JP2018158184A - 薬物懸濁液用の薬物送達装置 - Google Patents
薬物懸濁液用の薬物送達装置 Download PDFInfo
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- JP2018158184A JP2018158184A JP2018132615A JP2018132615A JP2018158184A JP 2018158184 A JP2018158184 A JP 2018158184A JP 2018132615 A JP2018132615 A JP 2018132615A JP 2018132615 A JP2018132615 A JP 2018132615A JP 2018158184 A JP2018158184 A JP 2018158184A
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- reservoir
- suspension
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- 239000000725 suspension Substances 0.000 title claims abstract description 64
- 239000003814 drug Substances 0.000 title claims abstract description 25
- 238000012377 drug delivery Methods 0.000 title claims abstract description 24
- 229940079593 drug Drugs 0.000 title description 17
- 239000007787 solid Substances 0.000 claims abstract description 32
- 239000007788 liquid Substances 0.000 claims abstract description 15
- 238000002347 injection Methods 0.000 claims abstract description 8
- 239000007924 injection Substances 0.000 claims abstract description 8
- 239000012530 fluid Substances 0.000 claims abstract description 7
- 230000007246 mechanism Effects 0.000 claims description 21
- 238000013019 agitation Methods 0.000 claims description 17
- 238000003756 stirring Methods 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 abstract description 7
- 238000009825 accumulation Methods 0.000 abstract description 3
- 238000010586 diagram Methods 0.000 description 9
- 239000002245 particle Substances 0.000 description 8
- 229940090048 pen injector Drugs 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 239000003085 diluting agent Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000013536 elastomeric material Substances 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000007634 remodeling Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000013543 active substance Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
- A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/343—Connection of needle cannula to needle hub, or directly to syringe nozzle without a needle hub
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims (11)
- 近位端および遠位端を有する筒であり、薬剤を収容するためのリザーバを少なくとも部分的に画定し、前記薬剤が、液体キャリアに固体を懸濁させた懸濁液を含む、筒と、
前記リザーバと流体連通した針であり、患者に注射するための遠位端および前記リザーバ内の近位端を有する針と、
前記リザーバ内に提供されたプランジャであり、前記リザーバからの前記懸濁液を前記針を通して押し出すために選択的に移動可能なプランジャと、
前記懸濁液と連通するように前記リザーバ内に配置された少なくとも1つの撹拌機構であり、前記針の周りに配置された1または複数のひれを備え、および、前記プランジャが移動する間、前記懸濁液を撹拌するように構成された撹拌機構と
を備えたことを特徴とする薬物送達装置。 - 前記1または複数のひれは前記針の前記近位端の近位側に延在することを特徴とする請求項1に記載の装置。
- 前記筒の前記遠位端を密封するセプタムをさらに備え、前記針は前記セプタムを貫き、および、前記1または複数のひれは前記針の周りで前記セプタム上に配置されることを特徴とする請求項1に記載の装置。
- 前記1または複数のひれは前記筒上に配置されていることを特徴とする請求項1に記載の装置。
- 前記筒内で動かないように配置された環状栓をさらに備え、前記1または複数のひれは前記環状栓上に形成されていることを特徴とする請求項1に記載の装置。
- 前記1または複数のひれはプレート状形状に形成され、遠位方向に延在していることを特徴とする請求項1に記載の装置。
- 前記1または複数のひれは少なくとも2つのひれを含み、および、前記少なくとも2つのひれの間に形成された1または複数の流路を備えたことを特徴とする請求項1に薬物送達装置。
