JP2017537066A5 - - Google Patents

Download PDF

Info

Publication number
JP2017537066A5
JP2017537066A5 JP2017521517A JP2017521517A JP2017537066A5 JP 2017537066 A5 JP2017537066 A5 JP 2017537066A5 JP 2017521517 A JP2017521517 A JP 2017521517A JP 2017521517 A JP2017521517 A JP 2017521517A JP 2017537066 A5 JP2017537066 A5 JP 2017537066A5
Authority
JP
Japan
Prior art keywords
compound
formula
pharmaceutically acceptable
acceptable salt
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017521517A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017537066A (ja
JP6567049B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/056686 external-priority patent/WO2016065019A1/en
Publication of JP2017537066A publication Critical patent/JP2017537066A/ja
Publication of JP2017537066A5 publication Critical patent/JP2017537066A5/ja
Application granted granted Critical
Publication of JP6567049B2 publication Critical patent/JP6567049B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017521517A 2014-10-21 2015-10-21 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 Active JP6567049B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462066771P 2014-10-21 2014-10-21
US62/066,771 2014-10-21
PCT/US2015/056686 WO2016065019A1 (en) 2014-10-21 2015-10-21 Carbidopa and l-dopa prodrugs and their use to treat parkinson's disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019139442A Division JP6750076B2 (ja) 2014-10-21 2019-07-30 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法

Publications (3)

Publication Number Publication Date
JP2017537066A JP2017537066A (ja) 2017-12-14
JP2017537066A5 true JP2017537066A5 (index.php) 2019-07-11
JP6567049B2 JP6567049B2 (ja) 2019-08-28

Family

ID=54478240

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2017521517A Active JP6567049B2 (ja) 2014-10-21 2015-10-21 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2019139442A Active JP6750076B2 (ja) 2014-10-21 2019-07-30 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2020135560A Active JP6932227B2 (ja) 2014-10-21 2020-08-11 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2021132161A Pending JP2021183628A (ja) 2014-10-21 2021-08-16 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2023174083A Active JP7688087B2 (ja) 2014-10-21 2023-10-06 カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法
JP2025084629A Pending JP2025118978A (ja) 2014-10-21 2025-05-21 カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2019139442A Active JP6750076B2 (ja) 2014-10-21 2019-07-30 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2020135560A Active JP6932227B2 (ja) 2014-10-21 2020-08-11 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2021132161A Pending JP2021183628A (ja) 2014-10-21 2021-08-16 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2023174083A Active JP7688087B2 (ja) 2014-10-21 2023-10-06 カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法
JP2025084629A Pending JP2025118978A (ja) 2014-10-21 2025-05-21 カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法

Country Status (37)

