JP6957136B2 - Disinfectant detergent composition for laundry - Google Patents

Description

The present invention relates to a bactericidal cleaning agent composition for laundry, which has an excellent cleaning effect on clothes and linens and also has an excellent bactericidal effect not only on vegetative bacteria but also on bacterial spores.

In hospitals, hotels, restaurants, etc., clothing such as lab coats, uniforms, and hats worn in the facility, towels, sheets, pillowcases, etc. used in the facility (hereinafter referred to as "linens") become microorganisms. When contaminated, problems such as nosocomial infections and food poisoning may occur, so hygienic conditions are always required. Therefore, in the field of commercial laundry such as commercial cleaning and linen supply, which cleans worn clothes and used linens, not only cleaning but also sterilization and removal of microorganisms attached to fibers are performed. At that time, hot water at 80 ° C. or higher, sodium hypochlorite, peracetic acid and the like are used.

However, among the microorganisms attached to clothing and linens, bacterial spores have high resistance to heat and chemical substances, and their sterilization and removal are particularly difficult. Of the above sterilization and sterilization treatments, hot water at 80 ° C has almost no effect on bacterial spores, and sodium hypochlorite and peracetic acid have some effect, but there are the following problems in use. be.
Sodium hypochlorite is highly corrosive and can damage fibers, and peracetic acid is an extremely powerful disinfectant and is widely effective against bacterial spores, but it has a pungent odor and skin irritation. It is not suitable for the human body due to the problem of, so care must be taken when handling it.

Furthermore, it is necessary to use a considerable amount of detergent component for cleaning clothes and linens, and the detergent component interacts with the sterilizing / disinfecting agent component used in combination to sterilize / disinfect. The activity or stability of the disinfectant component may decrease, or the detergency of the detergent component may decrease.

Under these circumstances, the search for a composition that has a bactericidal effect on bacterial blasts and can be used more safely is being pursued. Polyhexamethylene guanidine salt, a natural alcohol-based nonionic surfactant, and fatty acid alkylolamide ethylene oxide are being sought. A disinfectant cleaning agent using an adduct or an enzyme (Patent Document 1), a polyhexamethylene guanidine salt, a silicate, an alkylene oxide adduct of a secondary alcohol having 12 to 24 carbon atoms, and a sixth to 8 carbon atoms. It is disclosed that a bactericidal cleaning agent composition containing an alkylene oxide adduct of a primary alcohol (Patent Document 2) has a bactericidal effect on heat-resistant blast-forming bacteria.
In addition, the spores of Bacillus subtilis and Sporogenes can be reduced by treating the surface at 30 ° C. to 80 ° C. with a composition containing a high concentration of quaternary ammonium salt in excess of 1% by weight (Patent). Document 3) and a method for sterilizing bacterial spores (Patent Document 4) in which a solution of a dimer-type bis quaternary ammonium salt is brought into contact with each other while being heated or irradiated with ultrasonic waves are also disclosed.

However, the sterilizing effect of the sterilizing cleaning agent described in Patent Document 1 is that a certain amount of test bacteria is inoculated into a medium containing an appropriately diluted test drug and cultured at 37 ° C. for 18 to 20 hours. It was evaluated based on whether or not the growth of the test bacteria was observed, and the bactericidal effect of the bactericidal cleaning agent composition described in Patent Document 2 was formed by culturing the bactericidal bacteria in SCD agar medium at 35 ° C. for 24 hours. Since it is evaluated using a bacterial solution prepared by collecting bacterial cells from a colony, is the sterilizing effect or bactericidal effect shown in the examples of these patent documents an effect on bacterial blasts or an effect on vegetative bacteria? It is not clear what it is.
Further, the treatment or sterilization method described in Patent Document 3 or Patent Document 4 requires the addition of heating or ultrasonic treatment, and is efficient for use in commercial laundry for treating a large amount of clothes and linens. It is hard to say that it is a good method.

Japanese Unexamined Patent Publication No. 2002-047111 JP-A-2009-108184 Special Table 2008-504910 Japanese Unexamined Patent Publication No. 10-295785

Therefore, there is a demand for a bactericidal detergent composition for washing, which has excellent detergency, is safe for the human body, and is highly effective against bacterial spores.
Therefore, the present invention provides a bactericidal cleaning agent composition for laundry, which has an excellent bactericidal effect on bacterial spores and is excellent in safety and handleability without using oxides such as sodium hypochlorite and peracetic acid. The purpose is to provide.

As a result of diligent studies to solve the above problems, the present inventors have found a polyalkylene biguanide compound such as polyhexamethylene biguanide (PHMB) or a salt thereof, which does not show a bactericidal effect on bacterial spores by itself, and an alkaline agent. By using in combination and setting the pH of the composition to 12.5 or higher, a bactericidal effect on bacterial spores of the genus Bacillus can be obtained, and by further adding a quaternary ammonium salt and / or alcohol, it can be applied to bacterial spores. It was found that the bactericidal effect was improved.
When one or more selected from the group consisting of nonionic surfactants and amphoteric surfactants is used as the cleaning agent component, the effect on the bactericidal activity and stability of the bactericidal agent component is small. In addition, they have found that they are excellent in detergency, and have completed the present invention.