- 近位端および遠位端を有する筒であり、薬剤を収容するためのリザーバを少なくとも部分的に画定し、前記薬剤が、液体キャリアに固体を懸濁させた懸濁液を含む、筒と、
前記リザーバと流体連通した針であり、患者に注射するための遠位端および前記リザーバ内の近位端を有する針と、
前記リザーバ内に提供されたプランジャであり、前記リザーバからの前記懸濁液を前記針を通して押し出すために選択的に移動可能なプランジャと、
前記懸濁液と連通するように前記リザーバ内に配置された少なくとも1つの撹拌機構であり、前記プランジャが移動する間、前記懸濁液を撹拌するように構成された少なくとも1つの静止羽根を備えた撹拌機構と
を備えたことを特徴とする薬物送達装置。 - 前記少なくとも1つの静止羽根は、曲げられ、ねじられ、かつ/または丸められるように構成されていることを特徴とする請求項8に記載の装置。
- 前記少なくとも1つの静止羽根は、前記針の前記近位端の近位側に位置していることを特徴とする請求項8に記載の装置。
- 前記少なくとも1つの静止羽根は少なくとも2つの静止羽根を含み、および、前記少なくとも2つの静止羽根の間に形成された空隙を備えたことを特徴とする請求項8に薬物送達装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/422,315 | 2012-03-16 | ||
US13/422,315 US10207053B2 (en) | 2012-03-16 | 2012-03-16 | Drug delivery device for drug suspensions |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017014343A Division JP6404961B2 (ja) | 2012-03-16 | 2017-01-30 | 薬物懸濁液用の薬物送達装置 |
Related Child Applications (1)
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---|---|---|---|
JP2020134950A Division JP7058692B2 (ja) | 2012-03-16 | 2020-08-07 | 薬物懸濁液用の薬物送達装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2018158184A true JP2018158184A (ja) | 2018-10-11 |
JP6794407B2 JP6794407B2 (ja) | 2020-12-02 |
Family
ID=48045776
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015500677A Active JP6085665B2 (ja) | 2012-03-16 | 2013-03-18 | 薬物懸濁液用の薬物送達装置 |
JP2017014343A Active JP6404961B2 (ja) | 2012-03-16 | 2017-01-30 | 薬物懸濁液用の薬物送達装置 |
JP2018132615A Active JP6794407B2 (ja) | 2012-03-16 | 2018-07-12 | 薬物懸濁液用の薬物送達装置 |
JP2020134950A Active JP7058692B2 (ja) | 2012-03-16 | 2020-08-07 | 薬物懸濁液用の薬物送達装置 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015500677A Active JP6085665B2 (ja) | 2012-03-16 | 2013-03-18 | 薬物懸濁液用の薬物送達装置 |
JP2017014343A Active JP6404961B2 (ja) | 2012-03-16 | 2017-01-30 | 薬物懸濁液用の薬物送達装置 |
Family Applications After (1)
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JP2020134950A Active JP7058692B2 (ja) | 2012-03-16 | 2020-08-07 | 薬物懸濁液用の薬物送達装置 |
Country Status (7)
Country | Link |
---|---|
US (2) | US10207053B2 (ja) |
EP (3) | EP2825230B1 (ja) |
JP (4) | JP6085665B2 (ja) |
CN (2) | CN106039483B (ja) |
ES (2) | ES2748103T3 (ja) |
IN (1) | IN2014DN07772A (ja) |
WO (1) | WO2013138809A2 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2991221A1 (en) | 2015-07-02 | 2017-01-05 | Marc Andrew Koska | Single use delivery device prefilled with a reconstitutable agent |
EP3448466A1 (en) | 2016-04-25 | 2019-03-06 | Koska Family Ltd. | Medical delivery system |
ES2747370T3 (es) * | 2016-12-30 | 2020-03-10 | Becton Dickinson France | Dispositivo médico, conjunto que incluye dicho dispositivo médico y procedimiento para la fabricación de dicho dispositivo médico |
WO2019099954A1 (en) | 2017-11-17 | 2019-05-23 | Koska Family Limited | Systems and methods for fluid delivery manifolds |
USD992110S1 (en) | 2021-08-10 | 2023-07-11 | Koska Family Limited | Sealed fluid container |
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JPH0999034A (ja) * | 1995-06-02 | 1997-04-15 | Eli Lilly & Co | 液体医薬用容器 |