Country Link
US (7) US9446059B2 (index.php)
EP (3) EP3569587A1 (index.php)
JP (6) JP6567049B2 (index.php)
KR (3) KR20230066484A (index.php)
CN (4) CN111454290B (index.php)
AR (1) AR102389A1 (index.php)
AU (4) AU2015335941B2 (index.php)
BR (1) BR112017008198B1 (index.php)
CA (1) CA2965379A1 (index.php)
CY (2) CY1121826T1 (index.php)
DK (1) DK3209302T3 (index.php)
ES (1) ES2739536T3 (index.php)
FI (1) FIC20230014I1 (index.php)
FR (1) FR23C1035I2 (index.php)
HR (1) HRP20191285T1 (index.php)
HU (2) HUE044115T2 (index.php)
IL (3) IL251829B (index.php)
LT (2) LT3209302T (index.php)
LU (1) LUC00304I2 (index.php)
MX (2) MX393568B (index.php)
MY (1) MY189519A (index.php)
NL (1) NL301224I2 (index.php)
NO (1) NO2023013I1 (index.php)
PH (1) PH12017500746B1 (index.php)
PL (1) PL3209302T3 (index.php)
PT (1) PT3209302T (index.php)
RS (1) RS58972B1 (index.php)
RU (2) RU2021103000A (index.php)
SA (1) SA521421115B1 (index.php)
SG (1) SG11201703170RA (index.php)
SI (1) SI3209302T1 (index.php)
SM (1) SMT201900376T1 (index.php)
TR (1) TR201908296T4 (index.php)
TW (2) TWI755257B (index.php)
UA (1) UA120437C2 (index.php)
WO (1) WO2016065019A1 (index.php)
ZA (1) ZA201702760B (index.php)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10022320B2 (en) 2014-03-13 2018-07-17 Neuroderm, Ltd. Dopa decarboxylase inhibitor compositions
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
CN111454290B (zh) 2014-10-21 2022-12-23 艾伯维公司 卡比多巴和左旋多巴前药及它们治疗帕金森病的用途
JP2019515908A (ja) * 2016-04-20 2019-06-13 アッヴィ・インコーポレイテッド カルビドパ及びｌ−ドパプロドラッグ並びに使用方法
WO2017223182A1 (en) * 2016-06-22 2017-12-28 Medchem Partners, Llc. Nitric oxide donors
WO2018154447A1 (en) * 2017-02-21 2018-08-30 Neuroderm Ltd Dopa decarboxylase inhibitor compositions
US20180311238A1 (en) * 2017-04-28 2018-11-01 Saniona A/S Selective Agonist Of a6 Containing nAChRs
WO2019097120A1 (en) 2017-11-16 2019-05-23 Orion Corporation New use and pharmaceutical dosage forms
AR113908A1 (es) 2017-11-24 2020-06-24 H Lundbeck As Profármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson
CN110294789A (zh) * 2018-03-21 2019-10-01 海南大学 含多巴寡肽的合成方法及其在抗帕金森病前药方面的应用
CN112770734B (zh) 2018-09-13 2024-08-20 堪培拉大学 抑制方法
TW202031265A (zh) * 2018-11-15 2020-09-01 美商艾伯維有限公司 用於皮下投藥之醫藥調配物
WO2020178810A1 (en) * 2019-03-04 2020-09-10 Neuroderm, Ltd. Pharmaceutical compositions comprising levodopa amide derivatives and uses thereof
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
JP7514859B2 (ja) 2019-05-21 2024-07-11 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
US12391650B2 (en) 2019-05-21 2025-08-19 H. Lundbeck A/S Catecholamine prodrugs for use in the treatment of Parkinson's disease
CN113727979B (zh) 2019-05-21 2024-09-20 H.隆德贝克有限公司 用于治疗帕金森病的新儿茶酚胺前药
WO2020234277A1 (en) 2019-05-21 2020-11-26 H. Lundbeck A/S Catecholamine carbamate prodrugs for use in the treatment of parkinson s disease
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
EP4223288B1 (en) 2022-02-07 2024-03-06 Berlirem GmbH Novel kit of pharmaceutical preparations for the treatment of parkinson's disease
US12161612B2 (en) 2023-04-14 2024-12-10 Neuroderm, Ltd. Methods and compositions for reducing symptoms of Parkinson's disease

