JP2017537899A5 - - Google Patents

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Publication number
JP2017537899A5
JP2017537899A5 JP2017526088A JP2017526088A JP2017537899A5 JP 2017537899 A5 JP2017537899 A5 JP 2017537899A5 JP 2017526088 A JP2017526088 A JP 2017526088A JP 2017526088 A JP2017526088 A JP 2017526088A JP 2017537899 A5 JP2017537899 A5 JP 2017537899A5
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JP
Japan
Prior art keywords
compound
therapeutic agent
dissolution
formula
elution
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JP2017526088A
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English (en)
Japanese (ja)
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JP6829684B2 (ja
JP2017537899A (ja
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Priority claimed from PCT/US2015/061194 external-priority patent/WO2016081523A1/en
Publication of JP2017537899A publication Critical patent/JP2017537899A/ja
Publication of JP2017537899A5 publication Critical patent/JP2017537899A5/ja
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Publication of JP6829684B2 publication Critical patent/JP6829684B2/ja
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JP2017526088A 2014-11-17 2015-11-17 癌を処置する方法 Active JP6829684B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462080985P 2014-11-17 2014-11-17
US62/080,985 2014-11-17
US201562166572P 2015-05-26 2015-05-26
US62/166,572 2015-05-26
US201562251903P 2015-11-06 2015-11-06
US62/251,903 2015-11-06
PCT/US2015/061194 WO2016081523A1 (en) 2014-11-17 2015-11-17 Method for treating cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021008382A Division JP2021073241A (ja) 2014-11-17 2021-01-22 癌を処置する方法

Publications (3)

Publication Number Publication Date
JP2017537899A JP2017537899A (ja) 2017-12-21
JP2017537899A5 true JP2017537899A5 (OSRAM) 2018-12-27
JP6829684B2 JP6829684B2 (ja) 2021-02-10

Family

ID=56014476

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017526088A Active JP6829684B2 (ja) 2014-11-17 2015-11-17 癌を処置する方法
JP2021008382A Pending JP2021073241A (ja) 2014-11-17 2021-01-22 癌を処置する方法
JP2023027585A Active JP7485810B2 (ja) 2014-11-17 2023-02-24 癌を処置する方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021008382A Pending JP2021073241A (ja) 2014-11-17 2021-01-22 癌を処置する方法
JP2023027585A Active JP7485810B2 (ja) 2014-11-17 2023-02-24 癌を処置する方法

Country Status (21)

Country Link
US (3) US10786511B2 (OSRAM)
EP (2) EP3220916B1 (OSRAM)
JP (3) JP6829684B2 (OSRAM)
KR (3) KR102338802B1 (OSRAM)
CN (2) CN116650500A (OSRAM)
AU (3) AU2015350108B2 (OSRAM)
BR (1) BR112017010166A2 (OSRAM)
CA (1) CA2967664A1 (OSRAM)
DK (1) DK3220916T3 (OSRAM)
EA (1) EA201791095A1 (OSRAM)
ES (1) ES2947819T3 (OSRAM)
FI (1) FI3220916T3 (OSRAM)
HU (1) HUE062159T2 (OSRAM)
IL (4) IL296080B2 (OSRAM)
LT (1) LT3220916T (OSRAM)
MX (2) MX383484B (OSRAM)
PL (1) PL3220916T3 (OSRAM)
PT (1) PT3220916T (OSRAM)
SG (1) SG11201703806XA (OSRAM)
SI (1) SI3220916T1 (OSRAM)
WO (1) WO2016081523A1 (OSRAM)

