JP2017537100A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017537100A5 JP2017537100A5 JP2017528520A JP2017528520A JP2017537100A5 JP 2017537100 A5 JP2017537100 A5 JP 2017537100A5 JP 2017528520 A JP2017528520 A JP 2017528520A JP 2017528520 A JP2017528520 A JP 2017528520A JP 2017537100 A5 JP2017537100 A5 JP 2017537100A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- independently selected
- oxo
- carbocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(N(C1)*c2c1c(Nc(cc1)ccc1-c1cccnc1C)n[n]2C)=O Chemical compound CC(N(C1)*c2c1c(Nc(cc1)ccc1-c1cccnc1C)n[n]2C)=O 0.000 description 104
- LJPCNSSTRWGCMZ-YFKPBYRVSA-N C[C@@H]1COCC1 Chemical compound C[C@@H]1COCC1 LJPCNSSTRWGCMZ-YFKPBYRVSA-N 0.000 description 2
- OSFVDNCNHWEOKC-GHRIWEEISA-N C/C(/c(cc1C(CC#N)C2)ccc1N2c1n[n](C2COCC2)c(CC2)c1CN2C(C)=O)=C\NC Chemical compound C/C(/c(cc1C(CC#N)C2)ccc1N2c1n[n](C2COCC2)c(CC2)c1CN2C(C)=O)=C\NC OSFVDNCNHWEOKC-GHRIWEEISA-N 0.000 description 1
- JMKKEJMTPPICOA-FWWKRHBFSA-N CC(/C=C(/c(cc1)cc2c1N(C)CCC2)\NC)=N Chemical compound CC(/C=C(/c(cc1)cc2c1N(C)CCC2)\NC)=N JMKKEJMTPPICOA-FWWKRHBFSA-N 0.000 description 1
- PRLAZICSKJHWGO-UHFFFAOYSA-N CC(C)CN(CC1)c(cc2)c1c(C)c2-c1c[n](C)nc1 Chemical compound CC(C)CN(CC1)c(cc2)c1c(C)c2-c1c[n](C)nc1 PRLAZICSKJHWGO-UHFFFAOYSA-N 0.000 description 1
- MASSWOMVPSTTLQ-WZQAJMDKSA-N CC(C)CN/C=C(\C=N)/c(cc1)ccc1Nc1n[n](C)c(CC2)c1CN2C(C)=O Chemical compound CC(C)CN/C=C(\C=N)/c(cc1)ccc1Nc1n[n](C)c(CC2)c1CN2C(C)=O MASSWOMVPSTTLQ-WZQAJMDKSA-N 0.000 description 1
- LYZIQOQONJWUCM-UHFFFAOYSA-N CC(C)Oc1ncccc1-c(cc1)ccc1Nc1n[n](C)c(CC2)c1CN2C(C)=O Chemical compound CC(C)Oc1ncccc1-c(cc1)ccc1Nc1n[n](C)c(CC2)c1CN2C(C)=O LYZIQOQONJWUCM-UHFFFAOYSA-N 0.000 description 1
- NCMLBFFUDRTDQF-UHFFFAOYSA-N CC(C1)CN(C)c2c1cc(-c1c[n](C)nc1)c(C#N)c2 Chemical compound CC(C1)CN(C)c2c1cc(-c1c[n](C)nc1)c(C#N)c2 NCMLBFFUDRTDQF-UHFFFAOYSA-N 0.000 description 1
- CIVLIHPKSFHIFY-UHFFFAOYSA-N CC(CN(CC1)CCC1[n](c(CC1)c2CN1C(C)=O)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)(F)F Chemical compound CC(CN(CC1)CCC1[n](c(CC1)c2CN1C(C)=O)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)(F)F CIVLIHPKSFHIFY-UHFFFAOYSA-N 0.000 description 1
- DJTQTXGNRGBCOD-UHFFFAOYSA-O CC(Cc1c2)CN(C(C(CN(CC3)C(NC)=O)=C3[NH2+]C3CCOCC3)=N)c1cc(C(F)F)c2-c1c[n](C)nc1 Chemical compound CC(Cc1c2)CN(C(C(CN(CC3)C(NC)=O)=C3[NH2+]C3CCOCC3)=N)c1cc(C(F)F)c2-c1c[n](C)nc1 DJTQTXGNRGBCOD-UHFFFAOYSA-O 0.000 description 1
- HAPPNYAXWQZRAX-UHFFFAOYSA-N CC(N(CC1)CC(C(N(CCCc2c3)c2cc(Cl)c3-c2c[n](C)nc2)=N)=C1NC1CCOCC1)=O Chemical compound CC(N(CC1)CC(C(N(CCCc2c3)c2cc(Cl)c3-c2c[n](C)nc2)=N)=C1NC1CCOCC1)=O HAPPNYAXWQZRAX-UHFFFAOYSA-N 0.000 description 1
- PTDAQHCADOZUPK-XKHUQQNRSA-O CC(N(CC1)CC(C(N(CCc2c3)c2ccc3/C(/C=[NH2+])=C/NC)=N)=C1NC1COC1)=O Chemical compound CC(N(CC1)CC(C(N(CCc2c3)c2ccc3/C(/C=[NH2+])=C/NC)=N)=C1NC1COC1)=O PTDAQHCADOZUPK-XKHUQQNRSA-O 0.000 description 1
- NYTUWAJIDVYHTR-UHFFFAOYSA-O CC(N(CC1)CC(C(N2c3cc(-c4c[n](C)nc4)cc(F)c3CC2)=N)=C1[NH2+]C1COCC1)=O Chemical compound CC(N(CC1)CC(C(N2c3cc(-c4c[n](C)nc4)cc(F)c3CC2)=N)=C1[NH2+]C1COCC1)=O NYTUWAJIDVYHTR-UHFFFAOYSA-O 0.000 description 1
- PJUDVGOSAFFXOW-UHFFFAOYSA-N CC(N(CC1)CC(C(Nc(cc2)ccc2-c2cc(C#N)cnc2)=N)=C1NC)=O Chemical compound CC(N(CC1)CC(C(Nc(cc2)ccc2-c2cc(C#N)cnc2)=N)=C1NC)=O PJUDVGOSAFFXOW-UHFFFAOYSA-N 0.000 description 1
- CDQRJTOIKYLWHC-UHFFFAOYSA-N CC(N(CC1)CC(C(Nc2cccc(-c3ccccn3)c2)=N)=C1NCC1CC1)=O Chemical compound CC(N(CC1)CC(C(Nc2cccc(-c3ccccn3)c2)=N)=C1NCC1CC1)=O CDQRJTOIKYLWHC-UHFFFAOYSA-N 0.000 description 1
- TXJYCXYYANUKRH-JFIRURCGSA-O CC(N(CC1)Cc2c1[n](C(CC1)CCC1(F)F)nc2N(CCCc1c2)c1cc(C(F)F)c2/C(/C=[NH2+])=C/NC)=O Chemical compound CC(N(CC1)Cc2c1[n](C(CC1)CCC1(F)F)nc2N(CCCc1c2)c1cc(C(F)F)c2/C(/C=[NH2+])=C/NC)=O TXJYCXYYANUKRH-JFIRURCGSA-O 0.000 description 1
- FOSCIUXFLQMEMH-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C(CC1)CCN1S(C)(=O)=O)nc2N(CCCc1c2)c1cc(C(F)(F)F)c2-c1c[n](C)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C(CC1)CCN1S(C)(=O)=O)nc2N(CCCc1c2)c1cc(C(F)(F)F)c2-c1c[n](C)nc1)=O FOSCIUXFLQMEMH-UHFFFAOYSA-N 0.000 description 1
- NOZQJGBVNUQNRB-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C(CCN1)CC1=O)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C(CCN1)CC1=O)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O NOZQJGBVNUQNRB-UHFFFAOYSA-N 0.000 description 1
- GSHNESMBKPVUKK-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2NC(CC1)=CC=C1c1c[n](CCNC)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2NC(CC1)=CC=C1c1c[n](CCNC)nc1)=O GSHNESMBKPVUKK-UHFFFAOYSA-N 0.000 description 1
- UECNFCVMDPPWBS-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1C#N)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1C#N)=O UECNFCVMDPPWBS-UHFFFAOYSA-N 0.000 description 1
- HWPRLXIVOJPGBP-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1C(N(C)C)=O)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1C(N(C)C)=O)=O HWPRLXIVOJPGBP-UHFFFAOYSA-N 0.000 description 1
- DRXZJLSQJJGIGZ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1C(N)=O)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1C(N)=O)=O DRXZJLSQJJGIGZ-UHFFFAOYSA-N 0.000 description 1
- COVIVMNWGVXQCN-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1C(N1CCOCC1)=O)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1C(N1CCOCC1)=O)=O COVIVMNWGVXQCN-UHFFFAOYSA-N 0.000 description 1
- YFDFJEZICRPVLO-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1Cl)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1Cl)=O YFDFJEZICRPVLO-UHFFFAOYSA-N 0.000 description 1