That is, the present invention relates to the following [1] to [8].
[1] From the group consisting of one or more selected from the group consisting of the polyalkylene biguanide compound represented by the formula (1) and a salt thereof, an alkaline agent, and a nonionic surfactant and an amphoteric surfactant. A laundry sterilizing detergent composition containing one or more selected species and having a composition pH of 12.5 or higher.

Wherein, ^{R a} is an alkylene group having 2 to 8 carbon atoms, n is an integer of 2 to 18. ]
[2] One or more selected from the group consisting of a polyalkylene biguanide compound and a salt thereof is one or two or more selected from the group consisting of a polyhexamethylene biguanide and a salt thereof. 1] The sterilizing detergent composition according to.
[3] The bactericidal detergent composition according to the above [1] or [2], which further contains one or more of quaternary ammonium salts.
[4] The bactericidal detergent composition according to any one of the above [1] to [3], which further contains one or more alcohols.
[5] The above-mentioned [4], wherein one or more of the alcohols is one or more selected from the group consisting of alkanols having 5 to 10 carbon atoms, terpene alcohols and aromatic alcohols. Bactericidal cleaning agent composition.
[6] Non-ionic surfactants include glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene. The bactericidal cleaning agent composition according to any one of the above [1] to [5], which is selected from the group consisting of alkyl ether, fatty acid polyethylene glycol, fatty acid polyoxyethylene sorbitan, fatty acid alkanolamide, alkyl glucoside and acyl glucamide.
[7] Amphoteric surfactants are alkylbetaine-type surfactants, aminocarboxylic acid-type surfactants, alkylamide propylbetaine-type surfactants, alkylsulfobetaine-type surfactants, imidazoline-type surfactants and alkylamine oxides. The bactericidal cleaning agent composition according to any one of the above [1] to [6], which is selected from the group consisting of type surfactants.
[8] The bactericidal detergent composition according to any one of the above [1] to [7], which targets bacterial spores.

The bactericidal cleaning agent composition for laundry of the present invention has excellent detergency on clothes and linens, and also exhibits a good bactericidal effect on bacterial spores, which was ineffective with conventional bactericidal and sterilizing agents, and has an adverse effect on fibers. It is useful in the field of commercial laundry because it has few spores and is excellent in safety and handleability.

The laundry sterilizing detergent composition of the present invention (hereinafter, also simply referred to as "composition of the present invention" in the present specification) is one or two selected from the group consisting of a polyalkylene biguanide compound and a salt thereof. As described above, one or more selected from the group consisting of an alkaline agent and a nonionic surfactant and an amphoteric surfactant is contained, and the pH of the composition is adjusted to 12.5 or more.

The polyalkylene biguanide compound used in the present invention is represented by the following formula (1).

Wherein, ^{R a} is an alkylene group having 2 to 8 carbon atoms, n is an integer of 2 to 18. ]

In the above formula (1), ^{the alkylene group having 2 to 8 carbon atoms represented by Ra} includes ethylene, propylene, butylene, pentylene, hexylene (hexamethylene), heptylene (heptamethylene), octylene (octamethylene) and the like. In addition to linear ones, branched ones such as isopropylene, isobutylene, isopentylene, dimethylpropylene, and dimethylbutylene are also included, but linear alkylene groups are preferable. Further, from the viewpoint of the bactericidal effect on bacterial spores, an alkylene group having 4 to 8 carbon atoms is preferable, and a hexamethylene group is particularly preferable. In addition, n in the formula (1) is 2 to 18, and in consideration of a bactericidal effect on bacterial spores, handleability and the like, the n is preferably 10 to 14 and more preferably 11 to 13.

The polyalkylene biguanide compound represented by the formula (1) can also be used in the form of a salt with an inorganic acid such as hydrochloric acid, nitric acid or sulfuric acid, or a salt with an organic acid such as acetic acid, lactic acid or gluconic acid. Among such salts, hydrochlorides, acetates and gluconates are preferable, and hydrochlorides are most preferably used. For the composition of the present invention, one or more selected from the group consisting of the polyalkylene biguanide compound represented by the formula (1) and a salt thereof is used.

In the present invention, the polyalkylene biguanide compound or a salt thereof is a known compound, and a compound produced according to a known method, for example, the method described in British Patent No. 702,268, etc. can be used, but it is commercially available. The product may be used. Examples of commercially available products include "Eccrine Side BG" (manufactured by Riko Kyosan Co., Ltd.), "Proxel IB" (manufactured by Arch Chemicals Co., Ltd.), and "Lonza Back BG" (manufactured by Lonza Japan Co., Ltd.).

In the composition of the present invention, one or more selected from the group consisting of the above polyalkylene biguanide compound and a salt thereof has a concentration of usually 0 in the composition finally used for sterilization and washing. It is contained in an amount of 0.001% by mass to 0.2% by mass, preferably 0.003% by mass to 0.1% by mass, and more preferably 0.005% by mass to 0.05% by mass.

The alkaline agent contained in the composition of the present invention may be any one as long as the pH of the composition can be adjusted to 12.5 or higher, and the hydroxide of an alkali metal such as lithium hydroxide, sodium hydroxide, or potassium hydroxide is hydroxylated. Strongly basic inorganic bases such as hydroxides of alkaline earth metals such as calcium hydroxide, strontium hydroxide and barium hydroxide, and alkali metal salts of metasilicates such as sodium metasilicate and potassium metasilicate are preferable. , Sodium hydroxide, potassium hydroxide and sodium metasilicate are more preferred.
As the alkaline agent, commercially available products provided by each company can be used.