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-
2012
- 2012-03-16 US US13/422,315 patent/US10207053B2/en active Active
-
2013
- 2013-03-18 CN CN201610512826.5A patent/CN106039483B/zh active Active
- 2013-03-18 JP JP2015500677A patent/JP6085665B2/ja active Active
- 2013-03-18 ES ES17198874T patent/ES2748103T3/es active Active
- 2013-03-18 WO PCT/US2013/032829 patent/WO2013138809A2/en active Application Filing
- 2013-03-18 EP EP13714151.1A patent/EP2825230B1/en active Active
- 2013-03-18 IN IN7772DEN2014 patent/IN2014DN07772A/en unknown
- 2013-03-18 EP EP17198874.4A patent/EP3295980B1/en active Active
- 2013-03-18 CN CN201380020211.5A patent/CN104245021B/zh active Active
- 2013-03-18 EP EP17193217.1A patent/EP3284497B1/en active Active
- 2013-03-18 ES ES13714151.1T patent/ES2656269T3/es active Active
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2017
- 2017-01-30 JP JP2017014343A patent/JP6404961B2/ja active Active
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2018
- 2018-07-12 JP JP2018132615A patent/JP6794407B2/ja active Active
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2019
- 2019-01-02 US US16/238,212 patent/US11452816B2/en active Active
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2020
- 2020-08-07 JP JP2020134950A patent/JP7058692B2/ja active Active
Patent Citations (6)
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---|---|---|---|---|
US2798487A (en) * | 1952-05-09 | 1957-07-09 | Becton Dickinson Co | Syringe assembly |
JPH07213608A (ja) * | 1994-01-25 | 1995-08-15 | Becton Dickinson & Co | 注射器組立体 |
JPH0999034A (ja) * | 1995-06-02 | 1997-04-15 | Eli Lilly & Co | 液体医薬用容器 |
JPH09628A (ja) * | 1995-06-16 | 1997-01-07 | Material Eng Tech Lab Inc | 二液成分用注射器 |
JPH1057486A (ja) * | 1996-06-28 | 1998-03-03 | Becton Dickinson & Co | 多チャンバ注射器筒内に使用するためのバイパスを有するストッパ組立体 |
WO2005102423A1 (en) * | 2004-04-23 | 2005-11-03 | Imprint Pharmaceuticals Limited | Needles |
Also Published As
Publication number | Publication date |
---|---|
JP7058692B2 (ja) | 2022-04-22 |
US11452816B2 (en) | 2022-09-27 |
EP3284497A1 (en) | 2018-02-21 |
CN104245021A (zh) | 2014-12-24 |
JP6794407B2 (ja) | 2020-12-02 |
ES2748103T3 (es) | 2020-03-13 |
JP2017094184A (ja) | 2017-06-01 |
JP2020175283A (ja) | 2020-10-29 |
CN106039483B (zh) | 2019-12-06 |
WO2013138809A3 (en) | 2014-04-03 |
ES2656269T3 (es) | 2018-02-26 |
CN104245021B (zh) | 2018-05-29 |
JP6085665B2 (ja) | 2017-02-22 |
EP3284497B1 (en) | 2020-02-12 |
JP2015510798A (ja) | 2015-04-13 |
EP3295980B1 (en) | 2019-07-03 |
IN2014DN07772A (ja) | 2015-05-15 |
EP2825230A2 (en) | 2015-01-21 |
US20130245559A1 (en) | 2013-09-19 |
EP2825230B1 (en) | 2017-11-01 |
WO2013138809A2 (en) | 2013-09-19 |
JP6404961B2 (ja) | 2018-10-17 |
EP3295980A1 (en) | 2018-03-21 |
US20190134310A1 (en) | 2019-05-09 |
CN106039483A (zh) | 2016-10-26 |
US10207053B2 (en) | 2019-02-19 |
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