JP2018035280A - Sterilizing detergent composition for cleaning - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a sterilizing detergent composition for cleaning which has excellent sterilizing effect to bacterial spores, and is excellent in safety and handleability.SOLUTION: A sterilizing composition contains one or two or more kinds selected from the group consisting of a polyalkylene biguanide compound represented by formula (1) and its salt, an alkali agent, and one or two or more kinds selected from the group consisting of a non-ionic surfactant and an ampholytic surfactant, and has a pH of 12.5 or more. A composition containing a quaternary ammonium salt and/or alcohol improves a sterilizing effect. In formula (1), Rand n are as defined in the description of the specification.SELECTED DRAWING: None

Description

  The present invention relates to a sterilizing detergent composition for washing having excellent sterilizing effect on clothes and linens, and also having an excellent sterilizing effect not only on vegetative bacteria but also on bacterial spores.

  In hospitals, hotels, restaurants, etc., white clothes, uniforms, hats, and other clothing worn in the facility, towels, sheets, pillow covers, etc. used in the facility (hereinafter referred to as “linens”) are microorganisms. When contaminated, problems such as nosocomial infections and food poisoning may occur, so a sanitary condition is always required. For this reason, in the field of industrial laundry such as commercial cleaning and linen supply for cleaning worn clothing and used linens, not only cleaning but also sterilization and removal of microorganisms attached to the fibers are performed. At that time, hot water of 80 ° C. or higher, sodium hypochlorite, peracetic acid and the like are used.

However, among the microorganisms adhering to clothes and linens, bacterial spores are highly resistant to heat and chemical substances, and their disinfection and removal are particularly difficult. Of the above sterilization and sterilization treatments, hot water at 80 ° C has little effect on bacterial spores, and sodium hypochlorite and peracetic acid have some effects, but the following problems in use is there.
Sodium hypochlorite is highly corrosive and may damage fibers, and peracetic acid is a very powerful disinfectant and is effective against bacterial spores. Because of this problem, it is not suitable for the human body.

  Furthermore, it is necessary to use a considerable amount of detergent components for washing clothes and linens. However, this detergent component interacts with the sterilizing / disinfecting components used in combination, so The activity or stability of the disinfectant component may be reduced, or the cleaning power of the cleaning agent component may be reduced.

Under such circumstances, the search for a composition that has a bactericidal effect on bacterial spores and can be used more safely has been pursued. Polyhexamethylene guanidine salt, natural alcohol-based nonionic surfactant, fatty acid alkylolamide ethylene oxide Disinfectant cleaning agent using an adduct or an enzyme (Patent Document 1), polyhexamethylene guanidine salt, silicate, alkylene oxide adduct of secondary alcohol having 12 to 24 carbon atoms, and 6 to 8 carbon It is disclosed that a bactericidal detergent composition (Patent Document 2) containing an alkylene oxide adduct of a primary alcohol has a bactericidal effect against heat-resistant spore-forming bacteria.
Further, by treating the surface at 30 ° C. to 80 ° C. with a composition containing a high concentration of quaternary ammonium salt exceeding 1% by weight, spores of Bacillus subtilis and Sporogenes can be reduced (patent) Document 3) and a method for sterilizing bacterial spores in which a solution of a dimer-type bisquaternary ammonium salt is brought into contact with heating or ultrasonic irradiation (Patent Document 4) are also disclosed.

However, the disinfecting effect of the disinfecting detergent described in Patent Document 1 is inoculated with a certain amount of test cells in a medium to which an appropriately diluted test drug is added, and cultured at 37 ° C. for 18 to 20 hours. The bactericidal effect of the bactericidal detergent composition described in Patent Document 2 was formed by culturing Bacillus subtilis on an SCD agar medium at 35 ° C. for 24 hours. Since it has been evaluated using a bacterial solution prepared by collecting cells from colonies, the disinfection or bactericidal effect shown in the examples of these patent documents is an effect on bacterial spores or an effect on vegetative bacteria It is not clear what it is.
In addition, the treatment or sterilization method described in Patent Document 3 or Patent Document 4 requires heating and ultrasonic treatment, and is efficient for use in commercial laundry that processes a large amount of clothing and linens. It is hard to say that it is a good way.

Japanese Patent Laid-Open No. 2002-047111 JP 2009-108184 A Special table 2008-504910 Japanese Patent Laid-Open No. 10-295785

Therefore, there is a demand for a disinfecting detergent composition for washing that is excellent in detergency, safe for the human body, and highly effective for bacterial spores.
Accordingly, the present invention provides a sterilizing detergent composition for washing that has an excellent sterilizing effect on bacterial spores and is excellent in safety and handling without using oxides such as sodium hypochlorite and peracetic acid. The purpose is to provide.

As a result of intensive studies to solve the above problems, the present inventors, as a result, a polyalkylene biguanide compound such as polyhexamethylene biguanide (PHMB) or a salt thereof that does not exhibit bactericidal effects on bacterial spores alone, and an alkaline agent. In combination, the bactericidal effect on bacterial spores such as Bacillus can be obtained by adjusting the pH of the composition to 12.5 or higher, and further by adding a quaternary ammonium salt and / or alcohol, It has been found that the bactericidal effect is improved.
And when 1 type or 2 types or more selected from the group which consists of a nonionic surfactant and an amphoteric surfactant are used as a cleaning agent component, there is little influence with respect to the bactericidal activity and stability of the said bactericidal component. And it discovered that it was excellent also in detergency, and came to complete this invention.