- VKTQLUMELSJYIS-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1F)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1F)=O VKTQLUMELSJYIS-UHFFFAOYSA-N 0.000 description 1
- BNIJDOOXTWTXBB-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1OC)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)ccc1OC)=O BNIJDOOXTWTXBB-UHFFFAOYSA-N 0.000 description 1
- UFSZOWMSLVPJKA-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)cnc1C#N)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)cnc1C#N)=O UFSZOWMSLVPJKA-UHFFFAOYSA-N 0.000 description 1
- MHLYKCLCUQKRIA-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)cnc1N)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)cnc1N)=O MHLYKCLCUQKRIA-UHFFFAOYSA-N 0.000 description 1
- VGBJSBQUSBOSFQ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)cnc1O)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1)cnc1O)=O VGBJSBQUSBOSFQ-UHFFFAOYSA-N 0.000 description 1
- SBYNYIDQDRKIQN-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1F)ccc1F)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c(cc1F)ccc1F)=O SBYNYIDQDRKIQN-UHFFFAOYSA-N 0.000 description 1
- FSTSATFXXMERTN-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1c(C)ccnc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1c(C)ccnc1)=O FSTSATFXXMERTN-UHFFFAOYSA-N 0.000 description 1
- XKHATCVYWKUWMR-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1c(C)nc(C)cc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1c(C)nc(C)cc1)=O XKHATCVYWKUWMR-UHFFFAOYSA-N 0.000 description 1
- KQOCGYHXPOAIKM-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1c(CCCC2)[n]2nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1c(CCCC2)[n]2nc1)=O KQOCGYHXPOAIKM-UHFFFAOYSA-N 0.000 description 1
- SSTRQKVGFZOZCS-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1c[n](C)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1c[n](C)nc1)=O SSTRQKVGFZOZCS-UHFFFAOYSA-N 0.000 description 1
- APFIMVUTPXXCGR-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1c[n](C)nc1C1CC1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1c[n](C)nc1C1CC1)=O APFIMVUTPXXCGR-UHFFFAOYSA-N 0.000 description 1
- ZXSVBIKPEDHJHL-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1c[n](C2CC2)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1c[n](C2CC2)nc1)=O ZXSVBIKPEDHJHL-UHFFFAOYSA-N 0.000 description 1
- ILHQYEASSOOYPH-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cc(C#N)ccc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cc(C#N)ccc1)=O ILHQYEASSOOYPH-UHFFFAOYSA-N 0.000 description 1
- ORAGEWAFIXGRFQ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cc(C(F)(F)F)ccc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cc(C(F)(F)F)ccc1)=O ORAGEWAFIXGRFQ-UHFFFAOYSA-N 0.000 description 1
- SAKMOVGKLKFYOY-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cc(CO)ccc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cc(CO)ccc1)=O SAKMOVGKLKFYOY-UHFFFAOYSA-N 0.000 description 1
- DIBRXRVMEOFHEB-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cc(F)cc(F)c1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cc(F)cc(F)c1)=O DIBRXRVMEOFHEB-UHFFFAOYSA-N 0.000 description 1
- QIUPBVSHQMFACO-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cc(F)ccc1F)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cc(F)ccc1F)=O QIUPBVSHQMFACO-UHFFFAOYSA-N 0.000 description 1
- KPJLTNBOUVBDAV-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1ccc(C(F)(F)F)cc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1ccc(C(F)(F)F)cc1)=O KPJLTNBOUVBDAV-UHFFFAOYSA-N 0.000 description 1
- CFNPVNSKHBCVKD-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1ccc(C)cc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1ccc(C)cc1)=O CFNPVNSKHBCVKD-UHFFFAOYSA-N 0.000 description 1
- WXCLMMPHFVUIAO-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1ccc(C)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1ccc(C)nc1)=O WXCLMMPHFVUIAO-UHFFFAOYSA-N 0.000 description 1
- CQNCIJOYNCPJPT-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1ccc(CO)cc1)O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1ccc(CO)cc1)O CQNCIJOYNCPJPT-UHFFFAOYSA-N 0.000 description 1
- SARDUYMIJOPOTQ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cccc(Cl)c1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cccc(Cl)c1)=O SARDUYMIJOPOTQ-UHFFFAOYSA-N 0.000 description 1
- ITBMAEGNHCTABP-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cccc(N(C)C)c1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cccc(N(C)C)c1)=O ITBMAEGNHCTABP-UHFFFAOYSA-N 0.000 description 1
- YHFIVAUGWSMFCX-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cccc(NS(C)(=O)=O)c1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cccc(NS(C)(=O)=O)c1)=O YHFIVAUGWSMFCX-UHFFFAOYSA-N 0.000 description 1
- FRIOEGXJPBCNAX-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cccc(OC)c1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cccc(OC)c1)=O FRIOEGXJPBCNAX-UHFFFAOYSA-N 0.000 description 1
- OPGVATQMBWJEIZ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1ccccc1OC)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1ccccc1OC)=O OPGVATQMBWJEIZ-UHFFFAOYSA-N 0.000 description 1
- UGGSKEWBLNTYIP-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1ccncc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1ccncc1)=O UGGSKEWBLNTYIP-UHFFFAOYSA-N 0.000 description 1
- ZHECXPMTHGPGQQ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cncc(S=O)c1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cncc(S=O)c1)=O ZHECXPMTHGPGQQ-UHFFFAOYSA-N 0.000 description 1