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3132171A (en) 1962-06-18 1964-05-05 Strong Cobb Arner Inc 3, 4-diphosphatophenyl-alanine and process for making same
US4016288A (en) * 1975-08-13 1977-04-05 Merck & Co., Inc. Compositions and method of treating hypertension
DD230865B1 (de) * 1982-08-09 1987-05-20 Dresden Arzneimittel Verfahren zur herstellung von hydrazinocarbonsaeurederivaten durch n-aminierung von aminocarbonsaeurederivaten
US4508706A (en) * 1983-03-30 1985-04-02 Yale University Composition for increasing melanin in mammalian skin and hair
US4618484A (en) 1983-03-30 1986-10-21 Yale University Composition and method for treatment of melanomas
IT1213182B (it) * 1984-06-25 1989-12-14 Simes Derivati di composti a struttura catecolamminica.
US4616484A (en) 1984-11-30 1986-10-14 Kysor Industrial Corporation Vehicle refrigerant heating and cooling system
IT1200427B (it) 1985-03-22 1989-01-18 Afros Spa Procedimento ed impianto per lo stampaggio di pezzi in materiale plastico espanso,con parti o inserti preformati a spruzzo nello stesso stampo di formatura
JPH02138A (ja) 1987-09-18 1990-01-05 Banyu Pharmaceut Co Ltd Ｌ‐ドーパ誘導体
IT1226727B (it) 1988-07-29 1991-02-05 Simes Farmaci precursori della dopamina.
ATE118216T1 (de) * 1989-04-20 1995-02-15 Zambon Spa Dopamin-medikament-vorstufe.
GB9102812D0 (en) 1991-02-11 1991-03-27 Enzymatix Ltd Compounds
IT1255471B (it) 1992-07-30 1995-11-02 Zambon Spa Derivati di catecolammine,processo per la loro preparazione e composizioni farmaceutiche che li contengono
SE9203594D0 (sv) 1992-11-30 1992-11-30 Christer Nystroem Laekemedel i dispersa system
US6576766B1 (en) * 1997-11-12 2003-06-10 Ariad Pharmaceuticals, Inc. Signal transduction inhibitors, compositions containing them
US6365180B1 (en) 1998-01-20 2002-04-02 Glenn A. Meyer Oral liquid compositions
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
KR20050016449A (ko) * 2002-05-29 2005-02-21 임팩스 라보라토리즈, 인코포레이티드 레보도파/카르비도파의 즉시 방출 및 제어 방출 조합 투여형
EP1541579A1 (en) 2002-06-20 2005-06-15 Nippon Suisan Kaisha, Ltd. Produrg, medicinal utilization thereof and process for producing the same
US7101912B2 (en) 2002-12-06 2006-09-05 Xenoport, Inc. Carbidopa prodrugs and derivatives, and compositions and uses thereof
EP1596808A4 (en) 2003-02-07 2007-04-04 Yissum Res Dev Co L-DOPA AMID DERIVATIVES AND THEIR USE
DE602004031134D1 (de) 2003-08-29 2011-03-03 Transform Pharmaceuticals Inc Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa
ES2360759T3 (es) * 2003-08-29 2011-06-08 Centocor Ortho Biotech Inc. Composiciones farmacéuticas y procedimiento de utilización de la levodopa y de la carbidopa.
US20060094782A9 (en) 2003-10-31 2006-05-04 Wong Patrick S Compositions and dosage forms for enhanced absorption
DK1751087T3 (da) 2004-06-04 2012-07-16 Xenoport Inc Levodopa-derivater og sammensætninger og anvendelser deraf
WO2006014282A2 (en) 2004-07-06 2006-02-09 Abbott Laboratories Prodrugs of hiv protease inhibitors
DK1959948T3 (da) * 2005-12-05 2012-08-20 Xenoport Inc Levodopa prodrug-mesylat, sammensætninger deraf og anvendelser deraf
KR20090057349A (ko) * 2006-05-31 2009-06-05 솔베이 파머슈티컬스 게엠베하 레보도파／칼비도파의 ２４시간의 장기간 장내투여