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JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
CN110898067A (zh) 2012-10-15 2020-03-24 Epizyme股份有限公司 癌症治疗方法
CN116019921A (zh) 2013-12-06 2023-04-28 Epizyme股份有限公司 用于治疗癌症的组合疗法
PL3157527T3 (pl) 2014-06-17 2023-08-07 Epizyme, Inc. Inhibitory ezh2 do leczenia chłoniaka
BR112017010166A2 (en) * 2014-11-17 2018-02-14 Epizyme, Inc. solid tumor treatment method, activity inhibition method, oral dosage form for treating a solid tumor, solid pharmaceutical formulation, process for preparing a pharmaceutical formulation, and solid pharmaceutical composition
CN108135908A (zh) 2015-04-20 2018-06-08 Epizyme股份有限公司 用于治疗癌症的组合疗法
JP6890097B2 (ja) 2015-06-10 2021-06-18 エピザイム，インコーポレイティド リンパ腫を処置するためのｅｚｈ２阻害剤
CA2996412A1 (en) 2015-08-24 2017-03-02 Epizyme, Inc. Method for treating cancer
CA3011186A1 (en) 2016-01-29 2017-08-03 Epizyme, Inc. Combination therapy for treating cancer
JP7121660B2 (ja) 2016-06-01 2022-08-18 エピザイム，インコーポレイティド 癌を処置するためのｅｚｈ２阻害剤の使用
WO2017218953A1 (en) 2016-06-17 2017-12-21 Epizyme, Inc. Ezh2 inhibitors for treating cancer
US11311524B2 (en) 2017-01-19 2022-04-26 Daiichi Sankyo Company, Limited Pharmaceutical composition used for treatment of HTLV-1-associated myelopathy
WO2018183885A1 (en) 2017-03-31 2018-10-04 Epizyme, Inc. Combination therapy for treating cancer
US11602529B2 (en) 2017-06-02 2023-03-14 Epizyme, Inc. Use of EZH2 inhibitors for treating cancer
WO2019050924A1 (en) 2017-09-05 2019-03-14 Epizyme, Inc. POLY THERAPY FOR THE TREATMENT OF CANCER
JP2023509385A (ja) * 2019-12-20 2023-03-08 エピザイム インコーポレイテッド Ｅｚｈ２阻害剤の結晶性ヒドロブロミド塩、その調製及びがんの治療に有用な医薬組成物
JP7628876B2 (ja) 2021-04-23 2025-02-12 日立Astemo株式会社 情報処理装置、情報処理方法、プログラムおよび記憶媒体
US20250146080A1 (en) * 2022-02-17 2025-05-08 Memorial Sloan-Kettering Cancer Center Methods for overcoming tazemetostat-resistance in cancer patients
JP2025513620A (ja) 2022-04-27 2025-04-24 第一三共株式会社 抗体－薬物コンジュゲートとｅｚｈ１阻害剤および／またはｅｚｈ２阻害剤との組合せ

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US20070026064A1 (en) * 2005-07-29 2007-02-01 Yoder Steven L Pharmaceutical dosage forms having watermark-type identification and authentication inditia
US20100278921A1 (en) * 2009-04-30 2010-11-04 Fischer Cristina M Solid oral formulation of abt-263
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
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WO2012097222A1 (en) * 2011-01-14 2012-07-19 Bristol-Myers Squibb Company High drug load tablet formulation of brivanib alaninate
EP2681216B1 (en) 2011-02-28 2017-09-27 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
JO3438B1 (ar) * 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
TR201904660T4 (tr) * 2012-03-12 2019-05-21 Epizyme Inc İnsan EZH2 inhibitörleri ve bunun kullanım yöntemleri.
DK3184523T3 (da) 2012-04-13 2019-08-19 Epizyme Inc N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4' -(morphofinomethyl)-[1,1'-biphenyl]-3-carboxamidhydrobromid til anvendelse i behandlingen af en sygdom med celleproliferation i det hæmatologiske system.
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PE20150886A1 (es) 2012-10-15 2015-06-04 Epizyme Inc Compuestos de benceno sustituidos
CN110898067A (zh) * 2012-10-15 2020-03-24 Epizyme股份有限公司 癌症治疗方法
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EP2970306A4 (en) 2013-03-15 2016-08-03 Epizyme Inc SUBSTITUTED 6.5-CONDENSED BICYCLIC HETEROARYL COMPOUNDS
EP2970281A4 (en) 2013-03-15 2016-08-03 Epizyme Inc SUBSTITUTED BENZOL COMPOUNDS
WO2015010049A1 (en) 2013-07-19 2015-01-22 Epizyme, Inc. Substituted benzene compounds
SG11201602269QA (en) * 2013-10-16 2016-04-28 Epizyme Inc Hydrochloride salt form for ezh2 inhibition
US20160228447A1 (en) 2013-10-18 2016-08-11 Epizyme, Inc. Method of treating cancer
CN116019921A (zh) 2013-12-06 2023-04-28 Epizyme股份有限公司 用于治疗癌症的组合疗法
PL3157527T3 (pl) * 2014-06-17 2023-08-07 Epizyme, Inc. Inhibitory ezh2 do leczenia chłoniaka
WO2015200650A1 (en) 2014-06-25 2015-12-30 Epizyme, Inc. Substituted benzene and 6,5-fused bicyclic heteroaryl compounds
CN106794177A (zh) 2014-10-16 2017-05-31 Epizyme股份有限公司 治疗癌症的方法
BR112017010166A2 (en) 2014-11-17 2018-02-14 Epizyme, Inc. solid tumor treatment method, activity inhibition method, oral dosage form for treating a solid tumor, solid pharmaceutical formulation, process for preparing a pharmaceutical formulation, and solid pharmaceutical composition
JP6890097B2 (ja) * 2015-06-10 2021-06-18 エピザイム，インコーポレイティド リンパ腫を処置するためのｅｚｈ２阻害剤
WO2017218953A1 (en) * 2016-06-17 2017-12-21 Epizyme, Inc. Ezh2 inhibitors for treating cancer

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