- OIJFJYQRIPPLEI-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cncnc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1cncnc1)=O OIJFJYQRIPPLEI-UHFFFAOYSA-N 0.000 description 1
- STCRPPIWTJYFNV-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1n[n](C)cc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2Nc(cc1)ccc1-c1n[n](C)cc1)=O STCRPPIWTJYFNV-UHFFFAOYSA-N 0.000 description 1
- XJBFFRZIFUFSCO-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCN(C)CC1)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCN(C)CC1)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O XJBFFRZIFUFSCO-UHFFFAOYSA-N 0.000 description 1
- MVSOEOSCTVFUNY-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCN(CC(F)F)CC1)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCN(CC(F)F)CC1)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O MVSOEOSCTVFUNY-UHFFFAOYSA-N 0.000 description 1
- RYSZMJJZGAVVTR-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2N(CCCc1c2)c1cc(Cl)c2-c1ccc(C(NC)=O)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2N(CCCc1c2)c1cc(Cl)c2-c1ccc(C(NC)=O)nc1)=O RYSZMJJZGAVVTR-UHFFFAOYSA-N 0.000 description 1
- UQBXFDFEKJCZNR-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2N1c(cc(c(-c2c[n](C)nc2)c2)C#N)c2N(C)CC1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2N1c(cc(c(-c2c[n](C)nc2)c2)C#N)c2N(C)CC1)=O UQBXFDFEKJCZNR-UHFFFAOYSA-N 0.000 description 1
- NRFLQCHTKOFVMD-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1COC1)nc2N(CCc1c2)c1ccc2-c1c[n](C)nc1C(F)(F)F)=O Chemical compound CC(N(CC1)Cc2c1[n](C1COC1)nc2N(CCc1c2)c1ccc2-c1c[n](C)nc1C(F)(F)F)=O NRFLQCHTKOFVMD-UHFFFAOYSA-N 0.000 description 1
- QHKVSIFGMSAWIN-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1COC1)nc2N1c(cccc2)c2OCC1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1COC1)nc2N1c(cccc2)c2OCC1)=O QHKVSIFGMSAWIN-UHFFFAOYSA-N 0.000 description 1
- GUAPUOMXJMGULQ-QKMGMZOJSA-N CC(N(CC1)Cc2c1[n](C1COCC1)nc2N(CC1(CCC1)c1c2)c1ccc2/C(/C=N)=C/NC)=O Chemical compound CC(N(CC1)Cc2c1[n](C1COCC1)nc2N(CC1(CCC1)c1c2)c1ccc2/C(/C=N)=C/NC)=O GUAPUOMXJMGULQ-QKMGMZOJSA-N 0.000 description 1
- NIIYWMZVBGRPFQ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1COCC1)nc2N(CCc1c2)c1cc(-c1c[n](C)nc1)c2C#N)=O Chemical compound CC(N(CC1)Cc2c1[n](C1COCC1)nc2N(CCc1c2)c1cc(-c1c[n](C)nc1)c2C#N)=O NIIYWMZVBGRPFQ-UHFFFAOYSA-N 0.000 description 1
- ZZJJNIBOIICGMV-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1COCC1)nc2N(CCc1c2)c1ccc2-c1c(C)[n](C)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1COCC1)nc2N(CCc1c2)c1ccc2-c1c(C)[n](C)nc1)=O ZZJJNIBOIICGMV-UHFFFAOYSA-N 0.000 description 1
- VVKXKCAVGFHMJO-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1COCC1)nc2N(CCc1c2)c1ccc2-c1c[n](C)nc1C#N)=O Chemical compound CC(N(CC1)Cc2c1[n](C1COCC1)nc2N(CCc1c2)c1ccc2-c1c[n](C)nc1C#N)=O VVKXKCAVGFHMJO-UHFFFAOYSA-N 0.000 description 1
- VIIVDWHNVKREBX-VYRBHSGPSA-N CC(N(CC1)Cc2c1[n](C1COCC1)nc2N[C@H](C1)C=C(c2c[n](C)nc2)C(F)=C1F)=O Chemical compound CC(N(CC1)Cc2c1[n](C1COCC1)nc2N[C@H](C1)C=C(c2c[n](C)nc2)C(F)=C1F)=O VIIVDWHNVKREBX-VYRBHSGPSA-N 0.000 description 1
- XEIUTMNBFUKUEA-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1COCC1)nc2Nc(cc(cc1)-c2c[n](C)nc2)c1[I]=C)=N Chemical compound CC(N(CC1)Cc2c1[n](C1COCC1)nc2Nc(cc(cc1)-c2c[n](C)nc2)c1[I]=C)=N XEIUTMNBFUKUEA-UHFFFAOYSA-N 0.000 description 1
- ZNIQPKLUCOYTFF-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1COCC1)nc2Nc(cc1)ccc1-c1c[n](C)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1COCC1)nc2Nc(cc1)ccc1-c1c[n](C)nc1)=O ZNIQPKLUCOYTFF-UHFFFAOYSA-N 0.000 description 1
- NJYJBDLOOBAKLR-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1COCC1)nc2Nc(ccc(-c1c[n](C)nc1)c1)c1Cl)=O Chemical compound CC(N(CC1)Cc2c1[n](C1COCC1)nc2Nc(ccc(-c1c[n](C)nc1)c1)c1Cl)=O NJYJBDLOOBAKLR-UHFFFAOYSA-N 0.000 description 1
- PQOUPUVPGGSLQQ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1COCC1)nc2Nc1ccc(C2C=NN(C)C2C(F)(F)F)cc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1COCC1)nc2Nc1ccc(C2C=NN(C)C2C(F)(F)F)cc1)=O PQOUPUVPGGSLQQ-UHFFFAOYSA-N 0.000 description 1
- NKXTWOBELGVLPJ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](CC(CCN1)CC1=O)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](CC(CCN1)CC1=O)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O NKXTWOBELGVLPJ-UHFFFAOYSA-N 0.000 description 1
- MKHZYJVBJCVUJD-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](CC1CC1)nc2Nc1cc(-c2ccncc2)ccc1)=O Chemical compound CC(N(CC1)Cc2c1[n](CC1CC1)nc2Nc1cc(-c2ccncc2)ccc1)=O MKHZYJVBJCVUJD-UHFFFAOYSA-N 0.000 description 1
- WJCOZSIUTNNQCH-ZIGUYKLESA-N CC(N(CC1)Cc2c1[n](CCC(F)(F)F)nc2Nc(cc1)ccc1-c1c[n](CCC(N(CC2)Cc3c2[n](CCC(N)=O)nc3Nc(cc2)ccc2/C(/C=N)=C/NC)=O)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](CCC(F)(F)F)nc2Nc(cc1)ccc1-c1c[n](CCC(N(CC2)Cc3c2[n](CCC(N)=O)nc3Nc(cc2)ccc2/C(/C=N)=C/NC)=O)nc1)=O WJCOZSIUTNNQCH-ZIGUYKLESA-N 0.000 description 1
- QUDSANXOMKRWBR-FQEVSTJZSA-N CC(N(CC1)Cc2c1[n](CC[C@@H]1COCC1)nc2N(CCc1c2)c1ccc2-c1c(C)[n](C)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n](CC[C@@H]1COCC1)nc2N(CCc1c2)c1ccc2-c1c(C)[n](C)nc1)=O QUDSANXOMKRWBR-FQEVSTJZSA-N 0.000 description 1
- BYSDTPTWZYDBDL-OYRHEFFESA-N CC(N(CC1)Cc2c1[n]([C@H](CC1)CC[C@H]1O)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O Chemical compound CC(N(CC1)Cc2c1[n]([C@H](CC1)CC[C@H]1O)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O BYSDTPTWZYDBDL-OYRHEFFESA-N 0.000 description 1