That is, the present invention relates to the following [1] to [8].
[1] From the group consisting of one or more selected from the group consisting of the polyalkylene biguanide compound represented by formula (1) and a salt thereof, an alkali agent, and a nonionic surfactant and an amphoteric surfactant A sterilizing detergent composition for laundry, containing one or more selected, wherein the composition has a pH of 12.5 or more.

[Wherein, R ^a represents an alkylene group having 2 to 8 carbon atoms, and n represents an integer of 2 to 18]. ]
[2] The above, wherein one or more selected from the group consisting of a polyalkylene biguanide compound and a salt thereof is one or more selected from the group consisting of a polyhexamethylene biguanide and a salt thereof [ 1] The disinfectant cleaning composition described in 1].
[3] The sterilizing detergent composition according to the above [1] or [2], further comprising one or more quaternary ammonium salts.
[4] The sterilizing detergent composition according to any one of [1] to [3], further containing one or more alcohols.
[5] 1 type or 2 or more types of alcohol are 1 type or 2 or more types selected from the group which consists of C5-C10 alkanol, terpene alcohol, and aromatic alcohol as described in said [4]. Bactericidal cleaning composition.
[6] Nonionic surfactant is glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene The sterilizing detergent composition according to any one of the above [1] to [5], which is selected from the group consisting of alkyl ether, fatty acid polyethylene glycol, fatty acid polyoxyethylene sorbitan, fatty acid alkanolamide, alkyl glucoside and acyl glucamide.
[7] Amphoteric surfactants are alkyl betaine type surfactants, aminocarboxylic acid type surfactants, alkylamidopropyl betaine type surfactants, alkyl sulfobetaine type surfactants, imidazoline type surfactants and alkylamine oxides. The sterilizing detergent composition according to any one of the above [1] to [6], which is selected from the group consisting of type surfactants.
[8] The disinfectant cleaning composition according to any one of [1] to [7], which targets bacterial spores.

  The laundry disinfectant composition for washing of the present invention has excellent detergency for clothes and linens, exhibits a good disinfectant effect against bacterial spores that have been ineffective with conventional disinfectants, and has an adverse effect on fibers. Therefore, it is useful in the field of business laundry.

  The laundry disinfectant cleaning composition of the present invention (hereinafter also referred to simply as “the composition of the present invention”) is one or two selected from the group consisting of polyalkylene biguanide compounds and salts thereof. As mentioned above, 1 type or 2 types or more selected from the group which consists of an alkali agent and a nonionic surfactant and an amphoteric surfactant are contained, and pH of a composition is adjusted to 12.5 or more.

  The polyalkylene biguanide compound used in the present invention is represented by the following formula (1).

[Wherein, R ^a represents an alkylene group having 2 to 8 carbon atoms, and n represents an integer of 2 to 18]. ]

In the above formula (1), the alkylene group having 2 to 8 carbon atoms represented by ^Ra includes ethylene, propylene, butylene, pentylene, hexylene (hexamethylene), heptylene (heptamethylene), octylene (octamethylene) and the like. In addition to the linear one, branched chain ones such as isopropylene, isobutylene, isopentylene, dimethylpropylene, dimethylbutylene and the like are included, but a linear alkylene group is preferable. Moreover, from a viewpoint of the bactericidal effect with respect to a bacterial spore, a C4-C8 alkylene group is preferable and a hexamethylene group is especially preferable. In addition, n in Formula (1) is 2-18, and when the bactericidal effect with respect to a bacterial spore, a handleability, etc. are considered, it is preferable that the said n is 10-14, and it is more preferable that it is 11-13.

  The polyalkylene biguanide compound represented by the formula (1) can also be used in the form of a salt with an inorganic acid such as hydrochloric acid, nitric acid or sulfuric acid, or a salt with an organic acid such as acetic acid, lactic acid or gluconic acid. Among such salts, hydrochloride, acetate and gluconate are preferable, and hydrochloride is most preferably used. In the composition of this invention, 1 type (s) or 2 or more types are selected and used from the group which consists of the polyalkylene biguanide compound shown by Formula (1), and its salt.

  In the present invention, the polyalkylene biguanide compound or a salt thereof is a known compound, and a compound produced according to a known method such as the method described in British Patent No. 702,268 can be used. A product may be used. Examples of commercially available products include “Ecline Side BG” (manufactured by Riko Kyosan Co., Ltd.), “Proxel IB” (manufactured by Arch Chemicals), “Lonza Back BG” (manufactured by Lonza Japan Ltd.), and the like.

  In the composition of the present invention, one or more selected from the group consisting of the above polyalkylene biguanide compounds and salts thereof are usually 0 in terms of the concentration in the composition finally used for sterilization and washing. 0.001% by mass to 0.2% by mass, preferably 0.003% by mass to 0.1% by mass, and more preferably 0.005% by mass to 0.05% by mass.

