorders |
| CN114106013A (zh) | 2014-12-17 | 2022-03-01 | 维里卡制药有限公司 | 斑螯素和生物活性斑螯素衍生物的商业上可行的合成 |
| JP6898241B2 (ja) | 2015-01-20 | 2021-07-07 | ヴェリカ ファーマシューティカルズ, インコーポレイテッドVerrica Pharmaceuticals, Inc. | 医薬品グレードカンタリジンの定量および調製 |
| CN106674248B (zh) * | 2016-12-17 | 2019-02-26 | 重庆市中药研究院 | 一种斑蝥素的合成工艺 |
| JP7280870B2 (ja) | 2017-06-06 | 2023-05-24 | ヴェリカ ファーマシューティカルズ インコーポレーテッド | 皮膚障害の処置 |
| USD900312S1 (en) | 2017-06-15 | 2020-10-27 | Verrica Pharmaceuticals, Inc. | Applicator |
| JP7497980B2 (ja) | 2017-06-15 | 2024-06-11 | ヴェリカ ファーマシューティカルズ インコーポレーテッド | 体表面の障害の処置のためのデバイスおよび方法 |
| EP4339199A3 (en) * | 2017-10-04 | 2024-05-15 | Verrica Pharmaceuticals, Inc. | Synthesis of cantharidin |
| US20210393570A1 (en) * | 2017-10-31 | 2021-12-23 | Université de Bourgogne | Therapeutical compositions for use in the treatment of non-malignant conditions associated with phosphatidylinositol-3-kinase activation: overgrowth spectrum, cutaneous capillary malformations and seborrheic keratoses |
| CN113455515A (zh) * | 2021-06-24 | 2021-10-01 | 广东省农业科学院果树研究所 | 斑蝥素在制备防治柑橘采后绿霉菌的农药杀菌剂的应用 |
| KR20240012182A (ko) | 2022-07-20 | 2024-01-29 | 고려대학교 산학협력단 | 칸타리딘을 유효성분으로 포함하는 교모세포종 예방 또는 치료용 조성물 |
Family Cites Families (57)
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| JPS4739621Y1 (enExample) | 1968-04-18 | 1972-11-30 | ||
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| US4298752A (en) | 1980-09-19 | 1981-11-03 | Regents Of The University Of California | Cycloadduct precursors of cantharidin and method |
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| JP3117502B2 (ja) | 1991-08-27 | 2000-12-18 | 株式会社資生堂 | 皮膚外用剤 |
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| US5445462A (en) | 1993-08-03 | 1995-08-29 | Medi-Flex Hospital Products, Inc. | Liquid applicator |
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| FR2754175B1 (fr) | 1996-10-07 | 1999-07-02 | Oreal | Utilisation d'un organopolysiloxane de nature elastomerique associe a une phase organique dans un produit de demaquillage des ongles |
| US6030633A (en) | 1998-05-18 | 2000-02-29 | West Agro, Inc. | Film-forming compositions for protecting animal skin |
| JPH11335303A (ja) | 1998-05-26 | 1999-12-07 | Lion Corp | 苦味増強方法及び皮膚外用剤 |
| US6337076B1 (en) | 1999-11-17 | 2002-01-08 | Sg Licensing Corporation | Method and composition for the treatment of scars |
| US20030072814A1 (en) | 1999-12-16 | 2003-04-17 | Maibach Howard I. | Topical pharmaceutical composition for the treatment of warts |
| WO2002096413A1 (en) * | 2001-05-31 | 2002-12-05 | The Chinese University Of Hong Kong | Composition comprising demethylcantharidin in combination with platinum-containing anticancer agents and use thereof |
| US6899897B2 (en) | 2001-06-18 | 2005-05-31 | Jaleva, Inc. | Gum resin as a carrier for topical application of pharmacologically active agents |
| US6673031B2 (en) | 2001-09-25 | 2004-01-06 | Phillip Mark | Liquid applicator |