Further, the composition of the present invention preferably comprises one or more selected from the group consisting of a polyalkylene biguanide compound and a salt thereof, an alkaline agent, and a group consisting of a nonionic surfactant and an amphoteric surfactant. In addition to one or more selected from the above, it further contains a quaternary ammonium salt and / or an alcohol.
The composition of the present invention has an improved bactericidal effect and can exert an effective bactericidal effect on bacterial spores by a short treatment time of 5 to 10 minutes.

The quaternary ammonium salt used in the present invention can be well mixed with the composition of the present invention together with the above polyalkylene biguanide compound or a salt thereof, the above alkali agent, and the surfactant described below, or further with the following alcohol. It can be used without particular limitation as long as it can improve the bactericidal effect on bacterial spores by using it together with the above-mentioned components. For example, a quaternary ammonium salt represented by the following formula (2) or the following can be used. Examples thereof include a quaternary ammonium salt having a pyridinium ring represented by the formula (3).

[In the formula, R ^{1 to} R ⁴ are the same or different and represent an alkyl group, an aryl group or an aralkyl group, and A ₁ ⁻ represents an inorganic or organic anion. ]

Wherein, R ⁵ represents an alkyl group, A ₂ ^- indicates a inorganic or organic anion. ]

In the above formula (2), ^{examples of the alkyl group represented by R 1} , R ² , R ³ or R ⁴ include an alkyl group having about 1 to 18 carbon atoms, and examples of the aryl group include 6 to 12 carbon atoms. Aryl groups of about 7 to 12 can be mentioned as the aralkyl group.
Alkyl groups having about 1 to 18 carbon atoms include methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl (lauryl), tetradecyl (myristyl), hexadecyl (palmityl), and octadecyl. Linear alkyl groups such as (stearyl), 2-propyl (isopropyl), 1-methylpropyl (sec-butyl), 2-methylpropyl (isobutyl), 1,1-dimethylethyl (tert-butyl), 3 -Methylbutyl (isopentyl), 4-methylpentyl (isohexyl), 1-methylheptyl (sec-octyl), 6-methylheptyl (isooctyl), 1,1-dimethylhexyl, 2-ethylhexyl, 1-methyltridecyl, 12 Examples thereof include branched alkyl groups such as −methyltridecyl (isomyristyl), 1-methylpentadecyl, 14-methylpendadecyl (isopalmityl), 1-methylheptadecyl and 16-methylheptadecyl (isostearyl). , The alkyl group is substituted with an amino group, an alkylamino group, an alkaloylalkylamino group, a phenylcarbamoyl group, an alkoxy group, an aryloxy group (phenoxy group, etc.), an alkoxy group substituted with an alkylphenoxy group, or the like. Also included.
Examples of the aryl group having about 6 to 12 carbon atoms include phenyl, methylphenyl (trill) and naphthyl, and examples of the aralkyl group having about 7 to 12 carbon atoms include phenylmethyl (benzyl) and phenylethyl (phenethyl). ) Etc. can be mentioned.

In the above formula (2), _{examples of the inorganic or organic anion represented by A 1} ⁻ include halogen ion, inorganic acid ion, organic acid ion and the like.
Examples of the halogen ion include chlorine ion, bromine ion, iodine ion and the like. Examples of the inorganic acid ion include hydrochloric acid ion, nitrate ion, sulfate ion, phosphate ion and the like. Examples of the organic acid ion include alkyl sulfate ester ions having about 1 to 3 carbon atoms such as methyl sulfate ion; monocarboxylic acid ions having about 2 to 6 carbon atoms such as acetate ion, propionate ion, butyrate ion, and caproate ion; Hydroxycarboxylic acid ions having about 3 to 6 carbon atoms such as lactate ion, malate ion, citric acid ion; carbons such as oxalate ion, malonate ion, succinate ion, fumarate ion, maleate ion, adipate ion, etc. Examples thereof include dicarboxylic acid ions of several 2 to 6.
Of these, halogen ion, sulfate ion, alkyl sulfate ion, and dicarboxylic acid ion are preferable, and chlorine ion, bromine ion, and adipate ion are particularly preferable.

As the quaternary ammonium salt represented by the above formula (2), R ^{1 in} the formula is an alkyl having 8 to 18 carbon atoms, and R ² , R ³ and R ⁴ are the same or different, and have 1 to 4 carbon atoms. Alkyl ammonium salt; an alkyl having 8 to 18 carbon atoms, having the same or different ^{R 1} and R ^{2 in the formula, and having the same or different carbon atoms to R 3} and R ⁴ having 1 to 4 carbon atoms. ; and alkyl R ¹ in the formula is substituted benzyl, phenoxyalkyl or phenylcarbamoyl alkyl, R ² is alkyl having 8 to 18 carbon atoms, a phenoxy group or an alkoxy group substituted by an alkyl phenoxy group, or alk, Loylalkylaminoalkyls, R ³ and R ⁴ are the same or different, preferably ammonium salts that are alkyl with 1 to 4 carbon atoms, with R ¹ and R ² in the formula being the same or different and having 8 to 18 carbon atoms. Alkyl, R ³ and R ⁴ are the same or different, ammonium salts that are alkyl with 1 to 4 carbons; R ¹ is benzyl, R ² is alkyl with 8 to 18 carbons, R ³ and R ⁴ are the same or different. An ammonium salt which is an alkyl having 1 to 4 carbon atoms; and an alkyl substituted with an alkoxy group in which ^{R 1} is benzyl and R ^{2 is substituted with an alkylphenoxy group, and R 3} and R ⁴ are the same or different carbons. Ammonium salts which are alkyls of numbers 1 to 4 are more preferable.