The alkali agent contained in the composition of the present invention is not limited as long as the pH of the composition can be adjusted to 12.5 or more, and hydroxides of alkali metals such as lithium hydroxide, sodium hydroxide, potassium hydroxide, etc. Inorganic bases having strong basicity are preferred, such as alkaline earth metal hydroxides such as calcium hydroxide, strontium hydroxide and barium hydroxide, and alkali metal salts of metasilicic acid such as sodium metasilicate and potassium metasilicate. Sodium hydroxide, potassium hydroxide and sodium metasilicate are more preferred.
In addition, as said alkaline agent, the commercial product provided by each company can be used.

The composition of the present invention is preferably a group consisting of one or more selected from the group consisting of a polyalkylene biguanide compound and a salt thereof, an alkali agent, and a nonionic surfactant and an amphoteric surfactant. In addition to one or more selected from the above, it further contains a quaternary ammonium salt and / or an alcohol.
With such a composition of the present invention, the bactericidal effect is improved, and an effective bactericidal effect can be exerted against bacterial spores in a short treatment of 5 to 10 minutes.

  As the quaternary ammonium salt used in the present invention, the polyalkylene biguanide compound or a salt thereof, the alkali agent, the surfactant described later, or the alcohol described below can be mixed well with the composition of the present invention. It can be used without particular limitation as long as it can improve the bactericidal effect on bacterial spores by using together with the above-mentioned components. For example, a quaternary ammonium salt represented by the following formula (2), And a quaternary ammonium salt having a pyridinium ring represented by the formula (3).

[Wherein, R ^{1 to} R ⁴ are the same or different and each represents an alkyl group, an aryl group or an aralkyl group, and A ₁ ⁻ represents an inorganic or organic anion. ]

[Wherein, R ⁵ represents an alkyl group, and A ₂ ^— represents an inorganic or organic anion. ]

In the above formula (2), examples of the alkyl group represented by R ¹ , R ² , R ^3, or R ⁴ include an alkyl group having about 1 to 18 carbon atoms, and the aryl group includes 6 to 12 carbon atoms. About an aryl group, and examples of the aralkyl group include an aralkyl group having about 7 to 12 carbon atoms.
Examples of the alkyl group having about 1 to 18 carbon atoms include methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl (lauryl), tetradecyl (myristyl), hexadecyl (palmityl), octadecyl Linear alkyl groups such as (stearyl), 2-propyl (isopropyl), 1-methylpropyl (sec-butyl), 2-methylpropyl (isobutyl), 1,1-dimethylethyl (tert-butyl), 3 -Methylbutyl (isopentyl), 4-methylpentyl (isohexyl), 1-methylheptyl (sec-octyl), 6-methylheptyl (isooctyl), 1,1-dimethylhexyl, 2-ethylhexyl, 1-methyltridecyl, 12 -Methyltridecyl (isomyristyl , 1-methylpentadecyl, 14-methylpentadecyl (isopalmityl), 1-methylheptadecyl, 16-methylheptadecyl (isostearyl), and the like. A group, an alkylamino group, an alkaloylalkylamino group, a phenylcarbamoyl group, an alkoxy group, an aryloxy group (such as a phenoxy group), or an alkoxy group substituted by an alkylphenoxy group is also included.
Examples of the aryl group having about 6 to 12 carbon atoms include phenyl, methylphenyl (tolyl), naphthyl and the like, and examples of the aralkyl group having about 7 to 12 carbon atoms include phenylmethyl (benzyl) and phenylethyl (phenethyl). ) And the like.

In the above formula (2), examples of the inorganic or organic anion represented by A ₁ ^— include a halogen ion, an inorganic acid ion, and an organic acid ion.
Examples of the halogen ion include chlorine ion, bromine ion and iodine ion. Examples of inorganic acid ions include hydrochloric acid ions, nitrate ions, sulfate ions, phosphate ions, and the like. Examples of organic acid ions include alkyl sulfate ester ions having about 1 to 3 carbon atoms such as methyl sulfate ions; monocarboxylic acid ions having about 2 to 6 carbon atoms such as acetate ions, propionate ions, butyrate ions, and caproate ions; Hydroxycarboxylic acid ions having about 3 to 6 carbon atoms such as lactate ion, malate ion and citrate ion; carbon such as oxalate ion, malonate ion, succinate ion, fumarate ion, maleate ion and adipate ion Examples thereof include dicarboxylic acid ions of about 2 to 6.
Of these, halogen ions, sulfate ions, alkyl sulfate ester ions, and dicarboxylate ions are preferable, and chlorine ions, bromine ions, and adipate ions are particularly preferable.

As the quaternary ammonium salt represented by the above formula (2), R ¹ is alkyl having 8 to 18 carbon atoms, R ² , R ³ and R ⁴ are the same or different and have 1 to 4 carbon atoms. An ammonium salt in which R ¹ and R ² are the same or different and alkyl having 8 to 18 carbon atoms, and R ³ and R ⁴ are the same or different and are alkyl having 1 to 4 carbon atoms, And R ¹ in the formula is benzyl, phenoxyalkyl or phenylcarbamoylalkyl, R ² is alkyl having 8 to 18 carbon atoms, phenoxy, or alkyl substituted by an alkoxy group substituted by alkylphenoxy, or an alkenyl Roylalkylaminoalkyl, an ammonium salt in which R ³ and R ⁴ are the same or different and are alkyl having 1 to 4 carbon atoms Preferably, R ¹ and R ² in the formula are the same or different, an alkyl salt having 8 to 18 carbon atoms, and R ³ and R ⁴ are the same or different and are an alkyl salt having 1 to 4 carbon atoms; R ¹ is benzyl, the alkyl ^{R 2} is 8 to 18 carbon atoms, and ^{R 3} and ^{R 4} are the same or different, alkyl ammonium salt is a 1 to 4 carbon atoms; and ^{R 1} is benzyl, ^{R 2} is the alkyl phenoxy group-substituted More preferred is an alkyl salt substituted with an alkoxy group, and an ammonium salt in which R ³ and R ⁴ are the same or different and are alkyl having 1 to 4 carbon atoms.