- JDCXRWQQMMOJEQ-UHFFFAOYSA-N CC(Nc(cc1)ncc1-c(cc1)ccc1Nc1n[n](C)c(CC2)c1CN2C(C)=O)=O Chemical compound CC(Nc(cc1)ncc1-c(cc1)ccc1Nc1n[n](C)c(CC2)c1CN2C(C)=O)=O JDCXRWQQMMOJEQ-UHFFFAOYSA-N 0.000 description 1
- RKBYTUZWJBPSDE-UHFFFAOYSA-N CC(Nc(cc1)ncc1-c(cc1CCC2)c(C(F)F)cc1N2c1n[n](C2CCOCC2)c(CC2)c1CN2C(NC)=O)=O Chemical compound CC(Nc(cc1)ncc1-c(cc1CCC2)c(C(F)F)cc1N2c1n[n](C2CCOCC2)c(CC2)c1CN2C(NC)=O)=O RKBYTUZWJBPSDE-UHFFFAOYSA-N 0.000 description 1
- GCCHDQDWCOCDLK-UHFFFAOYSA-N CC1(c(cc2)ccc2Nc2n[n](C)c(CC3)c2CN3C(C)=O)NNC=C1 Chemical compound CC1(c(cc2)ccc2Nc2n[n](C)c(CC3)c2CN3C(C)=O)NNC=C1 GCCHDQDWCOCDLK-UHFFFAOYSA-N 0.000 description 1
- GSDYNJRRFBBEJS-UHFFFAOYSA-N CC1=CCOC1 Chemical compound CC1=CCOC1 GSDYNJRRFBBEJS-UHFFFAOYSA-N 0.000 description 1
- KAJXBJOCILTJII-UHFFFAOYSA-N CC1c(cc(cc2)-c3c[n](C)nc3)c2N(C)CC1 Chemical compound CC1c(cc(cc2)-c3c[n](C)nc3)c2N(C)CC1 KAJXBJOCILTJII-UHFFFAOYSA-N 0.000 description 1
- OQRQSVFKODEYMA-UHFFFAOYSA-N CCC(CC)N(CCC1)c(cc2C(F)F)c1cc2-c(ccnc1)c1N Chemical compound CCC(CC)N(CCC1)c(cc2C(F)F)c1cc2-c(ccnc1)c1N OQRQSVFKODEYMA-UHFFFAOYSA-N 0.000 description 1
- KHXCSFOBXLYDGJ-UHFFFAOYSA-O CCC1c2cc(C(C=N)=C[NH2+]C)ccc2N(C)C1 Chemical compound CCC1c2cc(C(C=N)=C[NH2+]C)ccc2N(C)C1 KHXCSFOBXLYDGJ-UHFFFAOYSA-O 0.000 description 1
- YHRDDTJESSMWLA-JZQXYNAISA-O CCCC(C)N(CC[C@@H]1C)c2c1cc(/C(/C=[NH2+])=C/NC)c(C#N)c2 Chemical compound CCCC(C)N(CC[C@@H]1C)c2c1cc(/C(/C=[NH2+])=C/NC)c(C#N)c2 YHRDDTJESSMWLA-JZQXYNAISA-O 0.000 description 1
- PFODMDCSNDGMPE-UHFFFAOYSA-N CCCC(CC)N(CC1)c2c1c(Cl)cc(-c1c[n](C)nc1)c2 Chemical compound CCCC(CC)N(CC1)c2c1c(Cl)cc(-c1c[n](C)nc1)c2 PFODMDCSNDGMPE-UHFFFAOYSA-N 0.000 description 1
- FBKNOQMUWJSRPK-UHFFFAOYSA-N CCCC(CC)N(CCC1)c(cc2)c1cc2-c1c[n](C(F)[I]=C)nc1 Chemical compound CCCC(CC)N(CCC1)c(cc2)c1cc2-c1c[n](C(F)[I]=C)nc1 FBKNOQMUWJSRPK-UHFFFAOYSA-N 0.000 description 1
- XOWDMKGWQQKRDZ-UHFFFAOYSA-N CCCC(CC)N(CCC1)c2c1cc(-c1cnc(N(C)C)[s]1)c(C(F)F)c2 Chemical compound CCCC(CC)N(CCC1)c2c1cc(-c1cnc(N(C)C)[s]1)c(C(F)F)c2 XOWDMKGWQQKRDZ-UHFFFAOYSA-N 0.000 description 1
- VUOLINRXKDODNT-UHFFFAOYSA-N CCCCC(CC)N(CC1)c2c1ccc(C#N)c2 Chemical compound CCCCC(CC)N(CC1)c2c1ccc(C#N)c2 VUOLINRXKDODNT-UHFFFAOYSA-N 0.000 description 1
- LYSZWOOLLBURRQ-UHFFFAOYSA-N CCCCC(CCC)N(CCC1)c(cc2)c1cc2-c1c[n](C)c(C)n1 Chemical compound CCCCC(CCC)N(CCC1)c(cc2)c1cc2-c1c[n](C)c(C)n1 LYSZWOOLLBURRQ-UHFFFAOYSA-N 0.000 description 1
- CLBDSPYJYDXQGV-UHFFFAOYSA-N CCCCC(CCC)N(CCC1)c2c1cc(-c1c[n](C)nc1)c(OC(F)(F)F)c2 Chemical compound CCCCC(CCC)N(CCC1)c2c1cc(-c1c[n](C)nc1)c(OC(F)(F)F)c2 CLBDSPYJYDXQGV-UHFFFAOYSA-N 0.000 description 1
- UISBXVKXXGYEOR-UHFFFAOYSA-N CCCCC(CCC)N(CCC1)c2c1cc(-c1c[n](C)nc1)nc2 Chemical compound CCCCC(CCC)N(CCC1)c2c1cc(-c1c[n](C)nc1)nc2 UISBXVKXXGYEOR-UHFFFAOYSA-N 0.000 description 1
- ZAOSJQKDPIERFK-QSVWIEALSA-N CCCCC(CCC)N(CC[C@@H]1CO)c(cc2)c1cc2-c1c[n](C)nc1 Chemical compound CCCCC(CCC)N(CC[C@@H]1CO)c(cc2)c1cc2-c1c[n](C)nc1 ZAOSJQKDPIERFK-QSVWIEALSA-N 0.000 description 1
- AABQTXWBISAECL-UHFFFAOYSA-N CCCCCC(CC)N(CCC1C)c2c1cc(-c1c[n](C)nc1)c(C#N)c2 Chemical compound CCCCCC(CC)N(CCC1C)c2c1cc(-c1c[n](C)nc1)c(C#N)c2 AABQTXWBISAECL-UHFFFAOYSA-N 0.000 description 1
- KAGWUEGUSFLQBK-UHFFFAOYSA-N CCN(C)c(cc1)ccc1-c1c[n](C)nc1 Chemical compound CCN(C)c(cc1)ccc1-c1c[n](C)nc1 KAGWUEGUSFLQBK-UHFFFAOYSA-N 0.000 description 1
- VGZJQQKSDVFGFA-UHFFFAOYSA-N CC[n]1ncc(-c(cc2)ccc2Nc2n[n](C)c(CC3)c2CN3C(C)=O)c1 Chemical compound CC[n]1ncc(-c(cc2)ccc2Nc2n[n](C)c(CC3)c2CN3C(C)=O)c1 VGZJQQKSDVFGFA-UHFFFAOYSA-N 0.000 description 1
- LRLZXUXUQXYOOB-UHFFFAOYSA-N CN(CCC1)c(cc2)c1cc2-c1cc(C#N)cnc1 Chemical compound CN(CCC1)c(cc2)c1cc2-c1cc(C#N)cnc1 LRLZXUXUQXYOOB-UHFFFAOYSA-N 0.000 description 1
- KMXBOEUIAAJSLA-UHFFFAOYSA-N CN(CCC1)c(cc2)c1cc2-c1cncnc1 Chemical compound CN(CCC1)c(cc2)c1cc2-c1cncnc1 KMXBOEUIAAJSLA-UHFFFAOYSA-N 0.000 description 1
- AMDLFSPNCBSFLZ-UHFFFAOYSA-N CN(CCC1)c(cc2C#N)c1cc2-c1ccncn1 Chemical compound CN(CCC1)c(cc2C#N)c1cc2-c1ccncn1 AMDLFSPNCBSFLZ-UHFFFAOYSA-N 0.000 description 1
- MBWCZXOGYULJOO-UHFFFAOYSA-N CN(CCC1)c2c1c(Cl)ccc2 Chemical compound CN(CCC1)c2c1c(Cl)ccc2 MBWCZXOGYULJOO-UHFFFAOYSA-N 0.000 description 1
- UDEULHRWMVNDEF-UHFFFAOYSA-N CN(CCC1)c2c1cc(C1SC=NC1)cc2 Chemical compound CN(CCC1)c2c1cc(C1SC=NC1)cc2 UDEULHRWMVNDEF-UHFFFAOYSA-N 0.000 description 1
- ZCOWMMYJJXWULI-UHFFFAOYSA-N CN(CCCc1c2)c1ccc2-c(cc1)cnc1C#N Chemical compound CN(CCCc1c2)c1ccc2-c(cc1)cnc1C#N ZCOWMMYJJXWULI-UHFFFAOYSA-N 0.000 description 1
- DNIOPDVYJJBBBS-UHFFFAOYSA-N CN(CCc1c2)c1cc(C#N)c2-c1c[n](C)nc1 Chemical compound CN(CCc1c2)c1cc(C#N)c2-c1c[n](C)nc1 DNIOPDVYJJBBBS-UHFFFAOYSA-N 0.000 description 1
- RDKUCKKETDMFBU-UHFFFAOYSA-N CN(c1ccccc1)c(cc1)ccc1-c1c[n](C)nc1 Chemical compound CN(c1ccccc1)c(cc1)ccc1-c1c[n](C)nc1 RDKUCKKETDMFBU-UHFFFAOYSA-N 0.000 description 1
- AKUXPVUGTVAHCD-RMTVOBLGSA-N CN/C=C(\C=N)/c(cc1)cc2c1N(C)C[C@H]2CC#N Chemical compound CN/C=C(\C=N)/c(cc1)cc2c1N(C)C[C@H]2CC#N AKUXPVUGTVAHCD-RMTVOBLGSA-N 0.000 description 1
- YUBKNKQXHGLULJ-PDVFJIAZSA-N CN/C=C(\C=N)/c(cc1)ccc1N(C)c1ccccc1 Chemical compound CN/C=C(\C=N)/c(cc1)ccc1N(C)c1ccccc1 YUBKNKQXHGLULJ-PDVFJIAZSA-N 0.000 description 1
- UTRSDTNSYNOFHK-BXBRPASWSA-O CN/C=C(\C=[NH2+])/c(cc1)cc(C2)c1N(C)CC2C1CC1 Chemical compound CN/C=C(\C=[NH2+])/c(cc1)cc(C2)c1N(C)CC2C1CC1 UTRSDTNSYNOFHK-BXBRPASWSA-O 0.000 description 1
- XSWFYGFHEHETNV-VVJXHRSYSA-O CN/C=C(\C=[NH2+])/c(cc1)cc2c1N(C)CC(CC(F)F)C2 Chemical compound CN/C=C(\C=[NH2+])/c(cc1)cc2c1N(C)CC(CC(F)F)C2 XSWFYGFHEHETNV-VVJXHRSYSA-O 0.000 description 1