Preferable specific examples of the quaternary ammonium salt represented by the above formula (2) include hexadecyltrimethylammonium salt <cetrimonium salt>, didecyldimethylammonium salt, alkyldimethylbenzylammonium salt <benzalconium salt>, and the like. N, N-dimethyl-N- [2- [2- [4- (1,1,3,3-tetramethylbutyl) phenoxy] ethoxy] ethyl] benzenemethaneammonium salt <benzethonium salt>, methylbenzethonium salt, dodecyl Examples thereof include dimethyl (2-phenoxyethyl) ammonium salt <domiphen salt>, [2- (lauroylmethylamino) ethyl] dimethyl (phenylcarbamoylmethyl) ammonium salt <dofanium salt> and the like.

In the above formula (3), the alkyl group represented by ^{R 5,} include alkyl groups having 8 to 18 carbon atoms, octyl, decyl, dodecyl (lauryl), tetradecyl (myristyl), hexadecyl (palmityl or cetyl), A linear alkyl group such as octadecyl (stearyl) is preferable, and dodecyl (lauryl) and hexadecyl (palmityl or cetyl) are particularly preferable.
Further, in the above formula (3), the _{inorganic or organic anion represented by A 2} ⁻ is a halogen ion, an inorganic acid ion, or an organic acid similar to the anion represented by _{A 1} ⁻ in the above formula (2). Examples thereof include halogen ion, sulfate ion, alkyl sulfate ion and dicarboxylic acid ion, and chlorine ion, bromine ion and adipate ion are particularly preferable.

In the present invention, one or more of the quaternary ammonium salts represented by the above formulas (2) and (3) can be selected and used.
Suitable quaternary ammonium salts include didecyldimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetrimonium bromide, domiphen bromide, dofanium chloride, laurylpyridinium chloride, cetylpyridinium chloride and the like. Among these, didecyldimethylammonium chloride, benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride are more preferable, and didecyldimethylammonium chloride is particularly preferable.

The quaternary ammonium salt used in the composition of the present invention can be produced and used according to a known method, but "Cotamin D86P", "Cotamin D2345P" (all manufactured by Kao Co., Ltd.), "Hyamine". ) 1622 ”,“ Hyamine 3500J ”,“ Bardac 2250 ”,“ Bardac 2280 ”(manufactured by Lonza Japan Co., Ltd.),“ Kachiogen DDM-PG ”,“ Kachiogen SV ”,“ Kachiogen BC50 (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.), "Cation DDC-50", "Osmorin DA-50", "Cation G-50" (manufactured by Sanyo Kasei Kogyo Co., Ltd.), "Osban S" (Nippon Pharmaceutical Co., Ltd.) Commercially available products such as "Cetylpyridinium Chloride (CPC)" (manufactured by Wako Pure Chemical Industries, Ltd.) can also be used.

In the composition of the present invention, one or more of the quaternary ammonium salts are usually 0.001% by mass to 0.5% by mass in terms of the concentration in the composition finally used for sterilization / washing. %, preferably 0.001% by mass to 0.2% by mass, more preferably 0.01% by mass to 0.1% by mass.

As the alcohol used in the composition of the present invention, the polyalkylene biguanide compound or a salt thereof, the alkaline agent, and the surfactant described later, or further together with the quaternary ammonium salt, are favorably used in the composition of the present invention. It can be mixed without particular limitation as long as it can be used together with the above-mentioned components to improve the bactericidal effect on bacterial spores, and examples thereof include alkanol, terpene alcohol, and aromatic alcohol.

Examples of the alkanol include linear or branched monovalent alkanols and alkanediols, and alkanols having 5 to 10 carbon atoms are preferable.
Examples of the linear or branched monovalent alkanol having 5 to 10 carbon atoms include pentanol, hexanol, heptanol, octanol, 2-ethylhexanol, nonanol, decanol and the like, and linear monovalent alkanol having 5 to 8 carbon atoms. Is more preferable, and linear monovalent alkanol having 5 to 7 carbon atoms is particularly preferable.
Examples of the alkanediol having 5 to 10 carbon atoms include 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, and 1,2-decanediol, which have 5 carbon atoms. 10, 1,2-alkanediol is more preferable.

Terpene alcohols include monoterpene alcohols such as geraniol, citronerol, terpinen-4-ol, nerol, menthol, lavageroll, linarol, tujol, and borneol, sesquiterpene alcohols such as guaiol, santalol, nerolidol, and bisabolol, and sclareol. , Diterpene alcohol such as phytol is preferable.