  Preferred specific examples of the quaternary ammonium salt represented by the above formula (2) include hexadecyltrimethylammonium salt <cetrimonium salt>, didecyldimethylammonium salt, alkyldimethylbenzylammonium salt <benzalkonium salt>, N, N-dimethyl-N- [2- [2- [4- (1,1,3,3-tetramethylbutyl) phenoxy] ethoxy] ethyl] benzenemethane ammonium salt <benzethonium salt>, methylbenzethonium salt, dodecyl Examples include dimethyl (2-phenoxyethyl) ammonium salt <domiphene salt>, [2- (lauroylmethylamino) ethyl] dimethyl (phenylcarbamoylmethyl) ammonium salt <dophanium salt>, and the like.

In the above formula (3), examples of the alkyl group represented by R ⁵ include an alkyl group having 8 to 18 carbon atoms, including octyl, decyl, dodecyl (lauryl), tetradecyl (myristyl), hexadecyl (palmityl or cetyl), A linear alkyl group such as octadecyl (stearyl) is preferable, and dodecyl (lauryl) and hexadecyl (palmityl or cetyl) are particularly preferable.
In the above formula (3), examples of the inorganic or organic anion represented by A ₂ ^— include the same halogen ions, inorganic acid ions, and organic acids as the anion represented by A ₁ ^— in the above formula (2). Ions, and the like. Halogen ions, sulfate ions, alkyl sulfate ester ions, and dicarboxylate ions are preferable, and chlorine ions, bromine ions, and adipate ions are particularly preferable.

In this invention, 1 type (s) or 2 or more types can be selected and used from the quaternary ammonium salt etc. which are shown by the said Formula (2) and Formula (3).
Suitable quaternary ammonium salts include didecyldimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetrimonium bromide, domifene bromide, dophanium chloride, laurylpyridinium chloride, cetylpyridinium chloride and the like. Among these, didecyldimethylammonium chloride, benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride are more preferable, and didecyldimethylammonium chloride is particularly preferable.

  The quaternary ammonium salt used in the composition of the present invention can be produced and used in accordance with a known method, but “Cotamine D86P”, “Cotamine D2345P” (manufactured by Kao Corporation), “Hyamine” ) 1622 "," Hyamine 3500J "," Bardac 2250 "," Bardac 2280 "(manufactured by Lonza Japan Ltd.)," Catiogen DDM-PG "," Catiogen SV "," Catiogen " BC50 "(Daiichi Kogyo Seiyaku Co., Ltd.)," Cation DDC-50 "," Osmolin DA-50 "," Cation G-50 "(Sanyo Kasei Kogyo Co., Ltd.)," Osban S "(Nippon Pharmaceutical Co., Ltd.) Co., Ltd.), “cetylpyridinium chloride (CPC)” (Wako It is also possible to use a commercially available product of medicine Kogyo Co., Ltd.), and the like.

  In the composition of the present invention, one or more quaternary ammonium salts are usually added in a concentration of 0.001% by mass to 0.5% by mass in the composition finally used for sterilization and cleaning. %, Preferably 0.001 mass% to 0.2 mass%, more preferably 0.01 mass% to 0.1 mass%.

  As the alcohol used in the composition of the present invention, the polyalkylene biguanide compound or a salt thereof, the alkali agent, and the surfactant described later, or further together with a quaternary ammonium salt, the composition of the present invention is excellent. Any compound that can be mixed and can be used without limitation as long as it can improve the bactericidal effect on bacterial spores when used together with the above-described components, and examples thereof include alkanol, terpene alcohol, aromatic alcohol and the like.

Examples of the alkanol include linear or branched monovalent alkanols and alkanediols, and alkanols having 5 to 10 carbon atoms are preferable.
Examples of the linear or branched monovalent alkanol having 5 to 10 carbon atoms include pentanol, hexanol, heptanol, octanol, 2-ethylhexanol, nonanol, decanol and the like, and linear monovalent alkanol having 5 to 8 carbon atoms. Is more preferable, and a linear monovalent alkanol having 5 to 7 carbon atoms is particularly preferable.
Examples of the alkanediol having 5 to 10 carbon atoms include 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, and the like. 10 to 1,2-alkanediol is more preferred.

  Terpene alcohols include monoterpene alcohols such as geraniol, citronellol, terpinen-4-ol, nerol, menthol, labangurol, linalool, tsujol, and borneol, sesquiterpene alcohols such as guaiol, santalol, nerolidol, bisabolol, and sclareol. Diterpene alcohols such as phytol are preferred.