- PYTBFFZXPKUFHY-FMBUXQRRSA-O CN/C=C(\C=[NH2+])/c1ccc2N(C)CC(CO)Cc2c1 Chemical compound CN/C=C(\C=[NH2+])/c1ccc2N(C)CC(CO)Cc2c1 PYTBFFZXPKUFHY-FMBUXQRRSA-O 0.000 description 1
- QWVPFQJBXPZUSK-UHFFFAOYSA-N CNC(N(CC1)CC(C(N(CCC2)c3c2cc(-c2c[n](C)nc2)c(C(F)F)c3)=N)=C1NC(CC1)CCC1OC)=O Chemical compound CNC(N(CC1)CC(C(N(CCC2)c3c2cc(-c2c[n](C)nc2)c(C(F)F)c3)=N)=C1NC(CC1)CCC1OC)=O QWVPFQJBXPZUSK-UHFFFAOYSA-N 0.000 description 1
- WISNGFXEEMWAHJ-UHFFFAOYSA-N CNC(N(CC1)CC(C(N(CCC2)c3c2cc(-c2c[n](C)nc2)c(C(F)F)c3)=N)=C1Nc1cccnc1)=O Chemical compound CNC(N(CC1)CC(C(N(CCC2)c3c2cc(-c2c[n](C)nc2)c(C(F)F)c3)=N)=C1Nc1cccnc1)=O WISNGFXEEMWAHJ-UHFFFAOYSA-N 0.000 description 1
- HXEBYFYBKCPGQZ-UHFFFAOYSA-O CNC(N(CC1)CC(C(N(CCCc2c3)c2cc(Cl)c3-c2c[n](C)nc2)=N)=C1[NH2+]C1CCOCC1)=O Chemical compound CNC(N(CC1)CC(C(N(CCCc2c3)c2cc(Cl)c3-c2c[n](C)nc2)=N)=C1[NH2+]C1CCOCC1)=O HXEBYFYBKCPGQZ-UHFFFAOYSA-O 0.000 description 1
- NHPSOTYCPZNXSW-UHFFFAOYSA-O CNC(N(CC1)CC(C(N2C3C=C(C(F)(F)F)C(c4c[n](C)nc4)=CC3CCC2)=N)=C1[NH2+]C1CCOCC1)=O Chemical compound CNC(N(CC1)CC(C(N2C3C=C(C(F)(F)F)C(c4c[n](C)nc4)=CC3CCC2)=N)=C1[NH2+]C1CCOCC1)=O NHPSOTYCPZNXSW-UHFFFAOYSA-O 0.000 description 1
- OLCHZCYSJRUSRX-UHFFFAOYSA-N CNC(N(CC1)Cc2c1[n](-c1ccccc1)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O Chemical compound CNC(N(CC1)Cc2c1[n](-c1ccccc1)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O OLCHZCYSJRUSRX-UHFFFAOYSA-N 0.000 description 1
- NKBOSLMTOJMTLZ-UHFFFAOYSA-N CNC(N(CC1)Cc2c1[n](-c1ccncc1)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O Chemical compound CNC(N(CC1)Cc2c1[n](-c1ccncc1)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1c[n](C)nc1)=O NKBOSLMTOJMTLZ-UHFFFAOYSA-N 0.000 description 1
- DCYODTYUBWATHC-UHFFFAOYSA-N CNC(N(CC1)Cc2c1[n](C1CCCCC1)nc2N(CCC1)c2c1cc(-c1c[n](C)nc1)c(C(F)F)c2)=O Chemical compound CNC(N(CC1)Cc2c1[n](C1CCCCC1)nc2N(CCC1)c2c1cc(-c1c[n](C)nc1)c(C(F)F)c2)=O DCYODTYUBWATHC-UHFFFAOYSA-N 0.000 description 1
- BLKIJAZMPMNLOV-UHFFFAOYSA-N CNC(N(CC1)Cc2c1[n](C1CCOCC1)nc2N(CCCc1c2)c1cc(C1CC1)c2-c1c[n](C)nc1)=O Chemical compound CNC(N(CC1)Cc2c1[n](C1CCOCC1)nc2N(CCCc1c2)c1cc(C1CC1)c2-c1c[n](C)nc1)=O BLKIJAZMPMNLOV-UHFFFAOYSA-N 0.000 description 1
- JQDHNNIGFYFJHU-UHFFFAOYSA-N CNC(N(CC1)Cc2c1[n](C1CCOCC1)nc2N(CCCc1c2)c1cc(C=C)c2-c1c[n](C)nc1)=O Chemical compound CNC(N(CC1)Cc2c1[n](C1CCOCC1)nc2N(CCCc1c2)c1cc(C=C)c2-c1c[n](C)nc1)=O JQDHNNIGFYFJHU-UHFFFAOYSA-N 0.000 description 1
- VDEXIQHMSLVIIG-UHFFFAOYSA-N CNC(N(CC1)Cc2c1[n](C1CCOCC1)nc2N(CCCc1c2)c1cc(S(C)(=O)=O)c2-c1c[n](C)nc1)=O Chemical compound CNC(N(CC1)Cc2c1[n](C1CCOCC1)nc2N(CCCc1c2)c1cc(S(C)(=O)=O)c2-c1c[n](C)nc1)=O VDEXIQHMSLVIIG-UHFFFAOYSA-N 0.000 description 1
- GESFMFCLSDLZCV-UHFFFAOYSA-N CNC(N(CC1)Cc2c1[n](C1CCOCC1)nc2N1c(cc(c(-c2c[n](C)nc2)c2)C#N)c2N(C)CC1)=O Chemical compound CNC(N(CC1)Cc2c1[n](C1CCOCC1)nc2N1c(cc(c(-c2c[n](C)nc2)c2)C#N)c2N(C)CC1)=O GESFMFCLSDLZCV-UHFFFAOYSA-N 0.000 description 1
- QIVDEDWWJMXDJB-MXVIHJGJSA-N CNC(N(CC1)Cc2c1[n]([C@H](CC1)CC[C@@H]1N)nc2N(CCC1)c2c1cc(-c1c[n](C)nc1)c(C(F)F)c2)=O Chemical compound CNC(N(CC1)Cc2c1[n]([C@H](CC1)CC[C@@H]1N)nc2N(CCC1)c2c1cc(-c1c[n](C)nc1)c(C(F)F)c2)=O QIVDEDWWJMXDJB-MXVIHJGJSA-N 0.000 description 1
- NCMLBFFUDRTDQF-NSHDSACASA-N C[C@@H](C1)CN(C)c2c1cc(-c1c[n](C)nc1)c(C#N)c2 Chemical compound C[C@@H](C1)CN(C)c2c1cc(-c1c[n](C)nc1)c(C#N)c2 NCMLBFFUDRTDQF-NSHDSACASA-N 0.000 description 1
- YWKGZWFAUXSDJY-OXJNMPFZSA-N C[C@@H](C1)c2cc(-c3c[n](C)nc3)ccc2N1c1n[n]([C@H]2COCC2)c(CC2)c1CN2C(C)=O Chemical compound C[C@@H](C1)c2cc(-c3c[n](C)nc3)ccc2N1c1n[n]([C@H]2COCC2)c(CC2)c1CN2C(C)=O YWKGZWFAUXSDJY-OXJNMPFZSA-N 0.000 description 1
- KTZSWHMPAOVIBK-PROIXAHCSA-N C[C@@H](C1)c2cc(/C(/C=N)=C/NC)ccc2N1c1n[n]([C@@H]2COCC2)c(CC2)c1CN2C(C)=O Chemical compound C[C@@H](C1)c2cc(/C(/C=N)=C/NC)ccc2N1c1n[n]([C@@H]2COCC2)c(CC2)c1CN2C(C)=O KTZSWHMPAOVIBK-PROIXAHCSA-N 0.000 description 1
- JYXKEWDWKKISID-INIZCTEOSA-N C[C@@H](C1CC1)[n](c(CC1)c2CN1C(NC)=O)nc2N(CCC1)c2c1cc(-c1c[n](C)nc1)c(C(F)F)c2 Chemical compound C[C@@H](C1CC1)[n](c(CC1)c2CN1C(NC)=O)nc2N(CCC1)c2c1cc(-c1c[n](C)nc1)c(C(F)F)c2 JYXKEWDWKKISID-INIZCTEOSA-N 0.000 description 1
- DJTQTXGNRGBCOD-KRWDZBQOSA-N C[C@@H](Cc1c2)CN(C(C(CN(CC3)C(NC)=O)=C3NC3CCOCC3)=N)c1cc(C(F)F)c2-c1c[n](C)nc1 Chemical compound C[C@@H](Cc1c2)CN(C(C(CN(CC3)C(NC)=O)=C3NC3CCOCC3)=N)c1cc(C(F)F)c2-c1c[n](C)nc1 DJTQTXGNRGBCOD-KRWDZBQOSA-N 0.000 description 1
- KAJXBJOCILTJII-NSHDSACASA-N C[C@@H]1c(cc(cc2)-c3c[n](C)nc3)c2N(C)CC1 Chemical compound C[C@@H]1c(cc(cc2)-c3c[n](C)nc3)c2N(C)CC1 KAJXBJOCILTJII-NSHDSACASA-N 0.000 description 1
- MLRPMBYWAALRFR-GOSISDBHSA-N C[C@H](C1)N(C)c(cc(-c2c[n](C)nc2)c(NC)c2)c2N1c1n[n](C2CCOCC2)c(CC2)c1CN2C(C)=O Chemical compound C[C@H](C1)N(C)c(cc(-c2c[n](C)nc2)c(NC)c2)c2N1c1n[n](C2CCOCC2)c(CC2)c1CN2C(C)=O MLRPMBYWAALRFR-GOSISDBHSA-N 0.000 description 1
- KTZSWHMPAOVIBK-OXODIXQHSA-N C[C@H](C1)c(cc(cc2)/C(/C=N)=C/NC)c2N1c1n[n]([C@@H]2COCC2)c(CC2)c1CN2C(C)=O Chemical compound C[C@H](C1)c(cc(cc2)/C(/C=N)=C/NC)c2N1c1n[n]([C@@H]2COCC2)c(CC2)c1CN2C(C)=O KTZSWHMPAOVIBK-OXODIXQHSA-N 0.000 description 1
- YWKGZWFAUXSDJY-OXQOHEQNSA-N C[C@H](C1)c2cc(-c3c[n](C)nc3)ccc2N1c1n[n]([C@H]2COCC2)c(CC2)c1CN2C(C)=O Chemical compound C[C@H](C1)c2cc(-c3c[n](C)nc3)ccc2N1c1n[n]([C@H]2COCC2)c(CC2)c1CN2C(C)=O YWKGZWFAUXSDJY-OXQOHEQNSA-N 0.000 description 1
- YBDQLHBVNXARAU-ZCFIWIBFSA-N C[C@H]1OCCCC1 Chemical compound C[C@H]1OCCCC1 YBDQLHBVNXARAU-ZCFIWIBFSA-N 0.000 description 1
- JGXJVICBEGNSIF-SJQKCGLASA-O C[C@H]1c(cc(cc2)/C(/C=[NH2+])=C/NC)c2N(C)CC1 Chemical compound C[C@H]1c(cc(cc2)/C(/C=[NH2+])=C/NC)c2N(C)CC1 JGXJVICBEGNSIF-SJQKCGLASA-O 0.000 description 1