Examples of the aromatic alcohol include alcohols having a hydroxyl group that does not directly bond to the aromatic ring such as a benzene ring, for example, benzyl alcohol, salicyl alcohol, cinnamyl alcohol, vanillyl alcohol and the like. The object of the present invention is phenyl. , Alkanol substituted with an aryl group such as naphthyl, or an aryloxy group such as phenoxy or naphthoxy is preferable, and an alkanol having 1 to 3 carbon atoms substituted with the aryl group or the aryloxy group is more preferable, and phenylmethanol (benzyl). Alcohol), 2-Phenylethanol (Phenylalcohol), 1-Phenylethanol, 2-Phenyl-1-propanol, 3-Phenyl-1-propanol, 2-Phenylethanol, 3-Phenyloxypropanol and other phenyl or phenoxy groups Alkanol with 1 to 3 carbon atoms is particularly preferable.

In the present invention, one or more of the above-mentioned alcohols and the like can be used.
From the viewpoint of bactericidal effect on bacterial blasts, alkanols having 5 to 10 carbon atoms, terpene alcohols and aromatic alcohols are preferable, and they are substituted with monohydric alkanols having 5 to 7 carbon atoms, monoterpene alcohols, and phenyl groups or phenoxy groups. Alcanol having 1 to 3 carbon atoms is more preferable, 2-phenylethanol, 2-phenyl-1-propanol, 3-phenyl-1-propanol, 2-phenoxyethanol and the like are more preferable, 2-phenylethanol and 3-phenyl. -1-propanol is most preferred.

In the composition of the present invention, the alcohol can be produced and used according to a known method, but commercially available products provided by each company can also be used.

In the composition of the present invention, one or more of the above alcohols has a concentration of usually 0.02% by mass to 5% by mass, preferably 0, in terms of the concentration in the composition finally used for sterilization / washing. It is contained in an amount of 0.05% by mass to 2% by mass, more preferably 0.2% by mass to 1% by mass.

Examples of the nonionic surfactant used in the composition of the present invention include glycerin fatty acid ester (for example, glyceryl stearate, glyceryl oleate, etc.) and sucrose fatty acid ester (for example, sucrose lauric acid ester, sucrose myristic acid ester). , Sucrose palmitate, etc.), sorbitan fatty acid esters (eg, sorbitan laurate, sorbitan stearate, sorbitan isostearate) and other ester-type surfactants; polyoxyethylene alkyl ethers (eg, polyoxyethylene lauryl ether, poly). Oxyethylene cetyl ether, polyoxyethylene isostearyl ether, etc.), polyoxyethylene alkylphenyl ether (eg, polyoxyethylene nonylphenyl ether, etc.), polyoxyethylene polyoxypropylene glycol (eg, polyoxyethylene (160) polyoxy) Ether-type surfactants such as propylene (30) glycol), polyoxyethylene polyoxypropylene alkyl ether (eg, polyoxyethylene polyoxypropylene lauryl ether); fatty acid polyethylene glycol (eg, polyethylene glycol stearate, polyethylene dilaurate). Ester ether type surfactants such as (glycol, etc.), fatty acid polyoxyethylene sorbitan (eg, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monooleate, etc.); fatty acid alkanolamide (eg, polyoxyethylene sorbitan). Alkanolamide-type surfactants such as coconut oil fatty acid diethanolamide, lauric acid diethanolamide, stearic acid monoethanolamide, etc .; for example, alkyl glucoside-type surfactants such as decyl glucoside, lauryl glucoside, myristyl glucoside; for example, octanoyl. Examples thereof include acyl glucamide-type surfactants such as -N-methylglucamide and coconut oil fatty acid acylmethylglucamide.

Examples of the amphoteric surfactant used in the composition of the present invention include alkyls such as N, N-dimethyl-N-alkyl-N-carboxymethylammonium betaine (for example, lauryldimethylaminoacetic acid betaine, stearyldimethylaminoacetic acid betaine, etc.). Betain type surfactant; Aminocarboxylic acid type such as N-acyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine (for example, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, etc.) Surfactants: Alkylamide propylbetaine-type surfactants such as lauric acid amide propyl betaine and coconut oil fatty acid amide propyl betaine; N, N, N-trialkyl-N-sulfoalkylene ammonium betaine (eg, lauryl hydroxysulfobetaine, etc.) ) And the like; imidazoline type surfactants such as 2-alkyl-1-hydroxyethyl-1-carboxymethylimidazolinium betaine; N, N-dimethylalkylamine = N-oxide (eg, for example). Alkylamine oxide-type surfactants such as lauryldimethylamine N-oxide, oleyldimethylamine N-oxide, etc.) are exemplified.

In the present invention, the nonionic surfactant and the amphoteric surfactant as described above can be used alone or in combination of two or more.
Further, the nonionic surfactant and the amphoteric surfactant as described above may be prepared and used by a production method known per se, but products commercially available as detergent components from each company can be used.

The composition of the present invention from the viewpoint of the cleaning effect on clothes and linens, and the effect on the bactericidal component such as one or more selected from the group consisting of the polyalkylene biguanide compound and its salt, and the quaternary ammonium salt. Detergent components contained in the product include nonionic surfactants such as polyoxyethylene alkyl ether and polyoxyethylene polyoxypropylene alkyl ether, and amphoteric surfactants such as N, N-dimethylalkylamine = N-oxide. Is preferable, and polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, and the like are more preferable.