  Examples of the aromatic alcohol include alcohols having a hydroxyl group that is not directly bonded to an aromatic ring such as a benzene ring, such as benzyl alcohol, salicyl alcohol, cinnamyl alcohol, vanillyl alcohol, etc. An alkanol substituted with an aryl group such as naphthyl or an aryloxy group such as phenoxy or naphthoxy is preferred, an alkanol having 1 to 3 carbon atoms substituted with the aryl group or aryloxy group is more preferred, and phenylmethanol (benzyl Alcohol), 2-phenylethanol (phenethyl alcohol), 1-phenylethanol, 2-phenyl-1-propanol, 3-phenyl-1-propanol, 2-phenoxyethanol, 3-phenoxypropanol and the like. Alkenyl group or phenoxy carbon atoms which is substituted by group are particularly preferable 1 to 3 alkanol.

In this invention, 1 type (s) or 2 or more types, such as above-mentioned alcohol, can be used.
From the viewpoint of the bactericidal effect on bacterial spores, alkanols having 5 to 10 carbon atoms, terpene alcohols and aromatic alcohols are preferable, and they are substituted with monovalent alkanols, monoterpene alcohols having 5 to 7 carbon atoms, and phenyl groups or phenoxy groups. More preferred are alkanols having 1 to 3 carbon atoms, more preferred are 2-phenylethanol, 2-phenyl-1-propanol, 3-phenyl-1-propanol, 2-phenoxyethanol, and the like, and 2-phenylethanol and 3-phenyl -1-propanol is most preferred.

  In the composition of the present invention, the alcohol can be produced and used according to a known method, but a commercially available product provided by each company can also be used.

  In the composition of the present invention, one or more of the above alcohols are usually 0.02% by mass to 5% by mass, preferably 0 in terms of the concentration in the composition finally used for sterilization / cleaning. 0.05% by mass to 2% by mass, more preferably 0.2% by mass to 1% by mass.

  Nonionic surfactants used in the composition of the present invention include glycerin fatty acid esters (for example, glyceryl stearate and glyceryl oleate), sucrose fatty acid esters (for example, sucrose laurate, sucrose myristate) , Sucrose palmitate, etc.), ester surfactants such as sorbitan fatty acid esters (eg, sorbitan laurate, sorbitan stearate, sorbitan isostearate); polyoxyethylene alkyl ethers (eg, polyoxyethylene lauryl ether, poly Oxyethylene cetyl ether, polyoxyethylene isostearyl ether, etc.), polyoxyethylene alkylphenyl ether (eg, polyoxyethylene nonylphenyl ether, etc.), polyoxy Ether type surface activity such as tylene polyoxypropylene glycol (eg, polyoxyethylene (160) polyoxypropylene (30) glycol), polyoxyethylene polyoxypropylene alkyl ether (eg, polyoxyethylene polyoxypropylene lauryl ether) Agent: fatty acid polyethylene glycol (for example, polyethylene glycol stearate, polyethylene glycol dilaurate, etc.), fatty acid polyoxyethylene sorbitan (for example, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monooleate) Ester ether type surfactants such as fatty acid alkanolamides (for example, coconut oil fatty acid diethanolamine) Alkanolamide type surfactants such as lauric acid diethanolamide, stearic acid monoethanolamide, etc .; for example, alkyl glucoside type surfactants such as decyl glucoside, lauryl glucoside, myristyl glucoside; for example, octanoyl-N-methylglucamide And acyl glucamide type surfactants such as coconut oil fatty acid acylmethyl glucamide.

  Examples of the amphoteric surfactant used in the composition of the present invention include alkyl such as N, N-dimethyl-N-alkyl-N-carboxymethylammonium betaine (for example, lauryldimethylaminoacetic acid betaine, stearyldimethylaminoacetic acid betaine). Betaine surfactants; aminocarboxylic acid types such as N-acyl-N′-carboxymethyl-N′-hydroxyethylethylenediamine (for example, N-lauroyl-N′-carboxymethyl-N′-hydroxyethylethylenediamine sodium) Surfactant; alkylamidopropyl betaine type surfactant such as lauric acid amidopropyl betaine, coconut oil fatty acid amidopropyl betaine; N, N, N-trialkyl-N-sulfoalkylene ammonium betaine (for example, lauryl hydroxide) Alkylsulfobetaine type surfactants such as sulfobetaine); imidazoline type surfactants such as 2-alkyl-1-hydroxyethyl-1-carboxymethylimidazolinium betaine; N, N-dimethylalkylamine = N-oxide Examples thereof include alkylamine oxide type surfactants (eg, lauryldimethylamine N-oxide, oleyldimethylamine N-oxide).

In the present invention, the nonionic surfactants and amphoteric surfactants described above can be used singly or in combination of two or more.
Moreover, although the above-mentioned nonionic surfactant and amphoteric surfactant may be prepared and used by a production method known per se, products commercially available as detergent components from various companies can be used.

  The composition of the present invention from the viewpoint of the cleaning effect on clothes and linens and the effect on fungicide components such as one or more selected from the group consisting of polyalkylene biguanide compounds and salts thereof, quaternary ammonium salts, etc. Examples of the detergent component contained in the product include nonionic surfactants such as polyoxyethylene alkyl ether and polyoxyethylene polyoxypropylene alkyl ether, and amphoteric surfactants such as N, N-dimethylalkylamine = N-oxide Are preferred, and polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, and the like are more preferred.