- FYMVTDZRRWWRBV-UHFFFAOYSA-N C[N+]1(CCC2(CC2)CC1)[O-] Chemical compound C[N+]1(CCC2(CC2)CC1)[O-] FYMVTDZRRWWRBV-UHFFFAOYSA-N 0.000 description 1
- HSZOMYJQTCPQFF-UHFFFAOYSA-N C[n](cc1)nc1-c(cc1)cc2c1N(C)CCC2 Chemical compound C[n](cc1)nc1-c(cc1)cc2c1N(C)CCC2 HSZOMYJQTCPQFF-UHFFFAOYSA-N 0.000 description 1
- HYRKQAWMRNJTNV-UHFFFAOYSA-N C[n]1nc(C(F)F)c(-c(cc2)cc3c2N(C)CCC3)c1 Chemical compound C[n]1nc(C(F)F)c(-c(cc2)cc3c2N(C)CCC3)c1 HYRKQAWMRNJTNV-UHFFFAOYSA-N 0.000 description 1
- YMTQPRIAAJEJJH-UHFFFAOYSA-N C[n]1ncc(-c(c(OC)c2)cc3c2N(C)CCC3)c1 Chemical compound C[n]1ncc(-c(c(OC)c2)cc3c2N(C)CCC3)c1 YMTQPRIAAJEJJH-UHFFFAOYSA-N 0.000 description 1
- QVTYVXATVZRULO-UHFFFAOYSA-N C[n]1ncc(-c(cc(CCCN2C)c2c2)c2C#N)c1 Chemical compound C[n]1ncc(-c(cc(CCCN2C)c2c2)c2C#N)c1 QVTYVXATVZRULO-UHFFFAOYSA-N 0.000 description 1
- VTYXZXKTLLVOSE-UHFFFAOYSA-N C[n]1ncc(-c(cc2)cc(C3)c2N(C)CC3c2ccccc2)c1 Chemical compound C[n]1ncc(-c(cc2)cc(C3)c2N(C)CC3c2ccccc2)c1 VTYXZXKTLLVOSE-UHFFFAOYSA-N 0.000 description 1
- CDPTWLTVTCIUCU-UHFFFAOYSA-N C[n]1ncc(-c(cc2)cc3c2N(C)CC(COC)C3)c1 Chemical compound C[n]1ncc(-c(cc2)cc3c2N(C)CC(COC)C3)c1 CDPTWLTVTCIUCU-UHFFFAOYSA-N 0.000 description 1
- PMARIRPNODGTDV-UHFFFAOYSA-N C[n]1ncc(-c(cc2)cc3c2N(C)CCC3CO)c1 Chemical compound C[n]1ncc(-c(cc2)cc3c2N(C)CCC3CO)c1 PMARIRPNODGTDV-UHFFFAOYSA-N 0.000 description 1
- TVRLTDQPAUCUOE-UHFFFAOYSA-N C[n]1ncc(-c(cc2)cc3c2N(C)CCN3)c1 Chemical compound C[n]1ncc(-c(cc2)cc3c2N(C)CCN3)c1 TVRLTDQPAUCUOE-UHFFFAOYSA-N 0.000 description 1
- QVFCQBWCSZMULB-UHFFFAOYSA-N Cc(cc(C(NC)=O)nc1)c1-c(c(C#N)c1)cc2c1N(C)CCC2 Chemical compound Cc(cc(C(NC)=O)nc1)c1-c(c(C#N)c1)cc2c1N(C)CCC2 QVFCQBWCSZMULB-UHFFFAOYSA-N 0.000 description 1
- AFZXPYWOBUSUHJ-UHFFFAOYSA-N Cc(cc(c(CCC1)c2)N1c1n[n](C3CCOCC3)c(CC3)c1CN3C(NC)=O)c2-c1c[n](C)nc1 Chemical compound Cc(cc(c(CCC1)c2)N1c1n[n](C3CCOCC3)c(CC3)c1CN3C(NC)=O)c2-c1c[n](C)nc1 AFZXPYWOBUSUHJ-UHFFFAOYSA-N 0.000 description 1
- KFVPUFFWZHPGKR-UHFFFAOYSA-N Cc1c(-c2c(C(F)F)cc3N(C)CCCc3c2)[s]c(C)n1 Chemical compound Cc1c(-c2c(C(F)F)cc3N(C)CCCc3c2)[s]c(C)n1 KFVPUFFWZHPGKR-UHFFFAOYSA-N 0.000 description 1
- IXRUIAJQIUHYEB-UHFFFAOYSA-N Cc1cc(-c(c(C#N)c2)cc3c2N(C)CCC3)cnc1C(NC)=O Chemical compound Cc1cc(-c(c(C#N)c2)cc3c2N(C)CCC3)cnc1C(NC)=O IXRUIAJQIUHYEB-UHFFFAOYSA-N 0.000 description 1
- TWJOIFSCBRNBBE-UHFFFAOYSA-N Cc1cc(-c(c(C(F)F)c2)cc3c2N(C)CCC3)n[n]1C Chemical compound Cc1cc(-c(c(C(F)F)c2)cc3c2N(C)CCC3)n[n]1C TWJOIFSCBRNBBE-UHFFFAOYSA-N 0.000 description 1
- DLJJEYCPQOXWES-UHFFFAOYSA-N Cc1cc(-c(cc(CCCN2C)c2c2)c2C#N)ncc1 Chemical compound Cc1cc(-c(cc(CCCN2C)c2c2)c2C#N)ncc1 DLJJEYCPQOXWES-UHFFFAOYSA-N 0.000 description 1
- CILODPACWHFOCO-UHFFFAOYSA-N Cc1cc(-c2c[n](C)nc2)cc(I)c1 Chemical compound Cc1cc(-c2c[n](C)nc2)cc(I)c1 CILODPACWHFOCO-UHFFFAOYSA-N 0.000 description 1
- LXTLBLFQNPYOTF-UHFFFAOYSA-N Cc1cc(N(C)CCC2)c2cc1-c1c[n](C)nc1 Chemical compound Cc1cc(N(C)CCC2)c2cc1-c1c[n](C)nc1 LXTLBLFQNPYOTF-UHFFFAOYSA-N 0.000 description 1
- ILGIZHJZQMOHKT-UHFFFAOYSA-N Cc1ccc(-c(c(C#N)c2)cc3c2N(C)CCC3)nc1 Chemical compound Cc1ccc(-c(c(C#N)c2)cc3c2N(C)CCC3)nc1 ILGIZHJZQMOHKT-UHFFFAOYSA-N 0.000 description 1
- WBFBGAIIYFQWBH-UHFFFAOYSA-N Cc1cnccc1-c(c(C#N)c1)cc2c1N(C)CCC2 Chemical compound Cc1cnccc1-c(c(C#N)c1)cc2c1N(C)CCC2 WBFBGAIIYFQWBH-UHFFFAOYSA-N 0.000 description 1
- CMVMLEAWGSGYEC-UHFFFAOYSA-N Cc1n[n](C)cc1-c(c(C#N)c1)cc2c1N(C)CCC2 Chemical compound Cc1n[n](C)cc1-c(c(C#N)c1)cc2c1N(C)CCC2 CMVMLEAWGSGYEC-UHFFFAOYSA-N 0.000 description 1
- MINYWMSCUCJKMH-UHFFFAOYSA-N Cc1nc(-c(c(C#N)c2)cc3c2N(C)CCC3)ccc1 Chemical compound Cc1nc(-c(c(C#N)c2)cc3c2N(C)CCC3)ccc1 MINYWMSCUCJKMH-UHFFFAOYSA-N 0.000 description 1
- FWBGXVWXBCQJRM-UHFFFAOYSA-N Cc1ncc(-c(c(C(F)F)c2)cc3c2N(C)CCC3)[s]1 Chemical compound Cc1ncc(-c(c(C(F)F)c2)cc3c2N(C)CCC3)[s]1 FWBGXVWXBCQJRM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014092380 | 2014-11-27 | ||
| CNPCT/CN2014/092380 | 2014-11-27 | ||
| CNPCT/CN2015/092965 | 2015-10-27 | ||
| CN2015092965 | 2015-10-27 | ||
| PCT/US2015/062794 WO2016086200A1 (en) | 2014-11-27 | 2015-11-25 | 4,5,6,7-tetrahydro-1 h-pyrazolo[4,3-c]pyridin-3-amine compounds as cbp and/or ep300 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537100A JP2017537100A (ja) | 2017-12-14 |
| JP2017537100A5 true JP2017537100A5 (https=) | 2019-01-10 |
| JP6771464B2 JP6771464B2 (ja) | 2020-10-21 |
Family
ID=55024234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528520A Active JP6771464B2 (ja) | 2014-11-27 | 2015-11-25 | Ｃｂｐおよび／またはｅｐ３００インヒビターとしての、４，５，６，７−テトラヒドロ−１ｈ−ピラゾロ［４，３−ｃ］ピリジン−３−アミン化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9763922B2 (https=) |
| EP (2) | EP3632915A1 (https=) |
| JP (1) | JP6771464B2 (https=) |
| CN (1) | CN107531690B (https=) |
| WO (1) | WO2016086200A1 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA40940A (fr) * | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| MA40943A (fr) | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| WO2016077375A1 (en) | 2014-11-10 | 2016-05-19 | Genentech, Inc. | Bromodomain inhibitors and uses thereof |
| CA2969417A1 (en) * | 2014-12-05 | 2016-06-09 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Bromodomain inhibitor as adjuvant in cancer immunotherapy |
| EP3250571B1 (en) | 2015-01-29 | 2022-11-30 | Genentech, Inc. | Therapeutic compounds and uses thereof |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| EP3464286B1 (en) * | 2016-05-24 | 2021-08-18 | Genentech, Inc. | Pyrazolopyridine derivatives for the treatment of cancer |