In the composition of the present invention, one or more selected from the group consisting of nonionic surfactants and amphoteric surfactants are set to the concentrations in the composition finally used for sterilization / washing. It is usually contained in an amount of 0.001% by mass to 0.5% by mass, preferably 0.003% by mass to 0.2% by mass, and more preferably 0.005% by mass to 0.1% by mass.

The pH of the composition of the present invention is adjusted to be 12.5 or higher, and more preferably 13 or higher.
When the pH of the composition of the present invention is 12.5 or more, an effective bactericidal effect on bacterial spores is recognized in a treatment time of about 60 minutes, and clothes and linens are efficiently sterilized and washed. be able to.
The pH of the composition of the present invention is 14 or less, preferably 13.5 or less from the viewpoint of the stability of the composition.

The pH of the composition of the present invention conforms to the Japanese Industrial Standards (JIS) K 3362: 2008 "8.3 pH value" or the pharmaceutical non-medicinal product raw material standard 2006 "General test method 55. pH measurement method". Be measured.
When the composition of the present invention is provided in a highly viscous form such as a paste described later, or in a solid form such as a gel, the electrode of a pH meter is provided at, for example, 25 ° C. Is measured by directly piercing or pressing the sample. When the composition of the present invention is provided in the form of powder, granules, etc., for example, the composition is suspended in purified water at a general usage concentration and measured at 25 ° C.

The composition of the present invention is selected from the group consisting of one or more selected from the group consisting of the above-mentioned polyalkylene biguanide compound and salts thereof, an alkaline agent, and a nonionic surfactant and an amphoteric surfactant. In addition to one or more, or more quaternary ammonium salts and / or alcohols, optionally with additives commonly used in detergent compositions, liquid, suspension, It can be provided in various forms such as emulsion, paste, gel, powder and granules.

Examples of the additive component include a water softener (for example, aluminosilicate, polycarboxylic acid salt, etc.), a chelating agent (for example, sodium ethylenediamine tetraacetate, tripolyphosphate, hexametaphosphate, sodium citrate, etc.), and a dispersant (for example, sodium citrate). , Polyethylene glycol, sodium carboxymethyl cellulose, hydroxycellulose, sodium polyacrylate, etc.), foam modifiers (eg, soap, silicone oil, etc.), solvents (eg, butyl carbitol, 3-methoxy-3-methylbutanol, etc.), Stabilizers (eg, ethanol, etc.), enzymes (eg, proteases, lipases, amylases, cellulase, etc.), fluorescent whitening agents (eg, bis (triazinylamide) stylbenzisulfonic acid, etc.) and the like can be mentioned. One type or two or more types can be used as long as the characteristics of the above are not impaired.

Further, the composition of the present invention may contain general antibacterial components such as chlorhexidine gluconate and alkyldiaminoethylglycine hydrochloride as long as the characteristics of the present invention are not impaired.
Further, pigments, fragrances and the like can also be used for the purpose of coloring, flavoring and the like.

From the viewpoint of efficiently washing and sterilizing a large amount of clothes and linens in a short time, the composition of the present invention is preferably a liquid composition.
The liquid composition of the present invention is nonionic with one or more selected from the group consisting of the above-mentioned polyalkylene biguanide compound and salts thereof, an alkaline agent, or a quaternary ammonium salt and / or alcohol. One or more selected from the group consisting of surfactants and amphoteric surfactants may be dissolved or suspended in a solvent, and if necessary, prepared by adding the above-mentioned general additive components. It can be provided by filling a bottle with a weighing cap, a trigger type spray container, a squeeze type or dispenser type pump spray container, or the like.
As the solvent, water (for example, purified water such as distilled water and deionized water); lower alcohol having about 2 to 4 carbon atoms (for example, ethanol, isopropanol, butanol, etc.), and polyhydric having about 2 to 4 carbon atoms. An organic solvent such as alcohol (for example, ethylene glycol, propylene glycol, glycerin, butylene glycol, etc.) can be used, but water or water and the organic solvent are considered in consideration of handleability such as corrosiveness to fibers and economic efficiency. It is preferable to use a mixture with.

