CN107531690B - 用作CBP和/或EP300抑制剂的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶-3-胺化合物 - Google Patents

用作CBP和/或EP300抑制剂的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶-3-胺化合物 Download PDF

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CN107531690B
CN107531690B CN201580074597.7A CN201580074597A CN107531690B CN 107531690 B CN107531690 B CN 107531690B CN 201580074597 A CN201580074597 A CN 201580074597A CN 107531690 B CN107531690 B CN 107531690B
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alkyl
independently selected
methyl
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CN107531690A (zh
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F·A·罗梅罗
S·马格努森
R·帕斯特
V·H-W·徐
J·默里
T·克劳福德
B·K·阿尔布雷克特
A·科特
A·M·泰勒
K·W·赖
K·X·陈
S·布朗纳
M·阿德勒
J·埃根
J·廖
F·王
P·西尔
B-Y·朱
S·考德
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Genentech Inc
Constellation Pharmaceuticals Inc
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Constellation Pharmaceuticals Inc
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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CN201580074597.7A 2014-11-27 2015-11-25 用作CBP和/或EP300抑制剂的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶-3-胺化合物 Active CN107531690B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2014092380 2014-11-27
CNPCT/CN2014/092380 2014-11-27
CNPCT/CN2015/092965 2015-10-27
CN2015092965 2015-10-27
PCT/US2015/062794 WO2016086200A1 (en) 2014-11-27 2015-11-25 4,5,6,7-tetrahydro-1 h-pyrazolo[4,3-c]pyridin-3-amine compounds as cbp and/or ep300 inhibitors

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CN107531690A CN107531690A (zh) 2018-01-02
CN107531690B true CN107531690B (zh) 2020-11-06

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US (2) US9763922B2 (https=)
EP (2) EP3632915A1 (https=)
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