| MA45122A (fr) * | 2016-05-24 | 2019-04-10 | Constellation Pharmaceuticals Inc | Inhibiteurs hétérocycliques de cbp/ep300 et leur utilisation dans le traitement du cancer |
| AU2017302554A1 (en) | 2016-07-25 | 2019-01-31 | Epizyme, Inc. | CREBBP related cancer therapy |
| GB201617630D0 (en) * | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201617627D0 (en) * | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| JP7134173B2 (ja) * | 2017-06-21 | 2022-09-09 | 第一三共株式会社 | Ｅｐ３００／ｃｒｅｂｂｐ阻害剤 |
| US11292791B2 (en) | 2017-09-15 | 2022-04-05 | Forma Therapeutics, Inc. | Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors |
| MA50520A (fr) | 2017-11-02 | 2020-09-09 | Aicuris Gmbh & Co Kg | Nouveaux indole-2-carboxamides à substitution pyrazolo-pipéridine hautement actifs agissant contre le virus de l'hépatite b (vhb) |
| AU2019245403B2 (en) * | 2018-03-29 | 2025-02-06 | Board Of Regents, The University Of Texas System | Imidazopiperazine inhibitors of transcription activating proteins |
| WO2019195846A1 (en) | 2018-04-06 | 2019-10-10 | Board Of Regents, The University Of Texas System | Imidazopiperazinone inhibitors of transcription activating proteins |
| GB201806320D0 (en) * | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
| GB201809295D0 (en) | 2018-06-06 | 2018-07-25 | Institute Of Cancer Res Royal Cancer Hospital | Lox inhibitors |
| IL279734B2 (en) * | 2018-06-29 | 2024-11-01 | Forma Therapeutics Inc | Inhibiting creb binding protein (cbp) |
| EP3587418B1 (en) * | 2018-06-29 | 2021-09-01 | Forma Therapeutics, Inc. | Inhibitors of creb binding protein (cbp) |
| CN109187832B (zh) * | 2018-09-30 | 2021-07-30 | 华润三九医药股份有限公司 | Lc-ms/ms测定去氧肾上腺素浓度的方法及样品的前处理方法 |
| GB201818750D0 (en) | 2018-11-16 | 2019-01-02 | Institute Of Cancer Res Royal Cancer Hospital | Lox inhibitors |
| CN111320621B (zh) * | 2018-12-14 | 2022-10-04 | 中国科学院广州生物医药与健康研究院 | 一种吲嗪类化合物及其制备方法和应用 |
| SMT202400386T1 (it) * | 2019-02-27 | 2024-11-15 | Constellation Pharmaceuticals Inc | Derivati di n-(piridinil)acetammide come inibitori di hat p300/cbp e metodi per il loro utilizzo |
| CN113646002A (zh) * | 2019-02-27 | 2021-11-12 | 上海睿跃生物科技有限公司 | 环amp反应元件结合蛋白(cbp)和/或300kda腺病毒e1a结合蛋白(p300)降解化合物和使用方法 |
| US12351577B2 (en) | 2019-03-15 | 2025-07-08 | Forma Therapeutics, Inc. | Inhibiting cyclic AMP-responsive element-binding protein (CREB) |
| AU2020241709B2 (en) * | 2019-03-15 | 2025-12-04 | Forma Therapeutics, Inc. | Compositions and methods for treating androgen receptor positive forms of cancer |
| US20220227760A1 (en) * | 2019-05-29 | 2022-07-21 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| CN110170052B (zh) * | 2019-06-21 | 2020-07-10 | 复旦大学 | Cbp-p300抑制剂在肠道损伤疾病中的应用 |
| TW202120095A (zh) * | 2019-08-05 | 2021-06-01 | 美商美國禮來大藥廠 | 7,8-二氫-4H-吡唑并[4,3-c]氮呯-6-酮化合物 |
| CN114761013A (zh) | 2019-09-27 | 2022-07-15 | 迪斯克医药公司 | 治疗骨髓纤维化和相关病症的方法 |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| AU2021259814B2 (en) * | 2020-04-25 | 2023-09-28 | Pharmablock Sciences (Nanjing), Inc. | CBP/EP300 inhibitor and use thereof |
| WO2021231798A1 (en) | 2020-05-13 | 2021-11-18 | Disc Medicine, Inc. | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| US20240100170A1 (en) * | 2020-08-27 | 2024-03-28 | Cullgen (Shanghai), Inc. | Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use |
| US11795168B2 (en) | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
| US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
| JP7777131B2 (ja) | 2020-10-02 | 2025-11-27 | ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム | 転写活性化タンパク質のイミダゾピペラジン阻害剤 |
| WO2022072648A1 (en) * | 2020-10-02 | 2022-04-07 | Board Of Regents, The University Of Texas System | Imidazopiperazine inhibitors of transcription activating proteins |
| US20240122941A1 (en) * | 2020-12-25 | 2024-04-18 | National Cancer Center | Therapy based on synthetic lethality in swi/snf complex-dysfunction cancer |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| AU2022271550B2 (en) * | 2021-05-14 | 2026-03-12 | Wuhan Ll Science And Technology Development Co., Ltd. | Acid addition salt of rock inhibitor, and crystal form, composition and pharmaceutical use thereof |
| CR20240191A (es) | 2021-11-12 | 2024-09-13 | Insilico Medicine Ip Ltd | Inhibidores de molécula pequeña de proteasa 1 específica de ubiquitina (usp1) y usos de los mismos |
| CN117843618A (zh) * | 2022-08-29 | 2024-04-09 | 北京沐华生物科技有限责任公司 | 一种ep300/cbp调节剂及其制备方法和用途 |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| CN121773104A (zh) * | 2023-06-30 | 2026-03-31 | 北京双鹤润创科技有限公司 | 肌成束蛋白抑制剂 |
| CN117069956B (zh) * | 2023-08-22 | 2025-04-08 | 南京科技职业学院 | 一种具有一维超分子结构的手性膦镍(ii)配合物及其制备方法和应用 |
| WO2025111184A1 (en) | 2023-11-21 | 2025-05-30 | Fmc Corporation | Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides |
| WO2025108411A1 (zh) * | 2023-11-24 | 2025-05-30 | 北京沐华生物科技有限责任公司 | 一种ep300/cbp调节剂及其制备方法和用途 |
| WO2025222158A1 (en) * | 2024-04-19 | 2025-10-23 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| EP0491007B1 (en) | 1989-09-08 | 1996-03-13 | The Johns Hopkins University | Structural alterations of the egf receptor gene in human gliomas |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| EP0659439B1 (en) | 1993-12-24 | 2001-10-24 | MERCK PATENT GmbH | Immunoconjugates |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| US5679683A (en) | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| PL179659B1 (pl) | 1994-07-21 | 2000-10-31 | Akzo Nobel Nv | Kompozycja cyklicznych nadtlenków ketonów sluzaca do modyfikowania (ko)polimerów zwlaszcza do degradacji polipropylenu PL PL PL PL PL PL PL |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| MX9707453A (es) | 1995-03-30 | 1997-12-31 | Pfizer | Derivados de quinazolina. |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| AU6267896A (en) | 1995-06-07 | 1996-12-30 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth oftumors |