  In the composition of the present invention, one or two or more selected from the group consisting of a nonionic surfactant and an amphoteric surfactant are used in the final composition used for sterilization and cleaning. Usually, 0.001 mass%-0.5 mass%, Preferably it is 0.003 mass%-0.2 mass%, More preferably, 0.005 mass%-0.1 mass% are contained.

The pH of the composition of the present invention is adjusted to be 12.5 or more, and more preferably 13 or more.
If the pH of the composition of the present invention is 12.5 or more, an effective bactericidal effect is recognized against bacterial spores in a treatment time of about 60 minutes, and clothes and linens are efficiently sterilized and washed. be able to.
Moreover, the pH of the composition of this invention is 14 or less, and it is preferable that it is 13.5 or less from a stability viewpoint of a composition.

The pH of the composition of the present invention is based on Japanese Industrial Standard (JIS) K 3362: 2008 “8.3 pH value” or quasi-drug raw material standard 2006 “General test method 55. pH measurement method”. Measured.
When the composition of the present invention is provided in a highly viscous form such as a paste, which will be described later, or in a solid form such as a gel, the electrode of the pH meter, for example, at 25 ° C. Is measured by sticking or pressing directly on the sample. When the composition of the present invention is provided in the form of powder, granules, etc., for example, the composition is suspended in purified water at a general use concentration and measured at 25 ° C.

  The composition of the present invention is selected from the group consisting of one or more selected from the group consisting of the polyalkylene biguanide compounds and salts thereof, an alkali agent, a nonionic surfactant and an amphoteric surfactant. In addition to one or more of the above, or further quaternary ammonium salt and / or alcohol, if necessary, an additive component generally used in a detergent composition may be added to form a liquid, suspension, It can be provided in various forms such as an emulsion, a paste, a gel, a powder, and a granule.

  Examples of the additive component include water softeners (for example, aluminosilicate, polycarboxylate, etc.), chelating agents (for example, sodium ethylenediaminetetraacetate, tripolyphosphate, hexametaphosphate, sodium citrate, etc.), dispersants (for example, Polyethylene glycol, sodium carboxymethylcellulose, hydroxycellulose, sodium polyacrylate, etc.), foam control agents (eg, soap, silicone oil, etc.), solvents (eg, butyl carbitol, 3-methoxy-3-methylbutanol, etc.), Stabilizers (for example, ethanol), enzymes (for example, protease, lipase, amylase, cellulase, etc.), fluorescent brighteners (for example, bis (triazinylamide) stilbene disulfonic acid, etc.), etc. Do not spoil the characteristics of In the range, it can be used either alone or in combination.

The composition of the present invention can also contain general antibacterial components such as chlorhexidine gluconate and alkyldiaminoethylglycine hydrochloride as long as the characteristics of the present invention are not impaired.
Furthermore, a pigment | dye, a fragrance | flavor, etc. can also be used for the purpose of coloring, flavoring, etc.

From the viewpoint of efficiently washing and sterilizing a large amount of clothes and linens in a short time, the composition of the present invention is preferably a liquid composition.
The liquid composition of the present invention comprises one or more selected from the group consisting of the polyalkylene biguanide compounds and salts thereof, an alkali agent, or further a quaternary ammonium salt and / or alcohol, a nonionic One or two or more selected from the group consisting of surfactants and amphoteric surfactants may be dissolved or suspended in a solvent, and prepared by adding the above-described general additive components as necessary. It can be provided by filling a bottle with a metering cap, a trigger type spray container, a squeeze type or dispenser type pump spray container or the like.
Examples of the solvent include water (for example, purified water such as distilled water and deionized water); lower alcohol having about 2 to 4 carbon atoms (for example, ethanol, isopropanol, butanol, etc.), and polyvalent having about 2 to 4 carbon atoms. An organic solvent such as alcohol (for example, ethylene glycol, propylene glycol, glycerin, butylene glycol, etc.) can be used. However, in consideration of handling properties such as corrosiveness to fibers and economic efficiency, water or water and the organic solvent are used. It is preferable to use a mixture thereof.