The composition of the present invention has an excellent cleaning effect on clothes and linens, and also has an excellent bactericidal effect on bacterial spores.
Examples of spore-forming bacteria include Bacillus anthracis (Bacillus anthracis), Bacillus cereus (Cereus), Bacillus subtilis (Bacillus subtilis), Bacillus coagulans (Bacillus coagulans), and Bacillus coagulans (Bacillus coagulans). Licheniformis), Bacillus megaterium, Bacillus thuringiensis, Bacillus pseudomycoides, and other bacteria belonging to the genus Bacillus, Alicyclobacillus, Alicyclobacillus Bacillus Acidiphilus (Alicyclobacillus acidiphilus), Alicyclobacillus herbarius (Alicyclobacillus herbarius) and other bacteria belonging to the genus Alicyclobacillus, Brevibacillus choshinensis (Brevibacillus choshinensis) etc. Geobacillus thermodenitrificans, Geobacillus caldoxylosilyticus, Geobacillus stearothermophilus, etc. Geobacillus stearothermophilus, etc. Bacteria belonging to the genus Paenibacillus such as Paenibacillus fukuinensis, the genus Sporolactobacillus such as Sporolactobacillus inulinus and Sporolactobacillus laevis. Clostridium tetani (Clostridium tetani), Clostridium botulinum (Clostridium botulinum), Clostridium perfringens (Welsh), Clostridium novyi, Clostridium novyi septicum) (gas necrosis group), Clostridium difficile, Clostridium thermocellum, Clostridium butyricum, Clostridium acetobutylicum, Clostridium acetobutylicum, etc. Clostridium nigrificans, Desulfotomaculum nigrificans, Desulfotomaculum thermoacetoxidans, Desulfotomaculum thermoacetoxidans, Desulfotomaculum thermoacetoxidans, Desulfotomaculum thermobenzoicum subsp. Thermobenzoicum, Desulfotomaculum thermobenzoicum subsp. Thermobenzoicum. subsp. Thermosyntrophicum (Desulfotomaculum thermobenzoicum subsp. Thermosyntrophicum), Desulfotomaculum thermocisternum, Desulfotomaculum thermosapovorans, Desulfotomaculum thermosapovorans Bacteria belonging to the genus Clostridium such as (Desulfotomaculum thermosubterraneum), Moorella thermoacetica, Moorella glycerine (Moorella) Glycerine), Moorella mulderi, Moorella thermoautotrophica and other bacteria belonging to the genus Moorella, Thermoanaerobacter mathranii, Thermoanaerobacter mathranii, Thermoanaerobacter acetoelicus Thermoanaerobacter brockii, Thermoanaerobacter cellulolyticus, Thermoanaerobacter ethanolicus, Thermoanaerobacter ethanolicus, Thermoanaerobacter italicus, Thermoanaerobacter italicus, Thermoanaerobacter Thermoanaerobacter siderophilus, Thermoanaerobacter sulfurophilus, Thermoanaerobacter sulfurophilus, Thermoanaerobacter thermocopriae, Thermoanaerobacter thermohydrosulfuricus, Thermoanaerobacter thermohydrosulfuricus, Thermoanaerobacter thermohydrosulfuricus, Thermoanaerobacter wierimo ) Bacteria belonging to the genus can be mentioned.
The composition of the present invention exhibits a good bactericidal effect not only on these vegetative cells but also on spores.

The composition of the present invention is used for cleaning clothes such as white coats, uniforms, hats, linens, etc., which are worn or used in places or facilities where bacterial spores may be present, such as hospitals, hotels, restaurants, etc. And can be suitably used for sterilization treatment.

The composition of the present invention can be used as it is, or diluted with water or the like as appropriate, or dissolved in water or the like, and used for washing and sterilizing clothes or linens. The composition of the present invention is one or more selected from the group consisting of polyalkylene biguanide compounds and salts thereof, and one or more selected from the group consisting of nonionic surfactants and amphoteric surfactants. Two or more, moreover, one or more quaternary ammonium salts, and one or more alcohols, at the final concentration for use in the washing and sterilization of clothing and linens. Each of these is in the above range, and the pH is adjusted to 12.5 or higher with an alkaline agent.
When the composition of the present invention is a liquid composition, it is selected from the group consisting of a polyalkylene biguanide compound and a salt thereof in consideration of handleability, efficiency and the like in the washing and sterilizing treatment of clothes or linens1 Concentration containing each component such as seeds or two or more, and one or two or more selected from the group consisting of nonionic surfactants and amphoteric surfactants at a concentration of 10 times or more the final concentration, respectively. It is preferable to prepare the prepared composition and dilute it with water or the like at the time of use.
With respect to such a concentrated composition, from the viewpoint of stability and the like, a composition containing a component other than the alkaline agent and a composition containing the alkaline agent may be separately prepared and mixed at the time of use. preferable.

The washing and sterilizing treatment of clothes or linens may be carried out by immersing clothes or linens in the composition of the present invention or a diluted product thereof and stirring or the like. It may be sprayed on clothing or linens.
Further, the treatment time of clothes or linens by the composition of the present invention may be relatively short, and a sufficient cleaning and bactericidal effect can be obtained in about 5 to 60 minutes.
In particular, in a composition containing a quaternary ammonium salt and / or an alcohol in addition to one or more selected from the group consisting of a polyalkylene biguanide compound and a salt thereof and an alkaline agent, 5 minutes to 10 minutes. Sufficient bactericidal effect is recognized by the degree of treatment.

Hereinafter, the present invention will be described in more detail with reference to Examples.

[Examples 1 and 2 and Comparative Example 1] Disinfectant detergent composition for washing Each component shown in Table 1 is sequentially added and dissolved in ion-exchanged water to disinfect and disinfect each component of Examples 1 and 2 and Comparative Example 1. The agent composition was prepared. The pH of each laundry sterilizing detergent composition was measured at 25 ° C., and the measurement results are also shown in Table 1.

[Test Example 1] Evaluation of bactericidal effect on bacterial spores (1) Test spores Bacillus cereus ATCC14579 was cultured in a liquid bouillon medium for 24 hours, smeared on a 1/2 concentration standard agar medium, and subjected to a polarization microscope. Under (“ECLIPSE E600”, manufactured by Nikon Corporation), the cells were cultured for 2 to 3 weeks until spore formation was confirmed in 90% or more of the observed bacteria. Next, cold sterilized water is added on the medium, colonies on the surface of the medium are collected with a spreader, centrifuged with cold sterilized water several times, heat-treated at 80 ° C. for 10 minutes, rapidly cooled with ice water, and then numbered with cold sterilized water. The cells were centrifuged once ^{and prepared so that the number of spores was 10 7} to ⁸ Colony Forming Unit (CFU) / mL, and the cells were stored frozen.