| SI1436321T1 (sl) * | 2001-10-19 | 2006-12-31 | Isotechnika Inc | Sinteza analogov ciklosporina |
| JP2004059446A (ja) * | 2002-07-25 | 2004-02-26 | Mitsui Chemicals Inc | 脂環式化合物及びその製造方法 |
| RU2326893C2 (ru) | 2003-04-16 | 2008-06-20 | Кориум Интернэшнл | Ковалентное и нековалентное сшивание гидрофильных полимеров и адгезивные композиции, полученные с ними |
| US20050019418A1 (en) | 2003-07-23 | 2005-01-27 | Crutchfield Charles E. | Wart treatment |
| US20070111954A1 (en) | 2003-07-23 | 2007-05-17 | Cuticeuticals, Inc. | Apparatus and method of wart treatment |
| JP2005187330A (ja) | 2003-12-24 | 2005-07-14 | Lion Corp | 歯牙貼布用製品及びゲル組成物の選定方法 |
| FR2865360B1 (fr) | 2004-01-22 | 2006-05-26 | Oreal | Applicateur comportant un element d'application solidaire, lors de l'utilisation, d'un recipient contenant un produit a appliquer |
| FR2872704B1 (fr) * | 2004-07-12 | 2007-11-02 | Laurent Schwartz | Pluritherapie contre le cancer |
| US20060110415A1 (en) | 2004-11-22 | 2006-05-25 | Bioderm Research | Topical Delivery System for Cosmetic and Pharmaceutical Agents |
| US20050111900A1 (en) | 2004-11-30 | 2005-05-26 | Francesca Fazzolari | Ampoule and method of use |
| FR2885779B1 (fr) | 2005-05-23 | 2007-08-10 | Oreal | Dispositif de conditionnement et d'application d'un produit cosmetique ou dermatologique |
| US20070187437A1 (en) | 2006-02-10 | 2007-08-16 | Nordson Corporation | Dispensing tip for liquid dispensing systems and method of making the same |
| JP5132071B2 (ja) | 2006-03-31 | 2013-01-30 | 小林製薬株式会社 | 皮膚外用剤 |
| DE102006034272A1 (de) | 2006-07-18 | 2008-01-24 | Aesculap Ag & Co. Kg | Flüssigkeitsspender in der Medizin in Form einer Handhabe sowie dessen Verwendung |
| CN100465176C (zh) | 2006-08-18 | 2009-03-04 | 芜湖天远科技开发有限责任公司 | 一种提取斑蝥素的方法 |
| US20080146674A1 (en) | 2006-12-15 | 2008-06-19 | Rosenberg E William | Use of gentian violet in treatment of atopic dermatitis |
| US8518076B2 (en) | 2007-01-08 | 2013-08-27 | Advanced Medical Solutions (Plymouth) Limited | Surgical adhesive applicator |
| JP5230023B2 (ja) | 2007-01-25 | 2013-07-10 | ハイパーブランチ メディカル テクノロジー, インコーポレイテッド | 複数成分製剤などのための塗布器および使用方法 |
| CN101036774B (zh) | 2007-04-17 | 2010-12-29 | 贵州益佰制药股份有限公司 | 一种复方斑蝥口服制剂的检测方法 |
| CN101108853B (zh) | 2007-07-27 | 2010-05-26 | 贵州大学 | 斑蝥素分离纯化方法 |
| CN100577665C (zh) * | 2007-08-16 | 2010-01-06 | 广东药学院 | 一种抗肿瘤活性斑蛰素衍生物及其制备方法 |
| DE102007046600A1 (de) | 2007-09-27 | 2009-04-02 | Linhardt Metallwarenfabrik Gmbh & Co Kg | Verfahren zum Applizieren eines flüssigen, medizinischen Behandlungsmediums auf einen zu behandelden Bereich sowie Medizinprodukt |
| WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
| JP5396125B2 (ja) | 2009-03-30 | 2014-01-22 | 有限会社日本健康科学研究センター | 被膜形成型製剤 |
| EP2485720B1 (en) | 2009-10-08 | 2018-08-22 | Bayer Consumer Care AG | Low ether composition and delivery apparatus |
| US20120016320A1 (en) | 2010-07-13 | 2012-01-19 | Lin Michael T | Method and Device for Liquid Delivery |