The composition of this invention is excellent in the washing | cleaning effect of clothing and linens, and is excellent in the bactericidal effect with respect to a bacterial spore.
The spore-forming bacteria include Bacillus anthracis (Bacillus anthracis), Bacillus cereus (Bacillus cereus), Bacillus subtilis (Bacillus subtilis), Bacillus coagulans, Bacillus cocilulans (Bacillus coagulans) Bacteria belonging to the genus Bacillus such as licheniformis, Bacillus megaterium, Bacillus thuringiensis, Bacillus pseudomycoides, Alicyclobacillus acid terrestris, Alicyclobacillus acidoterrestris Brevibacil, a bacterium belonging to the genus Alicyclobacillus such as Alicyclobacillus acidiphilus and Alicyclobacillus herbarius Brevibacillus choshinensis and other bacteria belonging to the genus Brevibacillus, Geobacillus thermodenitrificans, Geobacillus caldoxylosilyticus, Geobacillus caldoxylosilyticus, and others Bacteria belonging to the genus Paenibacillus, such as Paenibacillus vortex and Paenibacillus fukuinensis, Sporolactobacillus insulinus Bacteria belonging to the genus Sporolactobacillus such as Sporolactobacillus laevis), Clostridium tetani (tetanus), Clostridium botulinum, Clostridium perfringens (C. perfringens), Clostridium novyi, Clostridium septicum (Clostridium septicum), Clostridium septicum Bacteria belonging to the genus Clostridium, such as Clostridium thermocellum, Clostridium butyricum, Clostridium acetobutylicum, Desulfotomacrum nisulfifum, Dance (Desulfotomaculum thermoacetoxidans), Desulfotomaculum thermobenzoicum subsp. Benzoicum (Desulfotomaculum thermobenzoicum subsp. Thermobenzoicum), desulfotomaculum thermospynum, desulfotomaculum thermobenzonicum subsp. Thermosyntrophicum, desulfotomaculum thermocisternum, desulfotomaculum thermocisternum Bacteria belonging to the genus Desulfotomaculum such as Desulfotomaculum thermosapovorans, Desulfotomaculum thermosubterraneum, Moorella thermoacetica, Moorella glycerine ), Moorella mulderi, Moorella thermoautotrophica, and other bacteria belonging to the genus Moorella, Thermonelobacter maslani (Thermoanaerobacter mathranii), Thermoanaerobacter acetoethylicus (Thermoanaerobacter acetoethylicus), Thermoanaerobacter buroii (Thermoanaerobacter celloeractor) ), Thermoanaerobacter kivui, Thermoanaerobacter siderophilus, Thermoanaerobacter sulfurophilus, Thermocoper thermobacter thermothermobacter thermobacter thermobacter thermobacter thermobacter , Thermone Robacter Wiegeri Examples thereof include bacteria belonging to the genus Thermoanaerobacter such as Thermoanaerobacter wiegelii.
The composition of the present invention shows a good bactericidal effect not only on these vegetative cells but also on spores.

  The composition of the present invention is used to wash clothes such as lab coats, uniforms, hats, and linens that are worn or used in places or facilities where bacterial spores may exist, such as hospitals, hotels, restaurants, etc. And can be suitably used for sterilization treatment.

The composition of the present invention can be used as it is, or appropriately diluted with water or the like, or dissolved in water or the like for washing and sterilizing treatment of clothes or linens. The composition of the present invention is one or more selected from the group consisting of polyalkylene biguanide compounds and salts thereof, and one or more selected from the group consisting of nonionic surfactants and amphoteric surfactants. Two or more types, or one or more types of quaternary ammonium salts, and one or more types of alcohols are used as final concentrations when used for washing and sterilizing clothes and linens, Each of the above ranges is prepared, and the pH is adjusted to 12.5 or more with an alkali agent.
When the composition of the present invention is a liquid composition, it is selected from the group consisting of a polyalkylene biguanide compound and a salt thereof in consideration of handling property, efficiency, etc. in washing and sterilization treatment of clothes or linens. Concentration containing one or more species, and one or more components selected from the group consisting of nonionic surfactants and amphoteric surfactants, each at a concentration of 10 times or more of the final concentration It is preferable to prepare the prepared composition and dilute it with water at the time of use.
For such a concentrated composition, from the viewpoint of stability and the like, a composition containing a component other than an alkaline agent and a composition containing an alkaline agent may be prepared separately and mixed and used at the time of use. preferable.

Washing and sterilization treatment of clothing or linens may be performed by immersing clothing or linens in the composition of the present invention or a dilution thereof, stirring, etc. You may spray on clothes and linens.
In addition, the treatment time of clothing or linens with the composition of the present invention may be relatively short, and a sufficient cleaning and sterilizing effect can be obtained in about 5 to 60 minutes.
Particularly, in the case of a composition containing a quaternary ammonium salt and / or an alcohol in addition to one or more selected from the group consisting of a polyalkylene biguanide compound and a salt thereof and an alkali agent, 5 minutes to 10 minutes. A sufficient bactericidal effect is recognized by the treatment of the degree.

  Hereinafter, the present invention will be described in more detail with reference to examples.

[Examples 1 and 2 and Comparative Example 1] Disinfecting detergent composition for laundry Each component shown in Table 1 was added to and dissolved in ion-exchanged water in turn, and then the laundry disinfecting detergents of Examples 1 and 2 and Comparative Example 1 were used. An agent composition was prepared. About each washing | cleaning disinfecting | cleaning detergent composition, pH in 25 degreeC was measured and the measurement result was combined with Table 1 and shown.

[Test Example 1] Evaluation of bactericidal effect on bacterial spores (1) Test spores Bacillus cereus ATCC 14579 was cultured in liquid bouillon medium for 24 hours, then smeared on a standard agar medium of 1/2 concentration, and polarized light microscope ("ECLIPSE E600", manufactured by Nikon Corporation) was cultured for 2 to 3 weeks until spore formation was confirmed in 90% or more of the observed bacteria. Next, add cold sterilized water to the medium, collect colonies on the surface of the medium with a conical rod, centrifuge and wash with cold sterilized water several times, heat-treat at 80 ° C. for 10 minutes, rapidly cool with ice water, and then add several After centrifugal washing, the number of spores was adjusted to 10 ⁷ to 10 ⁸ Colony Forming Unit (CFU) / mL, and stored frozen.