(2) Preparation of test cloth 5 g of polysorbate 80 and 5 g of sodium carbonate were dissolved in water and diluted to 1000 mL, which was used as a wetting agent. 2.5 mL of this wetting agent and 2.5 g of sodium carbonate were dissolved in water to prepare 5 L of a washing solution.
A cotton cloth (Kanakin No. 3) was placed in 4 to 5 L of the above cleaning solution and boiled for 1 hour. In order to remove a trace amount of wetting agent, the water was changed and the mixture was boiled for another 5 minutes. Further, the mixture was stirred with 5 L of cold water for about 5 minutes and then naturally dried.
The dried cotton cloth was cut into a size of 2 cm × 2 cm, sterilized in an autoclave at 121 ° C. for 20 minutes, and then dried in a dryer to obtain a test cloth.

(3) Test Method test spores were suspended in sterilized water such that ¹⁰ 7 CFU / mL, was tested spore suspension.
Place 5 test cloths on a plastic petri dish so that they do not overlap, inoculate 0.02 mL of the test spore suspension per test cloth, close the lid of the plastic petri dish, and leave it in a constant temperature bath at 35 ° C for 1 hour. The test cloth was placed and dried.
Next, each sterilizing detergent composition of Examples 1 and 2 and Comparative Example 1 was used as a test solution, and 5 of the above test cloths were placed in 20 mL of each of the test solutions, and the temperature was 40 ° C. while stirring slowly (at 300 rpm). Was treated for 10 minutes.
After the above treatment, the test cloth was taken out from each test solution, placed in 20 mL of lecithin polysorbate 80-added soybean casein digest (SCDLP) broth in a container with a lid, and stirred for 1 minute. The stirrer was diluted 10-fold in steps. 0.1 mL each of this serial diluent was smeared on a plate of SCDLP agar medium and cultured at 35 ° C. for 48 hours.
After culturing, the number of colonies grown on the medium was measured, and the number of viable bacteria present on the test cloth treated with each disinfectant cleaning agent composition was calculated.
As a control, a 0.05 (w / v)% aqueous solution of polysorbate 80 was used and treated in the same manner.
Difference between the viable cell count (log value) when treated with each of the bactericidal detergent compositions of Examples 1 and 2 and Comparative Example 1 and the viable cell count (log value) when treated with a control (Δlog ₁₀ CFU). / Test cloth) was requested. In this test, when Δlog ₁₀ CFU / test cloth was 2.0 or more, it was evaluated to have a bactericidal effect on bacterial spores.

The results of the above tests are also shown in Table 1.

As shown in Table 1, in the bactericidal detergent compositions of Examples 1 and 2, the bacterial spores of the test bacterium inoculated on the test cloth were treated at 40 ° C. for 10 minutes to obtain Δlog ₁₀ CFU / test cloth value. Was 2 or more, and a bactericidal effect was recognized.
On the other hand, in the bactericidal detergent composition of Comparative Example 1, the Δlog ₁₀ CFU / test cloth value was 0.2, and no bactericidal effect on bacterial spores was observed.

As described in detail above, according to the present invention, there is an excellent bactericidal effect on bacterial spores without using oxides such as sodium hypochlorite and peracetic acid, there is no risk of damaging the fibers, and safety and safety. It is possible to provide a sterilizing and cleaning agent composition for washing, which is excellent in handleability.
The laundry sterilizing detergent composition of the present invention exhibits good cleaning and sterilizing effects in a short time treatment, has less risk of damaging fibers, and is worn in facilities such as hospitals, hotels, restaurants, etc. It is useful in the field of commercial laundry such as linen used in facilities.

Claims (5)

One or more selected from the group consisting of the polyalkylene biguanide compound represented by the formula (1) and a salt thereof, an alkali metal hydroxide, an alkaline earth metal hydroxide and an alkali metal salt of metasilicic acid. One or more selected from the group consisting of, and one selected from the group consisting of polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether and N, N-dimethylalkylamine = N-oxide. A sterilizing and cleaning agent composition for washing, which contains seeds or two or more kinds, and the pH of the composition is 13 or more.

Wherein, ^{R a} is an alkylene group having 2 to 8 carbon atoms, n is an integer of 2 to 18. ] The first aspect of claim 1, wherein one or more selected from the group consisting of a polyalkylene biguanide compound and a salt thereof is one or more selected from the group consisting of a polyhexamethylene biguanide and a salt thereof. Bactericidal detergent composition. The bactericidal detergent composition according to claim 1 or 2, further comprising one or more quaternary ammonium salts. The bactericidal detergent composition according to any one of claims 1 to 3, further comprising one or more alcohols. The bactericidal cleaning agent composition according to claim 4, wherein one or more of the alcohols is one or more selected from the group consisting of alkanols having 5 to 10 carbon atoms, terpene alcohols and aromatic alcohols. thing.