| MX9800215A (es) | 1995-07-06 | 1998-03-31 | Novartis Ag | Pirrolopirimidas y procesos para su preparacion. |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| HU228446B1 (en) | 1996-04-12 | 2013-03-28 | Warner Lambert Co | Kinazoline derivatives as irreversible inhibitors of protein-kinase, pharmaceutical compositions containing these compounds and use thereof |
| ID19609A (id) | 1996-07-13 | 1998-07-23 | Glaxo Group Ltd | Senyawa-senyawa heterosiklik |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| ATE241986T1 (de) | 1997-05-06 | 2003-06-15 | Wyeth Corp | Verwendung von chinazolin verbindungen zur behandlung von polyzystischer nierenkrankheit |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| CN1278176A (zh) | 1997-11-06 | 2000-12-27 | 美国氰胺公司 | 喹唑啉衍生物作为用于治疗结肠息肉的酪氨酸激酶抑制剂的应用 |
| WO2000031048A1 (en) | 1998-11-19 | 2000-06-02 | Warner-Lambert Company | N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, an irreversible inhibitor of tyrosine kinases |
| JP2005537290A (ja) | 2002-07-25 | 2005-12-08 | ファルマシア・イタリア・エス・ピー・エー | キナーゼ阻害剤として活性なビシクロピラゾール類、その製造方法、およびそれを含有する薬学的組成物 |
| CA2493625A1 (en) | 2002-07-25 | 2004-02-19 | Pharmacia Italia S.P.A. | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| MXPA05009719A (es) | 2003-03-11 | 2005-10-18 | Pharmacia Italia Spa | Derivados de biciclo-pirazol activos como inhibidores de cinasa, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden. |
| RU2494107C2 (ru) | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| US7947686B2 (en) | 2005-12-12 | 2011-05-24 | Nerviano Medical Sciences S.R.L. | Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors |
| WO2007099166A1 (en) | 2006-03-03 | 2007-09-07 | Nerviano Medical Sciences S.R.L. | Pyrazolo-pyridine derivatives active as kinase inhibitors |
| WO2009084693A1 (ja) * | 2007-12-28 | 2009-07-09 | Mitsubishi Tanabe Pharma Corporation | 抗癌剤 |
| PT2242773T (pt) | 2008-02-11 | 2017-09-15 | Cure Tech Ltd | Anticorpos monoclonais para o tratamento de tumores |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| CL2009001158A1 (es) | 2008-05-15 | 2009-10-23 | Nerviano Medical Sciences Srl | Compuestos derivados de los acidos carboxilicos, tales como 5,6-dihiro-4h-pirrolo[3,4-c]pirazol, furo[3,2-c]pirazol, tieno[2,3-c]pirazol, 4,5,6,7-tetrahidropirazol[4,3-c]piridina e indazol; composicion farmaceutica; y su uso en el tratamiento de trastornos proliferativos celulares asociados a la actividad de proteina quinasa alterada, tal como el cancer. |
| WO2010098788A2 (en) | 2008-08-25 | 2010-09-02 | Amplimmune, Inc. | Pd-i antagonists and methods for treating infectious disease |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| CN101812063B (zh) | 2010-03-18 | 2012-04-25 | 中国医学科学院医药生物技术研究所 | α-萘磺酰胺基五元杂环类化合物及其抑瘤活性 |
| WO2013097052A1 (en) * | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| WO2013148114A1 (en) * | 2012-03-30 | 2013-10-03 | University Of Florida Research Foundation, Inc. | P300/cbp inhibitors and methods of use |
| WO2014138727A1 (en) * | 2013-03-08 | 2014-09-12 | Board Of Regents, The University Of Texas System | Suppression of malignant mesothelioma by overexpression or stimulation of endothelial protein c receptors (epcr) |
-
2015
- 2015-11-25 US US14/952,821 patent/US9763922B2/en active Active
- 2015-11-25 JP JP2017528520A patent/JP6771464B2/ja active Active
- 2015-11-25 WO PCT/US2015/062794 patent/WO2016086200A1/en not_active Ceased
- 2015-11-25 EP EP19191423.3A patent/EP3632915A1/en not_active Withdrawn
- 2015-11-25 CN CN201580074597.7A patent/CN107531690B/zh active Active
- 2015-11-25 EP EP15816578.7A patent/EP3224258B1/en active Active
-
2017
- 2017-08-02 US US15/667,227 patent/US20170333406A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017537100A5 (https=) | ||
| JP2017530176A5 (https=) | ||
| JP2019516757A5 (https=) | ||
| JP2019516759A5 (https=) | ||
| JP2017526696A5 (https=) | ||
| JP2017533250A5 (https=) | ||
| JP2017533249A5 (https=) | ||
| JP6835472B2 (ja) | 癌の処置のための組成物 | |
| AU2017200269B2 (en) | Methods of using c-Met modulators | |
| JP2018501287A5 (https=) | ||
| JP2018510851A5 (https=) | ||
| CN102985403B (zh) | 具有抗雄激素性质的新型芳基酰胺衍生物 | |
| JP2016529312A5 (https=) | ||
| Li et al. | Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain | |
| ZA200307665B (en) | Combination comprising N-{5-[4-(4-methyl-piperazinomethyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and a chemotherapeutic agent. | |
| JP2018507191A5 (https=) | ||
| KR20140025433A (ko) | Ａｋｔ 억제제 화합물 및 베무라페닙의 조합물, 및 사용 방법 | |
| JP2014506601A5 (https=) | ||
| RU2020131507A (ru) | Имидазопиперазиновые ингибиторы белков-активаторов транскрипции | |
| US20220160672A1 (en) | Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof | |
| JP2019529444A5 (https=) | ||
| IL191803A (en) | Substances that bind intracranial receptors | |
| TW201016671A (en) | Novel imidazolidine compounds as androgen receptor modulators | |
| JP2011521938A5 (https=) | ||
| CA2604907A1 (en) | Combination cancer therapy with bis(thiohydrazide) amide compounds |