(2) Preparation of test cloth 5 g of polysorbate 80 and 5 g of sodium carbonate were dissolved in water, diluted to 1000 mL, and used as a wetting agent. 2.5 mL of this wetting agent and 2.5 g of sodium carbonate were dissolved in water to prepare a 5 L cleaning solution.
Cotton cloth (Kanakin No. 3) was placed in 4-5 L of the above washing solution and boiled for 1 hour. In order to remove a trace amount of wetting agent, the water was changed and the mixture was boiled for about 5 minutes. Further, the mixture was stirred for about 5 minutes with 5 L of cold water and then naturally dried.
The dried cotton cloth was cut into a size of 2 cm × 2 cm, sterilized in an autoclave at 121 ° C. for 20 minutes, and then dried in a dryer to obtain a test cloth.

(3) Test method The test spore was suspended in sterilized water so as to be 10 ⁷ CFU / mL to obtain a test spore suspension.
Place 5 test cloths on the plastic petri dish so that they do not overlap, inoculate 0.02 mL of the test spore suspension on each test cloth, close the lid of the plastic petri dish, and let stand in a thermostat at 35 ° C for 1 hour. And the test cloth was allowed to dry.
Next, each sterilizing detergent composition of Examples 1 and 2 and Comparative Example 1 was used as a test solution, and the above five test cloths were placed in 20 mL of each test solution and slowly stirred (at 300 rpm) at 40 ° C. For 10 minutes.
After the above treatment, the test cloth is taken out from each test solution, placed in 20 mL of lecithin polysorbate 80 added soy bean casein digest (SCDLP) broth in a container with a lid, and stirred for 1 minute. A 10-fold serial dilution of the stirring solution was performed. Each 0.1 mL of this serial dilution was smeared on a SCDLP agar plate and cultured at 35 ° C. for 48 hours.
After culturing, the number of colonies grown on the medium was measured, and the number of viable bacteria present on the test cloth treated with each bactericidal detergent composition was calculated.
As a control, 0.05 (w / v)% polysorbate 80 aqueous solution was used and treated in the same manner.
Difference (Δlog ₁₀ CFU) between the viable cell count (logarithmic value) when treated with each of the bactericidal detergent compositions of Examples 1 and 2 and Comparative Example 1 and the viable cell count (logarithmic value) when treated with the control / Test cloth). In this test, it was evaluated that there was a bactericidal effect on bacterial spores when Δlog ₁₀ CFU / test cloth was 2.0 or more.

  The results of the above test are also shown in Table 1.

As shown in Table 1, in the bactericidal detergent compositions of Examples 1 and 2, Δlog ₁₀ CFU / test cloth value was obtained by treating bacterial spores of the test bacteria inoculated on the test cloth at 40 ° C. for 10 minutes. Was 2 or more, and a bactericidal effect was recognized.
On the other hand, in the bactericidal detergent composition of Comparative Example 1, Δlog ₁₀ CFU / test cloth value was 0.2, and no bactericidal effect on bacterial spores was observed.

As described above in detail, the present invention has an excellent bactericidal effect on bacterial spores without using oxides such as sodium hypochlorite and peracetic acid, there is no risk of damaging the fibers, safety and It is possible to provide a sterilizing detergent composition for laundry having excellent handleability.
The sterilizing detergent composition for laundry of the present invention exhibits good cleaning and sterilizing effects in a short time treatment, has little risk of damaging fibers, and is worn in hospitals, hotels, restaurants and the like, It is useful in the field of laundry for business use such as linens used in the facility.

Claims (8)

One or more selected from the group consisting of a polyalkylene biguanide compound represented by formula (1) and a salt thereof, an alkali agent, and a group consisting of a nonionic surfactant and an amphoteric surfactant A sterilizing detergent composition for laundry, containing one or more kinds, wherein the composition has a pH of 12.5 or more.
[Wherein, R ^a represents an alkylene group having 2 to 8 carbon atoms, and n represents an integer of 2 to 18]. ]   The 1 type (s) or 2 or more types selected from the group which consists of a polyalkylene biguanide compound and its salt are 1 type (s) or 2 or more types selected from the group which consists of a polyhexamethylene biguanide and its salt. Sterilizing detergent composition.   Furthermore, the disinfectant | cleaner cleaning composition of Claim 1 or 2 containing the 1 type (s) or 2 or more types of a quaternary ammonium salt.   Furthermore, the bactericidal cleaning composition of any one of Claims 1-3 containing 1 type, or 2 or more types of alcohol.   The sterilizing detergent composition according to claim 4, wherein one or more of the alcohols are one or more selected from the group consisting of alkanols having 5 to 10 carbon atoms, terpene alcohols and aromatic alcohols. object.   Nonionic surfactant is glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene alkyl ether, The sterilizing detergent composition according to any one of claims 1 to 5, which is selected from the group consisting of fatty acid polyethylene glycol, fatty acid polyoxyethylene sorbitan, fatty acid alkanolamide, alkyl glucoside and acyl glucamide.   Amphoteric surfactants are alkyl betaine type surfactants, aminocarboxylic acid type surfactants, alkylamidopropyl betaine type surfactants, alkyl sulfobetaine type surfactants, imidazoline type surfactants and alkylamine oxide type surfactants. The sterilizing detergent composition according to any one of claims 1 to 6, which is selected from the group consisting of agents.   The disinfectant cleaning composition according to any one of claims 1 to 7, which is intended for bacterial spores.