JP2009539942A (ja) * 2006-06-16 2009-11-19 ソルベイ・フアーマシユーチカルズ・ベー・ブイ ビフェプルノックス及びｌ−ｄｏｐａを含む組み合わせ製剤
EP2125702A1 (en) 2006-12-21 2009-12-02 Xenoport, Inc. Levodopa dimethyl-substituted diester prodrugs, compositions, and methods of use
GB0713189D0 (en) 2007-07-06 2007-08-15 Proximagen Ltd Amino acid derivatives
ATE510537T1 (de) * 2008-02-06 2011-06-15 Wockhardt Research Center Pharmazeutische zusammensetzungen von entacapon, levodopa und carbidopa mit verbesserter bioverfügbarkeit
EP2291348A4 (en) 2008-05-20 2013-05-15 Neurogesx Inc WATER-SOLUBLE ACETAMINOPHENANALOGA
US20130253056A1 (en) 2009-05-19 2013-09-26 Neuroderm, Ltd. Continuous Administration of Levodopa and/or Dopa Decarboxylase Inhibitors and Compositions for Same
MX2011012315A (es) 2009-05-19 2011-12-16 Neuroderm Ltd Composiciones para la administracion continua de inhibidores de dopa descarboxilasa.
US8435562B2 (en) 2009-11-09 2013-05-07 Xenoport, Inc. Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use
WO2011109767A2 (en) 2010-03-04 2011-09-09 University Of Notre Dame Du Lac Gelatinase inhibitors and prodrugs
EP3326615B1 (en) 2010-11-15 2020-01-08 Neuroderm Ltd Continuous administration of l-dopa, dopa decarboxylase inhibitors, catechol-o-methyl transferase inhibitors and compositions for same
JP5423905B2 (ja) 2010-12-02 2014-02-19 小野薬品工業株式会社 新規化合物及びその医薬用途
CA2823642A1 (en) 2010-12-10 2012-06-14 Synagile Corporation Subcutaneously infusible levodopa prodrug compositions and methods of infusion
US8765189B2 (en) * 2011-05-13 2014-07-01 Howmedica Osteonic Corp. Organophosphorous and multivalent metal compound compositions and methods
KR20130070371A (ko) * 2011-12-19 2013-06-27 울산대학교 산학협력단 퇴행성 신경질환 예방 또는 치료용 조성물
PT2968218T (pt) 2013-03-13 2021-09-24 Neuroderm Ltd Combinação para tratamento da doença de parkinson
WO2014139161A1 (en) 2013-03-15 2014-09-18 Techfields Pharma Co., Ltd. Novel high penetration drugs and their compositions thereof for treatment of parkinson diseases
CN111454290B (zh) * 2014-10-21 2022-12-23 艾伯维公司 卡比多巴和左旋多巴前药及它们治疗帕金森病的用途
MA41377A (fr) 2015-01-20 2017-11-28 Abbvie Inc Gel intestinal de lévodopa et de carbidona et procédés d'utilisation
JP2019515908A (ja) 2016-04-20 2019-06-13 アッヴィ・インコーポレイテッド カルビドパ及びｌ−ドパプロドラッグ並びに使用方法
WO2018059739A1 (en) 2016-09-29 2018-04-05 Berlirem Gmbh L-dopa derivatives for the treatment of neurological diseases
WO2018154447A1 (en) 2017-02-21 2018-08-30 Neuroderm Ltd Dopa decarboxylase inhibitor compositions

Similar Documents

Publication Publication Date Title
JP2017537066A5 (index.php)
JP2013032389A5 (index.php)
JP2017509667A5 (index.php)
JP2016518337A5 (index.php)
JP2012255026A5 (index.php)
JP2013518107A5 (index.php)
JP2015078230A5 (index.php)
JP2011105738A5 (index.php)
JP2018024682A5 (index.php)
JP2012107057A5 (index.php)
JP2013014622A5 (index.php)
JP2014221779A5 (index.php)
JP2014507446A5 (index.php)
JP2013525444A5 (index.php)
JP2019516735A5 (index.php)
JP2016521119A5 (index.php)
JP2014515013A5 (index.php)
JP2018531941A5 (index.php)
JP2015155440A5 (index.php)
JP2013532687A5 (index.php)
JP2017514910A5 (index.php)
JP2018521020A5 (index.php)
JP2015512931A5 (index.php)
JP2011518833A5 (index.php)
JP2016510326A5 (index.php)