| US20120148520A1 (en) | 2010-12-10 | 2012-06-14 | Michael Strobel | Organic Iodine Complex Durable Barrier With Antimicrobial Preparations |
| FR2972928B1 (fr) | 2011-03-25 | 2013-11-29 | Urgo Lab | Composition contenant une cellulose, une huile vegetale et un solvant volatil, ses utilisations comme pansement |
| US20120312709A1 (en) | 2011-04-12 | 2012-12-13 | Velcera, Inc. | Device for storing and dispensing a medicament, and packaging for containing the same |
| CN102146086B (zh) | 2011-04-12 | 2012-03-07 | 贵州金桥药业有限公司 | 一种斑蝥酸钠的制备方法 |
| US9486829B2 (en) | 2011-06-04 | 2016-11-08 | Optmed, Inc. | Applicator |
| CN102268006B (zh) | 2011-06-15 | 2013-08-14 | 北京联合大学生物化学工程学院 | 一种复合酶提取斑蝥素的方法 |
| US8871801B2 (en) | 2011-08-01 | 2014-10-28 | Jacob LEVITT | Method of treating acquired perforating dermatosis with cantharidin |
| CN202920809U (zh) | 2012-09-27 | 2013-05-08 | 合肥诚者成医药科技有限公司 | 一种治疗尖锐湿疣的软膏 |
| US9463180B2 (en) | 2013-03-14 | 2016-10-11 | Quadex Pharmaceuticals, Llc | Treatment of molluscum contagiosum |
| IL283432B2 (en) | 2013-08-21 | 2025-02-01 | Verrica Pharmaceuticals Inc | Compositions, methods and systems for treating skin disorders |
| CN103923095A (zh) * | 2014-04-23 | 2014-07-16 | 遵义医学院 | 一种去甲基斑蝥素酸钙 |
| US9994584B2 (en) | 2014-10-15 | 2018-06-12 | Lixte Biotechnology, Inc. | Process of synthesizing 3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1] heptane-2-carboxylic acid |
| CN114106013A (zh) | 2014-12-17 | 2022-03-01 | 维里卡制药有限公司 | 斑螯素和生物活性斑螯素衍生物的商业上可行的合成 |
| JP6898241B2 (ja) | 2015-01-20 | 2021-07-07 | ヴェリカ ファーマシューティカルズ, インコーポレイテッドVerrica Pharmaceuticals, Inc. | 医薬品グレードカンタリジンの定量および調製 |
-
2015
- 2015-12-17 CN CN202111209225.4A patent/CN114106013A/zh active Pending
- 2015-12-17 JP JP2017532657A patent/JP6810693B2/ja active Active
- 2015-12-17 KR KR1020177019573A patent/KR102528106B1/ko active Active
- 2015-12-17 AU AU2015364524A patent/AU2015364524A1/en not_active Abandoned
- 2015-12-17 EP EP15871116.8A patent/EP3233865A4/en active Pending
- 2015-12-17 WO PCT/US2015/066487 patent/WO2016100732A2/en not_active Ceased
- 2015-12-17 BR BR112017013029-7A patent/BR112017013029B1/pt active IP Right Grant
- 2015-12-17 HK HK18105382.5A patent/HK1246276A1/zh unknown
- 2015-12-17 CA CA2971279A patent/CA2971279C/en active Active
- 2015-12-17 CN CN201580076312.3A patent/CN107530322B/zh active Active
- 2015-12-17 MX MX2017008097A patent/MX385473B/es unknown
- 2015-12-17 US US15/535,860 patent/US10745413B2/en active Active
-
2017
- 2017-06-14 IL IL252907A patent/IL252907B2/en unknown
- 2017-06-16 MX MX2021010078A patent/MX2021010078A/es unknown
-
2020
- 2020-05-27 IL IL274968A patent/IL274968A/en unknown
- 2020-08-17 US US16/995,606 patent/US20210070771A1/en not_active Abandoned
- 2020-10-01 AU AU2020244554A patent/AU2020244554B2/en active Active
- 2020-12-11 JP JP2020206344A patent/JP2021073173A/ja active Pending
-
2023
- 2023-12-18 JP JP2023212697A patent/JP7777726B2/ja active Active
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